Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T28213 | Target Info | |||
| Target Name | Free fatty acid receptor 2 (FFAR2) | ||||
| Synonyms |
Gprotein coupled receptor 43; FFAR2
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| Target Type | Clinical trial Target | ||||
| Gene Name | FFAR2 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 29 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Acetic Acid, Glacial
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Approved | Compound Info | ||
| Synonyms |
ethanoic acid; 64-19-7; Ethylic acid; Acetic acid glacial; Acetic acid, glacial; Methanecarboxylic acid; Glacial acetic acid; Vinegar acid; Acetasol; Acide acetique; Essigsaeure; Aci-jel; Azijnzuur; Vinegar; Kyselina octova; Acido acetico; Octowy kwas; Pyroligneous acid; HOAc; Azijnzuur [Dutch]; Ethanoic acid monomer; acetyl alcohol; Aceticum acidum; Essigsaeure [German]; ethoic acid; Caswell No 003; Otic Tridesilon; Octowy kwas [Polish]; Otic Domeboro; Acetic acid (natural); Kyselina octova [Czech]; Acide acetique [French]; Orlex; Vosol; Acetic Acid 025% In Plastic Container
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| Activity |
IC50 = 120000 nM
|
[1] | |||
| Compound Name |
Propanoic Acid
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Investigative | Compound Info | ||
| Synonyms |
propionic acid; Propanoic acid; 1979/9/4; ethylformic acid; methylacetic acid; Carboxyethane; Ethanecarboxylic acid; Pseudoacetic acid; Metacetonic acid; Monoprop; Luprosil; Prozoin; Propionoic acid; Acide propionique; Methyl acetic acid; Antischim B; Sentry grain preserver; C3 acid; Tenox P grain preservative; Caswell No. 707; Propionic acid grain preserver; Propionsaeure; Propcorn; Propkorn; propoic acid; Propioic acid; acide propanoique; Propionic acid (natural); Kyselina propionova; Carboxylic acids, C1-5; Acide propioniqu
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| Activity |
IC50 = 130000 nM
|
[1] | |||
| Compound Name |
2-(4-Chlorophenyl)-N-(5-fluorothiazol-2-yl)-2-methylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL611948; BDBM50305928
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
GSK137647A; GSK 137647; GSK-137647A; N-mesityl-4-methoxybenzenesulfonamide; CHEMBL3311308; MFCD02007969; 4-methoxy-N-(2,4,6-trimethylphenyl)-benzenesulfonamide; CBMicro_012617; Oprea1_349531; Oprea1_545891; SCHEMBL19357604; KS-00000TIW; AOB2991; ZINC184126; BCP17136; EX-A1097; GSK 137647A; SMSF0014079; BDBM50044849; STK899558; AKOS003261220; CB15818; CS-5549; GSK-137647; MCULE-5583867808; N-mesityl-4-methoxy-1-benzenesulfonamide; NCGC00387253-02; NCGC00387253-05; AK240703; AS-16737; HY-19995; BIM-0012523.P001; FFA4 (GPR120) agonist GSK137647A; B7793; EU-0076636; FT-0700296; S0001; ST50719559; GSK137647A, >=98% (HPLC); A14542; AJ-292/14925630; SR-01000478738; J-690285; SR-01000478738-1; [(4-methoxyphenyl)sulfonyl](2,4,6-trimethylphenyl)amine; 4-methoxy-N-(2,4,6-trimethylphenyl)benzene-1-sulfonamide; 4-Methoxy-N-(2,4,6-triMethylphenyl)benzenesulfonaMide, 97%
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| Activity |
EC50 ~ 50118.72 nM
|
[2] | |||
| Compound Name |
Rac-2-(4-chlorophenyl)-3-methyl-N-(pyrimidin-2-yl)butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL593351; BDBM50305952
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| Activity |
IC50 = 53000 nM
|
[1] | |||
| Compound Name |
(S)-2-(4-Chlorophenyl)-3-methyl-N-(pyridin-4-yl)butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL593433; BDBM50305947; ZINC12747800
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| Activity |
IC50 = 56000 nM
|
[1] | |||
| Compound Name |
(S)-2-(4-Chlorophenyl)-3-methyl-N-(1,2,3-thiadiazol-5-yl)butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL596580; BDBM50305963
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| Activity |
IC50 = 57000 nM
|
[1] | |||
| Compound Name |
(S)-2-(2-(4-Chlorophenyl)-3-methylbutanamido)thiazole-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL607691; BDBM50305903
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| Activity |
IC50 = 71000 nM
|
[1] | |||
| Compound Name |
(S)-2-(2-(4-Chlorophenyl)-3-methylbutanamido)thiazole-5-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL594140; BDBM50305983
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| Activity |
IC50 = 79000 nM
|
[1] | |||
| Compound Name |
(S)-2-(4-Chlorophenyl)-N,3-dimethyl-N-(thiazol-2-yl)butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL593733; BDBM50305976
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| Activity |
IC50 = 84000 nM
|
[1] | |||
| Compound Name |
(S)-N-Tert-butyl-2-(4-chlorophenyl)-3-methylbutanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL596154; BDBM50305944
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(4-Chlorophenyl)-3-methylbutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
2-(4-Chlorophenyl)-3-methylbutyric acid; alpha-isopropyl-4-chlorophenylacetic acid; 2-(p-Chlorophenyl)-3-methylbutyric acid; (RS)-Fenvaleric acid; 2-(4-Chloro-phenyl)-3-methyl-butyric acid; Benzeneacetic acid, 4-chloro-.alpha.-(1-methylethyl)-; 2-(4-Chloro-phenyl)-3-methylbutyric acid; CHEMBL593203; BUTYRIC ACID, 2-(p-CHLOROPHENYL)-3-METHYL-; .alpha.-(p-Chlorophenyl)isovaleric acid; 2-(p-chlorophenyl)-3-methyl-butyric acid; Benzeneacetic acid, 4-chloro-a-(1-methylethyl)-; alpha-Isopropyl-p-chlorophenylacetic acid; EINECS 217-934-1; MFCD04112625; MFCD11858304; Benzeneacetic acid, 4-chloro-alpha-(1-methylethyl)-; ACMC-1CMZE; Enamine_004948; Fenvalerate (free acid); SCHEMBL68169; KSC496G7B; CTK3J6370; KS-00000GBK; DTXSID00883537; 2-(4-chlorophenyl)isovaleric acid; HMS1408A20; a-Isopropyl-4-chlorophenylaceticacid; isopropyl(4-chlorophenyl)acetic acid; ANW-72193; BDBM50305939; MFCD00037763; SBB008321; alpha-(p-Chlorophenyl)isovaleric acid; AKOS001063747; AKOS016843430; MCULE-7165922745; SB35162; IDI1_007535; NCGC00329284-01; 2-(4-chlorophenyl)3-methyl butyric acid; 2-isopropyl-2-p-chlorophenyl-acetic acid; 4-Chloro-alpha-isopropylbenzeneacetic acid; AK-49543; AK106980; AS-16160; SY025357; SY025440; 2-(4-chlorophenyl)-3-methyl-butyric acid; DB-045102; 2-(4-Chlorophenyl)-3-methylbutanoic acid #; CS-0015834; FT-0608888; ST50320167; rac-2-(4-chlorophenyl)-3-methylbutanoic acid; A23954; Z-4919; 2-(4-Chlorophenyl)-3-methylbutyric acid, 96%; 4-chloro-alpha-(1-methylethyl)benzeneacetic acid; AB00633355-03; 012I740; 4-chloro-alpha-(1-methyl-ethyl)benzeneacetic acid; SR-01000039639; SR-01000039639-1; W-107646; Q27119827; Z56887655
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Rac-2-(4-chlorophenyl)-3-methyl-N-(4-(pyridin-3-yl)thiazol-2-yl)butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL594278; BDBM50305972
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Rac-2-(4-chlorophenyl)-3-methyl-N-(1H-tetrazol-5-yl)butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL593826; BDBM50305960
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| Activity |
IC50 = 100000 nM
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[1] | |||
| Compound Name |
(S)-Methyl 2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanimidate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL594838; BDBM50305937
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2,2-Bis(4-chlorophenyl)-N-(thiazol-2-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL594739; BDBM50305927
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(S)-N-(2-(4-Chlorophenyl)-3-methylbutyl)thiazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL593365; BDBM50305938
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(S)-N-(1-(4-Chlorophenyl)-2-methylpropyl)thiazole-2-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL608129; BDBM50305941
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(S)-2-(4-Chlorophenyl)-3-methyl-N-(1H-pyrazol-3-yl)butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593827; BDBM50305961
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
2-(4-Chlorophenyl)-3-methylbutanamide
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Investigative | Compound Info | ||
| Synonyms |
2-(4-chlorophenyl)-3-methylbutyramide; CHEMBL596152; 2-(4-CHLORO-PHENYL)-3-METHYL-BUTYRAMIDE; SCHEMBL1677071; 1162AJ; BDBM50305942; AKOS008977414; SB38366; rac-2-(4-chlorophenyl)-3-methylbutanamide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-(4-Chlorophenyl)-N-(5-fluorothiazol-2-yl)cyclopropanecarboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL594740; BDBM50305929
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(S)-2-Cyclopropyl-N-(5-fluorothiazol-2-yl)-2-(4-(methylsulfonyl)phenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL595001; BDBM50305934
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(S)-N-Benzyl-2-(4-chlorophenyl)-3-methylbutanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL608130; BDBM50305945
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(S)-N-(1-(4-Chlorophenyl)-2-methylpropyl)thiazole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL593517; BDBM50305977
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(S)-2-(4-Chlorophenyl)-3-methyl-N-phenylbutanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL594514; BDBM50305946
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
Rac-1-(4-chlorophenyl)-2-methyl-N-(thiazol-2-yl)propane-1-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL596151; BDBM50305940
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
(R)-2-(4-Chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL611647; (S)-2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide; ZINC405200; BDBM50305975; B5669
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
2-(4-Chlorophenyl)-N-(1,3-thiazol-2-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL594760; CBMicro_003743; ZINC380689; SMSF0011835; BDBM50305918; STK156575; AKOS000642663; CB05528; MCULE-6942432073; BIM-0003688.P001; 2-(4-chlorophenyl)-N-(thiazol-2-yl)acetamide; SR-01000225679; SR-01000225679-1
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
(S)-2-(4-Chlorophenyl)-4-methoxy-N-(thiazol-2-yl)butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL594597; BDBM50305925
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| Activity |
IC50 = 170000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators. Bioorg Med Chem Lett. 2010 Jan 15;20(2):493-8. | ||||
| REF 2 | Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg Med Chem Lett. 2014 Jul 15;24(14):3100-3. | ||||
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