TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T28213 Free fatty acid receptor 2 D0F1LZ Acetic Acid, Glacial Approved 176 C2H4O2 60.05 CC(=O)O IC50 = 120000 nM Poor binder T28213 Free fatty acid receptor 2 B0YJK1 (S)-2-(4-Chlorophenyl)-3-methyl-N-(1,2,3-thiadiazol-5-yl)butanamide Investigative 46226180 C13H14ClN3OS 295.79 CC(C)[C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=CN=NS2 IC50 = 57000 nM Poor binder T28213 Free fatty acid receptor 2 B0YKX8 Rac-2-(4-chlorophenyl)-3-methyl-N-(pyrimidin-2-yl)butanamide Investigative 46226146 C15H16ClN3O 289.76 CC(C)C(C1=CC=C(C=C1)Cl)C(=O)NC2=NC=CC=N2 IC50 = 53000 nM Poor binder T28213 Free fatty acid receptor 2 B1DXS3 (S)-N-Tert-butyl-2-(4-chlorophenyl)-3-methylbutanamide Investigative 46226107 C15H22ClNO 267.79 CC(C)[C@@H](C1=CC=C(C=C1)Cl)C(=O)NC(C)(C)C IC50 ~ 100000 nM Poor binder T28213 Free fatty acid receptor 2 B26CVM 4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide Investigative 743974 C16H19NO3S 305.4 CC1=CC(=C(C(=C1)C)NS(=O)(=O)C2=CC=C(C=C2)OC)C EC50 ~ 50118.72 nM Poor binder T28213 Free fatty acid receptor 2 B2I7JQ 2-(4-Chlorophenyl)-3-methylbutanoic acid Investigative 16197 C11H13ClO2 212.67 CC(C)C(C1=CC=C(C=C1)Cl)C(=O)O IC50 ~ 100000 nM Poor binder T28213 Free fatty acid receptor 2 B49XJE Rac-2-(4-chlorophenyl)-3-methyl-N-(4-(pyridin-3-yl)thiazol-2-yl)butanamide Investigative 46226237 C19H18ClN3OS 371.9 CC(C)C(C1=CC=C(C=C1)Cl)C(=O)NC2=NC(=CS2)C3=CN=CC=C3 IC50 ~ 100000 nM Poor binder T28213 Free fatty acid receptor 2 B4H8JQ Rac-2-(4-chlorophenyl)-3-methyl-N-(1H-tetrazol-5-yl)butanamide Investigative 46226177 C12H14ClN5O 279.72 CC(C)C(C1=CC=C(C=C1)Cl)C(=O)NC2=NNN=N2 IC50 = 100000 nM Poor binder T28213 Free fatty acid receptor 2 B5L7ND (S)-Methyl 2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanimidate Investigative 46226436 C15H17ClN2OS 308.8 CC(C)[C@@H](C1=CC=C(C=C1)Cl)/C(=N/C2=NC=CS2)/OC IC50 ~ 100000 nM Poor binder T28213 Free fatty acid receptor 2 B5WI1L 2,2-Bis(4-chlorophenyl)-N-(thiazol-2-yl)acetamide Investigative 46226357 C17H12Cl2N2OS 363.3 C1=CC(=CC=C1C(C2=CC=C(C=C2)Cl)C(=O)NC3=NC=CS3)Cl IC50 ~ 100000 nM Poor binder T28213 Free fatty acid receptor 2 B9L2XS (S)-N-(2-(4-Chlorophenyl)-3-methylbutyl)thiazol-2-amine Investigative 46226103 C14H17ClN2S 280.8 CC(C)[C@H](CNC1=NC=CS1)C2=CC=C(C=C2)Cl IC50 ~ 100000 nM Poor binder T28213 Free fatty acid receptor 2 BAQ14I (S)-N-(1-(4-Chlorophenyl)-2-methylpropyl)thiazole-2-sulfonamide Investigative 46226105 C13H15ClN2O2S2 330.9 CC(C)[C@@H](C1=CC=C(C=C1)Cl)NS(=O)(=O)C2=NC=CS2 IC50 ~ 100000 nM Poor binder T28213 Free fatty acid receptor 2 BD62VR (S)-2-(4-Chlorophenyl)-3-methyl-N-(1H-pyrazol-3-yl)butanamide Investigative 46226178 C14H16ClN3O 277.75 CC(C)[C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=CC=NN2 IC50 = 100000 nM Poor binder T28213 Free fatty acid receptor 2 BGE7H6 2-(4-Chlorophenyl)-3-methylbutanamide Investigative 12898176 C11H14ClNO 211.69 CC(C)C(C1=CC=C(C=C1)Cl)C(=O)N IC50 ~ 100000 nM Poor binder T28213 Free fatty acid receptor 2 BH8U3Q 1-(4-Chlorophenyl)-N-(5-fluorothiazol-2-yl)cyclopropanecarboxamide Investigative 46226359 C13H10ClFN2OS 296.75 C1CC1(C2=CC=C(C=C2)Cl)C(=O)NC3=NC=C(S3)F IC50 ~ 100000 nM Poor binder T28213 Free fatty acid receptor 2 BKI2N5 (S)-2-(4-Chlorophenyl)-3-methyl-N-(pyridin-4-yl)butanamide Investigative 25479840 C16H17ClN2O 288.77 CC(C)[C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=CC=NC=C2 IC50 = 56000 nM Poor binder T28213 Free fatty acid receptor 2 BKT3E8 (S)-2-Cyclopropyl-N-(5-fluorothiazol-2-yl)-2-(4-(methylsulfonyl)phenyl)acetamide Investigative 46226384 C15H15FN2O3S2 354.4 CS(=O)(=O)C1=CC=C(C=C1)[C@H](C2CC2)C(=O)NC3=NC=C(S3)F IC50 ~ 100000 nM Poor binder T28213 Free fatty acid receptor 2 BM7OF0 (S)-N-Benzyl-2-(4-chlorophenyl)-3-methylbutanamide Investigative 8713297 C18H20ClNO 301.8 CC(C)[C@@H](C1=CC=C(C=C1)Cl)C(=O)NCC2=CC=CC=C2 IC50 ~ 100000 nM Poor binder T28213 Free fatty acid receptor 2 BMLU45 (S)-N-(1-(4-Chlorophenyl)-2-methylpropyl)thiazole-2-carboxamide Investigative 46225341 C14H15ClN2OS 294.8 CC(C)[C@@H](C1=CC=C(C=C1)Cl)NC(=O)C2=NC=CS2 IC50 ~ 100000 nM Poor binder T28213 Free fatty acid receptor 2 BMT16H (S)-2-(4-Chlorophenyl)-3-methyl-N-phenylbutanamide Investigative 46226141 C17H18ClNO 287.8 CC(C)[C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=CC=CC=C2 IC50 ~ 100000 nM Poor binder T28213 Free fatty acid receptor 2 BNOF64 (S)-2-(2-(4-Chlorophenyl)-3-methylbutanamido)thiazole-5-carboxylic acid Investigative 46226271 C15H15ClN2O3S 338.8 CC(C)[C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=NC=C(S2)C(=O)O IC50 = 79000 nM Poor binder T28213 Free fatty acid receptor 2 BPD6V5 Rac-1-(4-chlorophenyl)-2-methyl-N-(thiazol-2-yl)propane-1-sulfonamide Investigative 46226104 C13H15ClN2O2S2 330.9 CC(C)C(C1=CC=C(C=C1)Cl)S(=O)(=O)NC2=NC=CS2 IC50 ~ 100000 nM Poor binder T28213 Free fatty acid receptor 2 BR8HZ5 (R)-2-(4-Chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanamide Investigative 854190 C14H15ClN2OS 294.8 CC(C)[C@H](C1=CC=C(C=C1)Cl)C(=O)NC2=NC=CS2 IC50 ~ 100000 nM Poor binder T28213 Free fatty acid receptor 2 BSB28H (S)-2-(4-Chlorophenyl)-4-methoxy-N-(thiazol-2-yl)butanamide Investigative 46226355 C14H15ClN2O2S 310.8 COCC[C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=NC=CS2 IC50 = 170000 nM Poor binder T28213 Free fatty acid receptor 2 BSGZ10 (S)-2-(4-Chlorophenyl)-N,3-dimethyl-N-(thiazol-2-yl)butanamide Investigative 46225340 C15H17ClN2OS 308.8 CC(C)[C@@H](C1=CC=C(C=C1)Cl)C(=O)N(C)C2=NC=CS2 IC50 = 84000 nM Poor binder T28213 Free fatty acid receptor 2 BSKT37 2-(4-Chlorophenyl)-N-(5-fluorothiazol-2-yl)-2-methylpropanamide Investigative 46226358 C13H12ClFN2OS 298.76 CC(C)(C1=CC=C(C=C1)Cl)C(=O)NC2=NC=C(S2)F IC50 = 50000 nM Poor binder T28213 Free fatty acid receptor 2 BSN6F1 2-(4-Chlorophenyl)-N-(1,3-thiazol-2-yl)acetamide Investigative 847243 C11H9ClN2OS 252.72 C1=CC(=CC=C1CC(=O)NC2=NC=CS2)Cl IC50 = 100000 nM Poor binder T28213 Free fatty acid receptor 2 BX8R9I (S)-2-(2-(4-Chlorophenyl)-3-methylbutanamido)thiazole-5-carboxamide Investigative 46226272 C15H16ClN3O2S 337.8 CC(C)[C@@H](C1=CC=C(C=C1)Cl)C(=O)NC2=NC=C(S2)C(=O)N IC50 = 71000 nM Poor binder T28213 Free fatty acid receptor 2 D0S5BG Propanoic Acid Investigative 1032 C3H6O2 74.08 CCC(=O)O IC50 = 130000 nM Poor binder