Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T25362 | Target Info | |||
| Target Name | Lysine-specific demethylase 3A (KDM3A) | ||||
| Synonyms |
TSGA; KIAA0742; Jumonji domain-containing protein 1A; JmjC domain-containing histone demethylation protein 2A; JMJD1A; JMJD1; JHDM2A
Click to Show/Hide
|
||||
| Target Type | Literature-reported Target | ||||
| Gene Name | KDM3A | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 24 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-[1-(1-Benzoylpiperidin-3-yl)triazol-4-yl]pyridine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621878; BDBM50498680
Click to Show/Hide
|
||||
| Activity |
IC50 = 50118.72 nM
|
[1] | |||
| Compound Name |
2-[1-[1-(3-Phenylpropanoyl)piperidin-3-yl]triazol-4-yl]pyridine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621880; BDBM50498667
Click to Show/Hide
|
||||
| Activity |
IC50 = 50118.72 nM
|
[1] | |||
| Compound Name |
2-[1-(1-Propanoylpiperidin-4-yl)triazol-4-yl]pyridine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621860; BDBM50498668
Click to Show/Hide
|
||||
| Activity |
IC50 = 50118.72 nM
|
[1] | |||
| Compound Name |
2-[1-(1-Acetylazetidin-3-yl)triazol-4-yl]pyridine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621865; BDBM50498661
Click to Show/Hide
|
||||
| Activity |
IC50 = 50118.72 nM
|
[1] | |||
| Compound Name |
2-[1-[1-(2-Phenylacetyl)pyrrolidin-3-yl]triazol-4-yl]pyridine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621873; BDBM50498683
Click to Show/Hide
|
||||
| Activity |
IC50 = 63095.73 nM
|
[1] | |||
| Compound Name |
2-[1-(1-Propanoylpiperidin-3-yl)triazol-4-yl]pyridine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621876; BDBM50498682
Click to Show/Hide
|
||||
| Activity |
IC50 = 63095.73 nM
|
[1] | |||
| Compound Name |
3-[5-[Butyl(octyl)amino]pentanoyl-hydroxyamino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3590431; BDBM50095451
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-[1-(1-Butanoylpyrrolidin-3-yl)triazol-4-yl]pyridine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621871; BDBM50498678
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-[Hydroxy-[5-[methyl(pentyl)amino]pentanoyl]amino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3590426; BDBM50095446
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-[1-[1-(3-Phenylpropanoyl)piperidin-4-yl]triazol-4-yl]pyridine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621864; BDBM50498685
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[1-(1-Butanoylpiperidin-4-yl)triazol-4-yl]pyridine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621861; BDBM50498692
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-[5-[Butyl(hexyl)amino]pentanoyl-hydroxyamino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3590430; BDBM50095448
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-[1-(1-Propanoylazetidin-3-yl)triazol-4-yl]pyridine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621866; BDBM50498670
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-[5-[Butyl(methyl)amino]pentanoyl-hydroxyamino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3590418; BDBM50095443
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-[1-[1-(3-Phenylpropanoyl)azetidin-3-yl]triazol-4-yl]pyridine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621870; BDBM50498684
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[1-[(3R)-1-Benzoylpiperidin-3-yl]triazol-4-yl]pyridine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621881; BDBM50498675; 2-[1-(1-Benzoylpiperidine-3alpha-yl)-1H-1,2,3-triazole-4-yl]pyridine-4-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[1-(1-Butanoylazetidin-3-yl)triazol-4-yl]pyridine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621867; BDBM50498664
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[1-[1-(2-Phenylacetyl)azetidin-3-yl]triazol-4-yl]pyridine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621869; BDBM50498693
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
2-[1-[1-(3-Phenylpropanoyl)pyrrolidin-3-yl]triazol-4-yl]pyridine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621874; BDBM50498674
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
5-Quinolinecarboxylic acid, 8-hydroxy-, octyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3785984; cmp5;compound 5; BDBM50158888
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[1-(1-Benzoylpiperidin-4-yl)triazol-4-yl]pyridine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3621862; BDBM50498687
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Tranylcypromine hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
trans-2-Phenylcyclopropanamine hydrochloride; trans-2-Phenylcyclopropylamine hydrochloride; (1R,2S)-2-phenyl-cyclopropylamine hydrochloride; 2-PCPA Hydrochloride; (1R,2S)-2-Phenylcyclopropanamine hydrochloride; (1R,2S)-tranylcypromine hydrochloride; (1R,2S)-2-phenylcyclopropan-1-amine hydrochloride; TRANS-2-PHENYL-CYCLOPROPYLAMINE HYDROCHLORIDE; trans-2-Phenylcyclopropylamine HCl; Tranylcypromine (2-PCPA) HCl; DSSTox_CID_27761; DSSTox_RID_82538; DSSTox_GSID_47781; Tranylcypromine HCl; SMR000875332; (2S,1R)-2-phenylcyclopropylamine, chloride; C9H11N.HCl; 2-Phenyl-Cyclopropylamine HCl; (+)-Tranylcypromine Hydrochloride; 2-PCPA; Tranylcypromine (2-PCPA) hydrochloride; trans-2-phenylcyclopropan-1-amine hydrochloride; Rel-Tranylcypromine HCl; trans-2-Phenylcyclopropylamine hydrochloride, 97%; NCGC00016598-01; SCHEMBL56351; KSC493A7B; MLS001335868; MLS002153363; D-tranylcypromine hydrochloride; Cyclopropanamine, 2-phenyl-, hydrochloride (1:1), (1R,2S)-rel-; CHEMBL1255743; DTXSID6047781; CTK3J3070; Cyclopropanamine, 2-phenyl-, hydrochloride, (1R,2S)-rel-; HMS1568D07; Tox21_110514; 8373AH; MFCD00063602; MFCD17976456; SBB003859; AKOS022185792; Tox21_110514_1; AM84681; DS-6561; NE64568; SB35126; SB36889; KS-000005F7; NCGC00016598-02; B7514; ST50406162; (trans)-2-phenylcyclopropanamine hydrochloride; (1R,2S)-2-phenylcyclopropan-1-aminium chloride; (+/-)-Trans-2-phenyl-cyclopropylamine hydrochloride; (+/-)-trans-2-Phenylcyclopropylamine hydrochloride; J-640402; J-800286; trans-(+/-)-2-phenyl-cyclopropylamine hydrochloride; trans-(+/-)-2-Phenylcyclopropylamine hydrochloride; Q27225148; UNII-7H4CZX4FYH component ZPEFMSTTZXJOTM-OULXEKPRSA-N
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
NCDM-82a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3590427; BDBM50095447
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5-Chloro-7-[benzoylamino(3-methyl-2-thienyl)methyl]-8-quinolinol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3785164; BDBM50158849
Click to Show/Hide
|
||||
| Activity |
IC50 = 191000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(carboxymethylamino)-2-oxoacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-Oxalylglycine; 5262-39-5; Oxalylglycine; Oxaloglycine; 2-((Carboxymethyl)amino)-2-oxoacetic acid; UNII-VVW38EB8YS; N-(carboxycarbonyl)glycine; N-OXALYOLGLYCINE; VVW38EB8YS; 2-oxo-3-azaglutaric acid; CHEMBL90852; Glycine, N-(carboxycarbonyl)-; CHEBI:44482; OGA; C4H5NO5; 4idz; 4nrp; 2xml; 3hqr; N-oxalyl glycine, 1a; 2oq6; 1h2k; AC1MIVD0; Glycine,N-(carboxycarbonyl)-; SCHEMBL435820; BDBM26106; CTK8F0807; DTXSID20200601; MolPort-000-141-021; ZINC1534133; N-Oxalylglycine, > 4958AE
Click to Show/Hide
|
||||
| Activity |
IC50 = 569000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor. Medchemcomm. 2014 Dec 1;5(12):1879-1886. | ||||
| REF 2 | Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells. ACS Med Chem Lett. 2015 Apr 23;6(6):665-70. | ||||
| REF 3 | Recent Progress in Histone Demethylase Inhibitors. J Med Chem. 2016 Feb 25;59(4):1308-29. | ||||
| REF 4 | Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities. J Med Chem. 2014 Jan 9;57(1):42-55. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.