Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T21661 | Target Info | |||
| Target Name | Methionine synthase (MTR) | ||||
| Synonyms |
Methionine synthase, vitamin-B12dependent; MTR; MS; Cobalamin-dependent methionine synthase; B12 dependent methionine synthetase; 5-methyltetrahydrofolate:homocysteine methyltransferase; 5-methyltetrahydrofolate-homocysteine methyltransferase; 5-methyltetrahydrofolate homocysteine methyltransferase
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| Target Type | Literature-reported Target | ||||
| Gene Name | MTR | ||||
| Biochemical Class | Methyltransferase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 7 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2S)-2-[[4-[[2,4-Diamino-5-(4-methylphenyl)sulfonyl-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-6-yl]methyl-methylamino]benzoyl]amino]pentanedioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2153710; BDBM50392655
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| Activity |
IC50 = 55000 nM
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[1] | |||
| Compound Name |
(2S)-2-[[4-(11,13-Diamino-2,4,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(9),10,12-trien-4-yl)benzoyl]amino]pentanedioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2153704; BDBM50392650
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| Activity |
IC50 = 66380 nM
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[1] | |||
| Compound Name |
(2S)-2-[[4-[(2,4-Diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2153708; BDBM50392659
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| Activity |
IC50 = 87910 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[4-[(2,4-Diaminopyrido[3,2-d]pyrimidin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2153707; BDBM50392653; N-[4-[[(2,4-Diaminopyrido[3,2-d]pyrimidine-6-yl)methyl]amino]benzoyl]-L-glutamic acid
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[4-[Acetyl-[(2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]amino]pentanedioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2151066; BDBM50392658
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[4-[(2,4-Diamino-5-prop-2-enyl-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2153705; BDBM50392657
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S)-2-[[4-[(2,4-Diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2153709; BDBM50392654
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Mechanism-based design, synthesis and biological studies of N5-substituted tetrahydrofolate analogs as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents. Eur J Med Chem. 2012 Dec;58:228-36. | ||||
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