TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T21661	Methionine synthase	B21CIN	(2S)-2-[[4-[(2,4-Diaminopyrido[3,2-d]pyrimidin-6-yl)methylamino]benzoyl]amino]pentanedioic acid	Investigative	71460350	C20H21N7O5	439.4	C1=CC(=CC=C1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCC2=NC3=C(C=C2)N=C(N=C3N)N	IC50 ~ 100000 nM	Poor binder
T21661	Methionine synthase	B6E5UC	(2S)-2-[[4-[Acetyl-[(2,4-diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]amino]pentanedioic acid	Investigative	71451328	C22H27N7O6	485.5	CC(=O)N(CC1CCC2=C(N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O	IC50 ~ 100000 nM	Poor binder
T21661	Methionine synthase	B82VTD	(2S)-2-[[4-(11,13-Diamino-2,4,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(9),10,12-trien-4-yl)benzoyl]amino]pentanedioic acid	Investigative	71453144	C21H25N7O5	455.5	C1CC2=C(C(=NC(=N2)N)N)N3C1CN(C3)C4=CC=C(C=C4)C(=O)N[C@@H](CCC(=O)O)C(=O)O	IC50 = 66380 nM	Poor binder
T21661	Methionine synthase	BH40FO	(2S)-2-[[4-[(2,4-Diamino-5-prop-2-enyl-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid	Investigative	71449539	C24H31N7O5	497.5	CN(CC1CCC2=C(N1CC=C)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O	IC50 ~ 100000 nM	Poor binder
T21661	Methionine synthase	BMW0A6	(2S)-2-[[4-[(2,4-Diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid	Investigative	71462049	C21H27N7O5	457.5	CN(CC1CCC2=C(N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O	IC50 ~ 100000 nM	Poor binder
T21661	Methionine synthase	BR3KW5	(2S)-2-[[4-[[2,4-Diamino-5-(4-methylphenyl)sulfonyl-7,8-dihydro-6H-pyrido[3,2-d]pyrimidin-6-yl]methyl-methylamino]benzoyl]amino]pentanedioic acid	Investigative	71454881	C28H33N7O7S	611.7	CC1=CC=C(C=C1)S(=O)(=O)N2C(CCC3=C2C(=NC(=N3)N)N)CN(C)C4=CC=C(C=C4)C(=O)N[C@@H](CCC(=O)O)C(=O)O	IC50 = 55000 nM	Poor binder
T21661	Methionine synthase	BXC58O	(2S)-2-[[4-[(2,4-Diamino-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidin-6-yl)methylamino]benzoyl]amino]pentanedioic acid	Investigative	25270307	C20H25N7O5	443.5	C1CC2=C(C(=NC(=N2)N)N)NC1CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O	IC50 = 87910 nM	Poor binder