Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T20891 | Target Info | |||
| Target Name | Phosphoinositide dependent protein kinase-1 (PDPK1) | ||||
| Synonyms |
PDK1; HPDK1; 3-phosphoinositide-dependent protein kinase 1; 3-Phosphoinositide-dependent kinase-1; 3'-phosphoinositide dependent kinase 1
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| Target Type | Clinical trial Target | ||||
| Gene Name | PDPK1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 64 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Niclosamide
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Approved | Compound Info | ||
| Synonyms |
niclosamide; 50-65-7; Niclocide; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide; Tredemine; Bayluscid; Phenasal; Yomesan; Fenasal; Dichlosale; Helmiantin; Sagimid; Iomezan; Devermine; Atenase; Vermitid; Radeverm; Mansonil; Iomesan; Devermin; Cestocid; Sulqui; Lintex; Nasemo; Mato; Fedal-Telmin; Bayer 73; Radewerm; Zestocarp; Bayer 2353; 2',5-Dichloro-4'-nitrosalicylanilide; Chemagro 2353; BAY 2353; Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-; 5-Chloro-2'-chloro-4'-nitrosalicylanilide; nicolsamide; HL 2447; Niclosamidum [I
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| Activity |
IC50 = 83900 nM
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[1] | |||
| Compound Name |
6-MORPHOLIN-4-YL-9H-PURINE
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Investigative | Compound Info | ||
| Synonyms |
2846-96-0; 6-Morpholinopurine; 6-(morpholin-4-yl)-9H-purine; 6-Morpholin-4-Yl-9h-Purine; 4-(1H-Purin-6-yl)morpholine; 4-(9h-purin-6-yl)morpholine; 4-(7H-purin-6-yl)morpholine; SMR000017638; MLS000080575; 2wmu; EINECS 220-645-3; 4-purin-6-ylmorpholine; 6-morpholino-9H-purine; 6-Morpholino-1H-purine; AC1Q4X9J; AC1Q1I5S; Oprea1_261650; Oprea1_519977; MLS000104086; SCHEMBL336612; CHEMBL271138; AC1L2Q64; BDBM33210; CTK4G1553; 9H-Purine,6-(4-morpholinyl)-; DTXSID80182656; MEOMXKNIFWDDGZ-UHFFFAOYSA-N; MolPort-002-610-718; HMS2298A04
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| Activity |
IC50 = 92000 nM
|
[2] | |||
| Compound Name |
N-[3-(2-Pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089082; SCHEMBL4656083; BDBM50314051; N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(S)-((R)-Tetralin-1-ylmethylamino)(4-fluorophenyl)methylphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3623846; BDBM50125790; ZINC12949501
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| Activity |
EC50 = 50000 nM
|
[4] | |||
| Compound Name |
2,6-Diaminopurine
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Investigative | Compound Info | ||
| Synonyms |
9H-Purine-2,6-diamine; 2-Aminoadenine; 7H-purine-2,6-diamine; 1H-Purine-2,6-diamine; 2,6-diamino-9h-purine; Purine, 2,6-diamino-; NSC 743; SQ 21065; 26-diaminopurine; 2,6-Diamino-purin-9-yl; 2,6-Diaminopurine, 98%; UNII-49P95BAU4Z; purine-2,6-diamine; 49P95BAU4Z; CHEMBL388596; MFCD00213668; Purine-2,6-diyldiamine; CCRIS 923; EINECS 217-605-2; AI3-25010; CCRIS 3903; 2-6-Diaminopurine; Purine,6-diamino-; 2,6-diamino-purine; PubChem9203; Purine, 2, 6-diamino-; Oprea1_670021; SCHEMBL24052; 9H-Purine-2,6-diamine #; KSC179A1B; MLS001066366; NSC743; DTXSID0062052; SCHEMBL16513167; CTK0H9010; CTK7E0750; NSC-743; (2-amino-7H-purin-6-yl)-amine; HMS2267N10; ALBB-023319; BCP30955; ZINC7486121; ANW-23487; BDBM50208879; MFCD00047146; MFCD00071537; SBB000103; AKOS003368184; AKOS015896933; AKOS028109333; 9H-Purine-2,6-diamine0.5M H2SO4; AC-8693; AM81387; GS-3048; LS20247; MCULE-1333744381; 9H-Purine-2,6-diamine;2-Aminoadenine; AK-68382; BP-13206; SC-02056; SMR000112503; ST012425; SY036886; TS-00060; AB0010986; DB-015922; D1625; FT-0610530; S-8021; 904D989; AC-907/34116038; Q-200204; Q4596802; W-203543
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| Activity |
IC50 = 50800 nM
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[5] | |||
| Compound Name |
5-[4-[5-Phenanthren-2-yl-3-(trifluoromethyl)pyrazol-1-yl]phenyl]-2H-tetrazole
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2605794; CHEMBL3665665; BDBM123442; US8741944, 64
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| Activity |
IC50 = 52000 nM
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[6] | |||
| Compound Name |
N-[(2-Hydroxy-5-phenylphenyl)carbamothioyl]-3,5-dimethylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL350752; CHEMBL3693949; BDBM112790; US8628961, PIT-7
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| Activity |
IC50 = 52300 nM
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[7] | |||
| Compound Name |
2-(3-(4-Methoxyphenylthio)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1171125; BDBM50321378
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| Activity |
EC50 = 53000 nM
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[8] | |||
| Compound Name |
1-(3-(1H-Benzo[d]imidazol-2-yl)-1H-indazol-5-yl)-3-cyclopentylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3659987; SCHEMBL12813161; BDBM103935; US8569511, 19; 1-[3-(benzimidazol-2-ylidene)-1,2-dihydroindazol-5-yl]-3-cyclopentylurea
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| Activity |
IC50 = 53900 nM
|
[9] | |||
| Compound Name |
6-Tert-Butyl-3H-thieno[3,2-d]pyrimidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2029511; 6-(tert-Butyl)thieno[3,2-d]pyrimidin-4(3H)-one; 1H,4H-6-t-Butylthieno[3,2-d]pyrimidin-4-one; 6-tert-butyl-3h,4h-thieno[3,2-d]pyrimidin-4-one; isopropyllaurate; Maybridge3_001730; 6-tert-butyl-1H-thieno[3,2-d]pyrimidin-4-one; SCHEMBL4421700; CTK7H0308; CTK7H5858; HMS1435O14; ZINC116336; BDBM50384062; MFCD01570181; SBB094072; AKOS024015397; AS-8976; CCG-240385; FS-1503; MCULE-8265532327; IDI1_013117; 6-tert-Butyl-thieno[3,2-d]pyrimidin-4-ol; DB-108164; CS-0088188; 6-(tert-Butyl)thieno[3,2-d]pyrimidin-4-ol; 6-tert-butylthieno[3,2-d]pyrimidin-4(3H)-one; 6-(tert-butyl)hydrothiopheno[3,2-d]pyrimidin-4-one; 6-TERT-BUTYLTHIENO[3,2-D]PYRIMIDIN-4(1H)-ONE; 6-tert-Butylthieno[3,2-d]pyrimidin-4(1H)-one, AldrichCPR
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| Activity |
IC50 = 55000 nM
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[2] | |||
| Compound Name |
3-(1H-Benzo[d]imidazol-2-yl)-5-(3-(trifluoromethyl)phenyl)-1H-indazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3659983; SCHEMBL12813312; BDBM103931; US8569511, 15; 2-[5-[3-(trifluoromethyl)phenyl]-1,2-dihydroindazol-3-ylidene]benzimidazole
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| Activity |
IC50 = 55700 nM
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[9] | |||
| Compound Name |
3-(1H-Benzimidazol-2-yl)-5-[4-(2-isocyanopropan-2-yl)phenyl]-1H-indazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3659984; BDBM103932; US8569511, 16
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| Activity |
IC50 = 58500 nM
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[9] | |||
| Compound Name |
Isoxanthohumol
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Investigative | Compound Info | ||
| Synonyms |
Isoxanthohumol(Sophora); CHEMBL492828; (2S)-Isoxanthohumol; 5-Methylsophoraflavanone B; Isoxanthohumol, HPLC Grade; SCHEMBL904557; CTK8G0403; Isoxanthohumol, >=99% (HPLC); Isoxanthohumol, analytical standard; BCP23864; BDBM50252521; LMPK12140553; MFCD00238718; SMP2_000215; 4',7-dihydroxy-5-methoxy-8-prenylflavanone; 4',7-dihydroxy-5-methoxy-8-c-prenylflavanone; Q6086616; Isoxanthohumol, primary pharmaceutical reference standard; 7-hydroxy-2-(4-hydroxy-phenyl)-5-methoxy-8-(3-methyl-but-2-enyl)-chroman-4-one; 7-Hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methylbut-2-en-1-yl)chroman-4-one; 7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methylbut-2-enyl)chroman-4-one
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| Activity |
IC50 = 58700 nM
|
[10] | |||
| Compound Name |
5-Phenyl[1,2,4]triazolo[1,5-c]quinazolin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779261; Oprea1_636521; Oprea1_732387; ZINC297632; BDBM50178297; AKOS001582761; CCG-103024; MCULE-1635389501; ST50978554; 6-phenyl-7-hydro-1,2,4-triazolo[1,5-c]quinazoline-9-ylamine
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| Activity |
IC50 = 60000 nM
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[11] | |||
| Compound Name |
2-[3-(4-Iodophenyl)-3-oxo-1-phenylpropyl]propanedioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2177670; SCHEMBL656820; BDBM50399647
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| Activity |
EC50 = 60000 nM
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[12] | |||
| Compound Name |
4-[1-(3,5-Difluorophenyl)ethylamino]quinazoline-8-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL665875; CHEMBL3680465; BDBM116735; US8637532, 445
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| Activity |
IC50 = 61000 nM
|
[13] | |||
| Compound Name |
N-(4-Methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2029513; CBMicro_031336; MixCom6_001640; Oprea1_228579; Oprea1_314291; ZINC1826570; BDBM50384064; CCG-20328; STK846550; STK948992; AKOS001664756; AKOS005626752; MCULE-7903123412; BIM-0031168.P001; EU-0011437; SR-01000492363; SR-01000492363-1; F0920-2110; N-[(4E)-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ylidene]-4-methoxyaniline
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| Activity |
IC50 = 61000 nM
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[2] | |||
| Compound Name |
4-[5-(1H-Indol-3-yl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL261143; SCHEMBL979123; BDBM50376854; US8741944, 44
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| Activity |
IC50 = 65000 nM
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[6] | |||
| Compound Name |
N-[(3-Chloro-2-hydroxy-5-nitrophenyl)carbamothioyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
PIT 1; PIT-1; N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide; N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-benzamide; CBMicro_008144; N-{[(3-chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl}benzamide; PIT-1;PIT1; PIT 1/; SCHEMBL9289577; CHEMBL3596523; DTXSID20394812; BDBM112784; BCP27689; SMSF0006015; ZINC4954743; ABP000450; STL043906; AKOS005697387; MCULE-8548476492; US8628961, PIT-1; ST097600; BIM-0008258.P001; B7601; FT-0756123; N-[(3-chloro-2-hydroxy-5-nitro-phenyl)carbamothioyl]benzamide; Benzamide, N-[[(3-chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-
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| Activity |
IC50 = 66700 nM
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[7] | |||
| Compound Name |
4-[[(1S)-2-[Cyclopropyl(methyl)amino]-1-phenylethyl]amino]-6,7-dihydroquinazoline-8-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3680501; SCHEMBL10256315; BDBM116772; US8637532, 489
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| Activity |
IC50 = 74000 nM
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[13] | |||
| Compound Name |
2-[3-(2,4-Dichlorophenyl)sulfanyl-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1171416; BDBM50321380; 4-(1-(carboxymethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylthio)benzoicacid
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| Activity |
EC50 = 75000 nM
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[8] | |||
| Compound Name |
4-[1-[3-[[4-(Trifluoromethoxy)benzoyl]amino]phenyl]propylamino]quinazoline-8-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3680394; SCHEMBL10255993; BDBM116663; US8637532, 364
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| Activity |
IC50 = 77000 nM
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[13] | |||
| Compound Name |
4-[2-(1H-Indol-3-yl)ethylamino]quinazoline-8-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL664495; CHEMBL3675452; BDBM116566; US8637532, 257
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| Activity |
IC50 = 79000 nM
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[13] | |||
| Compound Name |
N-[(2-Hydroxy-5-nitrophenyl)carbamothioyl]-3,5-dimethylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
3,5-dimethyl PIT-1; DM-PIT-1; N-(((2-Hydroxy-5-nitrophenyl)amino)thioxomethyl)-3,5-dimethyl-benzamide; DM-PIT 1; SCHEMBL9241040; CHEMBL3596524; BDBM112785; STK243033; ZINC35889470; AKOS000469068; MCULE-9369895425; US8628961, DM-PIT-1; 1-(2-Hydroxy-5-nitrophenyl)-3-(3,5-dimethylbenzoyl)thiourea; N-[(2-hydroxy-5-nitrophenyl)amino]carbonothioyl-3,5-dimethylbenzamide
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| Activity |
IC50 = 80500 nM
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[7] | |||
| Compound Name |
1-[[3-[[4-(4-Methylpiperazin-1-yl)-3-(trifluoromethyl)benzoyl]amino]phenyl]methylamino]phthalazine-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3680492; SCHEMBL10255634; BDBM116762; US8637532, 476
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| Activity |
IC50 = 82000 nM
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[13] | |||
| Compound Name |
6-Bromo-1H-indazol-3-amine
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Investigative | Compound Info | ||
| Synonyms |
3-Amino-6-bromo-1H-indazole; 6-BROMO-1H-INDAZOL-3-YLAMINE; 1H-INDAZOL-3-AMINE, 6-BROMO-; MFCD05665872; CHEMBL501406; 6-BROMO-1H-INDAZOLE-3-AMINE; 3-Amino-6-bromo-1H-indazole, 95%; PubChem17937; ACMC-209jef; SCHEMBL424831; 6-Bromo-3-amino-1H-indazole; 6-Bromo-2h-indazol-3-ylamine; 1H-Indazol-3-amine,6-bromo-; 6-bromo-1H-indazole-3-ylamine; SCHEMBL18340819; CTK4I3153; DTXSID40383026; ALBB-028238; BCP26665; KS-00000A2U; ZINC3883310; ANW-29413; BBL030369; BDBM50254987; SBB052082; SC1841; STL250230; AKOS000779557; CS-W003246; LS40886; MCULE-9201895154; PB26168; QC-9106; 6-Bromo-1H-indazol-3-amine, AldrichCPR; AC-23301; AK-28301; BC004311; BR-28301; SC-45063; SY006752; AB0002478; DB-026380; A6772; AM20040422; BB 0259389; FT-0677999; A-2900; 827B776; 10Y-0701; J-518297
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| Activity |
IC50 = 82400 nM
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[14] | |||
| Compound Name |
4-[[3-[(2-Piperidin-1-ylpyridine-4-carbonyl)amino]phenyl]methylamino]quinazoline-8-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3680464; SCHEMBL10255568; BDBM116734; US8637532, 444
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| Activity |
IC50 = 83000 nM
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[13] | |||
| Compound Name |
[1-Phenyl-3-oxo-3-[4-(trifluoromethyl)phenyl]propyl]malonic acid
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Investigative | Compound Info | ||
| Synonyms |
PS210; CHEMBL2177668; 2-(3-Oxo-1-phenyl-3-(4-(trifluoromethyl)phenyl)propyl)malonic acid; 2-[3-Oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]malonic Acid; SCHEMBL658661; EX-A4735; BDBM50399646; SY268644; HY-121629; CS-0082916; 2-[3-Oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]-propanedioic acid; 2-[3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]propanedioic acid
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| Activity |
EC50 = 85800 nM
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[12] | |||
| Compound Name |
4-[1-[3-[[4-(Trifluoromethoxy)benzoyl]amino]phenyl]ethylamino]quinazoline-8-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL664975; CHEMBL3680491; BDBM116761; US8637532, 475
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| Activity |
IC50 = 86000 nM
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[13] | |||
| Compound Name |
6-(4-Methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
6-(4-methoxyphenyl)-3H,4H-thieno[3,2-d]pyrimidin-4-one; MLS000530458; CHEMBL1612732; 6-(4-methoxyphenyl)-1H-thieno[3,2-d]pyrimidin-4-one; SMR000135436; 6-(4-Methoxy-phenyl)-3H-thieno[3,2-d]pyrimidin-4-one; CBMicro_016669; Oprea1_405083; cid_754900; SCHEMBL7116530; SCHEMBL15703311; BDBM51645; CTK7A2969; HMS2359M23; CCG-5819; ZINC5080713; SBB078250; STL337493; AKOS001147826; MCULE-3620015037; NE18138; BIM-0016828.P001; SR-01000204065; SR-01000204065-1; Z104343016; 6-(4-methoxyphenyl)-3-hydrothiopheno[3,2-d]pyrimidin-4-one
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| Activity |
IC50 = 86000 nM
|
[2] | |||
| Compound Name |
4-[[3-[[4-Methoxy-3-(trifluoromethyl)benzoyl]amino]phenyl]methylamino]quinazoline-8-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL664998; CHEMBL3680532; BDBM116803; US8637532, 525
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| Activity |
IC50 = 87000 nM
|
[13] | |||
| Compound Name |
4-[(2,3-Difluorophenyl)methylamino]quinazoline-8-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL665385; CHEMBL3680461; BDBM116731; US8637532, 441
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| Activity |
IC50 = 87000 nM
|
[13] | |||
| Compound Name |
4-[(2-Imidazol-1-yl-1-phenylethyl)amino]quinazoline-8-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL665393; CHEMBL3680484; BDBM116754; US8637532, 467
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| Activity |
IC50 = 89000 nM
|
[13] | |||
| Compound Name |
n-Methyl-1h-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688207; N-Methyl-5H-pyrazolo[3,4-d]pyrimidin-4-amine; NSC5197; SCHEMBL10094590; NSC-5197; ZINC4353394; BDBM50339010; MFCD17010189; AKOS008967345; MB69431; MCULE-2831628482; NE36973; DB-125784; CS-0067375; 4-(Methylamino)-1H-pyrazolo[3,4-d]pyrimidine; Methyl-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)amine; Methyl-(2H-pyrazolo[3,4-d]pyrimidin-4-yl)amine; Z57101324; F5285-0046
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| Activity |
IC50 = 90800 nM
|
[5] | |||
| Compound Name |
6-Methoxy-2-(1h-Pyrazol-5-Yl)-1h-Benzimidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3815097; BDBM50178296; AKOS014349818; Q27456176; 62O
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| Activity |
IC50 = 93000 nM
|
[11] | |||
| Compound Name |
10-[[(1S)-1-Cyclohexa-2,4-dien-1-yl-2-[ethyl(propan-2-yl)amino]ethyl]amino]-1,3-diazecine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3680482; SCHEMBL10255607; BDBM116752; US8637532, 465
Click to Show/Hide
|
||||
| Activity |
IC50 = 95000 nM
|
[13] | |||
| Compound Name |
N-(4-Oxo-3H-thieno[3,2-d]pyrimidin-7-yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2029520; BDBM50384072
Click to Show/Hide
|
||||
| Activity |
IC50 = 95000 nM
|
[2] | |||
| Compound Name |
2-Phenylthiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Thiazole, 2-phenyl-; 2-Phenyl-1,3-thiazole; CHEMBL1688208; 2-Phenylthiazole, 98%; phenylthiazole; 2-phenyl thiazole; SCHEMBL70646; 2-Phenyl-1,3-thiazole #; KSC174S8F; CTK0H4982; DTXSID70338201; BCP22878; KS-00000N7W; ANW-51619; BDBM50339011; MFCD00272327; ZINC14983497; AKOS006273932; BCP9000113; FS-2359; QC-4275; AK-45808; BR-45808; AB0022986; DB-028189; A4041; CS-0028754; FT-0656738; Thiazole, 2-phenyl-;2-Phenyl-1,3-thiazole; W3964; S-4560
Click to Show/Hide
|
||||
| Activity |
IC50 = 95100 nM
|
[5] | |||
| Compound Name |
4-[[3-[[2-(2-Hydroxyethylamino)pyridine-4-carbonyl]amino]phenyl]methylamino]quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3680497; SCHEMBL10255777; BDBM116767; US8637532, 484
Click to Show/Hide
|
||||
| Activity |
IC50 = 96000 nM
|
[13] | |||
| Compound Name |
4-[[3-Methoxy-1-[3-[(4-methoxybenzoyl)amino]phenyl]propyl]amino]quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3680499; SCHEMBL10256312; BDBM116770; US8637532, 487
Click to Show/Hide
|
||||
| Activity |
IC50 = 96000 nM
|
[13] | |||
| Compound Name |
4-[[3-[(4-Methylsulfonylbenzoyl)amino]phenyl]methylamino]quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL665443; CHEMBL3680481; BDBM116751; US8637532, 464
Click to Show/Hide
|
||||
| Activity |
IC50 = 97000 nM
|
[13] | |||
| Compound Name |
1H-Indole-7-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1H-Indole-7-carboxylic acid amide; CHEMBL1688213; SCHEMBL1651352; 1H-Indole-7-carboxamide(9CI); CTK0H1668; DTXSID10540109; 8511AA; ANW-59861; BDBM50339017; MFCD00572866; ZINC39644329; AKOS014316237; SB34151; KS-00003T41; TS-02126; DB-064631; FT-0730541; Z-5542; Z1273141513
Click to Show/Hide
|
||||
| Activity |
IC50 = 97500 nM
|
[5] | |||
| Compound Name |
N-[3-(Benzimidazol-2-ylidene)-1,2-dihydroindazol-5-yl]-1-pyridin-4-ylpiperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3659988; SCHEMBL12813477; BDBM103936; US8569511, 20; N-(3-(1H-benzo[d]imidazol-2-yl)-1H-indazol-5-yl)-1-(pyridin-4-yl)piperidine-4-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2,2-Difluoro-N-(3-(6-morpholino-1H-benzo[d]imidazol-2-yl)-1H-indazol-6-yl)cyclopropanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3659989; SCHEMBL12813148; BDBM103937; US8569511, 21
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-(3-(1H-Benzo[d]imidazol-2-yl)-1H-indazol-5-yl)-1,4-dimethylpiperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3659986; SCHEMBL12813379; BDBM103934; US8569511, 18; N-[3-(benzimidazol-2-ylidene)-1,2-dihydroindazol-5-yl]-1,4-dimethylpiperidine-4-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
1-(3-(1H-Benzo[d]imidazol-2-yl)-1H-indazol-5-yl)-3-(2,4-difluorophenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3659985; SCHEMBL12813328; BDBM103933; US8569511, 17; 1-[3-(benzimidazol-2-ylidene)-1,2-dihydroindazol-5-yl]-3-(2,4-difluorophenyl)urea
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-Benzyl-N-methyl-4-(phenylsulfamoyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3355482; BDBM50043416; ZINC17334508; AKOS008571954; Z31474376
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
Chembl4276946
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
GTPL9965; compound 3a [Pipionne et al, 2018]; 1-[5-amino-4-(3,4-dichlorophenyl)-3-methyl-1H-pyrazol-1-yl]ethan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
2-(2-Oxo-3-phenylsulfanyl-4,5-dihydro-3H-1-benzazepin-1-yl)acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1171225; BDBM50321376; 2-(2-oxo-3-(phenylthio)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)aceticacid
Click to Show/Hide
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||||
| Activity |
EC50 = 101000 nM
|
[8] | |||
| Compound Name |
5-Bromo-1H-indazol-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-Amino-5-bromo-1H-indazole; 3-Amino-5-bromoindazole; 5-bromo-1H-indazol-3-ylamine; 1H-INDAZOL-3-AMINE, 5-BROMO-; MFCD03426696; CHEMBL465091; 5-bromo-1H-indazole-3-ylamine; 3-Amino-5-Bromo-1H-Indazole 95%; 3-Amino-5-bromo-1H-indazole, 95%; PubChem18573; 3-Amino-5-bromo-indazole; ACMC-1B3H9; SCHEMBL786329; 5-Bromo-2H-indazol-3-amine; 5-bromo-1H-indazole-3-amine; 1H-Indazol-3-amine,5-bromo-; CTK5B2975; DTXSID30355873; ZINC332240; ACN-S003264; ALBB-005167; BCP27502; CS-D0991; ANW-33746; BBL104250; BDBM50254986; SBB047706; STK501613; AKOS005069353; AC-9113; MCULE-5490303203; PB20824; KS-00000A32; 5-Bromo-1H-indazol-3-amine, AldrichCPR; AK-39253; BC004387; BR-39253; SC-28267; SY007052; AB0010128; DB-011406; AM20040858; BB 0254193; FT-0679081; ST50946286; A-2654; AE-413/25046007; 10Y-0709; J-516795; Q27455606
Click to Show/Hide
|
||||
| Activity |
IC50 = 101900 nM
|
[14] | |||
| Compound Name |
4-[(3,4,5-Trifluorophenyl)methylamino]quinazoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL665707; CHEMBL3680537; BDBM116808; US8637532, 531
Click to Show/Hide
|
||||
| Activity |
IC50 = 102000 nM
|
[13] | |||
| Compound Name |
7-Chlorothieno[3,2-b]pyridin-5(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688209; Thieno[3,2-b]pyridin-5(4H)-one, 7-chloro-; 7-Chloro-4H-thieno[3,2-b]pyridin-5-one; CTK2G1317; DTXSID40504911; BDBM50339012; ZINC66114154
Click to Show/Hide
|
||||
| Activity |
IC50 = 102000 nM
|
[5] | |||
| Compound Name |
6-(4-Fluorophenyl)-7-methyl-3H-thieno[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2029522; BDBM50384079
Click to Show/Hide
|
||||
| Activity |
IC50 = 106000 nM
|
[2] | |||
| Compound Name |
N-[(3-Chloro-6-hydroxy-2,4-dimethylphenyl)carbamothioyl]-3,5-dimethylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL352146; CHEMBL3693945; BDBM112786; US8628961, PIT-3
Click to Show/Hide
|
||||
| Activity |
IC50 = 106800 nM
|
[7] | |||
| Compound Name |
Thieno[3,2-d]pyrimidin-4(3H)-one, 7-(dimethylamino)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2029519; BDBM50384071
Click to Show/Hide
|
||||
| Activity |
IC50 = 109000 nM
|
[2] | |||
| Compound Name |
6-(4-Fluorophenyl)thieno[3,2-d]pyrimidin-4(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2029517; 6-(4-Fluorophenyl)-3,4-dihydrothieno[3,2-d]-pyrimidin-4-one; 6-(4-fluorophenyl)-1H-thieno[3,2-d]pyrimidin-4-one; SCHEMBL4213116; CTK7C0114; ZINC82219; KS-00003KE3; 7338AD; BDBM50384078; CCG-52768; SBB078304; AKOS001261108; FS-1445; MCULE-7217427770; EN300-24721; SR-01000641978-1; 6-(4-fluorophenyl)-3H,4H-thieno[3,2-d]pyrimidin-4-one; 6-(4-fluorophenyl)-3,4-dihydrothieno[3,2-d]pyrimidin-4-one; 6-(4-fluorophenyl)-3-hydrothiopheno[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 122000 nM
|
[2] | |||
| Compound Name |
Acetic acid, 2-[[3-(4-chlorophenyl)-3-oxo-1-phenylpropyl]thio]-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL550259; 2-(3-(4-Chlorophenyl)-3-oxo-1-phenylpropylthio)acetic acid; 2-[3-(4-chlorophenyl)-3-oxo-1-phenylpropyl]sulfanylacetic acid; SCHEMBL2550325; CTK4B8903; DTXSID80369521; BDBM50321382; CCG-56261; MCULE-5261883588; SR-01000645230-1; 2-(3-(4-chlorophenyl)-3-oxo-1-phenylpropylthio)aceticacid; [[1-Phenyl-3-oxo-3-(4-chlorophenyl)propyl]thio]acetic acid; 2-{[3-(4-chlorophenyl)-3-oxo-1-phenylpropyl]thio}acetic acid; Acetic acid,2-[[3-(4-chlorophenyl)-3-oxo-1-phenylpropyl]thio]-
Click to Show/Hide
|
||||
| Activity |
EC50 = 133000 nM
|
[17] | |||
| Compound Name |
3,5-Diamino-[1,2,4]triazine-6-carboxylic acid amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688210; BDBM50339014; 3,5-diamino-1,2,4-triazine-6-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 145000 nM
|
[5] | |||
| Compound Name |
Thieno[3,2-d]pyrimidin-4(3H)-one, 7-(methylamino)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2029518; BDBM50384070
Click to Show/Hide
|
||||
| Activity |
IC50 = 154000 nM
|
[2] | |||
| Compound Name |
1,2,4-Benzotriazin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-amino-1,2,4-benzotriazine; Benzo[E][1,2,4]Triazin-3-Amine; CHEMBL1688211; NSC 286693; SR 4330; Win 60109; EINECS 243-470-4; SCHEMBL40932; 1,2,4-Benzotriazine-3-amine; CTK1A6734; DTXSID40173848; TQP0603; HMS1619G16; [1,2,4]benzotriazin-3-yl-amine; ZINC1866060; benzo[e]1,2,4-triazine-3-ylamine; BDBM50339015; NSC286693; AKOS004111517; MCULE-6364132251; NSC-286693; SR-4330; FT-0635698; ST51035630; Z57724710
Click to Show/Hide
|
||||
| Activity |
IC50 = 160000 nM
|
[5] | |||
| Compound Name |
4-Bromo-3-chloro-1H-indazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-bromo-3-chloro-2H-indazole; CHEMBL4225389; 1H-INDAZOLE,4-BROMO-3-CHLORO-; 1H-INDAZOLE, 4-BROMO-3-CHLORO-; PubChem20680; 3-chloro(bromo)indazole; CTK5I8631; CTK8F5819; DTXSID60646660; KS-000024KV; ANW-51214; BDBM50459978; MFCD09026985; SBB097803; ZINC14985774; AKOS005073921; DS-0634; PB29583; QC-5350; AK-28209; BC004584; BR-28209; SC-54763; AB0034327; AM20050387; CS-0033956; FT-0681743; X8462; C-1967; J-000009; J-514711; W-204325
Click to Show/Hide
|
||||
| Activity |
IC50 = 163600 nM
|
[14] | |||
| Compound Name |
3,4-Dihydroisoquinolin-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3,4-dihydro-2H-isoquinolin-1-one; 1,2,3,4-tetrahydroisoquinolin-1-one; 1(2H)-Isoquinolinone, 3,4-dihydro-; 3,4-dihydro-1-isoquinolinone; 1-Oxo-1,2,3,4-tetrahydroisoquinoline; CHEMBL1688212; MFCD00853963; F2189-0996; 3,4-dihydro-1H-isoquinolin-1-one; 3,4-Dihydro-2H-isoquinolin-1-one, 98%; Oprea1_511002; dihydroisoquinolone; 1-Keto-1,2,3,4-tetrahydroisoquinoline; 3,4-dihydroisocarbostyril; POLY(VINYLCINNAMATE); SCHEMBL67710; KSC180Q6J; hydroxy-3,4-dihydroisoquinoline; SCHEMBL11267501; CTK0I0864; DTXSID40152517; 2,3,4-trihydroisoquinolin-1-one; 3,4-Dihydro-1(2H)-isoquinolone; ACT03694; BCP27476; ZINC5603571; 3,4-dihydro-1(2H)-isoquinolinone; 3,4-dihydroisoquinoline-1(2H)-one; ANW-51566; BDBM50339016; STK926192; AKOS002232785; AKOS003625709; AB07451; AC-5218; CS-W008863; MCULE-1919291381; VZ25548; KS-0000056T; AK-25321; BR-25321; SC-25175; SY021304; AB0035118; DB-011138; AM20020275; FT-0600427; ST50112782; X9392; EN300-43275; S-5379; 52054-EP2308845A2; 52054-EP2308846A2; 196D389; 7R-1504; J-511194; Q27461749; Z56801375
Click to Show/Hide
|
||||
| Activity |
IC50 = 169000 nM
|
[5] | |||
| Compound Name |
4-(1-(Carboxymethyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylthio)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1171415; BDBM50321379
Click to Show/Hide
|
||||
| Activity |
EC50 = 187000 nM
|
[8] | |||
| Compound Name |
4-Amino-1H-pyrazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1H-Pyrazole-3-carboxamide, 4-amino-; CHEMBL1688205; 4-aminopyrazole-5-carboxamide; 1H-Pyrazole-3-carboxamide,4-amino-; 4-amino-1h-pyrazole-3-carboxylic acid amide; 4-amino-3-carbamoylpyrazole; Oprea1_165018; SCHEMBL956225; CTK1J3762; CTK7D2492; Pyrazole-5-carboxamide, 4-amino-; 4-amino-1h-pyrazole-3-carboxamide; ALBB-013991; ZINC1072662; BDBM50339008; MFCD02646740; SBB002084; STK763006; 4-Amino-1H-pyrazole-5-carboxamide #; AKOS001741291; AKOS005169605; AB11926; MCULE-4793687042; AS-61270; DA-21493; 1H-Pyrazole-3-carboxamide,4-amino-(9CI); ST4079722; 4-Amino-2H-pyrazole-3-carboxylic acid amide; CS-0060154; FT-0683178; Y-7832; 1H-pyrazole-5-carboxamide, 4-amino-, dihydrochloride
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 17 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-fluoro-1H-indole-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5-Fluoroindole-2-carboxylic acid; 399-76-8; 5-Fluoro-1H-indole-2-carboxylic acid; 2-Carboxy-5-fluoroindole; 1H-Indole-2-carboxylic acid, 5-fluoro-; CHEMBL23507; MLS000080089; WTXBRZCVLDTWLP-UHFFFAOYSA-N; MFCD00005612; SMR000037735; 5-Fluoroindole-2-carboxylic acid, 98%; Spectrum_001495; EINECS 206-919-5; PubChem1683; SpecPlus_000678; Spectrum5_001733; Opera_ID_1340; Spectrum4_001182; Spectrum3_001043; Spectrum2_001469; ACMC-209j9k; AC1Q4NE3; Lopac-265128; cid_1820; AC1Q73TI; AC1L1CB9; AC1Q73TJ; Lopac0_000071; Oprea1_012690
Click to Show/Hide
|
||||
| Activity |
IC50 = 297000 nM
|
[2] | |||
| Compound Name |
5,6,7,8-Tetrahydro[1,2,4]triazolo[4,3-a]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688206; 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine; 1,2,4-TRIAZOLO[4,3-A]PYRIDINE, 5,6,7,8-TETRAHYDRO-; SCHEMBL6850314; ALBB-013491; BDBM50339009; MFCD14702912; ZINC42384352; AKOS005174074; CCG-321344; MCULE-3681769120; AM804108; AS-54882; SY029497; FT-0684163; Y-7547; 5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridine; 5,6,7,8-Tetrahydro-1,2,4-triazolo[4,3-a]pyridine; Z1655103760; 1,2,4-triazolo[4,3-a]pyridine, 5,6,7,8-tetrahydro-, hydrochloride
Click to Show/Hide
|
||||
| Activity |
IC50 = 244000 nM
|
[5] | |||
| Compound Name |
2-Amino-4-hydroxybenzothiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-aminobenzo[d]thiazol-4-ol; 2-amino-1,3-benzothiazol-4-ol; 4-Benzothiazolol, 2-amino-; 2-Amino-benzothiazol-4-ol; 2-aminobenzothiazol-4-ol; 4-Hydroxy-2-aminobenzothiazole; UNII-OBI166S5VM; OBI166S5VM; BENZOTHIAZOLE, 2-AMINO-4-HYDROXY-; CHEMBL1269497; 2-Amino-4-hydroxy-1,3-benzothiazole; NSC403535; zlchem 917; NSC 403535; BRN 0136771; PubChem13340; PubChem20528; 4-Benzothiazolol,2-amino-; Oprea1_629632; SCHEMBL74065; KSC640G7J; 2-Amino-4-hydroxy-benzthiazol; CTK5E0374; KS-00000MSS; DTXSID20225692; ZLD0380; 4-hydroxybenzo[d]thiazol-2-amine; WLN: T56 BN DSJ CZ IQ; 2-azanyl-1,3-benzothiazol-4-ol; ACT10505; EBD33001; STR08126; 4-Benzothiazolol, 2-amino- (9CI); ANW-48343; BDBM50339018; MFCD00160060; SBB070133; ZINC17158381; 4-hydroxy-1,3-benzothiazol-2-amine; AKOS001592678; AC-6357; AS06683; CS-W006232; MCULE-1167436806; NSC-403535; SB18595; SS-3440; VT10048; AK-31877; AM804315; BR-31877; SC-17140; 2-AMINO-4-HYDROXYBENZO[D]THIAZOLE; 2-amino-4-hydroxybenzothiazole, AldrichCPR; DB-005936; A5224; EU-0067153; FT-0601002; V0515; A-2444; 4-27-00-05445 (Beilstein Handbook Reference); 471A036; A838203; SR-01000391909; SR-01000391909-1; W-204310; Q27285555
Click to Show/Hide
|
||||
| Activity |
IC50 = 256000 nM
|
[5] | |||
| Compound Name |
7,8,9,10-Tetrahydropyrazino[1,2-b]indazol-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2029516; 1H,2H,7H,8H,9H,10H-pyrazino[1,2-b]indazol-1-one; KS-00003HP3; ZINC8804338; BDBM50384067; HTS001278; MFCD09248470; AKOS026674578; BS-4035; MCULE-9434655701; VU0421926-2; F3222-0052
Click to Show/Hide
|
||||
| Activity |
IC50 = 273000 nM
|
[2] | |||
| Compound Name |
1H-Indazol-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-Amino-1H-indazole; 1H-indazol-3-ylamine; 3-AMINOINDAZOLE; 3-Indazolamine; 2H-Indazol-3-amine; 1H-Indazole, 3-amino-; aminoindazole; Amino-indazole; NSC44677; 1H-indazole-3-ylamine; MFCD00182045; CHEMBL1331627; NSC-44677; 3-Amino-1H-indazole, 95%; INDAZOL-3-AMINE; indazole amine; 3-amino benzpyrazole; NSC 44677; PubChem11848; NCIStruc1_001630; NCIStruc2_000161; Oprea1_470192; SCHEMBL18878; MLS001001985; SCHEMBL5299723; DTXSID5061243; SCHEMBL14041182; CTK1F9567; CTK3E8354; 1H-Indazol-3-amine, AldrichCPR; 1,2-dihydro-3H-indazol-3-imine; HMS2604G05; ACN-S003263; ALBB-028239; BCP27432; NCI44677; ZINC3954002; ANW-52134; AR2288; BBL104359; BDBM50339013; CCG-37665; NCGC00013536; NSC348887; SBB052086; STL414950; AKOS000115531; AKOS006222497; CCG-302505; CS-W002482; MB69235; MCULE-2731257324; NSC-348887; SB39259; KS-00000A34; NCGC00013536-02; NCGC00096649-01; AK-26928; BP-10432; BR-26928; DA-26181; NCI60_004031; SC-24031; SMR000353333; ST098326; SY007051; AB0001596; DB-005098; AM20060880; FT-0604095; FT-0647301; FT-0729924; V8216; EN300-02352; A10401; C-1180; Z-8163; 49722-EP2295412A1; 49722-EP2295413A1; 49722-EP2295432A1; 49722-EP2311825A1; 10.14272/YDTDKKULPWTHRV-UHFFFAOYSA-N.1; 10P-212; 126812-EP2295412A1; 126812-EP2295413A1; 126854-EP2295412A1; 126854-EP2295413A1; 874I055; AE-413/25046004; doi:10.14272/YDTDKKULPWTHRV-UHFFFAOYSA-N.1; J-504673; Q27182567; Z56820416
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| Activity |
IC50 = 311000 nM
|
[5] | |||
| Compound Name |
3-(Furan-2-yl)-1H-pyrazol-5-amine
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Investigative | Compound Info | ||
| Synonyms |
5-(furan-2-yl)-1H-pyrazol-3-amine; 3-(2-Furyl)-1H-Pyrazol-5-Amine; 5-Amino-3-(2-furyl)pyrazole; 3-Amino-5-(2-furyl)pyrazole; 5-(2-Furyl)-1H-pyrazol-3-amine; 3-Amino-5-(2-furyl)-1H-pyrazole; 5-(2-furanyl)-1H-pyrazol-3-amine; CHEMBL1688214; MFCD00082696; ACMC-20anlo; furanyl-5-aminopyrazole; SCHEMBL570420; SCHEMBL645062; 3-(2-Furyl)pyrazol-5-amine; 3-(2-furyl)pyrazole-5-ylamine; 3-amino-5-(2-furanyl)pyrazole; 3-amino-5-(2-furyl)-pyrazole; 5-(2-furyl)pyrazole-3-ylamine; CTK3J7319; DTXSID70335159; ACT08207; BCP13617; ZINC4695246; 5-(2-furyl)-2H-pyrazol-3-amine; 3-(2-Furyl)-1H-pyrazole-5-amine; BDBM50339019; SBB005496; 3-Furan-2-yl-2H-pyrazol-5-ylamine; 5-amino-3-(fur-2-yl)-1h-pyrazole; 5-furan-2-yl-1H-pyrazol-3-ylamine; 5-furan-2-yl-2H-pyrazol-3-ylamine; AKOS000174119; AKOS005199092; 1H-Pyrazol-3-amine,5-(2-furanyl)-; 3-Amino-5-(2-furyl)pyrazole, 97%; 5-(2-Furyl)-1H-pyrazol-3-amine #; DS-2883; MCULE-5368413608; PS-4701; SDCCGMLS-0066122.P001; VP20123; KS-00002A94; AK-36993; BP-10379; SC-58123; ST075416; DB-004184; CS-0109592; FT-0619988; Z5418; M-7084; 3-(Furan-2-yl)-1H-pyrazol-5-amine, AldrichCPR; A845638
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| Activity |
IC50 = 313000 nM
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[5] | |||
| Compound Name |
4-(1H-Pyrazol-3-yl)pyridine
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Investigative | Compound Info | ||
| Synonyms |
4-(1H-pyrazol-5-yl)pyridine; pyridine, 4-(1H-pyrazol-3-yl)-; 4-(Pyrazol-3-yl)-pyridine; CHEMBL116211; 3-(4-pyridyl)pyrazole; 4-pyrazolylpyridine; EC-000.1948; SCHEMBL2148569; 4-(1H-Pyrazole-3-yl)pyridine; 3-(pyridin-4-yl)-1H-pyrazole; CTK0H2164; KS-00001RHH; 4-(1H-Pyrazol-3-yl)-pyridine; 4-(2H-Pyrazol-3-yl)-pyridine; DTXSID30585916; ALBB-021869; ZINC9238267; BBL028216; BDBM50339020; MFCD00115150; SBB027184; STK790339; AKOS000345411; AKOS002658160; AB03476; ACN-000466; MCULE-6986538471; QC-9134; VP14619; NCGC00343057-01; AB0072136; ST4148405; CS-0044140; FT-0761415; R2153; EN300-69165; A-2548; A12252; AB01334946-02; 784P600; 10Y-0805; Z1258992467
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| Activity |
IC50 = 326000 nM
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[5] | |||
| Compound Name |
6-Methoxypurine
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Investigative | Compound Info | ||
| Synonyms |
6-Methoxy-9H-purine; 6-methoxy-7H-purine; 1H-Purine, 6-methoxy-; O-Methylhypoxanthine; Purine, 6-methoxy-; CHEMBL305107; 6-Methoxy-1H-purine; NSC 23723; 6-methoxy purine; 6-methoxypu-rine; EINECS 214-047-1; 9H-Purine,6-methoxy-; AI3-50266; 6-Methoxy-1H-purine #; 9H-Purine, 6-methoxy-; TimTec1_004752; ACMC-1C2X2; SCHEMBL284829; Purine, 6-methoxy- (8CI); Cl-917; CTK0H6830; DTXSID90148041; HMS1547H22; NSC23723; ZINC4692471; ANW-15812; ANW-60834; BBL036901; BDBM50339021; MFCD00127913; NSC-23723; SBB086692; STL553553; AKOS003621274; AKOS005257626; CCG-321462; CS-W001289; MCULE-4261910368; VZ35713; KS-000017M7; AC-14042; AS-57122; FT-0621196; FT-0655828; M1925; ST50331227; X5946; 74M891; 074M891; AC-907/25004537; W-108745; Q27465611
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| Activity |
IC50 = 340000 nM
|
[5] | |||
| Compound Name |
3-(Hydroxymethyl)-1H-pyrazol-5-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688204; 5-hydroxymethyl-2h-pyrazol-3-ol; SCHEMBL2652640; SCHEMBL11314931; CTK5D2513; 5-hydroxymethyl-1h-pyrazol-3-ol; DTXSID60500798; BDBM50339007; ZINC38538098; AKOS006285510; AB44010; DB-028072; 5-(hydroxymethyl)-1,2-dihydropyrazol-3-one; FT-0743955; 5-(Hydroxymethyl)-1,2-dihydro-3H-pyrazol-3-one; 5-(hydroxymethyl)-2,3-dihydro-1H-pyrazol-3-one
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| Activity |
IC50 = 344000 nM
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[5] | |||
| Compound Name |
4-Hydroxyquinazoline
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Investigative | Compound Info | ||
| Synonyms |
Quinazolin-4-ol; quinazolin-4(3H)-one; 4-Quinazolinol; 4(3H)-Quinazolinone; 4-Quinazolinone; 4-Quinazolone; 4(1H)-Quinazolinone; 4-HQN; 4-Oxoquinazoline; 3,4-Dihydroquinazolin-4-one; 4(3H)-Quinazolone; Quinazolin-4(1H)-one; 1H-quinazolin-4-one; 3-hydro-4-quinazolinone; quinazolin-4-one; UNII-84JOT4EY5X; NSC 5863; MFCD00511302; 4-hydroxy quinazoline; QUINAZOLONE, 4-; 4-Hydroxyquinazoline, 98%; 84JOT4EY5X; CHEMBL266540; 4(3H)-Quinazolinone (9CI); quinazolidin-4-one; CCRIS 6801; quinazoline-4(3H)-one; EINECS 207-735-8; 4-Oxo-3,4-dihydroquinazoline; quinazoline-4-one; 4 hydroxyquinazoline; 4H-quinazolin-4-one; 3H-Quinazolin-4-one; 4-(3h)-quinazolinone; 4(3H)a-aQuinazolinone; 4-(1H)-Quinazolinone; 3-hydroquinazolin-4-one; quinazolin-4-(3h)-one; Quinazoline, 4-hydroxy-; ACMC-1AFF0; ACMC-1CAJ2; UPCMLD-DP009; 3,4-dihydroquinazolin4-one; DSSTox_CID_29372; DSSTox_RID_83487; DSSTox_GSID_49412; SCHEMBL10418; KSC237E0N; MLS000551010; DTXSID8049412; UPCMLD-DP009:001; BDBM27504; CTK0H0048; CTK1D7206; QMNUDYFKZYBWQX-UHFFFAOYSA-; NSC5863; HMS1768L21; HMS2267F20; HMS3268P19; HMS3413K17; HMS3677K17; KUC112576N; ACN-S003374; ALBB-012761; BCP00749; KS-000004DY; NSC-5863; STR01100; Tox21_202920; 5960AA; ANW-30728; ANW-66803; BBL000422; GEO-01561; s9360; SBB005858; STK900177; STL412452; ZINC17970819; AKOS000120375; AKOS002667326; AKOS005144631; AC-2419; CCG-266178; CS-W019586; HY-W018800; MCULE-7060458724; SB11452; KSC-321-063; NCGC00092327-01; NCGC00092327-03; NCGC00185015-01; NCGC00260466-01; AK-27831; BR-27831; SC-27191; SMR000112527; AB0013605; AB0066406; DB-026878; AM20040556; BB 0242096; EU-0000466; FT-0618749; H2739; ST45024484; 51986-EP2277867A2; 51986-EP2280003A2; 51986-EP2308844A2; 51986-EP2308845A2; 51986-EP2308846A2; AB00572679-10; 491H361; AC-907/34125008; Q2816678; W-200389; BRD-K91758890-001-03-5; Z56862715; CC65A28C-4F60-4D22-81DC-326D7F32EEE0; F0914-0242
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| Activity |
IC50 = 345000 nM
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[5] | |||
| Compound Name |
3-Aminoisoquinoline
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Investigative | Compound Info | ||
| Synonyms |
isoquinolin-3-amine; 3-Isoquinolinamine; Isoquinolin-3-ylamine; Isoquinoline, 3-amino-; Isoquinoline-3-amine; CHEMBL61743; 3-isoquinolylamine; isoquinolin-3-imine; NSC218383; zlchem 309; PubChem6217; isoquinoline-3-ylamine; uPa_46; 3-Aminoisoquinoline, 97%; SCHEMBL177520; 3-aminoisoquinoline, AldrichCPR; CTK1A3054; CTK4C1857; ZLC0134; WT720; ZINC157801; ACT01923; ANW-50449; BBL101046; BDBM50091818; MFCD00102190; SBB051996; STL554840; 25475-67-6 isoquinolin-3-amine; AKOS005256578; AB03416; CS-W009009; LS20125; NSC-218383; PS-4190; QC-9358; SDCCGMLS-0065877.P001; VQ10150; KS-00002A44; AC-26693; AK-27774; BR-27774; SC-02915; AB0005934; DB-011136; A5134; AM20051003; C2373; FT-0627505; S-2565; 71442-EP2295432A1; 71442-EP2308833A2; 475I676; W-202073
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| Activity |
IC50 = 376000 nM
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[5] | |||
| Compound Name |
N-(6-Fluoro-1,3-benzothiazol-2-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
N-(6-Fluoro-benzothiazol-2-yl)-acetamide; CHEMBL2029515; BAS 07005470; SCHEMBL15521825; ZINC2591126; BDBM50384066; STK248481; AKOS000453776; MCULE-9793333569; N-(6-Fluoro-2-benzothiazolyl)acetamide; N-(6-fluorobenzothiazol-2-yl)acetamide; ST062228; Acetamide, N-(6-fluorobenzothiazol-2-yl)-; N-(6-fluorobenzo[d]thiazol-2-yl)acetamide; AP-970/42444743; N~1~-(6-fluoro-1,3-benzothiazol-2-yl)acetamide; SR-01000322271; SR-01000322271-1; Z27969799; F0412-0001
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| Activity |
IC50 = 402000 nM
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[2] | |||
| Compound Name |
7-Methylthieno[3,2-d]pyrimidin-4-ol
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Investigative | Compound Info | ||
| Synonyms |
7-methylthieno[3,2-d]pyrimidin-4(3H)-one; 7-Methylthieno[3,2-d]pyrimidin-4(1H)-one; 4-Hydroxy-7-methylthieno[3,2-d]pyrimidine; 7-methyl-3H,4H-thieno[3,2-d]pyrimidin-4-one; CHEMBL1877245; 7-Methyl-3,4-dihydrothieno[3,2-d]pyrimidin-4-one; 7-methyl-3-hydrothiopheno[3,2-d]pyrimidin-4-one; PubChem23124; 7-methyl-1H-thieno[3,2-d]pyrimidin-4-one; MLS000755256; SCHEMBL358129; CTK6C3821; CTK6C3824; KS-00003EYM; HMS2655F03; ANW-72195; BDBM50384069; CCG-47381; GEO-04038; MFCD00205194; MFCD13181517; SBB088015; ZINC18204419; AKOS005203486; AKOS015842602; AS-8936; MCULE-5253035365; NE15681; SMR000338133; SY045969; 7-Methyl-3H-thieno[3,2-d]pyrimid-4-one; DB-064996; 3-Methylthieno(3,2-d)pyrimidin-7(6H)-one; 7-methyl-3H-thieno[3,2-d]pyrimidin-4-one; CS-0088166; FT-0726145; ST51041818; 7-Methylthieno[3,2-d]pyrimidine-4(3H)-one; 8P-807; SR-01000637001-1; F6782-6939; Z1741962447
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| Activity |
IC50 = 461000 nM
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[2] | |||
| Compound Name |
7-Methyl-5,6-dihydroimidazo[4,5-d]pyridazin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2029512; SCHEMBL2515712; ZINC8914466; BDBM50384063; STL571812; STL581296; AKOS023412850; MCULE-2071128224; 7-methyl-1H-imidazo[4,5-d]pyridazin-4-ol; ST50419971; 7-methyl-5-hydroimidazo[4,5-d]pyridazin-4-one; 7-methyl-1H-imidazo[4,5-d]pyridazin-4(5H)-one; 7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one; Imidazo[4,5-d]pyridazin-4-one, 7-methyl-1,5-dihydro-; 4-Methyl-6,7-dihydro-1H-imidazo[4,5-d]pyridazine-7-one; 7-methyl-1,5-dihydro-4h-imidazo[4,5-d]-pyridazin-4-one; 7-methyl-1,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
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| Activity |
IC50 = 472000 nM
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[2] | |||
| Compound Name |
Thieno[3,2-d]pyrimidin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
thieno[3,2-d]pyrimidin-4-ol; 1H,4H-Thieno[3,2-d]pyrimidin-4-one; thieno[3,2-d]pyrimidin-4(1h)-one; 4-Hydroxythieno[3,2-d]pyrimidine; 3H,4H-thieno[3,2-d]pyrimidin-4-one; 3H-Thieno[3,2-d]pyrimidin-4-one; CHEMBL1891423; Thieno[3,2-d]pyrimidine-4(3H)-one; 1H-thieno[3,2-d]pyrimidin-4-one; PubChem23108; Maybridge1_003845; MLS000760656; SCHEMBL209626; thieno[3,2-d]pyrimidin-4-one; CTK4D1195; CTK7H5859; HMS552G17; DTXSID20375262; thiopheno[3,2-d]pyrimidin-4-ol; 3H-thieno[3,2-d]pyrimid-4-one; HMS2633N20; HMS3363C14; BCP22593; 3H-thieno[3,2-d]pyrimidine-4-one; AB1054; ANW-21990; AR2543; BBL004543; BDBM50384077; MFCD03407527; MFCD11040452; SBB086859; STK934165; ZINC13598177; 1-Cbz-4-(Boc-aminomethyl)piperidine; 3H-thieno[3,2-d]-pyrimidin-4-one; 3H-thieno[3,2-d]pyrimid-in-4-one; AKOS001209898; AKOS005073855; AKOS006228164; AC-7413; FS-1501; MCULE-6798971824; PB10096; KS-00000H68; AC-28405; AK-39957; BR-25195; GK 00357; SC-85579; SMR000370597; SY006112; AB0022630; AB0066407; AB0086742; DB-005722; DB-026910; AM20080309; AM20080449; CS-0044467; FT-0602443; W3536; EN300-23988; C-1467; K-4532; X-1155; 1Z-0222; W-205901; Z169511928
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| Activity |
IC50 = 492000 nM
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[2] | |||
| Compound Name |
5,6-Dimethylthieno[2,3-d]pyrimidin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
5,6-Dimethyl-3H-thieno[2,3-d]pyrimidin-4-one; 5,6-dimethylthieno[2,3-d]pyrimidin-4-ol; CHEMBL2029510; 5,6-dimethylthieno[2,3-d]pyrimidin-4-one; Timtec-Bb Sbb009541; 4-hydroxy-5,6-dimethylthieno[2,3-d]pyrimidine; 5,6-dimethyl-3H,4H-thieno[2,3-d]pyrimidin-4-one; 5,6-dimethyl-3-hydrothiopheno[2,3-d]pyrimidin-4-one; NSC717525; SCHEMBL6004291; CTK4D9105; CTK6C5854; DTXSID60328030; HMS1782B08; ALBB-019839; ZINC8826716; ANW-64490; BBL007783; BDBM50384061; MFCD00463622; SBB009541; STK279676; STK741257; AKOS000264990; AKOS000276335; FS-1491; MCULE-6210596022; NSC-717525; AC-28075; AK103776; ST059935; ST081058; DB-065547; EU-0051251; FT-0726792; Z2933; 5,6-dimethylthiopheno[2,3-d]pyrimidin-4-ol; EN300-04275; K-5598; thieno[2,3-d]pyrimidin-4-ol, 5,6-dimethyl-; thieno[2,3-d]pyrimidin-4(3H)-one, 5,6-dimethyl-; Z56887663; F0745-0903; F0906-0955; 5,6-Dimethylthieno[2,3-d]pyrimidin-4(3H)-one, AldrichCPR
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| Activity |
IC50 = 828000 nM
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[2] | |||
| Compound Name |
2-(3-Anilino-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1171192; BDBM50321375; 2-(2-oxo-3-(phenylamino)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)aceticacid
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| Activity |
EC50 = 900000 nM
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[8] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ACS Med Chem Lett. 2010 Sep 7;1(9):454-9. | ||||
| REF 2 | Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4023-7. | ||||
| REF 3 | Hit to lead optimization of pyrazolo[1,5-a]pyrimidines as B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6890-2. | ||||
| REF 4 | Small-Molecule Allosteric Modulators of the Protein Kinase PDK1 from Structure-Based Docking. J Med Chem. 2015 Oct 22;58(20):8285-8291. | ||||
| REF 5 | Aminoindazole PDK1 Inhibitors: A Case Study in Fragment-Based Drug Discovery. ACS Med Chem Lett. 2010 Jul 22;1(8):439-42. | ||||
| REF 6 | US patent application no. 8741944B2, Anti-infective agents against intracellular pathogens | ||||
| REF 7 | US patent application no. 8628961B2, Small molecule antagonists of phosphatidylinositol-3,4,5-triphosphate (PIP3) and uses thereof | ||||
| REF 8 | Design and synthesis of benzoazepin-2-one analogs as allosteric binders targeting the PIF pocket of PDK1. Bioorg Med Chem Lett. 2010 Jul 1;20(13):3897-902. | ||||
| REF 9 | US patent application no. 8569511B2, Substituted 3-(1H-benzo[d]imidazol-2-yl)-1H-indazole analogs as inhibitors of the PDK1 kinase | ||||
| REF 10 | Inverse Virtual Screening allows the discovery of the biological activity of natural compounds. Bioorg Med Chem. 2012 Jun 1;20(11):3596-602. | ||||
| REF 11 | Discovery of novel 7-azaindoles as PDK1 inhibitors. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3073-3080. | ||||
| REF 12 | 2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept. J Med Chem. 2012 Nov 26;55(22):9817-30. | ||||
| REF 13 | US patent application no. 8637532B2, Amino azaheterocyclic carboxamides | ||||
| REF 14 | Fragment-based design, synthesis, biological evaluation, and SAR of 1H-benzo[d]imidazol-2-yl)-1H-indazol derivatives as potent PDK1 inhibitors. Bioorg Med Chem Lett. 2017 Dec 15;27(24):5473-5480. | ||||
| REF 15 | Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation. ACS Med Chem Lett. 2014 Aug 7;6(1):53-7 | ||||
| REF 16 | N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK. Medchemcomm. 2018 Apr 12;9(6):963-968. | ||||
| REF 17 | Selective 3-phosphoinositide-dependent kinase 1 (PDK1) inhibitors: dissecting the function and pharmacology of PDK1. J Med Chem. 2013 Apr 11;56(7):2726-37. | ||||
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