Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06BFH
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| Former ID |
DNC002378
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| Drug Name |
5-fluoro-1H-indole-2-carboxylic acid
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| Synonyms |
5-Fluoroindole-2-carboxylic acid; 399-76-8; 5-Fluoro-1H-indole-2-carboxylic acid; 2-Carboxy-5-fluoroindole; 1H-Indole-2-carboxylic acid, 5-fluoro-; CHEMBL23507; MLS000080089; WTXBRZCVLDTWLP-UHFFFAOYSA-N; MFCD00005612; SMR000037735; 5-Fluoroindole-2-carboxylic acid, 98%; Spectrum_001495; EINECS 206-919-5; PubChem1683; SpecPlus_000678; Spectrum5_001733; Opera_ID_1340; Spectrum4_001182; Spectrum3_001043; Spectrum2_001469; ACMC-209j9k; AC1Q4NE3; Lopac-265128; cid_1820; AC1Q73TI; AC1L1CB9; AC1Q73TJ; Lopac0_000071; Oprea1_012690
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| Drug Type |
Small molecular drug
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| Indication | Glioma [ICD-11: 2A00.0] | Investigative | [1] | |
| Melanoma [ICD-11: 2C30] | Investigative | [1] | ||
| Structure |
 |
Download2D MOL |
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| Formula |
C9H6FNO2
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| Canonical SMILES |
C1=CC2=C(C=C1F)C=C(N2)C(=O)O
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| InChI |
1S/C9H6FNO2/c10-6-1-2-7-5(3-6)4-8(11-7)9(12)13/h1-4,11H,(H,12,13)
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| InChIKey |
WTXBRZCVLDTWLP-UHFFFAOYSA-N
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| CAS Number |
CAS 399-76-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
855691, 859279, 3153364, 3720224, 5491769, 8151299, 11110665, 11341949, 11362132, 11364389, 11366951, 11369513, 11371886, 11374981, 11377675, 11485133, 11487534, 11489285, 11490858, 11492996, 11495309, 15042000, 17404634, 24277978, 25770020, 26612296, 26679407, 26746960, 29221019, 47291302, 47662492, 47959953, 48110644, 49747479, 49832817, 50086821, 50100158, 50104011, 50104012, 50104013, 51091203, 53777177, 57321036, 57934717, 79163025, 85086129, 85230874, 85789664, 87561323, 87623487
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| ChEBI ID |
CHEBI:111276
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | AP endonuclease 1 (APEX1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Base excision repair | |||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
| WikiPathways | Spinal Cord Injury | |||
| TSH signaling pathway | ||||
| Base Excision Repair | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines. Br J Cancer. 2011 Feb 15;104(4):653-63. | |||
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