Target Poor or Non Binder(s) Information
Target General Information | Top | ||||
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Target ID | T20776 | Target Info | |||
Target Name | Fru-2,6-P2ase 2/6PF-2-K (PFK/FBPase 2) | ||||
Synonyms |
PFKFB2; PFK-2/FBPase-2; 6PF-2-K/Fru-2,6-P2ASE heart-typeisozyme
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Target Type | Literature-reported Target | ||||
Gene Name | PFKFB2 | ||||
Biochemical Class | Kinase | ||||
UniProt ID |
Poor Binders of This Target (in total, 9 binders) | Download | Top | |||
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Compound Name |
2-Amino-N-[4-[(2-amino-3-cyano-1H-indol-5-yl)oxy]phenyl]acetamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3422656; SCHEMBL5857288; BDBM50082130
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Activity |
IC50 = 53800 nM
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[1] | |||
Compound Name |
2-Azanyl-N-[4-[(3-Cyano-1h-Indol-5-Yl)oxy]phenyl]ethanamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3422660; SCHEMBL21856775; BDBM50082137; Q27463191; N-{4-[(3-cyano-1H-indol-5-yl)oxy]phenyl}glycinamide; 2-amino-N-[4-[(3-cyano-1H-indol-5-yl)oxy]phenyl]acetamide
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Activity |
IC50 = 63200 nM
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[1] | |||
Compound Name |
CCn1cc(C#N)c2cc(Oc3ccc(NC(=O)CN(C)C)cc3)ccc12
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3422663; SCHEMBL21857036; BDBM50082195
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Activity |
IC50 = 76100 nM
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[1] | |||
Compound Name |
Schembl21856723
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3422666; BDBM50082198
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Activity |
IC50 = 76500 nM
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[1] | |||
Compound Name |
5-(4-Acetylaminophenoxy)-2-amino-1H-indole-3-carbonitrile
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3422655; PFKFB3-IN-1; SCHEMBL5857153; N-[4-[(2-amino-3-cyano-1H-indol-5-yl)oxy]phenyl]acetamide; BDBM50082131
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Activity |
IC50 ~ 100000 nM
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[1] | |||
Compound Name |
Schembl21856804
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3421735; BDBM50082125
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Activity |
IC50 ~ 100000 nM
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[1] | |||
Compound Name |
(2R)-2-Amino-N-[4-[(2-amino-3-cyano-1H-indol-5-yl)oxy]phenyl]-3-hydroxypropanamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3421643; BDBM50082129
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Activity |
IC50 ~ 100000 nM
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[1] | |||
Compound Name |
Schembl21856730
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3422671; BDBM50082205
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Activity |
IC50 ~ 100000 nM
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[1] | |||
Compound Name |
Schembl21856796
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3422665; BDBM50082197
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Activity |
IC50 ~ 100000 nM
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[1] | |||
Click to Show/Hide the Information of All Poor Binders |
References | Top | ||||
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REF 1 | Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3. J Med Chem. 2015 Apr 23;58(8):3611-25. |
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