Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T20600 | Target Info | |||
| Target Name | Caspase-6 (CASP6) | ||||
| Synonyms |
MCH2; Caspase-6 subunit p18; Caspase-6 subunit p11; CASP-6; Apoptotic protease Mch-2
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|
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| Target Type | Patented-recorded Target | ||||
| Gene Name | CASP6 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 14 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-(pyrrolidin-1-ylsulfonyl)indoline-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
5-(pyrrolidin-1-ylsulfonyl)indoline-2,3-dione; 220510-17-8; 5-(Pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione; Isatin Sulfonamide 20; 5-pyrrolidinylsulfonylisatin; AC1N3S5K; 5-pyrrolidin-1-ylsulfonyl-1H-indole-2,3-dione; SCHEMBL2486952; CHEMBL305545; BDBM10309; DTXSID80399500; QKCWUYHXHMXOLG-UHFFFAOYSA-N; ZINC2944777; 5-[1-(pyrrolidinyl)sulfonyl]isatin; 2991AJ; AKOS024262065; AJ-44312; 5-(Pyrrolizinosulfonyl)indoline-2,3-dione; AX8291337; FT-0734877; 5-(Pyrrolidin-1-ylsulfonyl)-1H-indole-2,3-dione
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-[(2-phenoxyacetyl)amino]pentanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL100741; BDBM50119207; 4-Methyl-2-(2-phenoxy-acetylamino)-pentanoic acid (2-hydroxy-5-oxo-tetrahydro-furan-3-yl)-amide
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-2-[(2-isoquinolin-1-yloxyacetyl)amino]-4-methylpentanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL100578; BDBM50119225
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-[(2-quinolin-4-yloxyacetyl)amino]pentanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL100927; BDBM50119251
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-(3-phenoxypropanoylamino)pentanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL101714; BDBM50119217; 4-Methyl-2-(3-phenoxy-propionylamino)-pentanoic acid (2-hydroxy-5-oxo-tetrahydro-furan-3-yl)-amide
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
4-Methyl-2-phenylamino-pentanoic acid (2-hydroxy-5-oxo-tetrahydro-furan-3-yl)-amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL317530; BDBM50119229
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-[(2-quinolin-5-yloxyacetyl)amino]pentanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL318295; BDBM50119215
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(2S)-2-[[2-(4-Cyclopentylphenoxy)acetyl]amino]-N-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-4-methylpentanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL99999; BDBM50119224
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| Activity |
IC50 = 51200 nM
|
[2] | |||
| Compound Name |
5-(2-((Methyl(phenyl)amino)methyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62187; BDBM50297258; 5-{2-[(Methyl-phenyl-amino)-methyl]-pyrrolidine-1-sulfonyl}-1H-indole-2,3-dione
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|
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| Activity |
Ki = 57000 nM
|
[1] | |||
| Compound Name |
1-Butyl-7-fluoro-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359202; BDBM50031610
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|
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| Activity |
IC50 = 78900 nM
|
[3] | |||
| Compound Name |
(E,3S)-3-[[(2S)-1-[(2S)-2-[[(2S)-3-Carboxy-2-(phenylmethoxycarbonylamino)propanoyl]amino]-3,3-dimethylbutanoyl]azetidine-2-carbonyl]amino]-5-methylsulfonylpent-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323967; BDBM50426563
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(E,3S)-3-[[(2S)-1-[(2R)-2-[(4-Amino-3-chlorobenzoyl)amino]-3,3-dimethylbutanoyl]pyrrolidine-2-carbonyl]amino]-5-methylsulfonylpent-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323966; BDBM50426564
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(E,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-3-Carboxy-2-(phenylmethoxycarbonylamino)propanoyl]amino]-2-phenylacetyl]amino]-3-methylbutanoyl]amino]-6-ethoxy-6-oxohex-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2324341; SCHEMBL15462686; BDBM50426566
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(E,3S)-3-[[(2S,3S)-2-[[(2S)-5-Amino-2-[[(2S)-3-(1H-indol-3-yl)-2-(phenylmethoxycarbonylamino)propanoyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]amino]-5-methylsulfonylpent-4-enoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2324340; BDBM50426565
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|
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| Activity |
IC50 = 100000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 58 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-Butyl-5-[(2S)-2-(2-fluoroethoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348701; BDBM50431505
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|
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| Activity |
IC50 > 500000 nM
|
[5] | |||
| Compound Name |
5-[(2S)-2-(Ethoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348697; BDBM50431509
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|
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| Activity |
IC50 > 500000 nM
|
[5] | |||
| Compound Name |
1-(4-Fluorobutyl)-7-iodo-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359188; BDBM50031596
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|
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| Activity |
IC50 = 500000 nM
|
[3] | |||
| Compound Name |
1-[(2S)-3-Fluoro-2-hydroxypropyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL524017; BDBM50258335; (S)-1-[(S)-3-Fluoro-2-hydroxypropyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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| Activity |
IC50 > 500000 nM
|
[6] | |||
| Compound Name |
(S)-5-[1-(2-Methoxymethylpyrrolidinyl)sulfonyl]-1-(4-vinylbenzyl)isatin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL513663; BDBM50258694
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|
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| Activity |
IC50 > 500000 nM
|
[6] | |||
| Compound Name |
(S)-1-(4-(2-(4-Methylphenylsulfonyloxy)ethoxy)benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL216071; SCHEMBL8263984; BDBM50200312
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|
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| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
1-Butyl-7-chloro-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359199; BDBM50031607
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|
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| Activity |
IC50 = 500000 nM
|
[3] | |||
| Compound Name |
1-Methyl-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL293034; (s)-1-methyl-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin; (S)-1-Methyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl}isatin; Isatin Sulfonamide 31; SCHEMBL4156846; Pyrrolidine Isatin Analogue 11a; BDBM10320; DB08213; Q27097439; (S)-1-methyl-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione; 1-Methyl-5-[[(2S)-2-(phenoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione
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|
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| Activity |
IC50 > 500000 nM
|
[6] | |||
| Compound Name |
5-[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl-1-[9-(oxiran-2-yl)nonyl]indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521984; BDBM50258378; (S)-5-[1-(2-Methoxymethylpyrrolidinyl)sulfonyl]-1-[9-(oxiran-2-yl)nonyl]isatin
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|
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| Activity |
IC50 > 500000 nM
|
[6] | |||
| Compound Name |
(S)-1-(4-Iodobenzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL217457; SCHEMBL15029243; BDBM50200306
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|
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| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
(S)-1-(4-(2-(4-Methylphenylsulfonyloxy)ethoxy)benzyl)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]isatin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386510; BDBM50200310; 1-[4-[2-(Tosyloxy)ethoxy]benzyl]-5-[[2alpha-(phenoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione
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|
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| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
5-[2-(3-Methoxypropyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348694; BDBM50431512
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|
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| Activity |
IC50 > 500000 nM
|
[5] | |||
| Compound Name |
(S)-5-(2-(Methoxymethyl)pyrrolidin-1-ylsulfonyl)-1-methylindoline-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL216819; SCHEMBL15029242; BDBM50200302; (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-methylisatin
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|
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| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
5-[(2S)-2-(2,2,2-Trifluoroethoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348859; BDBM50431518
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|
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| Activity |
IC50 > 500000 nM
|
[5] | |||
| Compound Name |
(S)-1-(4-Hydroxybenzyl)-5-[1-(2-methoxymethylpyrrolidinyl)-sulfonyl]isatin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL217220; BDBM50200307
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|
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| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
(S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200677; 1-[(4-methoxyphenyl)methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione; SCHEMBL4152857; Pyrrolidine Isatin Analogue 11b; BDBM10330; 1-(4-Methoxybenzyl)-5-[[2alpha-(phenoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione
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|
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| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
(S)-5-[1-(2-Methoxymethylpyrrolidinyl)sulfonyl]-1-(4-(tributylstannyl)benzyl)isatin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL217822; BDBM50200313
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|
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| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
(S)-5-[1-(2-Phenoxymethylpyrrolidinyl)sulfonyl]-1-(4-(tributylstannyl)benzyl)isatin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386464; BDBM50200304
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|
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| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
5-[(2S)-2-(2-Methoxyethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348691; BDBM50431515
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|
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| Activity |
IC50 > 500000 nM
|
[5] | |||
| Compound Name |
5-[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl-1-[[4-(oxiran-2-ylmethoxy)phenyl]methyl]indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL494220; BDBM50258381; (S)-5-[1-(2-Methoxymethylpyrrolidinyl)sulfonyl]-1-[4-(oxiran-2-ylmethoxy)benzyl]isatin
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| Activity |
IC50 > 500000 nM
|
[6] | |||
| Compound Name |
Caspase-3/7 Inhibitor I
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL60190; 5-[(S)-(+)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin; Isatin Sulfonamide 16; SCHEMBL3681388; BDBM10305; DTXSID50431688; ZINC3871900; MFCD22581511; A14919; J-014451; (S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isatin; 5-[[(2S)-2-(Methoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione; 5-{[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl}-1H-indole-2,3-dione
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|
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| Activity |
IC50 = 500000 nM
|
[3] | |||
| Compound Name |
1-Butyl-5-[(2S)-2-(2-methoxyethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348692; BDBM50431514
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|
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| Activity |
IC50 > 500000 nM
|
[5] | |||
| Compound Name |
1-[[4-(3-Fluoro-2-hydroxypropoxy)phenyl]methyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL466422; BDBM50258698; (S)-1-[4-(3-Fluoro-2-hydroxypropoxy)benzyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-isatin
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| Activity |
IC50 > 500000 nM
|
[6] | |||
| Compound Name |
1-(4-Fluorobutyl)-5-[2-(3-methoxypropyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348696; BDBM50431510
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|
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| Activity |
IC50 > 500000 nM
|
[5] | |||
| Compound Name |
(S)-5-[1-(2-Methoxymethylpyrrolidinyl)sulfonyl]-1-[(S)-oxiran-2-ylmethyl]isatin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL513297; BDBM50258697
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|
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| Activity |
IC50 > 500000 nM
|
[6] | |||
| Compound Name |
(S)-1-[4-(Allyloxy)benzyl]-5-[1-(2-methoxymethylpyrrolidinyl)-sulfonyl]isatin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL467252; BDBM50258696
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|
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| Activity |
IC50 > 500000 nM
|
[6] | |||
| Compound Name |
(S)-1-(4-(2-Bromoethoxy)benzyl)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]isatin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL385930; BDBM50200315; 1-[4-(2-Bromoethoxy)benzyl]-5-[[2alpha-(phenoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione
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|
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| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
5-[(2S)-2-(Ethoxymethyl)pyrrolidin-1-yl]sulfonyl-1-(4-fluorobutyl)indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348699; BDBM50431507
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|
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| Activity |
IC50 > 500000 nM
|
[5] | |||
| Compound Name |
1-(4-Fluorobutyl)-5-[(2S)-2-(2-fluoroethoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348702; BDBM50431504
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|
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| Activity |
IC50 > 500000 nM
|
[5] | |||
| Compound Name |
(S)-1-(4-(2-Bromoethoxy)benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL216447; BDBM50200311
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|
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| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
(S)-1-Allyl-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL512101; BDBM50258667
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|
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| Activity |
IC50 > 500000 nM
|
[6] | |||
| Compound Name |
(S)-5-[1-(2-Methoxymethylpyrrolidinyl)sulfonyl]-1-[4-(oxiran-2-yl)benzyl]isatin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL523666; BDBM50258379
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|
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| Activity |
IC50 > 500000 nM
|
[6] | |||
| Compound Name |
5-[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl-1-[2-(oxiran-2-yl)ethyl]indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL493374; BDBM50258336; (S)-5-[1-(2-Methoxymethylpyrrolidinyl)sulfonyl]-1-[2-(oxiran-2-yl)ethyl]isatin
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|
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| Activity |
IC50 > 500000 nM
|
[6] | |||
| Compound Name |
5-[(2S)-2-(2-Fluoroethoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348700; BDBM50431506
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|
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| Activity |
IC50 > 500000 nM
|
[5] | |||
| Compound Name |
(S)-1-(4-Iodobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)isatin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384023; SCHEMBL2259426; BDBM50200305; (S)-1-(4-iodobenzyl)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]isatin; 1-[(4-iodophenyl)methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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|
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| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
(S)-1-[(S)-2,3-Dihydroxypropyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL511723; BDBM50258699
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|
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| Activity |
IC50 > 500000 nM
|
[6] | |||
| Compound Name |
7-Chloro-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359198; BDBM50031606
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|
||||
| Activity |
IC50 = 500000 nM
|
[3] | |||
| Compound Name |
1-Butyl-5-[2-(3-methoxypropyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348695; BDBM50431511
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| Activity |
IC50 > 500000 nM
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[5] | |||
| Compound Name |
7-Bromo-1-(4-hydroxybutyl)-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359197; BDBM50031605
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| Activity |
IC50 = 500000 nM
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[3] | |||
| Compound Name |
(S)-1-(4-(Tert-butyldimethylsilyloxy)benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL387041; BDBM50200308
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| Activity |
IC50 > 500000 nM
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[7] | |||
| Compound Name |
(S)-1-(4-Hydroxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL200927; SCHEMBL4143820; Pyrrolidine Isatin Analogue 11f; BDBM10334; 1-(4-Hydroxybenzyl)-5-[[2alpha-(phenoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione; 1-[(4-hydroxyphenyl)methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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| Activity |
IC50 > 500000 nM
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[7] | |||
| Compound Name |
1-[[4-(2-Bromo-1-fluoroethyl)phenyl]methyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL467251; BDBM50258695; (S)-1-[4-(2-Bromo-1-fluoroethyl)benzyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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| Activity |
IC50 > 500000 nM
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[6] | |||
| Compound Name |
(S)-1-(3,4-Dihydroxybutyl)-5-[1-(2-methoxymethylpyrrolidinyl)-sulfonyl]isatin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL466423; BDBM50258700
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| Activity |
IC50 > 500000 nM
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[6] | |||
| Compound Name |
(S)-5-(2-Phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL62993; (s)-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin; (S)-5-{1-[2-(Phenoxymethyl)pyrrolidinyl]sulfonyl}isatin; Isatin Sulfonamide 29; Pyrrolidine Isatin Analogue 10; SCHEMBL2263591; BDBM10318; 5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione; 5-[[2alpha-(Phenoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione; 5-{[(2S)-2-(Phenoxymethyl)pyrrolidin-1-yl]sulfonyl}-1H-indole-2,3-dione
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| Activity |
IC50 > 500000 nM
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[6] | |||
| Compound Name |
7-Chloro-1-(3-fluoropropyl)-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359200; BDBM50031608
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| Activity |
IC50 = 500000 nM
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[3] | |||
| Compound Name |
(S)-1-(4-(Tert-butyldimethylsilyloxy)benzyl)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]isatin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL217821; BDBM50200314
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| Activity |
IC50 > 500000 nM
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[7] | |||
| Compound Name |
7-Fluoro-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359201; BDBM50031609
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| Activity |
IC50 = 500000 nM
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[3] | |||
| Compound Name |
1-Butyl-5-[(2S)-2-(2,2,2-trifluoroethoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348860; BDBM50431517
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| Activity |
IC50 > 500000 nM
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[5] | |||
| Compound Name |
(S)-1-(4-Methoxybenzyl)-5-[1-(2-methoxymethylpyrrolidinyl)-sulfonyl]isatin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL217777; SCHEMBL8263985; BDBM50200303
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| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
(S)-1-(4-(2-Fluoroethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL213759; WC-II-89; SCHEMBL15029245; BDBM50192784; (S)-1-(4-(2-fluoroethoxy)benzyl)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]isatin; 1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
Click to Show/Hide
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| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
1-Butyl-7-iodo-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359186; BDBM50031594
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| Activity |
IC50 = 500000 nM
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[3] | |||
| Compound Name |
(S)-5-[1-(2-Methoxymethylpyrrolidinyl)sulfonyl]-1-(undec-10-enyl)isatin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL513513; BDBM50258669
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| Activity |
IC50 > 500000 nM
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[6] | |||
| Compound Name |
1-(4-Hydroxybutyl)-7-iodo-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359189; BDBM50031597
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| Activity |
IC50 = 500000 nM
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[3] | |||
| Compound Name |
(S)-1-(But-3-enyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL468088; BDBM50258668
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| Activity |
IC50 > 500000 nM
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[6] | |||
| Compound Name |
1-[[4-(1-Fluoro-2-hydroxyethyl)phenyl]methyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL492385; BDBM50258380; (S)-1-[4-(1-Fluoro-2-hydroxyethyl)benzyl]-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Click to Show/Hide
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| Activity |
IC50 > 500000 nM
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[6] | |||
| Compound Name |
1-(4-Fluorobutyl)-5-[(2S)-2-(2,2,2-trifluoroethoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2348861; BDBM50431516
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| Activity |
IC50 > 500000 nM
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[5] | |||
| Compound Name |
(S)-1-(4-Fluoro-3-hydroxybutyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL493375; BDBM50258337
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| Activity |
IC50 > 500000 nM
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[6] | |||
| Compound Name |
(4S)-5-[[(2S)-6-[6-[5-[(3As,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoylamino]-1-[[(2S)-1-carboxy-4-(2,6-dimethylbenzoyl)oxy-3-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-oxo-4-(phenylmethoxycarbonylamino)pentanoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL221870; BDBM50200932
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| Activity |
Ki = 550000 nM
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[8] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem. 2001 Jun 7;44(12):2015-26. | ||||
| REF 2 | Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2969-71. | ||||
| REF 3 | Synthesis of 7-halogenated isatin sulfonamides: nonradioactive counterparts of caspase-3/-7 inhibitor-based potential radiopharmaceuticals for molecular imaging of apoptosis. J Med Chem. 2014 Nov 26;57(22):9383-95. | ||||
| REF 4 | Irreversible inhibitors of cysteine proteases. ACS Med Chem Lett. 2013 Jan 28;4(2):163-4. | ||||
| REF 5 | Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: nonradioactive counterparts of putative PET-compatible apoptosis imaging agents. Bioorg Med Chem. 2013 Apr 1;21(7):2025-36. | ||||
| REF 6 | Fluorinated isatin derivatives. Part 2. New N-substituted 5-pyrrolidinylsulfonyl isatins as potential tools for molecular imaging of caspases in apoptosis. J Med Chem. 2009 Jun 11;52(11):3484-95. | ||||
| REF 7 | 5-pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis. J Med Chem. 2006 Nov 16;49(23):6704-15. | ||||
| REF 8 | Synthesis of novel caspase inhibitors for characterization of the active caspase proteome in vitro and in vivo. J Med Chem. 2006 Dec 28;49(26):7636-45. | ||||
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