TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T20600	Caspase-6	B08VAO	(E,3S)-3-[[(2S)-1-[(2S)-2-[[(2S)-3-Carboxy-2-(phenylmethoxycarbonylamino)propanoyl]amino]-3,3-dimethylbutanoyl]azetidine-2-carbonyl]amino]-5-methylsulfonylpent-4-enoic acid	Investigative	71716242	C28H38N4O11S	638.7	CC(C)(C)[C@@H](C(=O)N1CC[C@H]1C(=O)N[C@@H](CC(=O)O)/C=C/S(=O)(=O)C)NC(=O)[C@H](CC(=O)O)NC(=O)OCC2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T20600	Caspase-6	B4V1GJ	1-Butyl-7-fluoro-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione	Investigative	118723330	C18H23FN2O5S	398.5	CCCCN1C2=C(C=C(C=C2F)S(=O)(=O)N3CCC[C@H]3COC)C(=O)C1=O	IC50 = 78900 nM	Poor binder
T20600	Caspase-6	B6FZ4S	(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-[(2-phenoxyacetyl)amino]pentanamide	Investigative	44331676	C18H24N2O6	364.4	CC(C)C[C@@H](C(=O)N[C@H]1CC(=O)OC1O)NC(=O)COC2=CC=CC=C2	IC50 ~ 50000 nM	Poor binder
T20600	Caspase-6	B6LN1Y	5-(2-((Methyl(phenyl)amino)methyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione	Investigative	44304162	C20H21N3O4S	399.5	CN(CC1CCCN1S(=O)(=O)C2=CC3=C(C=C2)NC(=O)C3=O)C4=CC=CC=C4	Ki = 57000 nM	Poor binder
T20600	Caspase-6	B7L4DQ	(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-2-[(2-isoquinolin-1-yloxyacetyl)amino]-4-methylpentanamide	Investigative	44332029	C21H25N3O6	415.4	CC(C)C[C@@H](C(=O)N[C@H]1CC(=O)OC1O)NC(=O)COC2=NC=CC3=CC=CC=C32	IC50 ~ 50000 nM	Poor binder
T20600	Caspase-6	B8MQD0	(E,3S)-3-[[(2S)-1-[(2R)-2-[(4-Amino-3-chlorobenzoyl)amino]-3,3-dimethylbutanoyl]pyrrolidine-2-carbonyl]amino]-5-methylsulfonylpent-4-enoic acid	Investigative	71720507	C24H33ClN4O7S	557.1	CC(C)(C)[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)/C=C/S(=O)(=O)C)NC(=O)C2=CC(=C(C=C2)N)Cl	IC50 ~ 100000 nM	Poor binder
T20600	Caspase-6	B93XHP	(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-[(2-quinolin-4-yloxyacetyl)amino]pentanamide	Investigative	44332028	C21H25N3O6	415.4	CC(C)C[C@@H](C(=O)N[C@H]1CC(=O)OC1O)NC(=O)COC2=CC=NC3=CC=CC=C32	IC50 ~ 50000 nM	Poor binder
T20600	Caspase-6	BBP87H	(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-(3-phenoxypropanoylamino)pentanamide	Investigative	44331693	C19H26N2O6	378.4	CC(C)C[C@@H](C(=O)N[C@H]1CC(=O)OC1O)NC(=O)CCOC2=CC=CC=C2	IC50 ~ 50000 nM	Poor binder
T20600	Caspase-6	BCS2A9	(2S)-2-[[2-(4-Cyclopentylphenoxy)acetyl]amino]-N-[(3S)-2-hydroxy-5-oxooxolan-3-yl]-4-methylpentanamide	Investigative	44332078	C23H32N2O6	432.5	CC(C)C[C@@H](C(=O)N[C@H]1CC(=O)OC1O)NC(=O)COC2=CC=C(C=C2)C3CCCC3	IC50 = 51200 nM	Poor binder
T20600	Caspase-6	BCXK47	(E,3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-3-Carboxy-2-(phenylmethoxycarbonylamino)propanoyl]amino]-2-phenylacetyl]amino]-3-methylbutanoyl]amino]-6-ethoxy-6-oxohex-4-enoic acid	Investigative	71471109	C33H40N4O11	668.7	CCOC(=O)/C=C/[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C1=CC=CC=C1)NC(=O)[C@H](CC(=O)O)NC(=O)OCC2=CC=CC=C2	IC50 ~ 100000 nM	Poor binder
T20600	Caspase-6	BEB40F	4-Methyl-2-phenylamino-pentanoic acid (2-hydroxy-5-oxo-tetrahydro-furan-3-yl)-amide	Investigative	44331966	C16H22N2O4	306.36	CC(C)C[C@@H](C(=O)N[C@H]1CC(=O)OC1O)NC2=CC=CC=C2	IC50 ~ 50000 nM	Poor binder
T20600	Caspase-6	BLM9F1	(E,3S)-3-[[(2S,3S)-2-[[(2S)-5-Amino-2-[[(2S)-3-(1H-indol-3-yl)-2-(phenylmethoxycarbonylamino)propanoyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]amino]-5-methylsulfonylpent-4-enoic acid	Investigative	71718085	C36H46N6O10S	754.9	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(=O)O)/C=C/S(=O)(=O)C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)OCC3=CC=CC=C3	IC50 = 100000 nM	Poor binder
T20600	Caspase-6	BV4M7B	(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-[(2-quinolin-5-yloxyacetyl)amino]pentanamide	Investigative	44332121	C21H25N3O6	415.4	CC(C)C[C@@H](C(=O)N[C@H]1CC(=O)OC1O)NC(=O)COC2=CC=CC3=C2C=CC=N3	IC50 ~ 50000 nM	Poor binder
T20600	Caspase-6	D0N5MU	5-(pyrrolidin-1-ylsulfonyl)indoline-2,3-dione	Investigative	4117381	C12H12N2O4S	280.3	C1CCN(C1)S(=O)(=O)C2=CC3=C(C=C2)NC(=O)C3=O	Ki ~ 50000 nM	Poor binder