Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T20371 | Target Info | |||
| Target Name | Prolylcarboxypeptidase (PRCP) | ||||
| Synonyms |
Proline carboxypeptidase; PCP; Lysosomal carboxypeptidase C; Lysosomal Pro-X carboxypeptidase; Angiotensinase C
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|
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| Target Type | Patented-recorded Target | ||||
| Gene Name | PRCP | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 28 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
JTP-4819
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|
Discontinued in Phase 2 | Compound Info | ||
| Synonyms |
JTP-3399
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
PRE-084
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|
Terminated | Compound Info | ||
| Synonyms |
Pre-084; 138847-85-5; 2-Morpholinoethyl 1-Phenylcyclohexanecarboxylate; 2-(4-Morpholino)ethyl-1-phenylcyclohexane-1-carboxylate; CHEMBL305881; 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate; Cyclohexanecarboxylic acid, 1-phenyl-, 2-(4-morpholinyl)ethyl ester; Tocris-0589; Lopac-P-2607; AC1L2Q9Z; Lopac0_000927; PRE084; GTPL6678; SCHEMBL5564153; CHEBI:93007; DTXSID40160819; EX-A911; BCP25418; BDBM50039197; ZINC25756875; AKOS027439951; CCG-205008; NCGC00024669-03; NCGC00024669-02; NCGC00024669-01; NCGC00015808-04
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| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
N-Dodecylazetidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3979970; BDBM193279; US9193762, RS-48-01
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| Activity |
Ki = 50140 nM
|
[3] | |||
| Compound Name |
N-Dodecyl-1-(pyrrolidine-2-carbonyl)azetidine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3927214; BDBM193280; US9193762, RS-48-03
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| Activity |
Ki = 50400 nM
|
[3] | |||
| Compound Name |
Benzyl (2S)-2-[[4-(dodecylamino)-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3902738; BDBM193287; US9193762, RS-37-06
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| Activity |
Ki = 58000 nM
|
[3] | |||
| Compound Name |
Benzyl (2S)-2-[(2S)-2-(hexadecylcarbamoyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3901239; BDBM193262; US9193762, RS-33-6
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| Activity |
Ki = 61000 nM
|
[3] | |||
| Compound Name |
(2S)-N-Dodecylpyrrolidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3890664; BDBM193277; US9193762, RS-47-01
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| Activity |
Ki = 61500 nM
|
[3] | |||
| Compound Name |
(S)-Benzyl-2-((S)-2-(pentadecylcarbamoyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL9277484; CHEMBL3927320; BDBM193263; US9193762, RS-33-7; benzyl (2S)-2-[(2S)-2-(pentadecylcarbamoyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
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| Activity |
Ki = 61500 nM
|
[3] | |||
| Compound Name |
Benzyl (2S)-2-[(2S)-2-(dodecylcarbamoyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3896136; BDBM193275; US9193762, RS-33-20
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| Activity |
Ki = 61500 nM
|
[3] | |||
| Compound Name |
3-(Biphenyl-4-yl)-1-{2-[5-(furan-2-yl)-1H-imidazol-2-yl]pyrrolidin-1-yl}propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1259219; BDBM50328573
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| Activity |
IC50 = 74000 nM
|
[4] | |||
| Compound Name |
3-(Biphenyl-4-yl)-1-[2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1259030; BDBM50328579
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|
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| Activity |
IC50 = 78000 nM
|
[4] | |||
| Compound Name |
Benzyl (2S)-2-[(2S)-2-(heptylcarbamoyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3899494; BDBM193274; US9193762, RS-33-19
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|
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| Activity |
Ki = 80000 nM
|
[3] | |||
| Compound Name |
Benzyl (2S)-2-[(2S)-2-[(3,4-dichlorophenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3895355; BDBM193259; US9193762, RS-33-2
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| Activity |
Ki = 80600 nM
|
[3] | |||
| Compound Name |
3-(Biphenyl-4-yl)-1-{(2S)-2-[5-(prop-1-en-2-yl)-1H-imidazol-2-yl]pyrrolidin-1-yl}propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1259117; BDBM50328565
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|
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| Activity |
IC50 = 92000 nM
|
[4] | |||
| Compound Name |
(R)-Preclamol
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|
Investigative | Compound Info | ||
| Synonyms |
UNII-8L7H229K4I; CHEMBL7393; 3-[(3R)-1-propylpiperidin-3-yl]phenol; R-3-PPP hydrochloride; 8L7H229K4I; R-3-(3-Hydroxyphenyl)-N-propylpiperidine hydrochloride; Preclamol, (R)-; MFCD00055194; (R)-(+)-3-(3-Hydroxy-phenyl)-N-propylpiperidine; 3-(1-Propyl-piperidin-3-yl)-phenol; Lopac-P-102; Lopac-P-103; R-3-(3-Hydroxyphenyl)-N-propylpiperidine HCl; Lopac0_000986; ZINC393; cid_202478; SCHEMBL8354256; DTXSID101017364; R(+)-3-PPP; 3PPP,(-); BDBM50010618; PDSP1_000628; PDSP2_000624; CCG-205066; SDCCGSBI-0050959.P002; (R)-3-(1-Propylpiperidin-3-yl)phenol; NCGC00015776-01; NCGC00015776-02; NCGC00162308-02; NCGC00162308-04; (+)-3-(1-Propyl-piperidin-3-yl)-phenol; 3-((R)-1-Propyl-piperidin-3-yl)-phenol; (r)-3-(3-hydroxyphenyl)-N-propylpiperidine; Q27270713; SR-01000075393-11
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|
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| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
1-(3,4-Dihydro-2H-1,4-methano-naphthalen-1-yl)-piperidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL356757; BDBM50062778
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|
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| Activity |
IC50 = 107000 nM
|
[2] | |||
| Compound Name |
1-(Azetidine-2-carbonyl)-N-dodecylazetidine-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3897254; BDBM193281; US9193762, RS-48-05
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| Activity |
Ki = 108900 nM
|
[3] | |||
| Compound Name |
Benzyl (2S)-2-[[4-[(3,4-dichlorophenyl)methylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3973708; BDBM193286; US9193762, RS-37-05
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|
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| Activity |
Ki = 110800 nM
|
[3] | |||
| Compound Name |
Benzyl (2S)-2-[(2S)-2-[2-(4-bromophenyl)ethylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3904972; BDBM193272; US9193762, RS-33-17
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|
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| Activity |
Ki = 110800 nM
|
[3] | |||
| Compound Name |
1-[(1,4-Ethano-1,2,3,4-tetrahydronaphthalen)-1-yl]piperidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL145722; ZINC13777947
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|
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| Activity |
IC50 = 117500 nM
|
[2] | |||
| Compound Name |
Benzyl (2S)-2-[(2S)-2-[[2-(trifluoromethyl)phenyl]methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3917293; BDBM193266; US9193762, RS-33-11
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|
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| Activity |
Ki = 135400 nM
|
[3] | |||
| Compound Name |
3-(Biphenyl-4-yl)-1-[2-(4,5-dimethyl-1H-benzimidazol-2-yl)-pyrrolidin-1-yl]propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1259048; BDBM50328580
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|
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| Activity |
IC50 = 146000 nM
|
[4] | |||
| Compound Name |
Benzyl (2S)-2-[[4-[(2,4-dichlorophenyl)methylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3911756; BDBM193285; US9193762, RS-37-04
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|
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| Activity |
Ki = 147700 nM
|
[3] | |||
| Compound Name |
(S)-Benzyl 2-((S)-2-((4-chlorophenethyl)carbamoyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3967661; BDBM193260; US9193762, RS-33-3
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|
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| Activity |
Ki = 160000 nM
|
[3] | |||
| Compound Name |
3-(Biphenyl-4-yl)-1-[2-(5,6-difluoro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1259012; BDBM50328577
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|
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| Activity |
IC50 = 163000 nM
|
[4] | |||
| Compound Name |
3-(Biphenyl-4-yl)-1-[2-(6-chloro-5-fluoro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1259029; BDBM50328578
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|
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| Activity |
IC50 = 184000 nM
|
[4] | |||
| Compound Name |
Benzyl (2S)-2-[(2S)-2-[(2,4-dichlorophenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3964939; BDBM193265; US9193762, RS-33-10
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|
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| Activity |
Ki = 192900 nM
|
[3] | |||
| Compound Name |
Benzyl (2S)-2-[[4-[3-[2-(2-ethoxyethoxy)ethoxy]propylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3901633; BDBM193288; US9193762, RS-37-07
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|
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| Activity |
Ki = 192900 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 20 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Benzyl (2S)-2-[(2S)-2-[(2-chlorophenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3904767; BDBM193264; US9193762, RS-33-9
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|
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| Activity |
Ki = 203100 nM
|
[3] | |||
| Compound Name |
3-(Biphenyl-4-yl)-1-[2-(6-chloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258994; BDBM50328576
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|
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| Activity |
IC50 = 221000 nM
|
[4] | |||
| Compound Name |
Benzyl (2S)-2-[[4-[(3-chlorophenyl)methylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3986066; BDBM193283; US9193762, RS-37-02
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|
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| Activity |
Ki = 227700 nM
|
[3] | |||
| Compound Name |
Benzyl (2S)-2-[(2S)-2-[(4-chlorophenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3910614; BDBM193267; US9193762, RS-33-12
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|
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| Activity |
Ki = 257100 nM
|
[3] | |||
| Compound Name |
Benzyl (2S)-2-[[4-[(4-chlorophenyl)methylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3984977; BDBM193284; US9193762, RS-37-03
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|
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| Activity |
Ki = 258500 nM
|
[3] | |||
| Compound Name |
3-(Biphenyl-4-yl)-1-{2-[5-(4-methylthiophen-2-yl)-1H-imidazol-2-yl]pyrrolidin-1-yl}propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1259220; BDBM50328574
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|
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| Activity |
IC50 = 274000 nM
|
[4] | |||
| Compound Name |
3-(Biphenyl-4-yl)-1-[2-(6-fluoro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1258993; BDBM50328575
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|
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| Activity |
IC50 = 280000 nM
|
[4] | |||
| Compound Name |
Benzyl (2S)-2-[(2S)-2-(pentylcarbamoyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3975750; BDBM193273; US9193762, RS-33-18
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|
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| Activity |
Ki = 289200 nM
|
[3] | |||
| Compound Name |
Benzyl (2S)-2-[(2S)-2-[(2-methoxyphenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3938907; BDBM193270; US9193762, RS-33-15
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|
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| Activity |
Ki = 289200 nM
|
[3] | |||
| Compound Name |
3-(Biphenyl-4-yl)-1-{2-[5-(3-chloro-4-fluorophenyl)-1H-imidazol-2-yl]pyrrolidin-1-yl}propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1259206; BDBM50328572
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|
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| Activity |
IC50 = 320000 nM
|
[4] | |||
| Compound Name |
Benzyl (2S)-2-[[4-[(2-chlorophenyl)methylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3957379; BDBM193282; US9193762, RS-37-01
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|
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| Activity |
Ki = 332300 nM
|
[3] | |||
| Compound Name |
3-(Biphenyl-4-yl)-1-[2-(4-methyl-5-phenyl-1H-imidazol-2-yl)-pyrrolidin-1-yl]propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1259161; BDBM50328568
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|
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| Activity |
IC50 = 338000 nM
|
[4] | |||
| Compound Name |
(S)-Benzyl 2-((S)-2-(benzylcarbamoyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3897505; BDBM193258; US9193762, RS-33-1
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|
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| Activity |
Ki = 338400 nM
|
[3] | |||
| Compound Name |
Benzyl (2S)-2-[(2S)-2-[(3-methoxyphenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3889473; BDBM193271; US9193762, RS-33-16
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|
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| Activity |
Ki = 393800 nM
|
[3] | |||
| Compound Name |
Benzyl (2S)-2-[(2S)-2-[2-(2-methoxyphenyl)ethylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3946392; BDBM193261; US9193762, RS-33-4
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|
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| Activity |
Ki = 424600 nM
|
[3] | |||
| Compound Name |
Benzyl (2S)-2-[(2S)-2-[(3-chlorophenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3910655; BDBM193269; US9193762, RS-33-14
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|
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| Activity |
Ki = 467700 nM
|
[3] | |||
| Compound Name |
3-(Biphenyl-4-yl)-1-{(2S)-2-[5-(2,2,2-trifluoroethyl)-1H-imidazol-2-yl]pyrrolidin-1-yl}propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1259101; BDBM50328563
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|
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| Activity |
IC50 = 476000 nM
|
[4] | |||
| Compound Name |
Benzyl (2S)-2-[(2S)-2-[(2,6-difluorophenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3980739; BDBM193268; US9193762, RS-33-13
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|
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| Activity |
Ki = 541500 nM
|
[3] | |||
| Compound Name |
3-(Biphenyl-4-yl)-1-{(2S)-2-[5-(propan-2-yl)-1H-imidazol-2-yl]-pyrrolidin-1-yl}propan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1259132; BDBM50328566
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|
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| Activity |
IC50 = 710000 nM
|
[4] | |||
| Compound Name |
3-(2-{1-[3-(Biphenyl-4-yl)propanoyl]pyrrolidin-2-yl}-1H-imidazol-5-yl)benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1259205; BDBM50328571
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|
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| Activity |
IC50 = 827000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors. J Med Chem. 2010 May 13;53(9):3423-38. | ||||
| REF 2 | Rigid phencyclidine analogues. Binding to the phencyclidine and sigma 1 receptors. J Med Chem. 1998 Feb 12;41(4):468-77. | ||||
| REF 3 | US patent application no. 9193762B2, Selective inhibitors of prolylcarboxypeptidase | ||||
| REF 4 | Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity. J Med Chem. 2010 Oct 14;53(19):7251-63. | ||||
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