TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T20371	Prolylcarboxypeptidase	D01XGX	JTP-4819	Discontinued in Phase 2	178060	C19H25N3O4	359.4	C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)NCC3=CC=CC=C3)C(=O)CO	IC50 ~ 100000 nM	Poor binder
T20371	Prolylcarboxypeptidase	D01KIU	PRE-084	Terminated	126402	C19H27NO3	317.4	C1CCC(CC1)(C2=CC=CC=C2)C(=O)OCCN3CCOCC3	IC50 = 100000 nM	Poor binder
T20371	Prolylcarboxypeptidase	B0IGJ9	Benzyl (2S)-2-[[4-(dodecylamino)-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate	Investigative	121596914	C29H47N3O4	501.7	CCCCCCCCCCCCNC(=O)CCCNC(=O)[C@@H]1CCCN1C(=O)OCC2=CC=CC=C2	Ki = 58000 nM	Poor binder
T20371	Prolylcarboxypeptidase	B1A9TW	N-Dodecyl-1-(pyrrolidine-2-carbonyl)azetidine-2-carboxamide	Investigative	67812364	C21H39N3O2	365.6	CCCCCCCCCCCCNC(=O)C1CCN1C(=O)C2CCCN2	Ki = 50400 nM	Poor binder
T20371	Prolylcarboxypeptidase	B1S3BY	(R)-Preclamol	Investigative	202478	C14H21NO	219.32	CCCN1CCC[C@@H](C1)C2=CC(=CC=C2)O	IC50 = 100000 nM	Poor binder
T20371	Prolylcarboxypeptidase	B20YOP	3-(Biphenyl-4-yl)-1-[2-(6-chloro-5-fluoro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]propan-1-one	Investigative	52945988	C27H23ClFN3O2	475.9	C1C[C@H](N(C1)C(=O)CCC2=CC=C(C=C2)C3=CC=CC=C3)C(=O)C4=NC5=CC(=C(C=C5N4)F)Cl	IC50 = 184000 nM	Poor binder
T20371	Prolylcarboxypeptidase	B3J0PI	1-(3,4-Dihydro-2H-1,4-methano-naphthalen-1-yl)-piperidine	Investigative	44362525	C16H21N	227.34	C1CCN(CC1)C23CCC(C2)C4=CC=CC=C34	IC50 = 107000 nM	Poor binder
T20371	Prolylcarboxypeptidase	B3N4RY	Benzyl (2S)-2-[(2S)-2-(heptylcarbamoyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Investigative	121596907	C25H37N3O4	443.6	CCCCCCCNC(=O)[C@@H]1CCCN1C(=O)[C@@H]2CCCN2C(=O)OCC3=CC=CC=C3	Ki = 80000 nM	Poor binder
T20371	Prolylcarboxypeptidase	B3T6XI	3-(Biphenyl-4-yl)-1-[2-(4,5-dimethyl-1H-benzimidazol-2-yl)-pyrrolidin-1-yl]propan-1-one	Investigative	52945989	C29H29N3O2	451.6	CC1=C(C2=C(C=C1)NC(=N2)C(=O)[C@@H]3CCCN3C(=O)CCC4=CC=C(C=C4)C5=CC=CC=C5)C	IC50 = 146000 nM	Poor binder
T20371	Prolylcarboxypeptidase	B40ECL	Benzyl (2S)-2-[(2S)-2-[(2,4-dichlorophenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Investigative	121596898	C25H27Cl2N3O4	504.4	C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)OCC3=CC=CC=C3)C(=O)NCC4=C(C=C(C=C4)Cl)Cl	Ki = 192900 nM	Poor binder
T20371	Prolylcarboxypeptidase	B4FAT1	Benzyl (2S)-2-[[4-[(3,4-dichlorophenyl)methylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate	Investigative	121596913	C24H27Cl2N3O4	492.4	C1C[C@H](N(C1)C(=O)OCC2=CC=CC=C2)C(=O)NCCCC(=O)NCC3=CC(=C(C=C3)Cl)Cl	Ki = 110800 nM	Poor binder
T20371	Prolylcarboxypeptidase	B5K3PJ	1-(Azetidine-2-carbonyl)-N-dodecylazetidine-2-carboxamide	Investigative	67812672	C20H37N3O2	351.5	CCCCCCCCCCCCNC(=O)C1CCN1C(=O)C2CCN2	Ki = 108900 nM	Poor binder
T20371	Prolylcarboxypeptidase	B7GOV5	Benzyl (2S)-2-[[4-[3-[2-(2-ethoxyethoxy)ethoxy]propylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate	Investigative	121596915	C26H41N3O7	507.6	CCOCCOCCOCCCNC(=O)CCCNC(=O)[C@@H]1CCCN1C(=O)OCC2=CC=CC=C2	Ki = 192900 nM	Poor binder
T20371	Prolylcarboxypeptidase	B7TK9D	3-(Biphenyl-4-yl)-1-[2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]propan-1-one	Investigative	52944768	C27H23Cl2N3O2	492.4	C1C[C@H](N(C1)C(=O)CCC2=CC=C(C=C2)C3=CC=CC=C3)C(=O)C4=NC5=CC(=C(C=C5N4)Cl)Cl	IC50 = 78000 nM	Poor binder
T20371	Prolylcarboxypeptidase	B8VRN5	(S)-Benzyl 2-((S)-2-((4-chlorophenethyl)carbamoyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate	Investigative	121596894	C26H30ClN3O4	484	C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)OCC3=CC=CC=C3)C(=O)NCCC4=CC=C(C=C4)Cl	Ki = 160000 nM	Poor binder
T20371	Prolylcarboxypeptidase	BCQ03J	Benzyl (2S)-2-[(2S)-2-(hexadecylcarbamoyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Investigative	121596896	C34H55N3O4	569.8	CCCCCCCCCCCCCCCCNC(=O)[C@@H]1CCCN1C(=O)[C@@H]2CCCN2C(=O)OCC3=CC=CC=C3	Ki = 61000 nM	Poor binder
T20371	Prolylcarboxypeptidase	BCU3B5	(2S)-N-Dodecylpyrrolidine-2-carboxamide	Investigative	9971039	C17H34N2O	282.5	CCCCCCCCCCCCNC(=O)[C@@H]1CCCN1	Ki = 61500 nM	Poor binder
T20371	Prolylcarboxypeptidase	BI54OU	3-(Biphenyl-4-yl)-1-{(2S)-2-[5-(prop-1-en-2-yl)-1H-imidazol-2-yl]pyrrolidin-1-yl}propan-1-one	Investigative	52948473	C26H27N3O2	413.5	CC(=C)C1=CN=C(N1)C(=O)[C@@H]2CCCN2C(=O)CCC3=CC=C(C=C3)C4=CC=CC=C4	IC50 = 92000 nM	Poor binder
T20371	Prolylcarboxypeptidase	BJG6E4	(S)-Benzyl-2-((S)-2-(pentadecylcarbamoyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate	Investigative	67812501	C33H53N3O4	555.8	CCCCCCCCCCCCCCCNC(=O)[C@@H]1CCCN1C(=O)[C@@H]2CCCN2C(=O)OCC3=CC=CC=C3	Ki = 61500 nM	Poor binder
T20371	Prolylcarboxypeptidase	BLUG92	N-Dodecylazetidine-2-carboxamide	Investigative	21019246	C16H32N2O	268.44	CCCCCCCCCCCCNC(=O)C1CCN1	Ki = 50140 nM	Poor binder
T20371	Prolylcarboxypeptidase	BLYU78	Benzyl (2S)-2-[(2S)-2-(dodecylcarbamoyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Investigative	121596908	C30H47N3O4	513.7	CCCCCCCCCCCCNC(=O)[C@@H]1CCCN1C(=O)[C@@H]2CCCN2C(=O)OCC3=CC=CC=C3	Ki = 61500 nM	Poor binder
T20371	Prolylcarboxypeptidase	BO30WG	Benzyl (2S)-2-[[4-[(2,4-dichlorophenyl)methylamino]-4-oxobutyl]carbamoyl]pyrrolidine-1-carboxylate	Investigative	121596912	C24H27Cl2N3O4	492.4	C1C[C@H](N(C1)C(=O)OCC2=CC=CC=C2)C(=O)NCCCC(=O)NCC3=C(C=C(C=C3)Cl)Cl	Ki = 147700 nM	Poor binder
T20371	Prolylcarboxypeptidase	BQ5UM0	Benzyl (2S)-2-[(2S)-2-[2-(4-bromophenyl)ethylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Investigative	121596905	C26H30BrN3O4	528.4	C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)OCC3=CC=CC=C3)C(=O)NCCC4=CC=C(C=C4)Br	Ki = 110800 nM	Poor binder
T20371	Prolylcarboxypeptidase	BUZ1G3	3-(Biphenyl-4-yl)-1-{2-[5-(furan-2-yl)-1H-imidazol-2-yl]pyrrolidin-1-yl}propan-1-one	Investigative	52949698	C27H25N3O3	439.5	C1C[C@H](N(C1)C(=O)CCC2=CC=C(C=C2)C3=CC=CC=C3)C(=O)C4=NC=C(N4)C5=CC=CO5	IC50 = 74000 nM	Poor binder
T20371	Prolylcarboxypeptidase	BVSQ07	Benzyl (2S)-2-[(2S)-2-[(3,4-dichlorophenyl)methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Investigative	121596893	C25H27Cl2N3O4	504.4	C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)OCC3=CC=CC=C3)C(=O)NCC4=CC(=C(C=C4)Cl)Cl	Ki = 80600 nM	Poor binder
T20371	Prolylcarboxypeptidase	BZ1X8E	Benzyl (2S)-2-[(2S)-2-[[2-(trifluoromethyl)phenyl]methylcarbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate	Investigative	121596899	C26H28F3N3O4	503.5	C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)OCC3=CC=CC=C3)C(=O)NCC4=CC=CC=C4C(F)(F)F	Ki = 135400 nM	Poor binder
T20371	Prolylcarboxypeptidase	BZ37DE	3-(Biphenyl-4-yl)-1-[2-(5,6-difluoro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]propan-1-one	Investigative	52947236	C27H23F2N3O2	459.5	C1C[C@H](N(C1)C(=O)CCC2=CC=C(C=C2)C3=CC=CC=C3)C(=O)C4=NC5=CC(=C(C=C5N4)F)F	IC50 = 163000 nM	Poor binder
T20371	Prolylcarboxypeptidase	BZD53O	1-[(1,4-Ethano-1,2,3,4-tetrahydronaphthalen)-1-yl]piperidine	Investigative	10354345	C17H23N	241.37	C1CCN(CC1)C23CCC(CC2)C4=CC=CC=C34	IC50 = 117500 nM	Poor binder