Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T20333 | Target Info | |||
| Target Name | Macrophage colony-stimulating factor 1 receptor (CSF1R) | ||||
| Synonyms |
Proto-oncogene c-Fms; M-CSF-R; FMS; CSF-1R; CSF-1-R; CSF-1 receptor; CD115
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| Target Type | Successful Target | ||||
| Gene Name | CSF1R | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
RPR-108518A
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL543904
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-Methyl-N-phenyl-5-{[3-(trifluoromethyl)benzoyl]amino}benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL461366; BDBM50244727
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
JAK3 Inhibitor, Negative Control
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL542484; SCHEMBL5475737; CTK8G0413; J-009017
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Methyl-phenyl-(2,6,7-trimethoxy-quinazolin-4-yl)-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL135928; BDBM50291117
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(2-Chloro-6,7-dimethoxy-quinazolin-4-yl)-methyl-phenyl-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL135417; BDBM50291108
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-[[1-Cyclopentyl-5-[1-(Oxetan-3-Yl)piperidin-4-Yl]pyrazol-3-Yl]amino]pyridine-4-Carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3629013; GTPL9989; SCHEMBL22137472; BDBM50128294; AKOS032960466; compound 11 [PMID: 26431428]; Q27455367; 2-(1-Cyclopentyl-5-(1-(oxetane-3-yl)-4-piperidinyl)-1H-pyrazole-3-ylamino)pyridine-4-carbonitrile
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| Activity |
IC50 = 57000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The synthesis and SAR of new 4-(N-alkyl-N-phenyl)amino-6,7-dimethoxyquinazolines and 4-(N-alkyl-N-phenyl)aminopyrazolo[3,4-d]pyrimidines, inhibitors of CSF-1R tyrosine kinase activity. Bioorg Med Chem Lett. 1997 Feb 18;7(4):421-4. | ||||
| REF 2 | Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4794-7. | ||||
| REF 3 | Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). J Med Chem. 2015 Oct 22;58(20):8182-99. | ||||
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