Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T20027 | Target Info | |||
| Target Name | Signal transducer and activator of transcription 5 (STAT5) | ||||
| Synonyms |
Signal transducer and activator of transcription 5
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| Target Type | Patented-recorded Target | ||||
| Gene Name | STAT5A; STAT5B | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 20 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-[Cyclopropylmethyl-[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358590; SCHEMBL18719966; BDBM50034007
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| Activity | Signal transducer and activator of transcription 5B |
Ki ~ 60000 nM
|
[1] | ||
| Compound Name |
2-Hydroxy-4-[[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]-(oxolan-2-ylmethyl)amino]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358587; SCHEMBL17308805; BDBM50034080
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| Activity | Signal transducer and activator of transcription 5B |
Ki ~ 60000 nM
|
[1] | ||
| Compound Name |
4-[Cyclopropylmethyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358602; SCHEMBL17308806; BDBM50033897
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| Activity | Signal transducer and activator of transcription 5B |
Ki ~ 60000 nM
|
[1] | ||
| Compound Name |
4-[(4-Fluorophenyl)methyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358606; SCHEMBL17308774; BDBM50033892
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| Activity | Signal transducer and activator of transcription 5B |
Ki ~ 60000 nM
|
[1] | ||
| Compound Name |
4-[Benzyl-[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358593; SCHEMBL17308730; BDBM50033993
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| Activity | Signal transducer and activator of transcription 5B |
Ki ~ 60000 nM
|
[1] | ||
| Compound Name |
4-[Benzyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358605; SCHEMBL18719969; BDBM50033893
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|
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| Activity | Signal transducer and activator of transcription 5B |
Ki ~ 60000 nM
|
[1] | ||
| Compound Name |
4-[1-Bicyclo[2.2.1]heptanylmethyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358603; BDBM50033896
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|
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| Activity | Signal transducer and activator of transcription 5B |
Ki ~ 60000 nM
|
[1] | ||
| Compound Name |
2-Hydroxy-4-[[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]-[(2,3,4,5,6-pentafluorophenyl)methyl]amino]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358607; SCHEMBL18719970; BDBM50033891
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|
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| Activity | Signal transducer and activator of transcription 5B |
Ki ~ 60000 nM
|
[1] | ||
| Compound Name |
2-Hydroxy-4-[[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]-(thiophen-2-ylmethyl)amino]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358588; SCHEMBL17308731; BDBM50034036
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|
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| Activity | Signal transducer and activator of transcription 5B |
Ki ~ 60000 nM
|
[1] | ||
| Compound Name |
2-Hydroxy-4-[[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]-(oxolan-2-ylmethyl)amino]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358599; SCHEMBL17308804; BDBM50033943
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|
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| Activity | Signal transducer and activator of transcription 5B |
Ki ~ 60000 nM
|
[1] | ||
| Compound Name |
2-Hydroxy-4-[(1-methylimidazol-2-yl)methyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358601; SCHEMBL17308808; BDBM50033939
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|
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| Activity | Signal transducer and activator of transcription 5B |
Ki ~ 60000 nM
|
[1] | ||
| Compound Name |
2-Hydroxy-4-[[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]-(thiophen-2-ylmethyl)amino]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358600; SCHEMBL17308842; BDBM50033940
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|
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| Activity | Signal transducer and activator of transcription 5B |
Ki ~ 60000 nM
|
[1] | ||
| Compound Name |
4-[(4-Tert-butylphenyl)methyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358609; SCHEMBL17308773; BDBM50033889
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|
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| Activity | Signal transducer and activator of transcription 5B |
Ki ~ 60000 nM
|
[1] | ||
| Compound Name |
2-Hydroxy-4-[[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]-[(2,3,4,5,6-pentafluorophenyl)methyl]amino]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358595; SCHEMBL18719968; BDBM50033947
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|
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| Activity | Signal transducer and activator of transcription 5B |
Ki ~ 60000 nM
|
[1] | ||
| Compound Name |
2-Hydroxy-4-[(1-methylimidazol-2-yl)methyl-[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]amino]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358589; SCHEMBL17308634; BDBM50034008
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|
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| Activity | Signal transducer and activator of transcription 5B |
Ki ~ 60000 nM
|
[1] | ||
| Compound Name |
4-[1-Bicyclo[2.2.1]heptanylmethyl-[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358591; BDBM50034006
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|
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| Activity | Signal transducer and activator of transcription 5B |
Ki ~ 60000 nM
|
[1] | ||
| Compound Name |
4-[(4-Fluorophenyl)methyl-[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358594; SCHEMBL18719967; BDBM50033963
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|
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| Activity | Signal transducer and activator of transcription 5B |
Ki ~ 60000 nM
|
[1] | ||
| Compound Name |
2-Hydroxy-4-[[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]-[(4-methylphenyl)methyl]amino]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358604; BDBM50033895
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|
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| Activity | Signal transducer and activator of transcription 5B |
Ki ~ 60000 nM
|
[1] | ||
| Compound Name |
4-[(4-Tert-butylphenyl)methyl-[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358597; SCHEMBL17308741; BDBM50033945
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|
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| Activity | Signal transducer and activator of transcription 5B |
Ki ~ 60000 nM
|
[1] | ||
| Compound Name |
2-Hydroxy-4-[(4-methylphenyl)methyl-[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]amino]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358592; SCHEMBL17308734; BDBM50034005
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|
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| Activity | Signal transducer and activator of transcription 5B |
Ki ~ 60000 nM
|
[1] | ||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein. ACS Med Chem Lett. 2014 Sep 19;5(11):1202-1206. | ||||
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