TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T20027 Signal transducer and activator of transcription 5B B1Z7JM 4-[Cyclopropylmethyl-[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid Investigative 118722967 C23H28N2O6S 460.5 CC1=CC(=C(C(=C1)C)S(=O)(=O)N(C)CC(=O)N(CC2CC2)C3=CC(=C(C=C3)C(=O)O)O)C Ki ~ 60000 nM Poor binder T20027 Signal transducer and activator of transcription 5B B2MY6X 2-Hydroxy-4-[[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]-(oxolan-2-ylmethyl)amino]benzoic acid Investigative 118554199 C24H30N2O7S 490.6 CC1=CC(=C(C(=C1)C)S(=O)(=O)N(C)CC(=O)N(CC2CCCO2)C3=CC(=C(C=C3)C(=O)O)O)C Ki ~ 60000 nM Poor binder T20027 Signal transducer and activator of transcription 5B B3TPX1 4-[Cyclopropylmethyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid Investigative 118554200 C20H17F5N2O6S 508.4 CN(CC(=O)N(CC1CC1)C2=CC(=C(C=C2)C(=O)O)O)S(=O)(=O)C3=C(C(=C(C(=C3F)F)F)F)F Ki ~ 60000 nM Poor binder T20027 Signal transducer and activator of transcription 5B B58WAE 4-[(4-Fluorophenyl)methyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid Investigative 118554171 C23H16F6N2O6S 562.4 CN(CC(=O)N(CC1=CC=C(C=C1)F)C2=CC(=C(C=C2)C(=O)O)O)S(=O)(=O)C3=C(C(=C(C(=C3F)F)F)F)F Ki ~ 60000 nM Poor binder T20027 Signal transducer and activator of transcription 5B B5NFV3 4-[Benzyl-[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid Investigative 118554131 C26H28N2O6S 496.6 CC1=CC(=C(C(=C1)C)S(=O)(=O)N(C)CC(=O)N(CC2=CC=CC=C2)C3=CC(=C(C=C3)C(=O)O)O)C Ki ~ 60000 nM Poor binder T20027 Signal transducer and activator of transcription 5B B69YPG 4-[Benzyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid Investigative 118722973 C23H17F5N2O6S 544.4 CN(CC(=O)N(CC1=CC=CC=C1)C2=CC(=C(C=C2)C(=O)O)O)S(=O)(=O)C3=C(C(=C(C(=C3F)F)F)F)F Ki ~ 60000 nM Poor binder T20027 Signal transducer and activator of transcription 5B B72JKR 4-[1-Bicyclo[2.2.1]heptanylmethyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid Investigative 118722971 C24H23F5N2O6S 562.5 CN(CC(=O)N(CC12CCC(C1)CC2)C3=CC(=C(C=C3)C(=O)O)O)S(=O)(=O)C4=C(C(=C(C(=C4F)F)F)F)F Ki ~ 60000 nM Poor binder T20027 Signal transducer and activator of transcription 5B B9WID2 2-Hydroxy-4-[[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]-[(2,3,4,5,6-pentafluorophenyl)methyl]amino]benzoic acid Investigative 118722974 C23H12F10N2O6S 634.4 CN(CC(=O)N(CC1=C(C(=C(C(=C1F)F)F)F)F)C2=CC(=C(C=C2)C(=O)O)O)S(=O)(=O)C3=C(C(=C(C(=C3F)F)F)F)F Ki ~ 60000 nM Poor binder T20027 Signal transducer and activator of transcription 5B BALX96 2-Hydroxy-4-[[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]-(thiophen-2-ylmethyl)amino]benzoic acid Investigative 118554132 C24H26N2O6S2 502.6 CC1=CC(=C(C(=C1)C)S(=O)(=O)N(C)CC(=O)N(CC2=CC=CS2)C3=CC(=C(C=C3)C(=O)O)O)C Ki ~ 60000 nM Poor binder T20027 Signal transducer and activator of transcription 5B BBC09J 2-Hydroxy-4-[[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]-(oxolan-2-ylmethyl)amino]benzoic acid Investigative 118554198 C21H19F5N2O7S 538.4 CN(CC(=O)N(CC1CCCO1)C2=CC(=C(C=C2)C(=O)O)O)S(=O)(=O)C3=C(C(=C(C(=C3F)F)F)F)F Ki ~ 60000 nM Poor binder T20027 Signal transducer and activator of transcription 5B BCQY14 2-Hydroxy-4-[(1-methylimidazol-2-yl)methyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]benzoic acid Investigative 118554202 C21H17F5N4O6S 548.4 CN1C=CN=C1CN(C2=CC(=C(C=C2)C(=O)O)O)C(=O)CN(C)S(=O)(=O)C3=C(C(=C(C(=C3F)F)F)F)F Ki ~ 60000 nM Poor binder T20027 Signal transducer and activator of transcription 5B BL42WY 2-Hydroxy-4-[[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]-(thiophen-2-ylmethyl)amino]benzoic acid Investigative 118554235 C21H15F5N2O6S2 550.5 CN(CC(=O)N(CC1=CC=CS1)C2=CC(=C(C=C2)C(=O)O)O)S(=O)(=O)C3=C(C(=C(C(=C3F)F)F)F)F Ki ~ 60000 nM Poor binder T20027 Signal transducer and activator of transcription 5B BNB95O 4-[(4-Tert-butylphenyl)methyl-[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid Investigative 118554170 C27H25F5N2O6S 600.6 CC(C)(C)C1=CC=C(C=C1)CN(C2=CC(=C(C=C2)C(=O)O)O)C(=O)CN(C)S(=O)(=O)C3=C(C(=C(C(=C3F)F)F)F)F Ki ~ 60000 nM Poor binder T20027 Signal transducer and activator of transcription 5B BQA67T 2-Hydroxy-4-[[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]-[(2,3,4,5,6-pentafluorophenyl)methyl]amino]benzoic acid Investigative 118722970 C26H23F5N2O6S 586.5 CC1=CC(=C(C(=C1)C)S(=O)(=O)N(C)CC(=O)N(CC2=C(C(=C(C(=C2F)F)F)F)F)C3=CC(=C(C=C3)C(=O)O)O)C Ki ~ 60000 nM Poor binder T20027 Signal transducer and activator of transcription 5B BS6NH7 2-Hydroxy-4-[(1-methylimidazol-2-yl)methyl-[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]amino]benzoic acid Investigative 118554053 C24H28N4O6S 500.6 CC1=CC(=C(C(=C1)C)S(=O)(=O)N(C)CC(=O)N(CC2=NC=CN2C)C3=CC(=C(C=C3)C(=O)O)O)C Ki ~ 60000 nM Poor binder T20027 Signal transducer and activator of transcription 5B BTE75U 4-[1-Bicyclo[2.2.1]heptanylmethyl-[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid Investigative 118722968 C27H34N2O6S 514.6 CC1=CC(=C(C(=C1)C)S(=O)(=O)N(C)CC(=O)N(CC23CCC(C2)CC3)C4=CC(=C(C=C4)C(=O)O)O)C Ki ~ 60000 nM Poor binder T20027 Signal transducer and activator of transcription 5B BV4Q3H 4-[(4-Fluorophenyl)methyl-[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid Investigative 118722969 C26H27FN2O6S 514.6 CC1=CC(=C(C(=C1)C)S(=O)(=O)N(C)CC(=O)N(CC2=CC=C(C=C2)F)C3=CC(=C(C=C3)C(=O)O)O)C Ki ~ 60000 nM Poor binder T20027 Signal transducer and activator of transcription 5B BY4P8E 2-Hydroxy-4-[[2-[methyl-(2,3,4,5,6-pentafluorophenyl)sulfonylamino]acetyl]-[(4-methylphenyl)methyl]amino]benzoic acid Investigative 118722972 C24H19F5N2O6S 558.5 CC1=CC=C(C=C1)CN(C2=CC(=C(C=C2)C(=O)O)O)C(=O)CN(C)S(=O)(=O)C3=C(C(=C(C(=C3F)F)F)F)F Ki ~ 60000 nM Poor binder T20027 Signal transducer and activator of transcription 5B BYX81Q 4-[(4-Tert-butylphenyl)methyl-[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]amino]-2-hydroxybenzoic acid Investigative 118554142 C30H36N2O6S 552.7 CC1=CC(=C(C(=C1)C)S(=O)(=O)N(C)CC(=O)N(CC2=CC=C(C=C2)C(C)(C)C)C3=CC(=C(C=C3)C(=O)O)O)C Ki ~ 60000 nM Poor binder T20027 Signal transducer and activator of transcription 5B BZG37V 2-Hydroxy-4-[(4-methylphenyl)methyl-[2-[methyl-(2,4,6-trimethylphenyl)sulfonylamino]acetyl]amino]benzoic acid Investigative 118554135 C27H30N2O6S 510.6 CC1=CC=C(C=C1)CN(C2=CC(=C(C=C2)C(=O)O)O)C(=O)CN(C)S(=O)(=O)C3=C(C=C(C=C3C)C)C Ki ~ 60000 nM Poor binder