Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T19531 | Target Info | |||
| Target Name | Adenylate cyclase type 5 (AC5) | ||||
| Synonyms |
Adenylyl cyclase 5; Adenylate cyclase type V; ATP pyrophosphate-lyase 5; AC5
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|
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| Target Type | Literature-reported Target | ||||
| Gene Name | ADCY5 | ||||
| Biochemical Class | Phosphorus-oxygen lyase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 17 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(1S,3R)-2-[3-(6-Amino-purin-9-yl)-cyclopentyl]-N-hydroxy-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL444839; SCHEMBL6045868; BDBM50128197
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|
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| Activity |
IC50 = 55000 nM
|
[1] | |||
| Compound Name |
(1S,3R)-3-(6-Amino-purin-9-yl)-cyclopentanecarboxylic acid hydroxyamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL68741; SCHEMBL6045709; BDBM50128201
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|
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| Activity |
IC50 ~ 70000 nM
|
[1] | |||
| Compound Name |
[[(1S,4S)-4-(6-Amino-9H-purine-9-yl)-2-cyclopentene-1-yl]oxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL322057; SCHEMBL6045595; BDBM50119853; 2-{[(1S,4S)-4-(6-amino-9H-purin-9-yl)cyclopent-2-en-1-yl]oxy}acetic acid
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|
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| Activity |
IC50 = 72000 nM
|
[2] | |||
| Compound Name |
(1S,3S)-[4-(6-Amino-purin-9-yl)-cyclopent-2-enyl]-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL304093; SCHEMBL6045829; BDBM50128190
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|
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| Activity |
IC50 = 73200 nM
|
[1] | |||
| Compound Name |
[[(1S,4R)-4-(6-Amino-9H-purine-9-yl)-2-cyclopentene-1-yl]oxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL106750; SCHEMBL6045743; BDBM50119860; 2-{[(1S,4R)-4-(6-amino-9H-purin-9-yl)cyclopent-2-en-1-yl]oxy}acetic acid
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|
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| Activity |
IC50 = 78000 nM
|
[2] | |||
| Compound Name |
(1R,3R)-3-(6-Amino-9H-purin-9-yl)-N-hydroxycyclopentanecarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL302508; PMC-6; SCHEMBL6045720; BDBM50128186; QC-10866; (1R,3R)-3-(6-aminopurin-9-yl)-N-hydroxycyclopentane-1-carboxamide; (1S,3S)-3-(6-Amino-purin-9-yl)-cyclopentanecarboxylic acid hydroxyamide
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|
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| Activity |
IC50 = 78000 nM
|
[1] | |||
| Compound Name |
[(S)-3-((S)-6-Amino-purin-9-yl)-cyclopentyloxy]-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL108067; SCHEMBL6045745; BDBM50119857; [[(1S,4R)-4-(6-Amino-9H-purine-9-yl)cyclopentyl]oxy]acetic acid
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|
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| Activity |
IC50 = 79000 nM
|
[2] | |||
| Compound Name |
2-[3-(6-Amino-9H-purine-9-yl)propoxy]acetohydroximic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL105178; BDBM50119821; 2-[3-(6-Amino-purin-9-yl)-propoxy]-N-hydroxy-acetamide
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|
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| Activity |
IC50 = 94000 nM
|
[2] | |||
| Compound Name |
2-[[(1R,4S)-4-(6-Amino-9H-purine-9-yl)-2-cyclopentene-1-yl]oxy]acetohydroximic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL105636; SCHEMBL6045597; BDBM50119854; 2-{[(1R,4S)-4-(6-amino-9H-purin-9-yl)cyclopent-2-en-1-yl]oxy}-N-hydroxyacetamide
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|
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| Activity |
IC50 = 96000 nM
|
[2] | |||
| Compound Name |
[[(1R,4S)-4-(6-Amino-9H-purine-9-yl)-2-cyclopentene-1-yl]oxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107243; SCHEMBL6045869; BDBM50119861; 2-{[(1R,4S)-4-(6-amino-9H-purin-9-yl)cyclopent-2-en-1-yl]oxy}acetic acid
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|
||||
| Activity |
IC50 = 98000 nM
|
[2] | |||
| Compound Name |
(1R,3R)-4-(6-Amino-purin-9-yl)-cyclopent-2-enecarboxylic acid hydroxyamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL418883; SCHEMBL6045806; BDBM50128194
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|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
(1S,3S)-[3-(6-Amino-purin-9-yl)-cyclopentyl]-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL302927; SCHEMBL6045752; BDBM50128189
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[(S)-3-((S)-6-Amino-purin-9-yl)-cyclopentyloxy]-N-hydroxy-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL322646; SCHEMBL6045626; BDBM50119858; 2-[[(1S,4R)-4-(6-Amino-9H-purine-9-yl)cyclopentyl]oxy]acetohydroximic acid
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|
||||
| Activity |
IC50 = 109000 nM
|
[2] | |||
| Compound Name |
2-[(R)-3-((R)-6-Amino-purin-9-yl)-cyclopentyloxy]-N-hydroxy-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL320979; SCHEMBL6045754; BDBM50119851; 2-[[(1R,4S)-4-(6-Amino-9H-purine-9-yl)cyclopentyl]oxy]acetohydroximic acid
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|
||||
| Activity |
IC50 = 110000 nM
|
[2] | |||
| Compound Name |
2-[[(1S,4R)-4-(6-Amino-9H-purine-9-yl)-2-cyclopentene-1-yl]oxy]acetohydroximic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL420654; SCHEMBL6045573; BDBM50119855; 2-{[(1S,4R)-4-(6-amino-9H-purin-9-yl)cyclopent-2-en-1-yl]oxy}-N-hydroxyacetamide
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|
||||
| Activity |
IC50 = 116000 nM
|
[2] | |||
| Compound Name |
[3-(6-Amino-purin-9-yl)-propoxy]-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104969; BDBM50119829; [3-(6-Amino-9H-purine-9-yl)propoxy]acetic acid
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|
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| Activity |
IC50 = 140500 nM
|
[3] | |||
| Compound Name |
(1S,3R)-4-(6-Amino-purin-9-yl)-cyclopent-2-enecarboxylic acid hydroxyamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL68924; SCHEMBL6045749; BDBM50128211
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|
||||
| Activity |
IC50 = 188000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 33 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
{Acetyl-[2-(6-amino-purin-9-yl)-ethyl]-amino}-acetic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL323360; BDBM50119843
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
(1S,3R)-[3-(6-Amino-purin-9-yl)-cyclopentyl]-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL68928; SCHEMBL6045742; BDBM50128200
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|
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| Activity |
IC50 > 200000 nM
|
[1] | |||
| Compound Name |
6-(6-Amino-purin-9-yl)-hexanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL103026; SCHEMBL6045717; 6-Amino-9H-purine-9-hexanoic acid; BDBM50119823; AKOS013622095
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
(1R,3S)-4-(6-Amino-purin-9-yl)-cyclopent-2-enecarboxylic acid hydroxyamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL69754; SCHEMBL6045781; BDBM50128193
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|
||||
| Activity |
IC50 > 200000 nM
|
[1] | |||
| Compound Name |
[3-(6-Amino-purin-9-yl)-propylamino]-acetic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL105760; BDBM50119834; N-[3-(6-Amino-9H-purine-9-yl)propyl]glycine methyl ester
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
6-(6-Amino-purin-9-yl)-hexanoic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL318742; SCHEMBL6045652; BDBM50119822; AKOS013616241; 6-Amino-9H-purine-9-hexanoic acid ethyl ester
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
5-(6-Aminopurin-9-yl)pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
NSC75749; 5-(6-amino-9H-purin-9-yl)pentanoic acid; CHEMBL101687; NSC-75749; NCIStruc1_000502; NCIStruc2_000508; SCHEMBL6045746; CTK3I7246; DTXSID10291467; 6-Amino-9H-purine-9-valeric acid; NCI75749; ZINC1701755; BDBM50119820; CCG-38210; NCGC00013828; AKOS010941763; 5-(6-Amino-purin-9-yl)-pentanoic acid; NCGC00013828-02; NCGC00096938-01; NCI60_041661; DS-005589; Z2689172039
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
[[(1R,4R)-4-(6-Amino-9H-purine-9-yl)-2-cyclopentene-1-yl]oxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL326449; SCHEMBL6045782; BDBM50119850; 2-{[(1R,4R)-4-(6-amino-9H-purin-9-yl)cyclopent-2-en-1-yl]oxy}acetic acid
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|
||||
| Activity |
IC50 > 200000 nM
|
[2] | |||
| Compound Name |
{Acetyl-[2-(6-amino-purin-9-yl)-ethyl]-amino}-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL105001; BDBM50119849
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
[3-(6-Amino-purin-9-yl)-propoxy]-acetic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104972; BDBM50119825; [3-(6-Amino-9H-purine-9-yl)propoxy]acetic acid ethyl ester
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
[3-(6-Amino-purin-9-yl)-propylamino]-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL105211; BDBM50119848; N-[3-(6-Amino-9H-purine-9-yl)propyl]glycine
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
(1R,3R)-[4-(6-Amino-purin-9-yl)-cyclopent-2-enyl]-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL68569; SCHEMBL6045726; BDBM50128208
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|
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| Activity |
IC50 > 200000 nM
|
[1] | |||
| Compound Name |
2-[Tert-Butoxycarbonyl[2-(6-amino-9H-purine-9-yl)ethyl]amino]acetohydroximic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL322025; BDBM50119824; [2-(6-Amino-purin-9-yl)-ethyl]-hydroxycarbamoylmethyl-carbamic acid tert-butyl ester
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
[[(1S,4S)-4-(6-Amino-9H-purine-9-yl)cyclopentyl]oxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL323341; SCHEMBL6045769; BDBM50119852; 2-{[(1S,3S)-3-(6-amino-9H-purin-9-yl)cyclopentyl]oxy}acetic acid
Click to Show/Hide
|
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| Activity |
IC50 > 200000 nM
|
[2] | |||
| Compound Name |
{[2-(6-Amino-purin-9-yl)-ethyl]-methyl-amino}-acetic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL105062; BDBM50119836
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
{[2-(6-Amino-purin-9-yl)-ethyl]-tert-butoxycarbonyl-amino}-acetic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL320109; BDBM50119846; N-(tert-Butoxycarbonyl)-N-[2-(6-amino-9H-purin-9-yl)ethyl]glycine methyl ester
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
[2-(6-Amino-purin-9-yl)-ethylamino]-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL106792; BDBM50119839; N-[2-(6-Amino-9H-purine-9-yl)ethyl]glycine
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
{[3-(6-Amino-purin-9-yl)-propyl]-tert-butoxycarbonyl-amino}-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL319262; BDBM50119835; N-(tert-Butoxycarbonyl)-N-[3-(6-amino-9H-purine-9-yl)propyl]glycine
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
6-Amino-9H-purine-9-heptanehydroximic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL105033; SCHEMBL6045760; BDBM50119833; 7-(6-Amino-purin-9-yl)-heptanoic acid hydroxyamide
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
(1R,3S)-[3-(6-Amino-purin-9-yl)-cyclopentyl]-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL303911; SCHEMBL6045662; BDBM50128198
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|
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| Activity |
IC50 > 200000 nM
|
[1] | |||
| Compound Name |
[(R)-3-((R)-6-Amino-purin-9-yl)-cyclopentyloxy]-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL106689; SCHEMBL6045770; BDBM50119856; [[(1R,4S)-4-(6-Amino-9H-purine-9-yl)cyclopentyl]oxy]acetic acid
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|
||||
| Activity |
IC50 > 200000 nM
|
[2] | |||
| Compound Name |
2-[2-(6-Amino-9H-purine-9-yl)ethylamino]acetohydroximic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL105246; BDBM50119841; 2-[2-(6-Amino-purin-9-yl)-ethylamino]-N-hydroxy-acetamide
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
[2-(6-Amino-purin-9-yl)-ethylamino]-acetic acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL322237; BDBM50119830; N-[2-(6-Amino-9H-purine-9-yl)ethyl]glycine methyl ester
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
[[(1R,4R)-4-(6-Amino-9H-purine-9-yl)cyclopentyl]oxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104185; SCHEMBL6045813; BDBM50119859; 2-{[(1R,3R)-3-(6-amino-9H-purin-9-yl)cyclopentyl]oxy}acetic acid
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|
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| Activity |
IC50 > 200000 nM
|
[2] | |||
| Compound Name |
{[2-(6-Amino-purin-9-yl)-ethyl]-tert-butoxycarbonyl-amino}-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL102338; BDBM50119845; N-(tert-Butoxycarbonyl)-N-[2-(6-amino-9H-purine-9-yl)ethyl]glycine
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|
||||
| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
N-[2-(6-Amino-purin-9-yl)-ethyl]-N-hydroxycarbamoylmethyl-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL105583; BDBM50119838; 2-[Acetyl[2-(6-amino-9H-purine-9-yl)ethyl]amino]acetohydroximic acid
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
6-Amino-9H-purine-9-propanehydroximic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL322655; SCHEMBL6045601; BDBM50119828; 3-(6-Amino-purin-9-yl)-N-hydroxy-propionamide
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
2-[Tert-Butoxycarbonyl[3-(6-amino-9H-purine-9-yl)propyl]amino]acetohydroximic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107240; BDBM50119847; [3-(6-Amino-purin-9-yl)-propyl]-hydroxycarbamoylmethyl-carbamic acid tert-butyl ester
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|
||||
| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
7-(6-Amino-purin-9-yl)-heptanoic acid ethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL317455; SCHEMBL6045566; BDBM50119840; 6-Amino-9H-purine-9-heptanoic acid ethyl ester
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
(1R,3S)-[4-(6-Amino-purin-9-yl)-cyclopent-2-enyl]-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308678; SCHEMBL6045675; BDBM50128196
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[1] | |||
| Compound Name |
6-Amino-9H-purine-9-valeric acid methyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104142; SCHEMBL6045668; BDBM50119827; 5-(6-Amino-purin-9-yl)-pentanoic acid methyl ester
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
7-(6-Amino-purin-9-yl)-heptanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
NSC88907; CHEMBL104919; NCIOpen2_005442; SCHEMBL6045556; CTK1D8884; DTXSID70293361; ZINC1569549; 6-Amino-9H-purine-9-heptanoic acid; BDBM50119831; NSC-88907; 9H-Purine-9-heptanoicacid, 6-amino-; N9-(omega-hydroxycarbonyl-n-hexyl)adenine; 7-(6-Amino-9H-purin-9-yl)heptanoic acid
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|
||||
| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
2-[3-(6-Amino-9H-purine-9-yl)propylamino]acetohydroximic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL418993; BDBM50119837; 2-[3-(6-Amino-purin-9-yl)-propylamino]-N-hydroxy-acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Metal coordination-based inhibitors of adenylyl cyclase: novel potent P-site antagonists. J Med Chem. 2003 May 22;46(11):2177-86. | ||||
| REF 2 | Hydroxamate based inhibitors of adenylyl cyclase. Part 2: the effect of cyclic linkers on P-site binding. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3089-92. | ||||
| REF 3 | Hydroxamate based inhibitors of adenylyl cyclase. Part 1: the effect of acyclic linkers on P-site binding. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3085-8. | ||||
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