Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T17523 | Target Info | |||
| Target Name | Sphingosine-1-phosphate receptor 4 (S1PR4) | ||||
| Synonyms |
Sphingosine 1-phosphate receptor Edg-6; Sphingosine 1-phosphate receptor 4; S1P4; S1P receptor Edg-6; S1P receptor 4; Endothelial differentiation G-protein coupled receptor 6; EDG6
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| Target Type | Literature-reported Target | ||||
| Gene Name | S1PR4 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 30 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-Cyclopropyl-N,N-bis(2-methylcyclohexyl)-1,2-oxazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1969371; BDBM50494319; SR-03000000621; SR-03000000621-2
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Cyclohexyl-5-cyclopropyl-N-(2-methylcyclohexyl)-1,2-oxazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2004782; MLS003675930; BDBM50494315; SMR002356555; SR-03000000623; SR-03000000623-2
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N,N-Dicyclohexyl-5-(4-methoxyphenyl)-1,2-oxazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1984536; MLS003675928; BDBM50494307; SMR002356553; SR-03000000605; SR-03000000605-2
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Cycloheptyl-5-cyclopropyl-N-(2-methylcyclohexyl)-1,2-oxazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1965004; MLS003675926; BDBM50494314; SMR002356551; SR-03000000624; SR-03000000624-2
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N,N-Dicyclohexyl[5-(methylethyl)isoxazol-3-yl]carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1968913; MLS003675927; BDBM50494310; ZINC20550160; AKOS003398015; MCULE-5325429407; SMR002356552; ST50676741; SR-03000000651; SR-03000000651-2
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
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Investigative | Compound Info | ||
| Synonyms |
CYM 5541; CYM5541; CYM-5541; ML249; ML-249; CHEMBL1970071; N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide; MLS003675929; GTPL9494; AOB1281; CYM 554; BDBM50494318; MFCD09782785; s6552; ZINC20428865; AKOS003403809; CS-6415; MCULE-9777169244; AK688819; AS-16635; SMR002356554; ST092984; HY-101419; SR-03000000611; SR-03000000611-2; N,N-dicyclohexyl(5-cyclopropylisoxazol-3-yl)carboxamide
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N,N-Dicyclohexyl-5-phenyl-1,2-oxazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1973788; BDBM50494308; SR-03000000612; SR-03000000612-2
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
S1P1 Agonist III
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Investigative | Compound Info | ||
| Synonyms |
TC-G 1006; CHEMBL1938952; S1P1 Agonist 8; SCHEMBL20101626; 4088AH; BDBM50361891; ZINC72317473; AKOS024458323; CS-4219; NCGC00379192-01; DA-39190; HY-12835; FT-0710784; 1-[2-(Trifluoromethyl)-4-biphenylyl]-3-(4-methoxy-3-pyridylcarbonyl)urea; 4-Methoxy-N-((2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)carbamoyl)nicotinamide
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| Activity |
EC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N,N-Dicyclohexyl-5-propyl-3-isoxazolecarboxamide
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Investigative | Compound Info | ||
| Synonyms |
SMR000093349; MLS000116372; N,N-dicyclohexyl-5-propyl-1,2-oxazole-3-carboxamide; SR-01000624234; ChemDiv3_008445; CHEMBL1455786; BDBM37340; cid_5309153; HMS1496P19; HMS2246C14; ML004; ZINC3908927; MCULE-1836110190; IDI1_026355; N,N-dicyclohexyl-5-propylisoxazole-3-carboxamide; N,N-dicyclohexyl-5-propyl-isoxazole-3-carboxamide; SR-01000624234-2; SR-01000624234-4; SR-01000624234-5; BRD-K14048378-001-01-0; Q27164008
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-Amino-3-[[4-(2-ethylphenyl)-1-benzothiophen-2-yl]methylamino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884862; BDBM50209049
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|
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| Activity |
EC50 = 57600 nM
|
[3] | |||
| Compound Name |
1-[(7-Naphthalen-2-yl-1-benzothiophen-2-yl)methyl]azetidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883579; BDBM50209062
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-[[7-(2-Ethylphenyl)-1-benzothiophen-2-yl]methylamino]-2-methylpropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883401; BDBM50209030
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-[[4-(2-Ethylphenyl)-1-benzothiophen-2-yl]methylamino]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3885034; BDBM50209058
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[[[4-(2-Ethylphenyl)-1-benzothiophen-2-yl]methylamino]methyl]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3885068; BDBM50209022
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[[[7-(2-Ethylphenyl)-1-benzothiophen-2-yl]methylamino]methyl]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883521; BDBM50209040
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-[(5-Naphthalen-2-yl-1-benzothiophen-2-yl)methyl]azetidine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883597; BDBM50209025
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[[7-(2-Ethylphenyl)-1-benzothiophen-2-yl]methylamino]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884740; BDBM50209048
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[4-[(5-Naphthalen-2-yl-1-benzothiophen-2-yl)methylamino]phenyl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883502; BDBM50209063
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[[(5-Naphthalen-2-yl-1-benzothiophen-2-yl)methylamino]methyl]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884941; BDBM50209047
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-[[7-(2-Ethylphenyl)-1-benzothiophen-2-yl]methylamino]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884172; BDBM50209031
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[3-[(5-Naphthalen-2-yl-1-benzothiophen-2-yl)methylamino]phenyl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884077; BDBM50209020
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-[[4-(2-Ethylphenyl)-1-benzothiophen-2-yl]methyl]azetidine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883646; BDBM50209037
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-(7-(5-(3-Cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2048293; SCHEMBL949280; BDBM50386859
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|
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| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-[[4-(2-Ethylphenyl)-1-benzothiophen-2-yl]methylamino]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884517; BDBM50209076
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
5-[[7-(2-Ethylphenyl)-1-benzothiophen-2-yl]methylamino]pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884048; BDBM50209072
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[[(4-Naphthalen-2-yl-1-benzothiophen-2-yl)methylamino]methyl]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884011; BDBM50209044
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[[(7-Naphthalen-2-yl-1-benzothiophen-2-yl)methylamino]methyl]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883805; BDBM50209034
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[4-[(4-Naphthalen-2-yl-1-benzothiophen-2-yl)methylamino]phenyl]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884270; BDBM50209066
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-[[7-(2-Ethylphenyl)-1-benzothiophen-2-yl]methyl]azetidine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3885035; BDBM50209032
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[[7-(2-Ethylphenyl)-1-benzothiophen-2-yl]methylamino]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3885499; BDBM50209038
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
[3-Hydroxy-4-(4-octylphenoxy)-butyl]-phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228137; BDBM50198839
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| Activity |
EC50 = 440000 nM
|
[5] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6346-9. | ||||
| REF 2 | 4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1. ACS Med Chem Lett. 2011 Jul 29;2(10):752-7. | ||||
| REF 3 | A benzo[b]thiophene-based selective type 4 S1P receptor agonist. Bioorg Med Chem Lett. 2017 Jan 1;27(1):1-5. | ||||
| REF 4 | Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4404-9. | ||||
| REF 5 | Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorg Med Chem. 2007 Jan 15;15(2):663-77. | ||||
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