Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T16891 | Target Info | |||
| Target Name | Cathepsin E (CTSE) | ||||
| Synonyms |
Cathepsin E
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| Target Type | Literature-reported Target | ||||
| Gene Name | CTSE | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 1 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-4-oxo-butyramide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL94762; BDBM50045683
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
oxazine 89
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|
Clinical trial | Compound Info | ||
| Synonyms |
CHEMBL2347208; N-{3-[(4s,6s)-2-Amino-4-Methyl-6-(Trifluoromethyl)-5,6-Dihydro-4h-1,3-Oxazin-4-Yl]-4-Fluorophenyl}-5-Cyanopyridine-2-Carboxamide; oxazine 89; GTPL6944; SCHEMBL15991481; BDBM50432601; 1HL
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| Activity |
IC50 > 200000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Renin inhibitors containing a pyridyl amino diol derived C-terminus. J Med Chem. 1993 Sep 17;36(19):2788-800. | ||||
| REF 2 | beta-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. J Med Chem. 2013 May 23;56(10):3980-95. | ||||
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