Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0CG8S
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| Former ID |
DIB018010
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| Drug Name |
oxazine 89
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| Synonyms |
CHEMBL2347208; N-{3-[(4s,6s)-2-Amino-4-Methyl-6-(Trifluoromethyl)-5,6-Dihydro-4h-1,3-Oxazin-4-Yl]-4-Fluorophenyl}-5-Cyanopyridine-2-Carboxamide; oxazine 89; GTPL6944; SCHEMBL15991481; BDBM50432601; 1HL
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| Drug Type |
Small molecular drug
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| Indication | Diabetic nephropathy [ICD-11: GB61.Z; ICD-9: 250.4] | Clinical trial | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C19H15F4N5O2
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| Canonical SMILES |
CC1(CC(OC(=N1)N)C(F)(F)F)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)C#N)F
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| InChI |
1S/C19H15F4N5O2/c1-18(7-15(19(21,22)23)30-17(25)28-18)12-6-11(3-4-13(12)20)27-16(29)14-5-2-10(8-24)9-26-14/h2-6,9,15H,7H2,1H3,(H2,25,28)(H,27,29)/t15-,18-/m0/s1
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| InChIKey |
MELQHVBGGSKVJQ-YJBOKZPZSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Beta-secretase (BACE) | Target Info | Inhibitor | [1] |
| References | Top | |||
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| REF 1 | beta-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. J Med Chem. 2013 May 23;56(10):3980-95. | |||
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