Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T14597 | Target Info | |||
| Target Name | Erbb2 tyrosine kinase receptor (HER2) | ||||
| Synonyms |
p185erbB2; Tyrosine kinase-type cell surface receptor HER2; Receptor tyrosine-protein kinase erbB-2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; NGL; NEU; Metastatic lymph node gene 19 protein; MLN19; MLN 19; HER2; CD340
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| Target Type | Successful Target | ||||
| Gene Name | ERBB2 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 120 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Romiplostim
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Approved | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
PF-06651600
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Phase 2/3 | Compound Info | ||
| Synonyms |
CBRJPFGIXUFMTM-WDEREUQCSA-N; 1792180-81-4; UNII-2OYE00PC25; 2OYE00PC25; PF06651600; 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one; GTPL9559; SCHEMBL16764638; BCP24778; EX-A2613; ZINC526061581; example 5 [WO2015083028]; ACN-040697; compound 11 [PMID: 28139931]; HY-100754; CS-0020243; 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malonate; 1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]prop-2-en-1-one
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
PD-158780
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Investigative | Compound Info | ||
| Synonyms |
171179-06-9; PD158780; pd 158780; N4-(3-bromophenyl)-N6-methylpyrido[3,4-d]pyrimidine-4,6-diamine; AC1L1IRV; CHEMBL53753; PD 158780; 4-N-(3-bromophenyl)-6-N-methylpyrido[3,4-d]pyrimidine-4,6-diamine; AK160389; 4-(3-bromoanilino)-6-methylaminopyrido[3,4-d]pyrimidine; 4-[(3-bromophenyl)amino]-6-(methylamino)pyrido[3,4-d]pyrimidine; 4-[(3-Bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyridimine; Pyrido[3,4-d]pyrimidine-4,6-diamine, N4-(3-bromophenyl)-N6-methyl-
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| Activity |
IC50 = 52000 nM
|
[3] | |||
| Compound Name |
SU4984
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Investigative | Compound Info | ||
| Synonyms |
SU-4984; CHEMBL315546; 3[4-(1-Formylpiperazin-4-yl)benzylidenyl]-2-indolinone; (Z)-4-(4-((2-Oxoindolin-3-ylidene)methyl)phenyl)piperazine-1-carbaldehyde; 186610-89-9; AC1NZT45; SCHEMBL141892; BDBM50065306; ZINC12832813; 4-[4-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]phenyl]piperazine-1-carbaldehyde
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| Activity |
IC50 = 90200 nM
|
[1] | |||
| Compound Name |
(Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
oxindole i; CHEMBL86755; 3-(1H-Pyrrol-2-ylmethylene)-1,3-dihydroindol-2-one; oxindole 1; AC1NZGXV; K00027; (Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-one; Indolinone based inhibitor, 1; SCHEMBL1162655; SCHEMBL13819612; BDBM17015; MolPort-023-197-743; SEZFNTZQMWJIAI-FLIBITNWSA-N; ZINC3874586; HSCI1_000049; NCGC00343760-01; BRD-K51816706-001-01-7; (3Z)-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-one; 3-[(1H-Pyrrole-2-yl)methylene]-1H-indole-2(3H)-one; Z-(1H-Pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one; Oxindole I
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
VEGF receptor 2 kinase inhibitor I
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Investigative | Compound Info | ||
| Synonyms |
VEGF Receptor 2 Kinase Inhibitor I; UNII-U07H877HUF; CHEMBL86943; U07H877HUF; 15966-93-5; (Z)-3-[(2,4-Dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl)methylidenyl]indolin-2-one; Vegfr-2 inhi; ethyl 2,4-dimethyl-5-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrole-3-carboxylate; Ethyl 2,4-dimethyl-5-(((3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene)methyl)-1H-pyrrole-3-carboxylate; AC1O4WEX; K00004; Vegfr 2 kinase inhibitor I; SCHEMBL378979; VEGFR2 KiN/Ase Inhibitor I; GTPL6053; MolPort-044-561-167; HMS3229O05; ZINC3875265
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
SU5402
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Investigative | Compound Info | ||
| Synonyms |
su5402; 215543-92-3; SU 5402; SU-5402; 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone; (Z)-3-(4-methyl-2-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid; CHEMBL89363; 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE; J-502595; 3-{[3-(2-carboxyethyl)-4-methylpyrrol-2-yl]methylene}-2-indolinone; 3-[4-methyl-2-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid; (Z)-3-(4-Methyl-2-((2-oxoindolin-3-ylidene)-methyl)-1H-pyrrol-3-yl)propanoic acid
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-(4-Fluorobenzyl)-1-(2-hydroxy-3,5-dimethylbenzyl)-3-phenylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL592210; BDBM50308642
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1-Butyl-1-(5-chloro-2-hydroxybenzyl)-3-phenylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL591706; BDBM50308635
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
4-[4-(5-Bromo-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-phenyl]-piperazine-1-carbaldehyde
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL88405; BDBM50065299; 4-{4-[5-Bromo-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-phenyl}-piperazine-1-carbaldehyde
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-Butyl-1-(2-hydroxy-5-methylbenzyl)-3-phenylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL591707; BDBM50308649
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
6,6-Dimethyl-8-(1-(oxetan-3-yl)piperidin-4-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779202; SCHEMBL897210; BDBM50344664; 6,6-dimethyl-8-[1-(oxetan-3-yl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
1-Butyl-1-(2-hydroxy-3,5-dimethylbenzyl)-3-phenylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL590997; BDBM50308652
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1-Butyl-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylthiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL589590; BDBM50308633
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
4-(3,4-Dimethoxyphenyl)-5-cyano-2H-1,2,3-triazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL238616; SCHEMBL17969125; BDBM50200760; 5-(3,4-dimethoxyphenyl)-2H-triazole-4-carbonitrile
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
CID 49806721
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1823221; SCHEMBL896410; BDBM50352760; 9-ethyl-6,6-dimethyl-8-[4-(oxetan-3-yl)piperazin-1-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-(2,3-Dimethoxyphenyl)-5-cyano-2H-1,2,3-triazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL396897; SCHEMBL17969110; 5-(2,3-Dimethoxy-phenyl)-2H-[1,2,3]triazole-4-carbonitrile; BDBM50200762; ZINC28876107; 5-(2,3-dimethoxyphenyl)-2H-triazole-4-carbonitrile
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
5-(4-Methoxyphenyl)-2H-1,2,3-triazole-4-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL239896; 5-(4-methoxyphenyl)-2H-triazole-4-carbonitrile; SCHEMBL17969189; CTK4I1919; CTK7A3170; DTXSID50408097; KS-000028TF; ZINC5210850; BDBM50200761; MFCD00171193; SBB056040; AKOS005110853; AKOS015967719; MCULE-5092272559; MS-6814; 4-(4-methoxyphenyl)-5-cyano-2H-1,2,3-triazole; 5-(4-Methoxyphenyl)-4-cyano-1H-1,2,3-triazole; 5-(4-methoxyphenyl)-1,2,3-triazole-4-carbonitrile; 4-(4-Methoxyphenyl)-1H-1,2,3-triazole-5-carbonitrile; 1H-1,2,3-Triazole-5-carbonitrile,4-(4-methoxyphenyl)-; 5-(4-Methoxyphenyl)-2H-1,2,3-triazole-4-carbonitrile, AldrichCPR
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(E)-2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl 3-(2-methoxyphenyl)acrylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1171273; BDBM50322323
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL201511; SCHEMBL1155440; BDBM47167; CTK3C7420; DTXSID40468140; US8957103, Z1; 1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-; 3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)-2,5-dihydro-1H-pyrrole-2,5-dione
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| Activity |
IC50 = 50000 nM
|
[8] | |||
| Compound Name |
1-(5-Bromo-2-hydroxybenzyl)-1-butyl-3-phenylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL590962; BDBM50308648
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1-Butyl-1-(2-hydroxy-5-methylbenzyl)-3-phenylthiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL591437; BDBM50308631
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1-Butyl-1-(3,5-dichloro-2-hydroxybenzyl)-3-phenylturea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL591708; BDBM50308650
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
4-(Bis(2-chloroethyl)amino)-N-(3-morpholinopropyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL589846; BDBM50308942
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
4-(3,4,5-Trimethoxyphenyl)-5-cyano-2H-1,2,3-triazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL393013; SCHEMBL17969154; BDBM50200756; 5-(3,4,5-trimethoxyphenyl)-2H-triazole-4-carbonitrile
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
4-(Bis(2-chloroethyl)amino)-N-dodecylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL590081; BDBM50308940
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| Activity |
IC50 ~ 50000 nM
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[9] | |||
| Compound Name |
Tyrphostin deriv. 39
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL55993; BDBM4300; 2-(2,4,6-Trimethylbenzoyl)-3-(3,4-dihydroxyphenyl)acrylonitrile; (2E)-3-(3,4-dihydroxyphenyl)-2-[(2,4,6-trimethylphenyl)carbonyl]prop-2-enenitrile
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| Activity |
IC50 = 50000 nM
|
[10] | |||
| Compound Name |
3-[[5-Cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino]-4-methyl-N-(1,2-oxazol-3-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino}-4-methyl-N-(1,2-oxazol-3-yl)benzamide; CHEMBL383172; 5-Cyanopyrimidine Derivative 3b; SCHEMBL16576397; BDBM16326; 3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino}-N-isoxazol-3-yl-4-methylbenzamide
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
1-Butyl-1-(2-hydroxy-3,5-dimethylbenzyl)-3-phenylthiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL589365; BDBM50308634
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N-Cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-yl)methylamino)benzamide
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Investigative | Compound Info | ||
| Synonyms |
BMS-605541; CHEMBL377734; BMS 605541; SCHEMBL2861987; BDBM50189603; AKOS034831603
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| Activity |
IC50 ~ 50000 nM
|
[12] | |||
| Compound Name |
2-(4-Methoxyphenyl)-N-(4-methylphenyl)sulfonylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1828881; BDBM50353981
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| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
1-Butyl-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL590759; BDBM50308651
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
2-(1H-Benzimidazol-2-ylmethyl)-5-(phenoxymethyl)-1,3,4-oxadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087921; BDBM50232323
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| Activity |
IC50 = 52400 nM
|
[14] | |||
| Compound Name |
2-[(6-Chloro-1H-benzimidazol-2-yl)methyl]-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102942; BDBM50232329
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| Activity |
IC50 = 52600 nM
|
[14] | |||
| Compound Name |
5-Phenyl-3H-[1,2,3]triazole-4-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL269528; 4-Phenyl-1H-1,2,3-triazole-5-carbonitrile; 5-phenyl-2H-triazole-4-carbonitrile; SCHEMBL9727230; CTK4C5097; KUC107932N; 4-phenyl-5-cyano-1,2,3-triazole; BDBM50200763; ZINC22004872; AKOS006280582; KSC-20-104; 5-Phenyl-2H-1,2,3-triazole-4-carbonitrile; 1H-1,2,3-Triazole-5-carbonitrile,4-phenyl-; 1H-1,2,3-Triazole-5-carbonitrile, 4-phenyl-
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| Activity |
IC50 = 53500 nM
|
[6] | |||
| Compound Name |
N-(3-Ethoxyphenyl)-6-morpholin-4-ylsulfonyl-9H-pyrido[2,3-b]indol-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133826
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| Activity |
IC50 = 54800 nM
|
[15] | |||
| Compound Name |
Tyrphostin deriv. 54
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL56219; BDBM4307; 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(2-chlorophenyl)acrylamide; (2E)-N-(2-chlorophenyl)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
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| Activity |
IC50 = 57000 nM
|
[10] | |||
| Compound Name |
2-Benzhydryl-5-(1H-benzimidazol-2-ylmethyl)-1,3,4-oxadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102214; BDBM50232326
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| Activity |
IC50 = 57600 nM
|
[14] | |||
| Compound Name |
2-(3,4-Dihydroxy-5-methylbenzylidene)malononitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL116423; SCHEMBL10186359; CTK8H0386; BDBM50036684; 2-(3,4-Dihydroxy-5-methyl-benzylidene)-malononitrile; 2-[3-Methyl-4,5-dihydroxybenzylidene]propanedinitrile
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| Activity |
IC50 = 58884.37 nM
|
[16] | |||
| Compound Name |
N-(4-(4-Amino-7-((1s,4s)-4-(4-methylpiperazin-1-yl)cyclohexyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-fluorophenyl)-5,7-dimethylbenzo[d]oxazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1256418; SCHEMBL6107989; SCHEMBL6107993; BDBM50327964
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| Activity |
IC50 ~ 62500 nM
|
[17] | |||
| Compound Name |
3-(3,5-Di-tert-butyl-4-hydroxybenzylidene)indolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL89505; SCHEMBL5472251; BDBM50065275; ZINC13780154; (3Z)-3-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]-1H-indol-2-one; 3-[1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
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| Activity |
IC50 = 64800 nM
|
[1] | |||
| Compound Name |
N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-5-methyl-6-phenylpyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683957; BDBM50338611
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| Activity |
IC50 = 65000 nM
|
[18] | |||
| Compound Name |
(Z)-4-Methyl-3-(4-morpholinobenzylidene)indolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL90277; BDBM50065312; 4-Methyl-3-(4-morpholin-4-yl-benzylidene)-1,3-dihydro-indol-2-one; 4-Methyl-3-[1-(4-morpholin-4-yl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
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| Activity |
IC50 = 66600 nM
|
[1] | |||
| Compound Name |
6-Bromo-N-(3-methoxyphenyl)-9H-pyrido[2,3-b]indol-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3133834
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| Activity |
IC50 = 91200 nM
|
[15] | |||
| Compound Name |
3-[5-[(E)-3-Amino-2-cyano-3-oxoprop-1-enyl]-2-hydroxy-3-methoxyphenyl]sulfanylpropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161235; BDBM50409733
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| Activity |
IC50 = 91201.08 nM
|
[16] | |||
| Compound Name |
(E)-N-[4-(3-Bromoanilino)quinazolin-6-yl]but-2-enamide
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Investigative | Compound Info | ||
| Synonyms |
4-anilinoquinazoline deriv. 18; CHEMBL93464; BDBM4596; SCHEMBL2988658; SCHEMBL2988661; 6-Substituted 4-Anilinoquinazoline 11; 4-(3-Bromoanilino)-6-[(E)-2-butenoylamino]quinazoline; N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-(E)-2-butenamide; N-[4-[(3-Bromophenyl)amino]quinazolin-6-yl]-E-but-2-enamide; (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}but-2-enamide
Click to Show/Hide
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||||
| Activity |
IC50 = 91325 nM
|
[19] | |||
| Compound Name |
4-Methyl-3-(5-methylsulfanyl-thiophen-2-ylmethylene)-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86432; BDBM50065274; 4-Methyl-3-[1-(5-methylsulfanyl-thiophen-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 91400 nM
|
[1] | |||
| Compound Name |
3-[1-(4-Piperidin-1-yl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL315701; SCHEMBL6001605; BDBM50065276
Click to Show/Hide
|
||||
| Activity |
IC50 = 92600 nM
|
[1] | |||
| Compound Name |
2-(6-Amino-9H-purine-9-yl)-1-(1H-indole-3-yl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521155; BDBM50268223
Click to Show/Hide
|
||||
| Activity |
IC50 = 95000 nM
|
[20] | |||
| Compound Name |
2-(1H-Benzimidazol-2-ylmethyl)-5-(2,3-dimethoxyphenyl)-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4065301; BDBM50232341
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-6-phenoxypyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683954; BDBM50338608
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
3-[(Z)-(4-Bromo-2-thienyl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316268; (3Z)-3-[(4-bromothiophen-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one; SCHEMBL5728269; ZINC5903417; BDBM50065319; MFCD03012811; AKOS005094253; 5T-0045; 3-[1-(4-Bromo-thiophen-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(Z)-1-Methyl-3-(4-dimethylaminobenzylidene)indoline-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86921; SCHEMBL14589616; ZINC586193; BDBM50065315; MCULE-4166796331; 3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-1-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(5-Isoquinolin-4-yl-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzoimidazole-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249501; SCHEMBL4033912; BDBM50214109; 2-(5-(isoquinolin-4-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzo[d]imidazole-4-carboxylic acid; 2-(5-isoquinolin-4-yl-1,2-dihydropyrazolo[3,4-b]pyridin-3-ylidene)benzimidazole-4-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
Methyl 5-(2-(3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)nicotinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL397549; SCHEMBL13596390; BDBM50215755
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
4-(3-(4-(Isopropoxymethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)isoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249094; SCHEMBL4038351; BDBM50214106
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-6-(pyridin-3-yl)pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683951; BDBM50338605
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
5-(2-(3-(6-Methoxy-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)nicotinonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL395393; SCHEMBL13596387; BDBM50215747
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
3-(4-(Dimethylamino)benzylidene)-1,3-dihydro-2H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SU 4312; SU-4312; NSC86429; NSC 86429; CHEMBL328710; 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one; SU4312; SR-01000076222; BiomolKI_000054; BiomolKI2_000060; UPCMLD-DP118; cis-SU 4312; Lopac0_001121; BMK1-F6; BSPBio_000998; SCHEMBL1982207; UPCMLD-DP118:001; UPCMLD-DP118:002; BDBM17747; HMS1362B19; HMS1792B19; HMS1990B19; HMS3263B03; HMS3403B19; HMS3412D03; HMS3676D03; BCP20743; Tox21_501121; NSC-86429; STK946565; ZINC12339625; AKOS005640946; CCG-100658; LP01121; SDCCGSBI-0051089.P002; SU4312(NSC86429); IDI1_002094; NCGC00025170-02; NCGC00025170-03; NCGC00025170-04; NCGC00025170-05; NCGC00025170-06; NCGC00025170-07; NCGC00025170-08; NCGC00025170-09; NCGC00025170-10; NCGC00025170-11; NCGC00025170-12; NCGC00025170-14; NCGC00261806-01; B6746; EU-0101121; EC-000.2453; S 8567; (Z)-3-(4-(dimethylamino)benzylidene)indolin-2-one; SR-01000076222-1; SR-01000076222-3; BRD-K20287671-001-01-0; (3Z)-3-[(4-dimethylaminophenyl)methylene]indolin-2-one; DMBI; (Z)-3-(4-(dimethylamino)benzylidene)indolin-2-one; (3Z)-3-[[4-(dimethylamino)phenyl]methylidene]-1H-indol-2-one; (3Z)-3-[4-(dimethylamino)benzylidene]-1,3-dihydro-2H-indol-2-one; (3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-dihydro-1H-indol-2-one; SU-4312; SU4312. DMBI; NSC 86429; NSC-86429; NSC86429
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(2-methoxyethyl)pyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL517745; SCHEMBL13873522; BDBM50245409
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-5-(pyrimidin-5-yl)-1H-pyrazolo[3,4-b]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249302; SCHEMBL4039269; BDBM50214112
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(3Z)-3-[(4-Bromophenyl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SU 4942; CHEMBL86837; 3-(4-Bromobenzylidene)-1,3-dihydroindol-2-one; 3-(4-Bromobenzylidene)indolin-2-one; SU4942; SCHEMBL5465141; ZINC574906; BCP20736; BDBM50065305; MFCD00435354; 3-(4-Bromobenzylidene)indoline-2-one; AKOS001575405; (3Z)-3-(4-bromobenzylidene)-1,3-dihydro-2H-indol-2-one; 3-[1-(4-Bromo-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-[1-(4-Piperidin-1-yl-phenyl)-ethylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314798; SCHEMBL19451599; BDBM50065293; 3-[1-(4-Piperidin-1-yl-phenyl)-eth-(E)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-(4-Dimethylamino-benzylidene)-4-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89809; BDBM50065294; 3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-4-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[4-(Morpholin-4-yl)benzylidene]-1,3-dihydro-2H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86480; SCHEMBL1452713; HMS1404H09; ZINC3262621; BDBM50065280; STK114426; AKOS005399481; IDI1_007326; 3-(4-Morpholinobenzylidene)indolin-2-one; (Z)-3-(4-Morpholinobenzylidene)indolin-2-one; 3-[1-(4-Morpholin-4-yl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-5-(pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400859; SCHEMBL4034433; BDBM50214116
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
5-Nitro-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87325; SCHEMBL6000878; BDBM50065287; 5-Nitro-3-[1-(1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-((2-(5-(Isoquinolin-4-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzo[d]imidazol-4-yl)methyl)propan-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL401064; SCHEMBL4035762; BDBM50214098
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
3-(5-Methyl-furan-2-ylmethylene)-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89697; BDBM50065309; 3-[1-(5-Methyl-furan-2-yl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-4-Methyl-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL85403; Indolinone based inhibitor, 1a; SCHEMBL5728466; BDBM17016
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-[(Z)-(3-Bromo-2-thienyl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87783; (3Z)-3-[(3-bromothiophen-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one; ZINC4038356; BDBM50065272; MFCD05975006; AKOS005076668; 10X-0879; 3-[1-(3-Bromo-thiophen-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-((5-(3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)-4-methylpyridin-3-yl)methyl)ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249519; SCHEMBL4036313; BDBM50214118
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(3Z)-3-(4-Hydroxybenzylidene)-1,3-dihydro-2H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313578; SCHEMBL5470603; ZINC2939076; BDBM50065304; STK946564; AKOS002131864; 3-(4-Hydroxybenzylidenyl)-indolin-2-one; 3-[(Z)-4-Hydroxybenzylidene]indoline-2-one; J3.666.327H; SR-01000594632; J-017472; SR-01000594632-1; 3-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(4-methoxyphenyl)pyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472383; SCHEMBL13873526; BDBM50245443
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(3Z)-3-[(4-Methoxyphenyl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87810; 3-(4-Methoxybenzylidene)-2-indolinone; SCHEMBL5475861; BDBM50065296; STL553883; ZINC12339635; AKOS016032064; 3-(4-Methoxybenzylidene)indoline-2-one; (Z)-3-(4-methoxybenzylidene)indolin-2-one; 3-[(Z)-4-Methoxybenzylidene]-1H-indol-2(3H)-one; (3Z)-3-(4-methoxybenzylidene)-1,3-dihydro-2H-indol-2-one; 3-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)isoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251740; SCHEMBL4035835; BDBM50214101
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(Z)-4-(4-((4-Methyl-2-oxoindolin-3-ylidene)methyl)phenyl)piperazine-1-carbaldehyde
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89040; BDBM50065290; 4-[4-(4-Methyl-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-phenyl]-piperazine-1-carbaldehyde; 4-{4-[4-Methyl-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-phenyl}-piperazine-1-carbaldehyde
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[(4-Chloro-1-methylpyrazol-3-yl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89646; SCHEMBL5999800; BDBM50065279; 3-[1-(4-Chloro-1-methyl-1H-pyrazol-3-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Fluorobenzyl 4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472382; SCHEMBL3977223; BDBM50245442; (3-fluorophenyl)methyl 4-amino-6-(3-chloro-4-phenylmethoxyanilino)pyrimidine-5-carboxylate
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
3-[1-(5-Ethyl-thiophen-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314146; SCHEMBL6001148; BDBM50065295; ZINC12352634
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-Methoxy-6-(decahydronaphthalene-1-ylidenemethyl)-1,4-benzoquinone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98934; BDBM50130358; 2-Methoxy-6-(octahydro-naphthalen-1-ylidenemethyl)-[1,4]benzoquinone
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
(3E)-3-(Furan-2-ylmethylidene)-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL312826; SCHEMBL20838; HMS1433A06; ZINC4693315; BDBM50065301; IDI1_012097; 3-Furan-2-ylmethylene-1,3-dihydro-indol-2-one; 3-[1-Furan-2-yl-meth-(E)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-4-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL330321; SCHEMBL13432277; BDBM50065288; 3-[1-(3,5-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-4-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-(3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)quinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249095; SCHEMBL4037124; BDBM50214103
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N,N-diethylpyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452727; SCHEMBL4090152; BDBM50245410; 4-amino-6-(3-chloro-4-phenylmethoxyanilino)-N,N-diethylpyrimidine-5-carboxamide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[2-(triazol-1-yl)ethoxy]quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
ZD-4190; ZD4190; SCHEMBL173259; BDBM4651; CHEMBL281872; BCP30854; ZINC1490292; HY-U00002; s6543; CS-6801; ZD 4190;ZD4190
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
6-Fluoro-3-[1-(1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87208; SCHEMBL5728248; BDBM50065302
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89483; BDBM50065292; (Z)-3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-5-methyl-1,3-dihydro-indol-2-one; 3-[1-(3,5-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-5-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[[6-Amino-4-butoxy-5-(2,6-difluorobenzoyl)pyridin-2-yl]amino]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-Acyl-2,6-diaminopyridine deriv. 11; BDBM6913; SCHEMBL4551602; CHEMBL2113092; 4-({6-amino-4-butoxy-5-[(2,6-difluorophenyl)carbonyl]pyridin-2-yl}amino)benzene-1-sulfonamide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
3-Acyl-2,6-diaminopyridine deriv. 2p
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM6896; CHEMBL193456; 4-({6-amino-5-[(2,6-difluorophenyl)carbonyl]pyridin-2-yl}amino)-N,N-dimethylbenzene-1-sulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
3-[1-(4-Chloro-1H-pyrazol-3-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87402; SCHEMBL6001442; BDBM50065284
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[2-Oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313259; BDBM50065281
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-[1-(3,4-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316020; SCHEMBL6001449; BDBM50065311
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(2-(3-(6-Methoxy-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)isoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL395392; SCHEMBL4783686; SCHEMBL13596388; BDBM50215754
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
3-(2-(3-(4-(Trifluoromethyl)-1H-imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL246165; SCHEMBL4420876; BDBM50215757
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
3-(5-Ethyl-furan-2-ylmethylene)-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL328452; SCHEMBL5728117; BDBM50065291; 3-[1-(5-Ethyl-furan-2-yl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[[4-(Dimethylamino)phenyl]methylidene]-6-fluoro-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL329367; BDBM50065298; 3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-6-fluoro-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Methyl 3-[4-methyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316009; SCHEMBL14519114; BDBM50065289
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(3-(5-Morpholino-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)isoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249500; SCHEMBL4043577; BDBM50214110
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
N-(4-Methoxyphenethyl)-4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461115; SCHEMBL13873524; BDBM50245408
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(3Z)-3-[(5-Methylsulfanylthiophen-2-yl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89721; BDBM50065273; 3-[1-(5-Methylsulfanyl-thiophen-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylidene]-6-fluoro-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87324; BDBM50065282; 3-[1-(3,5-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-6-fluoro-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[[6-Amino-5-(2,6-difluorobenzoyl)pyridin-2-yl]amino]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-Acyl-2,6-diaminopyridine deriv. 2r; BDBM6898; CHEMBL193643; SCHEMBL4419524; 4-({6-amino-5-[(2,6-difluorophenyl)carbonyl]pyridin-2-yl}amino)benzene-1-sulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
5-Chloro-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL431025; SCHEMBL3912682; BDBM50065317; ZINC33034247; AKOS001473500; 5-Chloro-3-[1-(1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-(4-(2-(Pyridin-3-yl)vinyl)-1H-pyrazol-3-yl)-1H-imidazole-4-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394466; SCHEMBL4431291; BDBM50215751
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(5-(3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-N-methylmethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400749; SCHEMBL4036699; BDBM50214107
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
3-[1-(4-Pyrrolidin-1-yl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314217; SCHEMBL6001567; SCHEMBL14519135; ZINC574986; BDBM50065314
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3Z)-3-[(1-Methylpyrrol-2-yl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86631; SCHEMBL21465; BDBM50065300; 3-[1-(1-Methyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-(3-Chloro-4-(3-fluorobenzyloxy)phenyl)-6-(pyrrolidin-1-yl)pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683953; BDBM50338607
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
(3Z)-3-[(3-Ethyl-4,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313433; SCHEMBL6000845; BDBM50065303; 3-[1-(3-Ethyl-4,5-dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(5-(3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-N,N-dimethylmethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249518; SCHEMBL4037695; BDBM50214114
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
2-(5-Isoquinolin-4-yl-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzoimidazole-4-carboxylic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399042; SCHEMBL4037517; BDBM50214104; methyl 2-(5-(isoquinolin-4-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-benzo[d]imidazole-4-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(3Z)-3-[(4-Ethyl-3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL420411; SCHEMBL5728018; BDBM50065286; 3-[1-(4-Ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-((5-(2-(3-(4-(Trifluoromethyl)-1H-imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)pyridin-3-yl)methyl)ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245376; SCHEMBL4434427; BDBM50215748
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
3-(4-(Methoxymethyl)-1H-benzo[d]imidazol-2-yl)-5-(pyridin-4-yl)-1H-pyrazolo[3,4-b]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249096; SCHEMBL4035751; BDBM50214105
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
5-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358966
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
4-Methyl-5-[2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-1H-pyrrole-3-carboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316008; SCHEMBL5388917; BDBM50065283
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[3-Methyl-4-hydroxy-5-methoxybenzylidene]propanedinitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL120564; BDBM50036699; 2-(4-Hydroxy-3-methoxy-5-methyl-benzylidene)-malononitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 112201.85 nM
|
[16] | |||
| Compound Name |
8-(2,5-Dichlorophenylthio)-9H-purin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364272; BDBM50165314; 8-(2,5-Dichloro-phenylsulfanyl)-9H-purin-6-ylamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 120000 nM
|
[28] | |||
| Compound Name |
Tyrphostin deriv. 64
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL57251; BDBM4312; N-(2,4-Dimethoxyphenyl)-alpha-cyano-3,4-dihydroxycinnamamide; 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(2,4-dimethoxyphenyl)acrylamide; (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(2,4-dimethoxyphenyl)prop-2-enamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 165958.69 nM
|
[16] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 8 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Adenosine
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Adenosine, homopolymer; Adenine 9-beta-D-arabinofuranoside; Adenine-9-beta-D-ribofuranoside; Beta-D-Ribofuranoside, adenine-9; EA6C60C2-6AFB-4264-A2F0-541373DB950E; (2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; 4-Aminopyrazolo[3,4-d]pyrimidine ribonucleoside; 6-Amino-9-.beta.-ribofuranosyl-9H-purine; 6-Amino-9-beta-D-ribofuranosyl-9H-purine; 6-Amino-9beta-D-ribofuranosyl-9H-purine; 9-(beta-D-Arabinofuranosyl)adenine; 9-beta-D-Ribofuranosidoadenine; 9-beta-D-Ribofuranosyl-9H-purin-6-amine; 9-beta-D-Ribofuranosyladenine; 9beta-D-Ribofuranosyladenine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 1600000 nM
|
[29] | |||
| Compound Name |
PD158780 Analog 5n
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM3710; CHEMBL162622; PD-0165557; 4-[(3-Bromophenyl)amino]-6-[[2-(4-morpholino)ethyl]amino]pyrido[3,4-d]pyrimidine; 4-N-(3-bromophenyl)-6-N-[2-(morpholin-4-yl)ethyl]pyrido[3,4-d]pyrimidine-4,6-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 219000 nM
|
[3] | |||
| Compound Name |
9-Butyl-8-(3,4,5-trimethoxybenzene-1-sulfonyl)-9H-purin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL190654; CTK3D7321; DTXSID00658747; BDBM50165304; 8-(3,4,5-Trimethoxyphenylsulfonyl)-9-butyl-9H-purine-6-amine; 9-butyl-8-(3,4,5-trimethoxyphenylsulfonyl)-9H-purin-6-amine; 9-Butyl-8-((3,4,5-trimethoxyphenyl)sulfonyl)-9H-purin-6-amine; 9-Butyl-8-(3,4,5-trimethoxy-benzenesulfonyl)-9H-purin-6-ylamine; 9H-Purin-6-amine, 9-butyl-8-[(3,4,5-trimethoxyphenyl)sulfonyl]-
Click to Show/Hide
|
||||
| Activity |
IC50 = 310000 nM
|
[28] | |||
| Compound Name |
Tyrphostin deriv. 58
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL56319; BDBM4309; 2-[2-Cyano-3-(3,4-dihydroxyphenyl)acryloylamino]-3-phenylpropionic acid ethyl ester; ethyl 2-[(2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamido]-3-phenylpropanoate
Click to Show/Hide
|
||||
| Activity |
IC50 = 331131.12 nM
|
[16] | |||
| Compound Name |
PD158780 Analog 5h
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-N-(3-bromophenyl)-6-N-[2-(dimethylamino)ethyl]pyrido[3,4-d]pyrimidine-4,6-diamine; BDBM3704; CHEMBL162034; 4-[(3-Bromophenyl)amino]-6-[[2-(dimethylamino)-ethyl]amino]pyrido[3,4-d]pyrimidine
Click to Show/Hide
|
||||
| Activity |
IC50 = 379000 nM
|
[3] | |||
| Compound Name |
2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AG 556; AG-556; CHEMBL440298; (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)acrylamide; (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)prop-2-enamide; Tyrphostin B56; 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)acrylamide; Tyrphostin AG556; SR-01000597669; Tyrphostin AG-556; Tocris-0616; Tyrphostin deriv. 56; BDBM4308; SCHEMBL2533402; alpha-Cyano-(3,4-dihydroxy)-N-(4-phenylbutyl)cinnamide; HMS3414I03; HMS3678I03; ZINC2557954; HSCI1_000058; AKOS024458582; NCGC00024686-01; B6376; J-006405; SR-01000597669-1; SR-01000597669-2; BRD-K81048131-001-01-6; N-(4-Phenylbutyl)-3,4-dihydroxybenzylidene-cyanoacetamide; (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)prop-2-enamide; 2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-,(2E)-; (E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-(4-PHENYLBUTYL)-2-PROPENAMIDE
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[30] | |||
| Compound Name |
4-Phenyl-[1]benzofuro[2,3-b]pyridine-3,6-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163772; BDBM50395892
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[31] | |||
| Compound Name |
PD158780 Analog 5k
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM3707; CHEMBL433520; 4-[(3-Bromophenyl)amino]-6-[[3-(diethylamino)-2-hydroxypropyl]amino]pyrido[3,4-d]pyrimidine; 4-N-(3-bromophenyl)-6-N-[3-(diethylamino)-2-hydroxypropyl]pyrido[3,4-d]pyrimidine-4,6-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 1100000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem. 1998 Jul 2;41(14):2588-603. | ||||
| REF 2 | Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans. J Med Chem. 2017 Mar 9;60(5):1971-1993. | ||||
| REF 3 | Tyrosine kinase inhibitors. 14. Structure-activity relationships for methylamino-substituted derivatives of 4-[(3-bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyrimidine (PD 158780), a potent and specific inhibitor of the tyrosine kinase activity of receptors for the EGF family of growth factors. J Med Chem. 1998 Feb 26;41(5):742-51. | ||||
| REF 4 | Synthesis and structure-activity relationships of N-benzyl-N-(X-2-hydroxybenzyl)-N'-phenylureas and thioureas as antitumor agents. Bioorg Med Chem. 2010 Jan 1;18(1):305-13. | ||||
| REF 5 | 9-substituted 6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as highly selective and potent anaplastic lymphoma kinase inhibitors. J Med Chem. 2011 Sep 22;54(18):6286-94. | ||||
| REF 6 | Synthesis and biological evaluation of 4-aryl-5-cyano-2H-1,2,3-triazoles as inhibitor of HER2 tyrosine kinase. Bioorg Med Chem. 2007 Feb 1;15(3):1533-8. | ||||
| REF 7 | Synthesis, molecular modeling, and biological evaluation of cinnamic acid metronidazole ester derivatives as novel anticancer agents. Bioorg Med Chem. 2010 Jul 15;18(14):4991-6. | ||||
| REF 8 | Profile and molecular modeling of 3-(indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1 H-pyrrole-2,5-dione (1) as a highly selective VEGF-R2/3 inhibitor. J Med Chem. 2006 Dec 14;49(25):7549-53. | ||||
| REF 9 | Synthesis, biological evaluation and molecular docking studies of amide-coupled benzoic nitrogen mustard derivatives as potential antitumor agents. Bioorg Med Chem. 2010 Jan 15;18(2):880-6. | ||||
| REF 10 | Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine... J Med Chem. 1991 Jun;34(6):1896-907. | ||||
| REF 11 | 5-Cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38alpha MAP kinase. J Med Chem. 2005 Oct 6;48(20):6261-70. | ||||
| REF 12 | Discovery and evaluation of N-cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2. J Med Chem. 2006 Jun 29;49(13):3766-9. | ||||
| REF 13 | Metronidazole acid acyl sulfonamide: a novel class of anticancer agents and potential EGFR tyrosine kinase inhibitors. Bioorg Med Chem. 2011 Oct 15;19(20):6069-76. | ||||
| REF 14 | Design, synthesis, docking and QSAR study of substituted benzimidazole linked oxadiazole as cytotoxic agents, EGFR and erbB2 receptor inhibitors. Eur J Med Chem. 2017 Jan 27;126:853-869. | ||||
| REF 15 | Novel inhibitors of breast cancer relevant kinases Brk and HER2. Medchemcomm. 2014;5:659-64. | ||||
| REF 16 | Receptor-guided alignment-based comparative 3D-QSAR studies of benzylidene malonitrile tyrphostins as EGFR and HER-2 kinase inhibitors. J Med Chem. 2003 Oct 23;46(22):4657-68. | ||||
| REF 17 | Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6067-71. | ||||
| REF 18 | Synthesis and evaluation of novel pyrimidine-based dual EGFR/Her-2 inhibitors. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1601-6. | ||||
| REF 19 | 6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity. J Med Chem. 2001 Aug 16;44(17):2719-34. | ||||
| REF 20 | Design, synthesis and characterization of N9/N7-substituted 6-aminopurines as VEGF-R and EGF-R inhibitors. Eur J Med Chem. 2009 Apr;44(4):1788-93. | ||||
| REF 21 | Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4297-302. | ||||
| REF 22 | Design, synthesis, and evaluation of 3,4-disubstituted pyrazole analogues as anti-tumor CDK inhibitors. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4557-61. | ||||
| REF 23 | A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine having dual EGFR/HER2 kinase activity: design, synthesis, and biological activity. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4896-9. | ||||
| REF 24 | Development of natural product-derived receptor tyrosine kinase inhibitors based on conservation of protein domain fold. J Med Chem. 2003 Jul 3;46(14):2917-31. | ||||
| REF 25 | Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors. J Med Chem. 2002 Mar 14;45(6):1300-12. | ||||
| REF 26 | 3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: synthesis and biological evaluation. Bioorg Med Chem Lett. 2005 May 2;15(9):2221-4. | ||||
| REF 27 | Optimization of potent DFG-in inhibitors of platelet derived growth factor receptor (PDGF-R) guided by water thermodynamics. J Med Chem. 2015 Jan 8;58(1):170-82. | ||||
| REF 28 | Discovery of novel small-molecule inhibitors of human epidermal growth factor receptor-2: combined ligand and target-based approach. J Med Chem. 2008 Jun 26;51(12):3367-77. | ||||
| REF 29 | Structure-based design of a potent, selective, and irreversible inhibitor of the catalytic domain of the erbB receptor subfamily of protein tyrosine kinases. J Med Chem. 1997 Mar 28;40(7):1130-5. | ||||
| REF 30 | Structure-activity relationship of N-(phenylalkyl)cinnamides as novel NR2B subtype-selective NMDA receptor antagonists. J Med Chem. 1999 Aug 26;42(17):3412-20. | ||||
| REF 31 | Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases. Bioorg Med Chem Lett. 2012 Nov 15;22(22):6914-8. | ||||
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