| Target and Pathway |
Top |
| Target(s) |
PDK-1 messenger RNA (PDK-1 mRNA) |
Target Info
|
Inhibitor |
[1] |
| Proto-oncogene c-Ret (RET) |
Target Info
|
Inhibitor |
[2] |
| RAC-alpha serine/threonine-protein kinase (AKT1) |
Target Info
|
Inhibitor |
[1] |
|
KEGG Pathway
|
PPAR signaling pathway
|
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FoxO signaling pathway
|
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Sphingolipid signaling pathway
|
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mTOR signaling pathway
|
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PI3K-Akt signaling pathway
|
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AMPK signaling pathway
|
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Focal adhesion
|
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T cell receptor signaling pathway
|
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Fc epsilon RI signaling pathway
|
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Neurotrophin signaling pathway
|
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Insulin signaling pathway
|
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Thyroid hormone signaling pathway
|
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Aldosterone-regulated sodium reabsorption
|
|
Toxoplasmosis
|
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Hepatitis C
|
|
Proteoglycans in cancer
|
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Endometrial cancer
|
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Prostate cancer
|
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Non-small cell lung cancer
|
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Choline metabolism in cancer
|
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MAPK signaling pathway
|
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ErbB signaling pathway
|
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Ras signaling pathway
|
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Rap1 signaling pathway
|
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cGMP-PKG signaling pathway
|
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cAMP signaling pathway
|
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Chemokine signaling pathway
|
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HIF-1 signaling pathway
|
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Apoptosis
|
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Adrenergic signaling in cardiomyocytes
|
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VEGF signaling pathway
|
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Osteoclast differentiation
|
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Tight junction
|
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Signaling pathways regulating pluripotency of stem cells
|
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Platelet activation
|
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Toll-like receptor signaling pathway
|
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Jak-STAT signaling pathway
|
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B cell receptor signaling pathway
|
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Fc gamma R-mediated phagocytosis
|
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TNF signaling pathway
|
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Cholinergic synapse
|
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Dopaminergic synapse
|
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Progesterone-mediated oocyte maturation
|
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Estrogen signaling pathway
|
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Prolactin signaling pathway
|
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Adipocytokine signaling pathway
|
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Glucagon signaling pathway
|
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Regulation of lipolysis in adipocytes
|
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Non-alcoholic fatty liver disease (NAFLD)
|
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Carbohydrate digestion and absorption
|
|
Chagas disease (American trypanosomiasis)
|
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Tuberculosis
|
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Hepatitis B
|
|
Measles
|
|
Influenza A
|
|
HTLV-I infection
|
|
Epstein-Barr virus infection
|
|
Pathways in cancer
|
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Colorectal cancer
|
|
Renal cell carcinoma
|
|
Pancreatic cancer
|
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Glioma
|
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Melanoma
|
|
Chronic myeloid leukemia
|
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Acute myeloid leukemia
|
|
Small cell lung cancer
|
|
Central carbon metabolism in cancer
|
|
Endocytosis
|
|
Thyroid cancer
|
|
NetPath Pathway
|
TSH Signaling Pathway
|
|
Panther Pathway
|
Inflammation mediated by chemokine and cytokine signaling pathway
|
|
Insulin/IGF pathway-protein kinase B signaling cascade
|
|
Interleukin signaling pathway
|
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PDGF signaling pathway
|
|
PI3 kinase pathway
|
|
p53 pathway
|
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Ras Pathway
|
|
p53 pathway feedback loops 2
|
|
CCKR signaling map ST
|
|
Angiogenesis
|
|
Apoptosis signaling pathway
|
|
EGF receptor signaling pathway
|
|
Endothelin signaling pathway
|
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FGF signaling pathway
|
|
Huntington disease
|
|
Hypoxia response via HIF activation
|
|
T cell activation
|
|
VEGF signaling pathway
|
|
p53 pathway by glucose deprivation
|
|
Pathwhiz Pathway
|
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
|
Insulin Signalling
|
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Fc Epsilon Receptor I Signaling in Mast Cells
|
|
Leucine Stimulation on Insulin Signaling
|
|
Pathway Interaction Database
|
BCR signaling pathway
|
|
Insulin Pathway
|
|
TCR signaling in naï
|
|
|
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
|
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TCR signaling in naï
|
|
|
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FAS (CD95) signaling pathway
|
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mTOR signaling pathway
|
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CXCR4-mediated signaling events
|
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IGF1 pathway
|
|
Class I PI3K signaling events
|
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ErbB1 downstream signaling
|
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IL8- and CXCR2-mediated signaling events
|
|
CXCR3-mediated signaling events
|
|
VEGFR1 specific signals
|
|
Signaling events mediated by Stem cell factor receptor (c-Kit)
|
|
Signaling events mediated by VEGFR1 and VEGFR2
|
|
Class I PI3K signaling events mediated by Akt
|
|
IL8- and CXCR1-mediated signaling events
|
|
Trk receptor signaling mediated by PI3K and PLC-gamma
|
|
FGF signaling pathway
|
|
TGF-beta receptor signaling
|
|
Regulation of nuclear SMAD2/3 signaling
|
|
Fc-epsilon receptor I signaling in mast cells
|
|
Endothelins
|
|
LPA receptor mediated events
|
|
IL4-mediated signaling events
|
|
Plasma membrane estrogen receptor signaling
|
|
CD40/CD40L signaling
|
|
Signaling events mediated by PTP1B
|
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S1P3 pathway
|
|
Coregulation of Androgen receptor activity
|
|
Reelin signaling pathway
|
|
Integrin-linked kinase signaling
|
|
Angiopoietin receptor Tie2-mediated signaling
|
|
Thromboxane A2 receptor signaling
|
|
Regulation of Telomerase
|
|
FOXA2 and FOXA3 transcription factor networks
|
|
Glucocorticoid receptor regulatory network
|
|
FoxO family signaling
|
|
IL2 signaling events mediated by PI3K
|
|
Ceramide signaling pathway
|
|
p75(NTR)-mediated signaling
|
|
E-cadherin signaling in the nascent adherens junction
|
|
amb2 Integrin signaling
|
|
Integrins in angiogenesis
|
|
IFN-gamma pathway
|
|
ErbB2/ErbB3 signaling events
|
|
IL6-mediated signaling events
|
|
E-cadherin signaling in keratinocytes
|
|
Nephrin/Neph1 signaling in the kidney podocyte
|
|
Retinoic acid receptors-mediated signaling
|
|
Signaling events mediated by the Hedgehog family
|
|
Nongenotropic Androgen signaling
|
|
Hedgehog signaling events mediated by Gli proteins
|
|
Caspase Cascade in Apoptosis
|
|
a6b1 and a6b4 Integrin signaling
|
|
Aurora A signaling
|
|
Insulin-mediated glucose transport
|
|
HIF-1-alpha transcription factor network
|
|
p53 pathway
|
|
VEGFR3 signaling in lymphatic endothelium
|
|
Signaling events regulated by Ret tyrosine kinase
|
|
Posttranslational regulation of adherens junction stability and dissassembly
|
|
Reactome
|
GPVI-mediated activation cascade
|
|
PIP3 activates AKT signaling
|
|
Activation of AKT2
|
|
Role of LAT2/NTAL/LAB on calcium mobilization
|
|
FCERI mediated NF-kB activation
|
|
Integrin alphaIIb beta3 signaling
|
|
CD28 dependent PI3K/Akt signaling
|
|
CTLA4 inhibitory signaling
|
|
G beta:gamma signalling through PI3Kgamma
|
|
VEGFR2 mediated vascular permeability
|
|
VEGFR2 mediated cell proliferation
|
|
CLEC7A (Dectin-1) signaling
|
|
RHO GTPases activate PKNs
|
|
Constitutive Signaling by AKT1 E17K in Cancer
|
|
Activation of BAD and translocation to mitochondria
|
|
Translocation of GLUT4 to the plasma membrane
|
|
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
|
|
AKT phosphorylates targets in the cytosol
|
|
AKT phosphorylates targets in the nucleus
|
|
Negative regulation of the PI3K/AKT network
|
|
eNOS activation
|
|
AKT-mediated inactivation of FOXO1A
|
|
Deactivation of the beta-catenin transactivating complex
|
|
KSRP (KHSRP) binds and destabilizes mRNA
|
|
TP53 Regulates Metabolic Genes
|
|
WikiPathways
|
Serotonin HTR1 Group and FOS Pathway
|
|
TCR Signaling Pathway
|
|
Insulin Signaling
|
|
EGF/EGFR Signaling Pathway
|
|
Cardiac Hypertrophic Response
|
|
Fc epsilon receptor (FCERI) signaling
|
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
|
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
|
PIP3 activates AKT signaling
|
|
BDNF signaling pathway
|
|
Interleukin-11 Signaling Pathway
|
|
B Cell Receptor Signaling Pathway
|
|
Signaling Pathways in Glioblastoma
|
|
TSH signaling pathway
|
|
TCR signaling
|
|
Signaling by Insulin receptor
|
|
Integrin-mediated Cell Adhesion
|
|
GPVI-mediated activation cascade
|
|
GPCR downstream signaling
|
|
Costimulation by the CD28 family
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
|
Toll-like receptor signaling pathway
|
|
DNA Damage Response (only ATM dependent)
|
|
Notch Signaling Pathway
|
|
EPO Receptor Signaling
|
|
IL-2 Signaling Pathway
|
|
Endochondral Ossification
|
|
IL-4 Signaling Pathway
|
|
TGF beta Signaling Pathway
|
|
IL-6 signaling pathway
|
|
Wnt Signaling Pathway Netpath
|
|
Copper homeostasis
|
|
Extracellular vesicle-mediated signaling in recipient cells
|
|
Apoptosis-related network due to altered Notch3 in ovarian cancer
|
|
IL-3 Signaling Pathway
|
|
Translocation of GLUT4 to the Plasma Membrane
|
|
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
|
|
Signal Transduction of S1P Receptor
|
|
T-Cell Receptor and Co-stimulatory Signaling
|
|
Primary Focal Segmental Glomerulosclerosis FSGS
|
|
Apoptosis
|
|
Alpha 6 Beta 4 signaling pathway
|
|
Integrated Pancreatic Cancer Pathway
|
|
Oncostatin M Signaling Pathway
|
|
Corticotropin-releasing hormone
|
|
AGE/RAGE pathway
|
|
TNF alpha Signaling Pathway
|
|
Prostate Cancer
|
|
TSLP Signaling Pathway
|
|
IL17 signaling pathway
|
|
IL-7 Signaling Pathway
|
|
Regulation of Microtubule Cytoskeleton
|
|
TWEAK Signaling Pathway
|
|
FSH signaling pathway
|
|
Leptin signaling pathway
|
|
RANKL/RANK Signaling Pathway
|
|
Integrated Breast Cancer Pathway
|
|
SREBP signalling
|
|
Integrated Cancer pathway
|
|
IL-1 signaling pathway
|
|
Metabolism of nitric oxide
|
|
TFs Regulate miRNAs related to cardiac hypertrophy
|
|
Angiogenesis
|
|
TOR Signaling
|
|
Regulation of toll-like receptor signaling pathway
|
|
AMPK Signaling
|
|
Androgen receptor signaling pathway
|
|
IL-5 Signaling Pathway
|
|
SIDS Susceptibility Pathways
|
|
Dopaminergic Neurogenesis
|
