Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T14065 | Target Info | |||
| Target Name | Integrin beta-7 (ITGB7) | ||||
| Synonyms |
Gut homing receptor beta subunit
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| Target Type | Successful Target | ||||
| Gene Name | ITGB7 | ||||
| Biochemical Class | Integrin | ||||
| UniProt ID | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-(1-Carbamoyl-2-hydroxy-propyl)-3-{2-[(isoquinoline-3-carbonyl)-amino]-4-methyl-pentanoylamino}-succinamic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL409117; BDBM50070619
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| Activity |
IC50 = 280000 nM
|
[1] | |||
| Compound Name |
2-[[(1R,4S,6R,7R,8S,10S)-1,10-Dimethoxy-4-(2-methylpropoxymethyl)-7-phenylmethoxy-2,5,9-trioxatricyclo[8.4.0.03,8]tetradecan-6-yl]oxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2374235; BDBM50137078
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| Activity |
IC50 = 420000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and structure-activity relationship of mannose-based peptidomimetics selectively blocking integrin alpha4beta7 binding to mucosal addressin cell adhesion molecule-1. J Med Chem. 2003 Dec 18;46(26):5752-62. | ||||
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