Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T13852 | Target Info | |||
| Target Name | Sphingosine-1-phosphate receptor 1 (S1PR1) | ||||
| Synonyms |
Sphingosine 1-phosphate receptor Edg-1; S1P1; S1P receptor Edg-1; S1P receptor 1; Endothelial differentiation G-protein coupled receptor 1; CHEDG1; CD363
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| Target Type | Successful Target | ||||
| Gene Name | S1PR1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 23 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
5-Cyclopropyl-N,N-bis(2-methylcyclohexyl)-1,2-oxazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1969371; BDBM50494319; SR-03000000621; SR-03000000621-2
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Cyclohexyl-5-cyclopropylisoxazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1392307; SR-01000105096; MLS000730243; SCHEMBL19730718; HMS2744I14; ZINC2497937; BDBM50494321; AKOS009098848; MCULE-1255258989; SMR000308519; SR-01000105096-1; SR-01000105096-4
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N,N-Dicyclohexyl-5-cyclopentyl-1,2-oxazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3088204; BDBM50494323; SR-02000002121; SR-02000002121-1
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Cyclohexyl-5-cyclopropyl-N-(oxan-4-yl)-1,2-oxazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1967913; MLS003675925; BDBM50494330; SMR002356550; SR-03000000625; SR-03000000625-2
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Cyclopentyl-5-cyclopropyl-N-(2-methylcyclohexyl)-1,2-oxazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1995815; BDBM50494320; SR-03000000636; SR-03000000636-2
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Cyclohexyl-N-cyclopentyl-5-cyclopropyl-1,2-oxazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1972130; BDBM50494317; SR-03000000616; SR-03000000616-2
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Cyclohexyl-N-(cyclohexylmethyl)-5-cyclopropyl-1,2-oxazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1975200; BDBM50494316; SR-03000000619; SR-03000000619-2
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N,N-Dicyclohexyl-5-methylisoxazole-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
SMR000023524; MLS000087301; SR-01000105088; ChemDiv3_008311; N,N-dicyclohexyl-5-methyl-1,2-oxazole-3-carboxamide; CHEMBL1369793; BDBM37337; cid_3245758; HMS1496J17; HMS2432B18; ZINC2497926; AKOS001800287; MCULE-4482829629; IDI1_026221; EU-0023704; ST50593938; N,N-dicyclohexyl-5-methyl-3-isoxazolecarboxamide; N,N-dicyclohexyl-5-methyl-isoxazole-3-carboxamide; N,N-dicyclohexyl(5-methylisoxazol-3-yl)carboxamide; SR-01000105088-1; SR-01000105088-4; BRD-K55535892-001-01-3
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Benzyl-5-cyclopropyl-N-pyridin-2-yl-1,2-oxazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3088201; BDBM50494328; SR-03000000314; SR-03000000314-2
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N,N,5-Tricyclohexyl-1,2-oxazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3088203; BDBM50494309; SR-02000002120; SR-02000002120-1
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Cyclohexyl-5-propyl-3-isoxazolecarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1478485; SR-01000104852; MLS000116363; N-cyclohexyl-5-propyl-1,2-oxazole-3-carboxamide; HMS1622N02; HMS2239F24; HMS3368O10; ZINC2498043; BDBM50494326; MCULE-6985115621; SMR000093340; N-cyclohexyl-5-propylisoxazole-3-carboxamide; SR-01000104852-1; SR-01000104852-4; Q27193416
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|
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Cyclohexyl-N-phenyl-5-propyl-1,2-oxazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3088202; BDBM50494311
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| Activity |
EC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
US9187437, 42 (comparative)
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3931826; SCHEMBL15132943; BDBM192147
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| Activity |
EC50 ~ 62000 nM
|
[2] | |||
| Compound Name |
4-Chloro-N-[1-(2,3-dimethylimidazol-4-yl)-2-phenylethyl]benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3402540; BDBM50069677
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[2-[4-[(2-Chlorophenyl)methoxy]phenyl]ethyl]-2-oxo-1,3-oxazolidine-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1935662; BDBM50360522
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|
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| Activity |
EC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
5-[(4-Naphthalen-2-yl-1-benzothiophen-2-yl)methylamino]pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883572; BDBM50209070
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|
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| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
1-[(5-Naphthalen-2-yl-1-benzothiophen-2-yl)methyl]azetidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883597; BDBM50209025
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|
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| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-[(4-Naphthalen-2-yl-1-benzothiophen-2-yl)methylamino]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883447; BDBM50209035
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|
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| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
4-[(4-Naphthalen-2-yl-1-benzothiophen-2-yl)methylamino]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3885331; BDBM50209074
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|
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| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N-[1-(4-Benzyl-5-methyl-1,2,4-triazol-3-yl)-2-phenylethyl]-4-chlorobenzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3402531; BDBM50069662
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|
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| Activity |
EC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-[(4-Naphthalen-2-yl-1-benzothiophen-2-yl)methylamino]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3883812; BDBM50209028
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|
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| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
4-[[(4-Naphthalen-2-yl-1-benzothiophen-2-yl)methylamino]methyl]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884011; BDBM50209044
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|
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| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
4-({[7-(Naphthalen-2-yl)-1-benzothiophen-2-yl]methyl}amino)butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3884038; GTPL9495; BDBM50209027; compound 5c [PMID: 27894870]
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|
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| Activity |
EC50 ~ 100000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6346-9. | ||||
| REF 2 | US patent application no. 9187437B2, Substituted oxadiazole compounds | ||||
| REF 3 | Discovery of heterocyclic sulfonamides as sphingosine 1-phosphate receptor 1 (S1P1) antagonists. Bioorg Med Chem Lett. 2015;25(10):2041-5. | ||||
| REF 4 | Novel immunomodulators based on an oxazolin-2-one-4-carboxamide scaffold. Bioorg Med Chem Lett. 2012 Jan 1;22(1):553-7. | ||||
| REF 5 | A benzo[b]thiophene-based selective type 4 S1P receptor agonist. Bioorg Med Chem Lett. 2017 Jan 1;27(1):1-5. | ||||
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