Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T12241 | Target Info | |||
| Target Name | Cystathionine gamma-lyase (CTH) | ||||
| Synonyms |
Gamma-cystathionase; Cysteine-protein sulfhydrase
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| Target Type | Patented-recorded Target | ||||
| Gene Name | CTH | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 8 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4167710
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Investigative | Compound Info | ||
| Synonyms |
BDBM50280024
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
[1-(2-Pyridinyl)ethylidene]hydrazinecarbodithioic acid, methyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL73007; [((1E)-2-(2-pyridyl)-1-azaprop-1-enyl)amino]methylthiomethane-1-thione; NSC251190; DTXSID00421433; ZINC5503076; BDBM50148051; SBB057468; AKOS024368644; NSC-251190; ST51003138; methyl (2E)-2-(1-pyridin-2-ylethylidene)hydrazinecarbodithioate; N''-[1-Pyridin-2-yl-eth-(E)-ylidene]-hydrazinecarbodithioic acid methyl ester
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
Chembl4160038
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Investigative | Compound Info | ||
| Synonyms |
BDBM50279977
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Methyl N-[[(Z)-indol-3-ylidenemethyl]amino]carbamodithioate
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Investigative | Compound Info | ||
| Synonyms |
MLS000332556; CHEMBL3199120; SMR000221755; N'-[1-(1H-Indol-3-yl)-meth-(E)-ylidene]-hydrazinecarbodithioic acid methyl ester; BDBM96907; cid_6538175; BDBM50279976; N-[[(Z)-3-indolylidenemethyl]amino]carbamodithioic acid methyl ester; N-[[(Z)-indol-3-ylidenemethyl]amino]carbamodithioic acid methyl ester
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4170671
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Investigative | Compound Info | ||
| Synonyms |
BDBM50280033
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4174582
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Investigative | Compound Info | ||
| Synonyms |
BDBM50279939
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4166666
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Investigative | Compound Info | ||
| Synonyms |
BDBM50280016
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4161625
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Investigative | Compound Info | ||
| Synonyms |
BDBM50280021
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 6 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Penicillamine
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Approved | Compound Info | ||
| Synonyms |
D-Penicillamine; penicillamine; 52-67-5; Cuprimine; D-(-)-Penicillamine; 3-Mercapto-D-valine; Depen; Cuprenil; D-Penamine; (-)-Penicillamine; (2S)-2-Amino-3-methyl-3-sulfanylbutanoic acid; D-Mercaptovaline; Mercaptovaline; Perdolat; Penicillamin; Pendramine; Kuprenil; Depamine; Mercaptyl; Trolovol; Metalcaptase; Artamine; Cupripen; (S)-3,3-Dimethylcysteine; D-Valine, 3-mercapto-; Penicillaminum; Penicilamina; Sufirtan; beta-Thiovaline; Dimethylcysteine; D-beta,beta-Dimethylcysteine; D-3-Mercaptovaline; beta,beta-Dimethylcysteine; Penicillamina; Penicilllamine; Sufortan; Copper penicillaminate; D Penicillamine; Penicillamina [DCIT]; Reduced penicillamine; D 3 Mercaptovaline; TBB068824; Beta,beta Dimethylcysteine; Beta-Thiovaline; Cuprimine (TN); D-Penicilamine; D-Penicyllamine; Depen (TN); P-1280; Penicilamina [INN-Spanish]; Penicillaminate, Copper; Penicillaminum [INN-Latin]; Reduced D-penicillamine; Beta,beta-Dimethylcysteine; D,3-Mercaptovaline; D-beta-Mercaptovaline; Distamine (*Hydrochloride*); Metalcaptase (*Hydrochloride*); Penicillamine (JAN/USP/INN); Penicillamine [USAN:INN:BAN:JAN]; Alpha-Amino-beta-methyl-beta-mercaptobutyric acid; D-(-)-2-Amino-3-mercapto-3-methylbutanoic acid; (2S)-2-amino-3-methyl-3-sulfanyl-butanoic acid; (D)-PENICILLAMINE; (S)-Penicillamin; (S)-Penicillamine; 2-Amino-3-mercapto-3-methylbutanoic acid; 3,3-Dimethyl-D-cysteine; 3-Mercaptovaline; 3-sulfanyl-D-valine; D-penicillamine
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| Activity |
IC50 = 270000 nM
|
[1] | |||
| Compound Name |
Chembl4164543
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Investigative | Compound Info | ||
| Activity |
IC50 > 400000 nM
|
[2] | |||
| Compound Name |
Cupressuflavone
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Investigative | Compound Info | ||
| Synonyms |
8,8''-Biapigenin; MLS002472961; CHEMBL1208973; CUPRESSUFLAVONE 3-HYDRATE; SMR001397068; CUPRESSUFLAVONETRIHYDRATE; C10034; SCHEMBL505213; DTXSID80415153; HMS2271A07; ZINC4098511; BDBM50323213; LMPK12040010; MFCD00210489; MCULE-2769205494; SR-01000872418; SR-01000872418-2; Q27068159; 4',4''',5,5'',7,7''-hexahydroxy-8-8''-biflavone
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| Activity |
IC50 > 400000 nM
|
[2] | |||
| Compound Name |
Agathisflavone
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Investigative | Compound Info | ||
| Synonyms |
6,8''-Biapigenin; CHEMBL65320; SCHEMBL616142; DTXSID30182641; ZINC4098505; BDBM50478418; LMPK12040008; MCULE-8296467023; C10017; Q27105695; 5,5',7,7'-tetrahydroxy-2,2'-bis(4-hydroxyphenyl)-6,8'-bichromene-4,4'-dione
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| Activity |
IC50 > 400000 nM
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[2] | |||
| Compound Name |
Sikokianin C
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1172216; (2S,3R)-3-[(2S,3R)-5,7-dihydroxy-2-(4-methoxyphenyl)-4-oxo-2,3-dihydrochromen-3-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
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| Activity |
IC50 > 400000 nM
|
[2] | |||
| Compound Name |
2'',4''-Di-O-(Z-p-coumaroyl)afzelin
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Investigative | Compound Info | ||
| Synonyms |
C39H32O14; 2',4'-Di-O-(Z-p-coumaroyl)afzelin; CHEMBL4167976; 9200AF; ZINC85648732; 3-[2-O,4-O-Bis(4-hydroxy-cis-cinnamoyl)-alpha-L-rhamnopyranosyloxy]-5,7,4'-trihydroxyflavone
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| Activity |
IC50 > 400000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 2-Arylidene Hydrazinecarbodithioates as Potent, Selective Inhibitors of Cystathionine -Lyase (CSE). ACS Med Chem Lett. 2017 Nov 21;8(12):1241-1245. | ||||
| REF 2 | Discovery of selective cystathionine -synthase inhibitors by high-throughput screening with a fluorescent thiol probe. Medchemcomm. 2016 Nov 15;8(1):198-201. | ||||
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