Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D08HZC
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| Former ID |
DAP000821
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| Drug Name |
Penicillamine
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| Synonyms |
D-Penicillamine; penicillamine; 52-67-5; Cuprimine; D-(-)-Penicillamine; 3-Mercapto-D-valine; Depen; Cuprenil; D-Penamine; (-)-Penicillamine; (2S)-2-Amino-3-methyl-3-sulfanylbutanoic acid; D-Mercaptovaline; Mercaptovaline; Perdolat; Penicillamin; Pendramine; Kuprenil; Depamine; Mercaptyl; Trolovol; Metalcaptase; Artamine; Cupripen; (S)-3,3-Dimethylcysteine; D-Valine, 3-mercapto-; Penicillaminum; Penicilamina; Sufirtan; beta-Thiovaline; Dimethylcysteine; D-beta,beta-Dimethylcysteine; D-3-Mercaptovaline; beta,beta-Dimethylcysteine; Penicillamina; Penicilllamine; Sufortan; Copper penicillaminate; D Penicillamine; Penicillamina [DCIT]; Reduced penicillamine; D 3 Mercaptovaline; TBB068824; Beta,beta Dimethylcysteine; Beta-Thiovaline; Cuprimine (TN); D-Penicilamine; D-Penicyllamine; Depen (TN); P-1280; Penicilamina [INN-Spanish]; Penicillaminate, Copper; Penicillaminum [INN-Latin]; Reduced D-penicillamine; Beta,beta-Dimethylcysteine; D,3-Mercaptovaline; D-beta-Mercaptovaline; Distamine (*Hydrochloride*); Metalcaptase (*Hydrochloride*); Penicillamine (JAN/USP/INN); Penicillamine [USAN:INN:BAN:JAN]; Alpha-Amino-beta-methyl-beta-mercaptobutyric acid; D-(-)-2-Amino-3-mercapto-3-methylbutanoic acid; (2S)-2-amino-3-methyl-3-sulfanyl-butanoic acid; (D)-PENICILLAMINE; (S)-Penicillamin; (S)-Penicillamine; 2-Amino-3-mercapto-3-methylbutanoic acid; 3,3-Dimethyl-D-cysteine; 3-Mercaptovaline; 3-sulfanyl-D-valine; D-penicillamine
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| Drug Type |
Small molecular drug
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| Indication | Rheumatoid arthritis [ICD-11: FA20] | Approved | [1], [2] | |
| Therapeutic Class |
Antidotes
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| Structure |
 |
Download2D MOL |
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| Formula |
C5H11NO2S
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| Canonical SMILES |
CC(C)(C(C(=O)O)N)S
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| InChI |
1S/C5H11NO2S/c1-5(2,9)3(6)4(7)8/h3,9H,6H2,1-2H3,(H,7,8)/t3-/m0/s1
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| InChIKey |
VVNCNSJFMMFHPL-VKHMYHEASA-N
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| CAS Number |
CAS 771431-20-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9622, 596289, 840659, 3134151, 7847562, 8153615, 11335489, 11360728, 11363177, 11365739, 11368301, 11371781, 11374059, 11376463, 11461700, 11484953, 11488845, 11490357, 11492285, 11494097, 15194697, 24886985, 24898564, 29215023, 29224881, 47588905, 47810654, 48035010, 48035011, 49748395, 50062240, 50101003, 50104281, 56311290, 56313697, 56313776, 56313999, 56352880, 57322997, 57391522, 74615128, 87574400, 94570926, 103508277, 104091801, 104253403, 104310436, 117365388, 117365389, 118055369
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| ChEBI ID |
CHEBI:7959
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| ADReCS Drug ID | BADD_D01709 | |||
| SuperDrug ATC ID |
M01CC01
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| SuperDrug CAS ID |
cas=000052675
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human immunodeficiency virus Tat protein (HIV tat) | Target Info | Inhibitor | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7264). | |||
| REF 2 | How many modes of action should an antibiotic have Curr Opin Pharmacol. 2008 Oct;8(5):564-73. | |||
| REF 3 | Docking studies reveal a selective binding of D-penicillamine to the transactivator protein of human immunodeficiency virus type 1. FEBS Lett. 2002 Apr 10;516(1-3):43-6. | |||
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