Target Poor or Non Binder(s) Information
Target General Information | Top | ||||
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Target ID | T11288 | Target Info | |||
Target Name | Multidrug resistance-associated protein 1 (ABCC1) | ||||
Synonyms |
MRP1; MRP; Leukotriene C(4) transporter; LTC4 transporter; ATP-binding cassette sub-family C member 1
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Target Type | Successful Target | ||||
Gene Name | ABCC1 | ||||
Biochemical Class | ABC transporter | ||||
UniProt ID |
Poor Binders of This Target (in total, 93 binders) | Download | Top | |||
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Compound Name |
Doxorubicin
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Approved | Compound Info | ||
Synonyms |
doxorubicin; 23214-92-8; Doxil; Doxorubicine; Adriablastin; Doxorubicinum; 14-Hydroxydaunomycin; 14-Hydroxydaunorubicine; Doxorubicina; Adriamycin semiquinone; Doxorubicinum [INN-Latin]; Doxorubicine [INN-French]; Doxorubicina [INN-Spanish]; Myocet; FI 106; Doxorubicin [USAN:INN:BAN]; CCRIS 739; NDC 38242-874; HSDB 3070; UNII-80168379AG; NCI-C01514; EINECS 245-495-6; CHEMBL53463; CHEBI:28748; 5,12-Naphthacenedione,; ADM; ADR; ThermoDox; Aerosolized Doxorubicin; Doxorubicin citrate; RDF Rubex; Conjugate of doxorubicin with humanized monoclonal antibody LL1 against CD74; DM2; JT9100000; Adiblastine (hydrochloride salt); Adr iablatina (hydrochloride salt); Adriablastine (hydrochloride salt); Adriablatina (hydrochloride salt); Adriacin (hydrochloride salt); Adriamycin PFS (TN); Adriamycin PFS (hydrochloride salt); Adriamycin RDF (TN); Adriamycin RDF (hydrochloride salt); Adriblastina (TN); Adriblastina (hydrochloride salt); Adriblatina (hydrochloride salt); Caelyx (TN); Conjugate of doxorubicin with monoclonal antibody P4/D10 against GP120; DOX-SL; Doxorubicin hydrochloride (hydrochloride salt); Doxorubicin-hLL1; Doxorubicin-hLL1 conjugate; Farmablastina (hydrochloride salt); Hydroxydaunomycin hydrochlor ide (hydrochloride salt); Hydroxydaunomycin hydrochloride (hydrochloride salt); Hydroxydaunorubicin hydrochloride (hydrochloride salt); Myocet (TN); Rubex (TN); Rubex (hydrochloride salt); TLC D-99; Doxorubicin (USAN/INN); Doxorubicin-P4/D10; Doxorubicin-P4/D10 conjugate; Cantide + adriamycin
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Activity |
IC50 = 50000 nM
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[1] | |||
Compound Name |
Vincristine
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Approved | Compound Info | ||
Synonyms |
LCR; Leurocristine; Marqibo; Oncovine; Tecnocris; VCR; VIN; Vincasar; Vincristina; Vincristinum; Vincrstine; Vincrystine; Vinkristin; Indole alkaloid; Liposomal Vincristine; Onco TCS; Vincristina [DCIT]; Oncovin (TN); Tecnocris (TN); Vincristine (INN); Vincristine [INN:BAN]; Vincristinum [INN-Latin]; Lilly37231 (1:1 sulfate salt); Oncovin (1:1 sulfate salt); Vincasar (1:1 sulfate salt); Vincrex (1:1 sulfate salt); Vincaleukoblastine, 22-oxo-22-Oxovincaleukoblastine; Z-D-Val-Lys(Z)-OH; 22-Oxovincaleukoblastine
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Activity |
IC50 = 70000 nM
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[1] | |||
Compound Name |
PMID25991433-Compound-Q2
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Patented | Compound Info | ||
Activity |
IC50 ~ 100000 nM
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[2] | |||
Compound Name |
4-{4-[2-(4-Methoxy-phenyl)-ethyl]-piperazin-1-yl}-6,7,8,9-tetrahydro-pyrimido[4,5-b]indolizine-10-carbonitrile
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Investigative | Compound Info | ||
Synonyms |
CHEMBL26530; SCHEMBL6919699; BDBM50140811
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Activity |
IC50 ~ 50000 nM
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[3] | |||
Compound Name |
Ayanin
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Investigative | Compound Info | ||
Synonyms |
3,7,4'-Tri-O-methylquercetin; 5,3'-Dihydroxy-3,7,4'-trimethoxyflavone; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,7-dimethoxychromen-4-one; CHEMBL74898; 3',5-Dihydroxy-3,4',7-trimethoxyflavone; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,7-dimethoxy-4H-chromen-4-one; 3,7,4'-trimethylquercetin; SCHEMBL1252843; DTXSID20205833; HY-N2913; ZINC6484603; 9106AF; BDBM50064888; LMPK12112762; NSC691652; NSC-691652; 3,5-dihydroxy-3,4',7-trimethoxyflavone; NCI60_032905; CS-0023515; 3'',5-dihydroxy-3,4'',7-trimethoxyflavone; C04444; Q3277926; 4H-Benzopyran-4-one, 5-hydroxy-2-(3-hydroxy-4methoxyphenyl)-3,7-dimethoxy-; 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,7-dimethoxy-4H-1-benzopyran-4-one
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Activity |
IC50 = 50000 nM
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[4] | |||
Compound Name |
Retusin
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Investigative | Compound Info | ||
Synonyms |
Retusin (Ariocarpus); Retusine (Ariocarpus); Quercetin-3,7,3',4'-tetramethyl ether; Quercetin 3,7,3',4'-tetramethyl ether; Retusin(Ariocarpus); UNII-M8591903SD; 5-hydroxy-3,7,3',4'-tetramethoxyflavone; NSC61837; NSC 61837; NSC-61837; 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,7-dimethoxychromen-4-one; CHEMBL77966; 2-(3,4-Dimethoxyphenyl)-5-hydroxy-3,7-dimethoxy-4-benzopyrone; 3,7,3',4'-tetramethylquercetin; 2-(3,4-Dimethoxyphenyl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one; 3,3',4',7-Tetramethylquercetin; M8591903SD; Quercetin-3,3',4',7-tetramethylether; 5-Hydroxy-3,3',4',7-tetramethoxyflavone; 4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,7-dimethoxy-; Retusine (VAN); 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,7-dimethoxy-chromen-4-one; Quercetin tetramethylether; 2-(3,4-Dimethoxyphenyl)-5-hydroxy-3,7-dimethoxy-4H-1-benzopyran-4-one; Retusin (VAN); NSC408169; EINECS 214-991-4; Quercetin 3,7,3',4'-tetramethylether; Quercetin 3,3',4',7-O-tetramethyl ether; Flavone, 5-hydroxy-3,3',4',7-tetramethoxy-; MEGxp0_001881; SCHEMBL1421755; ACon1_000513; CTK1D6465; DTXSID60924839; Flavone,3',4',7-tetramethoxy-; HY-N6829; ZINC5733766; 3,3',4',7-O-tetramethylquercetin; BDBM50338974; LMPK12112770; MFCD00017420; NSC618937; Quercetin, 3,7,3',4'-tetramethyl; 3,7,3',4'-tetra-O-methylquercetin; Quercetin 3,3',4'-tetramethyl ether; CCG-214740; MCULE-6610076111; NSC-618937; 5-hydroxy-3,7,3,4-tetramethoxyflavone; Quercetin 3,3',4',7-tetramethylether; Quercetin-3,7,3',4'-tetramethylether; NCGC00169008-01; quercetin 3,3',4',7-tetramethyl ether; NCI60_003907; NCI60_003908; NCI60_003909; NCI60_005562; DB-041775; quercitin-3,7,3'',4''-tetramethyl ether; CS-0100247; FT-0633509; ST50331647; Q7317388; BRD-K49158532-001-01-9; BRD-K49158532-001-02-7; Flavone, 5-hydroxy-3,3',4',7-tetramethoxy- (8CI); 2-(3,4-Dimethoxyphenyl)-5-hydroxy-3,7-dimethoxy-4-benzopyron; 2-(3,4-Dimethoxy-phenyl)-5-hydroxy-3,7-dimethoxy-chromen-4-one; 4H-1-Benzopyran-4-one,4-dimethoxyphenyl)-5-hydroxy-3,7-dimethoxy-; 2-(3,4-Dimethoxyphenyl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one #; 4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,7-dimethoxy- (9CI)
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Activity |
IC50 = 50000 nM
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[4] | |||
Compound Name |
5,7-Dimethoxy-2-(3-morpholin-4-ylpropylamino)chromen-4-one
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3765272; BDBM50139438
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Activity |
IC50 = 53300 nM
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[5] | |||
Compound Name |
Methyl 4-[[4-(5,7-dimethoxy-4-oxochromen-2-yl)piperazin-1-yl]methyl]benzoate
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3764960; BDBM50139426
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Activity |
IC50 = 58300 nM
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[5] | |||
Compound Name |
Chembl4288620
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Investigative | Compound Info | ||
Activity |
EC50 = 62000 nM
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[6] | |||
Compound Name |
4-Isopropoxy-3-phenylsulfonylfuroxan
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1215647; BDBM50324372
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Activity |
EC50 = 63000 nM
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[7] | |||
Compound Name |
3-Benzenesulfonyl-4-phenyl-furazan 2-oxide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL507014; SCHEMBL6437002; ZINC5966; BDBM50324359; 4-phenyl-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide; 3-(benzenesulfonyl)-2-oxido-4-phenyl-1,2,5-oxadiazol-2-ium
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Activity |
EC50 = 64000 nM
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[7] | |||
Compound Name |
4-Phenylsulfonylfuroxan-3-carbonitrile
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1215577; SCHEMBL9240268; BDBM50324368; 4-(benzenesulfonyl)-2-oxido-1,2,5-oxadiazol-2-ium-3-carbonitrile
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Activity |
EC50 = 72000 nM
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[7] | |||
Compound Name |
N-[4-(3,4-Dihydroxy-5-methoxyphenyl)-2-nitrophenyl]-3,4-dihydroxy-5-methoxybenzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1945976; BDBM50363113
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Activity |
IC50 = 74500 nM
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[2] | |||
Compound Name |
3,4-Dihydroxy-5-methoxy-N-(4-phenylphenyl)benzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1945978; BDBM50363115
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Activity |
IC50 = 75800 nM
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[2] | |||
Compound Name |
3,4,5-Trimethoxy-N-(2-nitro-4-phenylphenyl)benzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1944867; SCHEMBL16179942; BDBM50363083
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Activity |
IC50 = 80000 nM
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[2] | |||
Compound Name |
3-Phenyl-4-cyano-furoxan
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Investigative | Compound Info | ||
Synonyms |
CHEMBL500095; 1,2,5-Oxadiazole-3-carbonitrile, 4-phenyl-, 5-oxide; cyano(phenyl)furoxane; ACMC-20mrjj; 5-oxido-4-phenyl-1,2,5-oxadiazol-5-ium-3-carbonitrile; CTK0C2329; DTXSID90416010; 3-Phenyl-4-cyanofurazan 2-oxide; BDBM50324355; 5-Oxy-4-phenyl-furazan-3-carbonitrile; NCGC00167930-01; 4-cyano-3-phenyl-1,2,5-oxadiazole 2-oxide
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Activity |
EC50 = 85000 nM
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[7] | |||
Compound Name |
3-Phenylsulfonylfuroxan-4-carboxamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1215574; BDBM50324366
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Activity |
EC50 = 85800 nM
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[7] | |||
Compound Name |
N-(2-Fluoro-4-pyridin-3-ylphenyl)-3,4-dimethoxybenzenesulfonamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3317934; BDBM50056310
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Activity |
IC50 = 94500 nM
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[8] | |||
Compound Name |
2-(2-Hydroxyphenyl)-3-[2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-yl)ethyl]-3,4-dihydroquinazoline-4-one
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Investigative | Compound Info | ||
Synonyms |
CHEMBL347213; BDBM50109791; 3-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-2-(2-hydroxy-phenyl)-3H-quinazolin-4-one
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Activity |
IC50 = 95000 nM
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[9] | |||
Compound Name |
4-Nitro-3-phenylfuroxan
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1215506; 4-Nitro-3-phenyl-furazan 2-oxide; 3-phenyl-4-nitrofuroxan; 4-nitro-2-oxido-3-phenyl-1,2,5-oxadiazol-2-ium; SCHEMBL9173319; CTK5I4546; 3-Phenyl-4-nitro-furazan-2-oxide; ZINC4955491; BDBM50324354; AKOS000505939; 4-nitro-3-phenyl-1,2,5-oxadiazol-2-ol; ST50215940; 4-Nitro-3-phenyl-1,2,5-oxadiazole 2-oxide; 4-NITRO-3-PHENYL-1,2,5-OXADIAZOL-2-IUM-2-OLATE
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Activity |
EC50 = 98000 nM
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[7] | |||
Compound Name |
N-(2-Amino-4-phenylphenyl)-3,4,5-trimethoxybenzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1944865; SCHEMBL16179680; BDBM50363081
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Activity |
IC50 ~ 100000 nM
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[2] | |||
Compound Name |
N-(2-Fluoro-4-pyridin-3-ylphenyl)pyridine-3-carboxamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3317930; BDBM50056306
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Activity |
IC50 ~ 100000 nM
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[8] | |||
Compound Name |
5-Carbamoyl-2-(3,3-diethylthioureido)-4-methylthiophene-3-carboxylic Acid
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Investigative | Compound Info | ||
Synonyms |
CHEMBL552960; BDBM50294031
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Activity |
IC50 ~ 100000 nM
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[10] | |||
Compound Name |
3,4-Diphenyl-1,2,5-oxadiazole 2-oxide
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Investigative | Compound Info | ||
Synonyms |
Diphenylfuroxan; NSC52230; CHEMBL1212966; 2-oxido-3,4-diphenyl-1,2,5-oxadiazol-2-ium; 3,4-Diphenyl-1,2lambda(5),5-oxadiazol-2-ol; NSC 52230; CBDivE_005725; SCHEMBL7796584; CTK8J2983; DTXSID80204443; HMS1675N18; NSC54398; ZINC2819563; BDBM50324378; NSC-52230; NSC-54398; STK366156; AKOS000583632; 3,4-diphenyl-1,2,5-oxadiazol-2-ol; EU-0033409; ST50230611; 3,4-diphenyl-1,2,5-oxadiazol-2-ium-2-olate; 2-oxido-3,4-diphenyl-[1,2,5]oxadiazol-2-ium; 3,4-Diphenyl-1,2.lambda.~5~,5-oxadiazol-2-ol; SR-01000389263; SR-01000389263-1
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Activity |
EC50 ~ 100000 nM
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[7] | |||
Compound Name |
2-[4-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)butoxy]quinoline
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2397131; BDBM50436429
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Activity |
EC50 ~ 100000 nM
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[11] | |||
Compound Name |
N-[2-Fluoro-4-(4-methoxyphenyl)phenyl]-2,4,5-trimethoxybenzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3317933; BDBM50056309
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Activity |
IC50 ~ 100000 nM
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[8] | |||
Compound Name |
3-Hexyloxy-4-phenylsulfonylfurazan
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1215715; BDBM50324376
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Activity |
EC50 ~ 100000 nM
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[7] | |||
Compound Name |
3-Methoxy-4-phenylfuroxan
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1215438; 3-Methoxy-4-phenyl-furazan-2-oxide; BDBM50324352; ZINC19878176; 3-methoxy-4-phenyl-1,2,5-oxadiazole 2-oxide
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Activity |
EC50 ~ 100000 nM
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[7] | |||
Compound Name |
4-Methyl-3-phenylfuroxan
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1215437; Methylphenylfuroxan; SCHEMBL14390587; CTK1J1584; DTXSID00521649; 3-Methyl-4-phenylfurazan 5-oxide; BDBM50324379; 4-methyl-3-phenyl-1,2,5-oxadiazole 2-oxide; 1,2,5-Oxadiazole, 3-methyl-4-phenyl-, 5-oxide; 4-Methyl-2-oxo-3-phenyl-1,2,5lambda~5~-oxadiazole
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Activity |
EC50 ~ 100000 nM
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[7] | |||
Compound Name |
2-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethoxy]quinoline
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2397135; BDBM50436425
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Activity |
EC50 ~ 100000 nM
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[11] | |||
Compound Name |
N-[4-(1,3-Benzodioxol-5-yl)-2-nitrophenyl]-3,4,5-trimethoxybenzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1945306; SCHEMBL16179746; BDBM50363091
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Activity |
IC50 ~ 100000 nM
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[2] | |||
Compound Name |
6,7-Dimethoxy-2-[[5-(6-methoxynaphthalen-2-yl)furan-2-yl]methyl]-3,4-dihydro-1H-isoquinoline
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2338106; BDBM50429193
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Activity |
EC50 ~ 100000 nM
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[12] | |||
Compound Name |
3-Butoxy-4-phenylsulfonylfurazan
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1215714; BDBM50324375
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Activity |
EC50 ~ 100000 nM
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[7] | |||
Compound Name |
2-[6-[4-[(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]phenoxy]pyridin-3-yl]-4-(4-nitrophenyl)-1,3-thiazole
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2335008; BDBM50429665
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Activity |
EC50 ~ 100000 nM
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[13] | |||
Compound Name |
CID 44451264
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Investigative | Compound Info | ||
Synonyms |
CHEMBL259582; CHEMBL1830683; SCHEMBL14060863; BDBM50353279; 6,7-dimethoxy-2-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-3,4-dihydro-1H-isoquinoline
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Activity |
EC50 ~ 100000 nM
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[12] | |||
Compound Name |
N-[2-Fluoro-4-(4-pyridyl)phenyl]-2,4,5-trimethoxybenzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3317932; BDBM50056308
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Activity |
IC50 ~ 100000 nM
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[8] | |||
Compound Name |
2-[6-[4-[(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]phenoxy]pyridin-3-yl]-4-(4-fluorophenyl)-1,3-thiazole
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2335002; BDBM50429664
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Activity |
EC50 ~ 100000 nM
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[13] | |||
Compound Name |
6-[4-[(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]phenoxy]pyridine-3-carboxamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2335004; BDBM50429661
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Activity |
EC50 ~ 100000 nM
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[13] | |||
Compound Name |
3,4-Dimethoxy-N-(2-nitro-4-phenylphenyl)benzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1945311; SCHEMBL16180113; BDBM50363096
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Activity |
IC50 ~ 100000 nM
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[2] | |||
Compound Name |
3,4,5-Trimethoxy-N-[4-(1-methylpyridin-1-ium-3-yl)-2-nitrophenyl]benzamide;iodide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1945310
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Activity |
IC50 ~ 100000 nM
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[2] | |||
Compound Name |
3-[2-[6-[4-[(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]phenoxy]pyridin-3-yl]-1,3-thiazol-4-yl]phenol
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Investigative | Compound Info | ||
Synonyms |
CHEMBL2335007; BDBM50429667
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Activity |
EC50 ~ 100000 nM
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[13] | |||
Compound Name |
N-(2-Fluoro-4-pyridin-3-ylphenyl)-3,5-dimethoxybenzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3317927; BDBM50056303
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Activity |
IC50 ~ 100000 nM
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[8] | |||
Compound Name |
2-(4-Benzylpiperazin-1-yl)-5,7-dimethoxychromen-4-one
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3764042; BDBM50139449
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Activity |
IC50 ~ 100000 nM
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[5] | |||
Compound Name |
2-[4-[(4-Aminophenyl)methyl]piperazin-1-yl]-5,7-dimethoxychromen-4-one
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Investigative | Compound Info | ||
Synonyms |
CHEMBL3764821; BDBM50139433
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Activity |
IC50 ~ 100000 nM
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[5] | |||
Compound Name |
3,4,5-Trimethoxy-N-(4-methoxy-2-nitrophenyl)benzamide
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Investigative | Compound Info | ||
Synonyms |
CHEMBL1945301; Cambridge id 5365252; Oprea1_120913; SCHEMBL7917543; ZINC3960317; BDBM50363086; STL482896; AKOS002265481; MCULE-2633362480; ST50183096; n-(2-nitro-4-methoxyphenyl)(3,4,5-trimethoxybenzamide); N-(4-METHOXY-2-NITROPHENYL)-3,4,5-TRIMETHOXYBENZAMIDE; N-(4-methoxy-2-nitrophenyl)(3,4,5-trimethoxyphenyl)carboxamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[2] | |||
Compound Name |
N-(3,4-Dihydroxy-5-methoxyphenyl)-2-nitro-4-phenylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1945984; BDBM50363076
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[2] | |||
Compound Name |
N-[5-(3,5-Difluorophenyl)pyridin-2-yl]-2,4,5-trimethoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3317919; BDBM50056293
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[8] | |||
Compound Name |
N-(2-Fluoro-4-pyridin-3-ylphenyl)-2,3,4-trimethoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3317924; BDBM50056298
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[8] | |||
Compound Name |
6-[4-[(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]phenoxy]pyridine-3-carbothioamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2335005; BDBM50429660
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[13] | |||
Compound Name |
N-(2-Fluoro-4-phenylphenyl)-3,4,5-trimethoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1944866; SCHEMBL16180056; BDBM50363082
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[2] | |||
Compound Name |
N-(2-Acetamido-4-phenylphenyl)-3,4,5-trimethoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1944868; SCHEMBL16180659; BDBM50363084
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[2] | |||
Compound Name |
4-Phenyl-3-furoxancarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL500868; SCHEMBL6654477; 2-oxido-4-phenyl-1,2,5-oxadiazol-2-ium-3-carboxamide; BDBM50300754; 3-Carbamoyl-4-phenyl-furazan-2-oxide; NCGC00168363-01; 2-Oxy-4-phenyl-furazan-3-carboxylic acid amide; 3-carbamoyl-4-phenyl-1,2,5-oxadiazole 2-oxide
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[7] | |||
Compound Name |
5,7-Dimethoxy-2-[4-[(4-methoxyphenyl)methyl]piperazin-1-yl]chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3765802; BDBM50139447
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[5] | |||
Compound Name |
2-Nitro-4-phenyl-N-[(3,4,5-trimethoxyphenyl)methyl]aniline
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1945313; BDBM50363098
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[2] | |||
Compound Name |
N-(4-Bromo-2-nitrophenyl)-3,4,5-trihydroxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1945315; BDBM50363100
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[2] | |||
Compound Name |
N-(2-Fluoro-4-pyridin-3-ylphenyl)-2,4,6-trimethoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3317925; BDBM50056300
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[8] | |||
Compound Name |
6,7-Dimethoxy-2-[(5-naphthalen-2-ylfuran-2-yl)methyl]-3,4-dihydro-1H-isoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2338105; BDBM50429194
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[12] | |||
Compound Name |
3,4,5-Trimethoxy-N-[4-(3-nitrophenyl)phenyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1945309; SCHEMBL16180391; BDBM50363094
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[2] | |||
Compound Name |
5-Oxido-4-phenyl-1,2,5-oxadiazol-5-ium-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
4-amino-3-phenylfuroxane; CHEMBL459673; TimTec1_000175; 4-Phenylfurazanamine 5-oxide; MLS000517224; ZINC55139; HMS1534H21; HMS1757C02; HMS2668M06; 5-Oxy-4-phenyl-furazan-3-ylamine; BDBM50324349; AKOS001062044; NCGC00175393-01; SMR000343339; ST002758; 4-amino-3-phenyl-1,2,5-oxadiazol-2-ol; 4-amino-3-phenyl-1,2,5-oxadiazole 2-oxide; 4-amino-3-phenyl-1,2,5-oxadiazol-2-ium-2-olate; BRD-K09455164-001-01-2; Z56924892
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[7] | |||
Compound Name |
3-Methyl-4-phenylsulphonylfuroxan
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL320995; furazan,methyl(phenylsulfonyl)-,5-oxide; CTK1C6823; DTXSID20416008; BDBM50324361; ZINC26995372; 4-Benzenesulfonyl-3-methyl-furazan 2-oxide; 3-Methyl-4-(phenylsulfonyl)furazan 2-oxide; 3-methyl-4-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide; 1,2,5-Oxadiazole, 3-methyl-4-(phenylsulfonyl)-, 2-oxide
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[7] | |||
Compound Name |
3-Methyl-4-phenylfurazan 2-oxide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL574360; 3-methyl-4-phenylfuroxan; CTK1J1585; DTXSID40481016; BDBM50300758; NCGC00168362-01; 3-methyl-4-phenyl-1,2,5-oxadiazole 2-oxide; 1,2,5-Oxadiazole, 3-methyl-4-phenyl-, 2-oxide; 3-methyl-2-oxido-4-phenyl-1,2,5-oxadiazol-2-ium
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[7] | |||
Compound Name |
2-[2-(6-Methoxy-2-naphthyl)-4-thiazolylmethyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2338489; SCHEMBL14060388; BDBM50429189; 4-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]-2-(6-methoxynaphthalen-2-yl)-1,3-thiazole
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[12] | |||
Compound Name |
2-[6-[4-[(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)methyl]phenoxy]pyridin-3-yl]-4-(3-methoxyphenyl)-1,3-thiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2335006; BDBM50429666
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[13] | |||
Compound Name |
3,4,5-Trimethoxy-N-(2-nitro-4-thiophen-2-ylphenyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1945303; SCHEMBL16180274; BDBM50363088
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[2] | |||
Compound Name |
N-(4-Bromo-2-nitrophenyl)-3,4,5-trimethoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1944869; BDBM50363085
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[2] | |||
Compound Name |
N-(2-Fluoro-4-pyridin-3-ylphenyl)-3,4-dimethoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3317926; BDBM50056301
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[8] | |||
Compound Name |
3-Amino-4-phenyl-1,2,5-oxadiazol-2-ium-2-olate
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL507873; 3-amino-4-phenylfuroxane; 2-Oxy-4-phenyl-furazan-3-ylamine; Enamine_001115; 3-amino-4-phenylfuroxan; Oprea1_594492; HMS1397C15; ZINC375279; BDBM50324350; STK366155; AKOS000558887; ST002757; 3-amino-4-phenyl-1,2,5-oxadiazol-2-ol; 3-amino-4-phenyl-1,2,5-oxadiazole 2-oxide; Z56788743
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[7] | |||
Compound Name |
2-(4-Dimethylamino-phenyl)-3-hexyl-3H-quinazolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL152046; BDBM50109792; 2-[4-(Dimethylamino)phenyl]-3-hexyl-3,4-dihydroquinazoline-4-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[9] | |||
Compound Name |
N-[4-(3-Acetylphenyl)-2-nitrophenyl]-3,4,5-trimethoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1945307; BDBM50363092
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[2] | |||
Compound Name |
3-Phenyl-4-furoxancarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL459640; BDBM50324353; 3-Phenyl-4-carbamoyl-furazan-2-oxide; 4-carbamoyl-3-phenyl-1,2,5-oxadiazole 2-oxide; 5-Oxy-4-phenyl-furazan-3-carboxylic acid amide
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[7] | |||
Compound Name |
4-[3-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)propoxy]quinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2397133; BDBM50436427
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[11] | |||
Compound Name |
2-[2-(6-Bromo-2-naphthyl)-4-thiazolylmethyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2331623; SCHEMBL16975827; BDBM50429190
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[12] | |||
Compound Name |
3-Phenylfuroxan-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1215508; 3-phenyl-4-sulfamoyl-1,2,5-oxadiazole 2-oxide; BDBM50324356
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[7] | |||
Compound Name |
2-[5-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)pentoxy]quinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2397132; BDBM50436428
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[11] | |||
Compound Name |
N-(4-Bromophenyl)-3,4,5-trimethoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1944863; Oprea1_543452; ZINC682293; BDBM50363079; STK413094; AKOS002968958; MCULE-3484219756; ST50922355; AN-652/40097765; N-(4-bromophenyl)(3,4,5-trimethoxyphenyl)carboxamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[2] | |||
Compound Name |
5,7-Dimethoxy-2-[4-[(4-methylsulfonylphenyl)methyl]piperazin-1-yl]chromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3764262; BDBM50139429
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[5] | |||
Compound Name |
2-[3-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)propoxy]quinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2397130; BDBM50436430
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[11] | |||
Compound Name |
N-[4-[[4-(5,7-Dimethoxy-4-oxochromen-2-yl)piperazin-1-yl]methyl]phenyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3763435; BDBM50139434
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[5] | |||
Compound Name |
3,4,5-Trimethoxy-N-(2-nitro-5-phenylphenyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1945302; SCHEMBL16180104; BDBM50363087
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[2] | |||
Compound Name |
2-[2-(6-Hydroxy-2-naphthyl)-4-oxazolylmethyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2338111; SCHEMBL14060973; BDBM50429191
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[12] | |||
Compound Name |
3-Benzyl-2-(4-dimethylamino-phenyl)-3H-quinazolin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL153452; SCHEMBL10609253; BDBM50109803; 3-benzyl-2-[4-(dimethylamino)phenyl]quinazolin-4-one; 2-[4-(Dimethylamino)phenyl]-3-benzyl-3,4-dihydroquinazoline-4-one
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[9] | |||
Compound Name |
4-Phenylfuroxan-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1215509; BDBM50324357; 3-Sulfamoyl-4-phenyl-1,2,5-oxadiazole 2-oxide; 4-phenyl-3-sulfamoyl-1,2,5-oxadiazole 2-oxide
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[7] | |||
Compound Name |
N-[1,1'-Biphenyl]-4-yl-3,4,5-trimethoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1944864; ZINC2632372; BDBM50363080; AKOS007990085; MCULE-4433672470; AH-034/04909019; N-([1,1'-Biphenyl]-4-yl)-3,4,5-trimethoxybenzamide
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[2] | |||
Compound Name |
2-[2-(6-Bromo-2-naphthyl)-4-oxazolylmethyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2338109; BDBM50429192
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[12] | |||
Compound Name |
4-Methoxy-3-phenylfuroxan
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL456685; 4-methoxy-3-phenyl-1,2,5-oxadiazole 2-oxide; ZINC509848; 3-Phenyl-4-methoxy-furazan-2-oxide; BDBM50324351; STL330227; AKOS022114598
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[7] | |||
Compound Name |
3-Hydroxy-4-methoxy-N-(2-nitro-4-phenylphenyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1945982; BDBM50363074
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[2] | |||
Compound Name |
N-(2-Fluoro-4-pyridin-3-ylphenyl)-4-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3317928; BDBM50056304
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[8] | |||
Compound Name |
2-[2-(3,4-Dimethoxyphenyl)ethylamino]-5,7-dimethoxychromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3765286; BDBM50139437
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[5] | |||
Compound Name |
3,5-Dimethoxy-N-(2-nitro-4-phenylphenyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL1945312; SCHEMBL16180282; BDBM50363097
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[2] | |||
Compound Name |
N-(2-Fluoro-4-pyridin-3-ylphenyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL3317929; BDBM50056305
Click to Show/Hide
|
||||
Activity |
IC50 ~ 100000 nM
|
[8] | |||
Compound Name |
1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-2-quinolin-2-yloxyethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2397134; BDBM50436426
Click to Show/Hide
|
||||
Activity |
EC50 ~ 100000 nM
|
[11] | |||
Compound Name |
Verlukast
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
MK 571; MK-571; L 660711; MK 0571; L-660711; CHEMBL15177; MK-0571; L 660,711; SCHEMBL9231584; DTXSID5048390; BDBM86671; GTPL10346; BCP17188; BDBM50001285; NSC_60719; PDSP1_001581; PDSP2_001565; AKOS024457058; ACN-053040; C11239; 32258-EP2281815A1; 32258-EP2301933A1; 32258-EP2305640A2; 32258-EP2311827A1; A841842; L002207; SR-01000946824; J-004343; SR-01000946824-1; Q27107275
Click to Show/Hide
|
||||
Activity |
Ki = 134700 nM
|
[14] | |||
Compound Name |
2-(3-Methyl-3-phenylthioureido)benzoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL552767; BDBM50294058
Click to Show/Hide
|
||||
Activity |
IC50 = 198000 nM
|
[10] | |||
Click to Show/Hide the Information of All Poor Binders |
Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
---|---|---|---|---|---|
Compound Name |
2-(4-Benzylpiperazine-1-carbonyl)-5-phenylmethoxychromen-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
Synonyms |
CHEMBL2011285; BDBM50139423
Click to Show/Hide
|
||||
Activity |
IC50 > 200000 nM
|
[5] |
References | Top | ||||
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REF 1 | ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids. J Biol Chem. 1996 Apr 19;271(16):9683-9. | ||||
REF 2 | Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. J Med Chem. 2012 Jan 12;55(1):424-36. | ||||
REF 3 | Studies on pyrrolopyrimidines as selective inhibitors of multidrug-resistance-associated protein in multidrug resistance. J Med Chem. 2004 Mar 11;47(6):1329-38. | ||||
REF 4 | Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP). Bioorg Med Chem. 2011 Mar 15;19(6):2090-102. | ||||
REF 5 | Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization. Eur J Med Chem. 2016 Feb 15;109:124-33. | ||||
REF 6 | New tetrahydroisoquinoline-based P-glycoprotein modulators: decoration of the biphenyl core gives selective ligands. Medchemcomm. 2018 Apr 3;9(5):862-869. | ||||
REF 7 | Phenylsulfonylfuroxans as modulators of multidrug-resistance-associated protein-1 and P-glycoprotein. J Med Chem. 2010 Aug 12;53(15):5467-75. | ||||
REF 8 | Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding. J Med Chem. 2014 Aug 14;57(15):6403-18. | ||||
REF 9 | Studies on quinazolinones as dual inhibitors of Pgp and MRP1 in multidrug resistance. Bioorg Med Chem Lett. 2002 Feb 25;12(4):571-4. | ||||
REF 10 | Aromatic 2-(thio)ureidocarboxylic acids as a new family of modulators of multidrug resistance-associated protein 1: synthesis, biological evaluation, and structure-activity relationships. J Med Chem. 2009 Aug 13;52(15):4586-95. | ||||
REF 11 | Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3728-31. | ||||
REF 12 | Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters. Bioorg Med Chem. 2013 Mar 1;21(5):1324-32. | ||||
REF 13 | Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1370-4. | ||||
REF 14 | Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives. J Med Chem. 2009 Sep 10;52(17):5311-22. |
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