Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T06273 | Target Info | |||
| Target Name | Poly [ADP-ribose] polymerase 1 (PARP1) | ||||
| Synonyms |
Protein poly-ADP-ribosyltransferase PARP1; Poly[ADP-ribose] synthetase-1; Poly[ADP-ribose] synthase 1; Poly(ADP-ribose)polymerase-1; PPOL; PARP-1; NAD(+)Poly [ADP-ribose] polymerase-1 ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase-1; NAD(+) ADP-ribosyltransferase 1; DNA ADP-ribosyltransferase PARP1; ARTD1; ADPRT 1; ADPRT; ADP-ribosyltransferase diphtheria toxin-like 1
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| Target Type | Successful Target | ||||
| Gene Name | PARP1 | ||||
| Biochemical Class | Glycosyltransferases | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 83 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
APIGENIN
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Investigative | Compound Info | ||
| Synonyms |
apigenin; 520-36-5; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; Chamomile; Versulin; Spigenin; Apigenol; 4',5,7-Trihydroxyflavone; Apigenine; C.I. Natural Yellow 1; 5,7,4'-Trihydroxyflavone; Pelargidenon 1449; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone; 2-(p-Hydroxyphenyl)-5,7-dihydroxychromone; UCCF 031; NSC 83244; UNII-7V515PI7F6; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one; CCRIS 3789; CHEBI:18388; CHEMBL28; EINECS 208-292-3; 4H-1-Benzopyran-4-one, 5,7-di
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| Activity |
IC50 = 100000 nM
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[1] | |||
| Compound Name |
5-(Adamantan-1-ylcarboxamido)isoquinolin-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1765110; BDBM50341873
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Chembl4171592
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Investigative | Compound Info | ||
| Synonyms |
BDBM50276928
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-(3-(Trifluoromethyl)phenyl)quinoline-8-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL479635; BDBM50255265
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| Activity |
IC50 = 52000 nM
|
[4] | |||
| Compound Name |
CID 66716805
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407984; SCHEMBL531939; BDBM50438237; 4-[4-[(2,8-dimethyl-3-oxo-4H-1,4-benzoxazin-6-yl)methyl]piperazin-1-yl]-N-ethyl-3-methylbenzamide
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| Activity |
EC50 = 55000 nM
|
[5] | |||
| Compound Name |
3-Bromobenzamide
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Investigative | Compound Info | ||
| Synonyms |
Benzamide, 3-bromo-; m-Bromobenzamide; 3-Bromo-benzamide; Benzamide, m-bromo-; MFCD00017127; CHEMBL122690; UNII-694N917Z7T; 694N917Z7T; 3-(Carbamoyl)bromobenzene; 3-bromanylbenzamide; PubChem3734; 3-bromophenylcarboxamide; ACMC-209fyc; 3-Bromobenzoic acid amide; KSC205C2N; SCHEMBL163949; DTXSID5022277; SCHEMBL16803128; CTK1A5126; TIMTEC-BB SBB009893; OTAVA-BB 1375913; ZINC393845; KS-00000B9B; NSC81217; ANW-24946; BDBM50106197; NSC-81217; SBB009893; AKOS000193862; AS00919; CS-W021882; MB00265; MCULE-1762915886; PS-3519; AK-61366; BC002541; BR-61366; SC-49019; ST059638; SY020170; AB0023564; FT-0615195; W4642; B-8014; A816327; AC-907/41484593; Q27893908
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| Activity |
IC50 = 55000 nM
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[6] | |||
| Compound Name |
N-(5,6-Dihydrothiazolo[2,3-c][1,2,4]triazol-3-yl)-3-methylbutanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1707591; HMS1899L14; ZINC8600495; BDBM50440032; CCG-99405; MCULE-4972606593; NCGC00134885-01; G844-0167; F2079-0007; N-[5,6-Dihydrothiazolo[2,3-c][1,2,4]triazole-3-yl]-3-methylbutanamide; N-(5,6-dihydro[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl)-3-methylbutanamide
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| Activity |
IC50 = 55300 nM
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[7] | |||
| Compound Name |
4-Methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
p-Anisamide; p-Methoxybenzamide; 4-Methoxy benzamide; Benzamide, 4-methoxy-; 4-methoxy-benzamide; UNII-Z85FX3977E; CHEMBL449635; Z85FX3977E; MFCD00007995; 4-Methoxybenzamide, 97%; P-methyoxybenzamide; EINECS 222-319-6; BRN 1862847; ACMC-1CJJO; 4-Methoxybenzamide, 98%; Oprea1_456315; 4-10-00-00433 (Beilstein Handbook Reference); KSC225C6N; SCHEMBL201761; SCHEMBL12015238; CTK1C5166; KS-00000FKR; DTXSID40879434; ZINC161203; ACT03272; NSC11139; ANW-27812; BDBM50340090; NSC-11139; STL482885; AKOS000266484; AB00908; CS-W022205; GS-6794; MCULE-3713623573; VZ29332; AC-17055; AK114264; SC-65292; AB0016899; DB-006861; FT-0600843; M1679; ST50824264; 24M939; W-2595; W-106742; Q20059730; Z33546492
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| Activity |
IC50 = 57000 nM
|
[8] | |||
| Compound Name |
6-Oxo-5,6-dihydrophenanthridine-10-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL44692; BDBM50101130; 5h-phenanthridin-6-one-10-carboxylic; 6-Oxo-5,6-dihydro-phenanthridine-10-carboxylic acid
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| Activity |
IC50 ~ 60000 nM
|
[9] | |||
| Compound Name |
3-(4-Methoxyphenyl)quinoline-8-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL480233; BDBM50255326
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| Activity |
IC50 = 62000 nM
|
[4] | |||
| Compound Name |
2-[(3-Chloro-4-naphthalen-2-yloxyphenyl)carbamoyl]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1813887; BDBM50350109
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| Activity |
IC50 = 66000 nM
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[10] | |||
| Compound Name |
N-[(4-Oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]-3-phenyl-N-(thiophen-3-ylmethyl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2419716; SCHEMBL14645131; BDBM50439810
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| Activity |
IC50 = 71000 nM
|
[11] | |||
| Compound Name |
4-[4-[(2,8-Dimethyl-3-oxo-4H-1,4-benzoxazin-6-yl)methyl]piperazin-1-yl]-N-methylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407974; SCHEMBL531904; BDBM50438240
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| Activity |
EC50 = 75000 nM
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[5] | |||
| Compound Name |
4-[[3-(2-Amino-5-azatricyclo[6.3.1.04,12]dodeca-1(11),8(12),9-triene-5-carbonyl)-4-fluorophenyl]methyl]-2H-phthalazin-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323531; BDBM50427922
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| Activity |
IC50 = 76600 nM
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[12] | |||
| Compound Name |
CID 66716949
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407988; SCHEMBL532203; BDBM50438233
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| Activity |
EC50 = 77000 nM
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[5] | |||
| Compound Name |
N-{4-[(2-Chlorophenyl)(Pyrimidin-4-Yl)carbamoyl]phenyl}-4-Methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752492; BDBM50136772; Q27456886; 8IR
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| Activity |
IC50 = 77000 nM
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[13] | |||
| Compound Name |
CID 66716892
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407983; SCHEMBL532089; BDBM50438238; 4-[4-[(2,8-dimethyl-3-oxo-4H-1,4-benzoxazin-6-yl)methyl]piperazin-1-yl]-N,3-dimethylbenzamide
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| Activity |
EC50 = 78000 nM
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[5] | |||
| Compound Name |
3-Bromo-N-[2-(2-bromo-6-methyl-3-propan-2-ylphenoxy)-5-chlorophenyl]-5-chloro-2-hydroxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1813880; BDBM50350094
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| Activity |
IC50 = 78000 nM
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[10] | |||
| Compound Name |
5-(Cyclohexanecarboxamido)isoquinolin-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767059; BDBM50341871
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| Activity |
IC50 ~ 80000 nM
|
[2] | |||
| Compound Name |
2-Fluoro-N-(3-oxo-1,2-dihydroinden-1-yl)-5-[(4-oxo-3H-phthalazin-1-yl)methyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323532; BDBM50427921
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| Activity |
IC50 = 83900 nM
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[12] | |||
| Compound Name |
IWR-1-endo
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Investigative | Compound Info | ||
| Synonyms |
IWR-1; CHEMBL562310; C25H19N3O3; IWR1-endo; exo-IWR 1; IWR-1 endo; endo-IWR-1; cc-714; SCHEMBL15315470; EX-A642; BCP05700; ZINC2483738; 1806AH; 2489AH; BDBM50007583; MFCD18086875; CCG-208104; IWR-1, >=98% (HPLC); HY-12238; B2306; BRD-K61314889-001-01-0; Q27132252
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| Activity |
IC50 ~ 85000 nM
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[14] | |||
| Compound Name |
2-Amino-5-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]cyclohexyl]pyridine-3-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099718; SCHEMBL15272388; SCHEMBL15289173; BDBM50444584
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| Activity |
IC50 ~ 85000 nM
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[15] | |||
| Compound Name |
N-[4-[(4S)-5,5-Dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]cyclohexyl]-7-fluoro-1,5-naphthyridine-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2381936; SCHEMBL15289210; SCHEMBL16444265; BDBM50434158
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| Activity |
IC50 ~ 85000 nM
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[14] | |||
| Compound Name |
(4s)-3-{trans-4-[6-Amino-5-(Pyrimidin-2-Yl)pyridin-3-Yl]cyclohexyl}-5,5-Dimethyl-4-Phenyl-1,3-Oxazolidin-2-One
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099716; CHEMBL3099717; SCHEMBL15289095; SCHEMBL15289211; SCHEMBL16444735; BDBM231052; BDBM50444583; US9340549, 72; Q27452995
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| Activity |
IC50 ~ 85000 nM
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[15] | |||
| Compound Name |
1-[4-[(4S)-5,5-Dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]cyclohexyl]-6-fluoro-2-oxo-3H-benzimidazole-5-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2381945; SCHEMBL15289125; SCHEMBL16444220; BDBM50434156
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| Activity |
IC50 ~ 85000 nM
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[14] | |||
| Compound Name |
(4s)-3-{4-[6-Amino-5-(Pyrimidin-2-Yl)pyridin-3-Yl]phenyl}-5,5-Dimethyl-4-Phenyl-1,3-Oxazolidin-2-One
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3099720; SCHEMBL15269793; BDBM50444585; Q27452997; (4S)-3-[4-(6-amino-5-pyrimidin-2-ylpyridin-3-yl)phenyl]-5,5-dimethyl-4-phenyl-1,3-oxazolidin-2-one; (S)-3-(4-(6-Amino-5-(pyrimidin-2-yl)pyridin-3-yl)phenyl)-5,5-dimethyl-4-phenyloxazolidin-2-one
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| Activity |
IC50 ~ 85000 nM
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[15] | |||
| Compound Name |
1-[4-[(4S)-5,5-Dimethyl-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]cyclohexyl]-4-fluoro-2-oxo-3H-benzimidazole-5-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2381946; SCHEMBL15289088; SCHEMBL16444649; SCHEMBL16456028; BDBM50434155
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| Activity |
IC50 ~ 85000 nM
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[14] | |||
| Compound Name |
4-[[4-Fluoro-3-(2-hydroxy-5-azatricyclo[6.3.1.04,12]dodeca-1(11),8(12),9-triene-5-carbonyl)phenyl]methyl]-2H-phthalazin-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323227; BDBM50427924
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| Activity |
IC50 = 86200 nM
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[12] | |||
| Compound Name |
2-Fluoro-N-(1-oxo-3,4-dihydro-2H-isoquinolin-4-yl)-5-[(4-oxo-3H-phthalazin-1-yl)methyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2322614; BDBM50427917
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| Activity |
IC50 = 86340 nM
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[12] | |||
| Compound Name |
4-[4-[(2,8-Dimethyl-3-oxo-4H-1,4-benzoxazin-6-yl)methyl]piperazin-1-yl]-N-ethylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407975; SCHEMBL532666; BDBM50438239
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| Activity |
EC50 = 94000 nM
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[5] | |||
| Compound Name |
CID 66716841
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407973; SCHEMBL531993; BDBM50438241; 3-chloro-N-ethyl-4-[4-[(2-methyl-3-oxo-4H-1,4-benzoxazin-6-yl)methyl]piperazin-1-yl]benzamide
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| Activity |
EC50 = 100000 nM
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[5] | |||
| Compound Name |
4-(4-Carbamoylphenoxy)benzamide
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Investigative | Compound Info | ||
| Synonyms |
4,4'-oxydibenzamide; OUL35; 4,4'-Oxybis[benzamide]; MLS000736992; 4-(4-aminocarbonylphenoxy)benzamide; NSC39047; Oprea1_001354; IFLab1_001185; OUL 35; SCHEMBL3137816; CHEMBL1438938; CTK5B8808; DTXSID10284793; BDBM199181; HMS1415F19; HMS2754A23; ZINC235625; NSC-39047; AKOS001482413; MCULE-8450176580; IDI1_009052; OUL35, >=98% (HPLC); SMR000393949; EU-0000374; SR-01000391101; SR-01000391101-1; 4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carboxamide (OUL35)
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| Activity |
IC50 ~ 100000 nM
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[8] | |||
| Compound Name |
CID 66717219
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407986; SCHEMBL532968; BDBM50438235; 4-[4-[(8-methoxy-2-methyl-3-oxo-4H-1,4-benzoxazin-6-yl)methyl]piperazin-1-yl]-N,3-dimethylbenzamide
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| Activity |
EC50 = 100000 nM
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[5] | |||
| Compound Name |
(Z)-5-((1H-Indol-3-yl)methylene)thiazolidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1910509; (5Z)-5-(1H-indol-3-ylmethylidene)-1,3-thiazolidine-2,4-dione; SCHEMBL1249878; SCHEMBL1249881; (5Z)-5-((1H-indol-3-yl)methylene)thiazolidine-2,4-dione; BDBM50249336; STK036260; AKOS030744657; MCULE-4744925858; ST50062267; AB00123975-02; 5-(indol-3-ylmethylene)-1,3-thiazolidine-2,4-dione; 5-[(1h-indol-3-yl)methylene]thiazolidine-2,4-dione; F1418-0189
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| Activity |
IC50 ~ 100000 nM
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[16] | |||
| Compound Name |
12,14-Dimethyl-9,11,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,12,14,16-heptaen-8-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL596092; BDBM50304566; 8,10-Dimethyl-6H-pyrido[2'',1'':1,2]imidazo[5,4-c]isoquinolin-5-one
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| Activity |
IC50 ~ 100000 nM
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[17] | |||
| Compound Name |
2-(4-Bromophenyl)-8-methoxy-1H-quinazolin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827963; SCHEMBL15775408; BDBM50188561
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| Activity |
IC50 ~ 100000 nM
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[18] | |||
| Compound Name |
7-Methoxy-3,4-dihydroisoquinolin-1(2H)-one
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Investigative | Compound Info | ||
| Synonyms |
7-Methoxy-3,4-dihydro-2H-isoquinolin-1-one; 7-methoxy-1,2,3,4-tetrahydroisoquinolin-1-one; 1(2H)-Isoquinolinone, 3,4-dihydro-7-methoxy-; CHEMBL3629677; MFCD04114863; 1(2H)-Isoquinolinone,3,4-dihydro-7-methoxy-; SCHEMBL246378; ISO067; CTK4E8986; DTXSID60542855; ANW-54011; BDBM50126168; ZINC34079343; AKOS006292931; AB19125; FS-3566; MP-0800; QC-3610; AK-68685; SY097624; AB0059627; AM20030375; CS-0043695; FT-0692961; Z4434; 3,4-dihydro-7-methoxy-1 (2H)-isoquinolinone; A816045; [3'4':6,7]INDOLIZINO[1,2-B]QUINOLINE-3,14-DIONE; 4-ETHYL-4-HYDROXY-3,4,12,14-TETRAHYDRO-1H-PYRANO
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| Activity |
IC50 ~ 100000 nM
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[19] | |||
| Compound Name |
3,4-Dihydroisoquinolin-1(2H)-one
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Investigative | Compound Info | ||
| Synonyms |
3,4-dihydro-2H-isoquinolin-1-one; 1,2,3,4-tetrahydroisoquinolin-1-one; 1(2H)-Isoquinolinone, 3,4-dihydro-; 3,4-dihydro-1-isoquinolinone; 1-Oxo-1,2,3,4-tetrahydroisoquinoline; CHEMBL1688212; MFCD00853963; F2189-0996; 3,4-dihydro-1H-isoquinolin-1-one; 3,4-Dihydro-2H-isoquinolin-1-one, 98%; Oprea1_511002; dihydroisoquinolone; 1-Keto-1,2,3,4-tetrahydroisoquinoline; 3,4-dihydroisocarbostyril; POLY(VINYLCINNAMATE); SCHEMBL67710; KSC180Q6J; hydroxy-3,4-dihydroisoquinoline; SCHEMBL11267501; CTK0I0864; DTXSID40152517; 2,3,4-trihydroisoquinolin-1-one; 3,4-Dihydro-1(2H)-isoquinolone; ACT03694; BCP27476; ZINC5603571; 3,4-dihydro-1(2H)-isoquinolinone; 3,4-dihydroisoquinoline-1(2H)-one; ANW-51566; BDBM50339016; STK926192; AKOS002232785; AKOS003625709; AB07451; AC-5218; CS-W008863; MCULE-1919291381; VZ25548; KS-0000056T; AK-25321; BR-25321; SC-25175; SY021304; AB0035118; DB-011138; AM20020275; FT-0600427; ST50112782; X9392; EN300-43275; S-5379; 52054-EP2308845A2; 52054-EP2308846A2; 196D389; 7R-1504; J-511194; Q27461749; Z56801375
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| Activity |
IC50 = 100000 nM
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[19] | |||
| Compound Name |
7-(Trifluoromethyl)-3,4-dihydroisoquinolin-1(2H)-one
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Investigative | Compound Info | ||
| Synonyms |
7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinolin-1-one; CHEMBL3629675; SCHEMBL792895; 7-(trifluoromethyl)-3,4-dihydro-2H-isoquinolin-1-one; DTXSID30735797; BDBM50126167; MFCD22543895; ZINC95643127; SB21853; AS-41590; DB-124403; CS-0050124; 7-Trifluoromethyl-3,4-dihydro-2H-isoquinolin-1-one; 7-(Trifluoromethyl)-3,4-dihydroisoquinoline-1(2H)-one
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| Activity |
IC50 = 100000 nM
|
[19] | |||
| Compound Name |
Pratol
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Investigative | Compound Info | ||
| Synonyms |
7-Hydroxy-4'-methoxyflavone; 7-Hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one; C.I. 75570; 7-hydroxy-2-(4-methoxyphenyl)chromen-4-one; UNII-KU5R959MO7; 4H-1-Benzopyran-4-one, 7-hydroxy-2-(4-methoxyphenyl)-; MLS002707301; KU5R959MO7; Flavone, 7-hydroxy-4'-methoxy-; NSC123414; NSC-123414; 7-Hydroxy-2-(4-methoxyphenyl)-4-benzopyrone; EINECS 207-653-2; NSC 123414; BRN 0237239; 7-Hydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one; 7-Hydroxy-flavone, 5h; Flavone, 7-hydroxy-4'-methoxy- (7CI,8CI); 4'-methoxy-7-hydroxyflavone; Oprea1_854602; CHEMBL16751; SCHEMBL534596; BDBM85573; DTXSID20197587; TNP00065; ZINC5733557; MFCD00016937; AKOS004110700; CCG-208438; MCULE-4757451306; NCGC00017200-01; NCGC00017200-02; NCGC00017200-03; NCGC00142412-01; NCGC00142412-02; SMR001488172; ST055366; FT-0730316; AN-829/40761415; SR-05000002252; 7-Hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one #; SR-05000002252-2; BRD-K35651673-001-05-9; Q15424797
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(4-Formyl-phenoxy)-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4287655; 4-(4-Formylphenoxy)-benzamide; 4-(4-formylphenoxy)benzamide; SCHEMBL754740; BDBM50468581; ZINC20297191; A1-11748
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-(4-Hydroxyphenyl)-1H-1,3-benzodiazole-7-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL336859; 1H-Benzimidazole-7-carboxylicacid, 2-(4-hydroxyphenyl)-; SCHEMBL15958954; CTK1C1608; KS-00001OXJ; DTXSID90443482; 2-(4-HYDROXY-PHENYL)-3H-BENZOIMIDAZOLE-4-CARBOXYLICACID; ZINC6740850; BDBM50093367; MFCD06660425; ZINC39171806; AKOS005257250; MCULE-9428734691; SC-58478; 2-(4-hydroxyphenyl)- 1H-benzo[d]imidazole -4-carbo; 2-(4-Hydroxyphenyl)1H-benzimidazole-7-carboxylic acid; 2-(4-Hydroxyphenyl)-1H-benzimidazole-4-carboxylic acid; 2-(4-Hydroxyphenyl)-3H-benzoimidazole-4-carboxylic acid; 2-(4-Hydroxy-phenyl)-1H-benzoimidazole-4-carboxylic acid; 2-(4-hydroxyphenyl)-3h-benzo[d]imidazole-4-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[20] | |||
| Compound Name |
Chembl4125748
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50272959
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
N-Cyclopropyl-4-[4-[(8-ethoxy-2-methyl-3-oxo-4H-1,4-benzoxazin-6-yl)methyl]piperazin-1-yl]-3-methylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407970; SCHEMBL532064; BDBM50438230
Click to Show/Hide
|
||||
| Activity |
EC50 = 100000 nM
|
[5] | |||
| Compound Name |
4-[4-[(8-Ethoxy-2-methyl-3-oxo-4H-1,4-benzoxazin-6-yl)methyl]piperazin-1-yl]-N-ethyl-3-methylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407969; SCHEMBL532023; BDBM50438231
Click to Show/Hide
|
||||
| Activity |
EC50 = 100000 nM
|
[5] | |||
| Compound Name |
7-Bromo-3,4-dihydroisoquinolin-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-Bromo-3,4-dihydro-2H-isoquinolin-1-one; 7-bromo-1,2,3,4-tetrahydroisoquinolin-1-one; CHEMBL3629673; MFCD08437642; SCHEMBL123731; CTK5G2597; KS-00000DJR; DTXSID10648634; CS-D0454; ANW-49017; BDBM50126165; ZINC21304142; AKOS013546646; AB45191; FS-3440; QC-9847; AC-28296; AK-30172; BR-30172; SC-35642; SY024204; AB0027381; DB-078314; AM20041346; FT-0648760; W9209; 1(2H)-Isoquinolinone,7-bromo-3,4-dihydro-; S-6632; 7-BROMO-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE; J-519124; 7-Bromo-3,4-dihydro-2H-isoquinolin-1-one, AldrichCPR
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[19] | |||
| Compound Name |
8-Methoxy-2-[4-(Trifluoromethyl)phenyl]-3,4-Dihydroquinazolin-4-One
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL123798; 4(1h)-quinazolinone,8-methoxy-2-[4-(trifluoromethyl)phenyl]-; SCHEMBL7570390; SCHEMBL15775334; 8-methoxy-2-[4-(trifluoromethyl)phenyl]-1H-quinazolin-4-one; BDBM50068759; ZINC13782469; Q27459905; 2-[4-(Trifluoromethyl)phenyl]-8-methoxyquinazoline-4(3H)-one; 8-Methoxy-2-(4-trifluoromethyl-phenyl)-3H-quinazolin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
1,2-Dihydro-2-(4-isopropylphenyl)-4(3H)-quinazolinone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3594136; Oprea1_576221; 2-[4-(propan-2-yl)phenyl]-1,2,3,4-tetrahydroquinazolin-4-one; BDBM50104287; AKOS001314013; MCULE-7496308930; Z48978364; 2-(4-Isopropylphenyl)-2,3-dihydroquinazolin-4(1H)-one; 2-(4-Isopropylphenyl)-1,2,3,4-tetrahydroquinazoline-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
N-[3-Chloranyl-4-[[4-(4-Methoxyphenyl)oxan-4-Yl]methylcarbamoyl]phenyl]furan-2-Carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752386; SCHEMBL15057674; BDBM50136755; Q27464764; N-[3-chloro-4-[[4-(4-methoxyphenyl)oxan-4-yl]methylcarbamoyl]phenyl]furan-2-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
4-[(2-Fluorophenyl)methoxy]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4208737; OUL35 derivative 32; SCHEMBL20883219; 4-[(2-fluorobenzyl)oxy]benzamide; ZINC7509736; BDBM50452662; STL506080; AKOS017030557; MCULE-5507437194; Z26312097
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
CID 66717208
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407985; SCHEMBL532906; BDBM50438236
Click to Show/Hide
|
||||
| Activity |
EC50 = 100000 nM
|
[5] | |||
| Compound Name |
2-(4-Tert-Butylphenyl)-2,3-dihydroquinazoline-4(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3594137; Oprea1_675665; HMS1742P09; BDBM50104288; AKOS008017587; MCULE-4232890698; SR-01000074054; SR-01000074054-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
2-(4-Fluorophenyl)quinazolin-4-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL18688; 2-(4-fluorophenyl)quinazolin-4(3h)-one; 2-(4-Fluorophenyl)-quinazolin-4(3H)-one; 2-(4-fluorophenyl)-1H-quinazolin-4-one; 2-(4-fluorophenyl)-4(3H)-quinazolinone; Oprea1_188632; Oprea1_458111; Oprea1_594330; IFLab1_001006; SCHEMBL4836893; SCHEMBL8618978; CTK0A2256; DTXSID70360022; HMS1414N16; BDBM50188597; STL577108; ZINC11617361; AKOS001643367; AKOS003618637; MCULE-4870747309; 4-hydroxy-2-(4-fluorophenyl)quinazoline; 2-(4-Fluorophenyl)quinazolin-4(1H)-one; 2-(4-Fluorophenyl)quinazoline-4(3H)-one; 4-hydroxy-2-(4-fluorophenyl) quinazoline; 4(1H)-Quinazolinone, 2-(4-fluorophenyl)-; EU-0074561; SR-01000459325; SR-01000459325-1; F0306-2280
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
5-(2,2-Dimethylpropanamido)isoquinolin-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1767060; BDBM50341872
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-Cyclopropyl-4-[4-[(2,8-dimethyl-3-oxo-4H-1,4-benzoxazin-6-yl)methyl]piperazin-1-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407976; SCHEMBL532893; BDBM50438265
Click to Show/Hide
|
||||
| Activity |
EC50 = 100000 nM
|
[5] | |||
| Compound Name |
2-(4-Bromophenyl)-3,4-Dihydroquinazolin-4-One
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(4-bromophenyl)quinazolin-4(3h)-one; CHEMBL2058057; 2-(4-bromophenyl)quinazolin-4(1h)-one; 2-(4-bromophenyl)-1H-quinazolin-4-one; Cambridge id 5234833; Oprea1_095695; SCHEMBL5795292; SCHEMBL15775265; DTXSID50966728; HMS1579J06; ZINC289772; BDBM50188337; STL506688; AKOS034469035; MCULE-8062991764; 2-(4-Bromophenyl)quinazoline-4(3H)-one; Q27452728; Z56974849
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
2-[4-(Trifluoromethyl)phenyl]-3h-Quinazolin-4-One
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(4-(TRIFLUOROMETHYL)PHENYL)QUINAZOLIN-4(3H)-ONE; CHEMBL2419892; 2-[4-(Trifluoromethyl)phenyl]quinazolin-4(3H)-one; SCHEMBL11284110; CTK3D1284; DTXSID30568961; BDBM50439825; AKOS015943028; 4-Hydroxy-2-(4-trifluoromethylphenyl)quinazoline; 2-[4-(Trifluoromethyl)phenyl]quinazolin-4(1H)-one; 4(1H)-Quinazolinone, 2-[4-(trifluoromethyl)phenyl]-; Q27449876; 2-[4-(TRIFLUOROMETHYL)PHENYL]-1H-QUINAZOLIN-4-ONE
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
7-Methyl-3,4-dihydroisoquinolin-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-Methyl-3,4-dihydro-2H-isoquinolin-1-one; 7-METHYL-1,2,3,4-TETRAHYDROISOQUINOLIN-1-ONE; CHEMBL3629674; SCHEMBL2619126; CTK4H7860; DTXSID00573461; BDBM50126166; MFCD04114868; ZINC34574252; AKOS006293186; AB19138; AS-36711; DB-069502; FT-0752320; V5561; 7-Methyl-3,4-dihydroisoquinoline-1(2H)-one; A-7167; N-(5-Iodopyridin-3-yl)-2,2-dimethylpropionamide; 7-Methyl-3,4-dihydro-2H-isoquinolin-1-one, AldrichCPR; F8883-6510; Z2466252322
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[19] | |||
| Compound Name |
7-Fluoro-3,4-dihydroisoquinolin-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-FLUORO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE; CHEMBL3629672; 7-fluoro-1,2,3,4-tetrahydroisoquinolin-1-one; 7-FLUORO-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE; CTK5G0361; DTXSID00591009; 4209AC; BDBM50126163; MFCD04114878; ZINC36221930; AKOS006293436; AB19156; MCULE-6139055312; AS-36712; SC-34861; 1(2H)-Isoquinolinone,7-fluoro-3,4-dihydro-; 7-Fluoro-3,4-dihydroisoquinoline-1(2H)-one; Z-6632
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[19] | |||
| Compound Name |
12-Methyl-9,11,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,12,14,16-heptaen-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL595394; BDBM50304577; 8-Methyl-6H-pyrido[2'',1'':1,2]imidazo[5,4-c]isoquinolin-5-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(5Z)-5-[[1-[(4-Chlorophenyl)methyl]indol-3-yl]methylidene]-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4082372; SCHEMBL8688578; BDBM50249400; AKOS002396825
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
4-(4-Carbamoylphenoxy)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4287262; BDBM50468579; ZINC20297208; AKOS009229962; MCULE-8977258216; NE43435; EN300-70101; Z1222331858
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(5Z)-5-[(1-Benzylindol-3-yl)methylidene]-1,3-thiazolidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079898; SCHEMBL1248861; SCHEMBL12891974; BDBM50249370; AKOS002396735
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
1-[3-[4-(2-Chlorophenyl)-5-pyrimidin-4-yl-1,2,4-triazol-3-yl]cyclobutyl]-2-oxidanylidene-3~{H}-benzimidazole-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095003; SCHEMBL20302234; SCHEMBL20333643; SCHEMBL20333645; BDBM50250875
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
4-Amino-N-quinolin-8-ylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063631; SCHEMBL15093487; CTK7D7163; ZINC4933157; BDBM50234918; AKOS000152295; 4-AMINO-N-(QUINOLIN-8-YL)BENZAMIDE
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
Disodium;6-oxo-5H-phenanthridine-3,8-disulfonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL46267
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
Chembl4129789
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-[3-[4-(4-fluorophenyl)piperidin-1-yl]carbonylphenoxy]benzamide; BDBM50272966
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
7-Chloro-3,4-dihydroisoquinolin-1(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-CHLORO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE; 1(2H)-Isoquinolinone, 7-chloro-3,4-dihydro-; 7-CHLORO-3,4-DIHYDROISOQUINOLIN-1-ONE; CHEMBL3416132; 7-CHLORO-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE; SCHEMBL793493; CTK4E8982; DTXSID60595462; KS-000019IS; 3696AJ; BDBM50126164; MFCD04114870; ZINC36221920; AKOS006293188; AB19145; AS-64902; SC-34750; CS-0036532; FT-0692943; 1(2H)-Isoquinolinone,7-chloro-3,4-dihydro-; 7-Chloro-3,4-dihydroisoquinoline-1(2H)-one; Z-4843; Q27454274; 7-CHLORO-1,2,3,4-TETRAHYDROISOQUINOLIN-1-ONE
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[19] | |||
| Compound Name |
14-Methoxy-9,11,13,17-tetrazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(10),2,4,6,12,14,16-heptaen-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL595164; BDBM50304571; 10-Methoxy-6H-pyrimido[3'',4'':1,2]imidazo[5,4-c]isoquinolin-5-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
4-[(3Ar,4r,7s,7as)-1,3-Dioxooctahydro-2h-4,7-Methanoisoindol-2-Yl]-N-(Quinolin-8-Yl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956162; SCHEMBL14960033; BDBM50234919; Q27453509
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
2-(4-Chlorophenyl)quinazolin-4-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(4-Chlorophenyl)quinazolin-4(3H)-one; CHEMBL1163173; 2-(4-Chlorophenyl)-quinazolin-4(3H)-one; 2-(4-chlorophenyl)-1H-quinazolin-4-one; Maybridge3_004731; Cambridge id 6433363; SCHEMBL4836900; SCHEMBL8618923; CTK2G9989; CTK6G9828; CCG-615; DTXSID80341963; HMS1444H01; BDBM50321122; MFCD01989876; STL332425; STL508924; ZINC17994427; AKOS001645871; AKOS027254953; 2-(4-Chlorophenyl)-4-quinazolinol #; MCULE-7386778874; IDI1_016118; 2-(4-chlorophenyl)-3H-quinazolin-4-one; 2-(4-Chlorophenyl)-4(3H)-quinazolinone; 4(1H)-Quinazolinone, 2-(4-chlorophenyl)-; EU-0010572; ST50184947; SR-01000485210; SR-01000485210-1; BRD-K30346402-001-01-8
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
3,5-Dichloro-N-(3-chloro-4-naphthalen-2-yloxyphenyl)-2-hydroxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1813881; BDBM50350095
Click to Show/Hide
|
||||
| Activity |
IC50 = 120000 nM
|
[10] | |||
| Compound Name |
3-(Dimethylamino)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-(N,N-Dimethylamino)benzamide; 3-dimethylaminobenzamide; 3-Dimethylamino-benzamide; CHEMBL123205; Oprea1_711245; SCHEMBL893991; CTK6H9822; KS-00003KEC; DTXSID00374354; ZINC2573563; ANW-69709; BDBM50106193; SBB087809; AKOS008937486; FS-1469; MCULE-9973256474
Click to Show/Hide
|
||||
| Activity |
IC50 = 120000 nM
|
[6] | |||
| Compound Name |
N-[4-(3-Bromonaphthalen-2-yl)oxy-3-chlorophenyl]-3,5-dichloro-2-hydroxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1813879; BDBM50350093
Click to Show/Hide
|
||||
| Activity |
IC50 = 123000 nM
|
[10] | |||
| Compound Name |
N-(1-Oxo-3,4-dihydro-2H-isoquinolin-4-yl)-3-[(4-oxo-3H-phthalazin-1-yl)methyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2322615; BDBM50427916
Click to Show/Hide
|
||||
| Activity |
IC50 = 145750 nM
|
[12] | |||
| Compound Name |
Chembl4290954
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17824734; 6WJ
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 150000 nM
|
[25] | |||
| Compound Name |
Chembl4293745
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17825128
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 150000 nM
|
[25] | |||
| Compound Name |
Chembl4290899
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17825002
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 150000 nM
|
[25] | |||
| Compound Name |
CID 66717080
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407978; SCHEMBL532535; BDBM50438263; N-ethyl-4-[4-[(8-methoxy-2-methyl-3-oxo-4H-1,4-benzoxazin-6-yl)methyl]piperazin-1-yl]benzamide
Click to Show/Hide
|
||||
| Activity |
EC50 = 151000 nM
|
[5] | |||
| Compound Name |
4-[[3-(2,11-Diazatricyclo[7.3.1.05,13]trideca-5(13),6,8-triene-2-carbonyl)-4-fluorophenyl]methyl]-2H-phthalazin-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323223; BDBM50427928
Click to Show/Hide
|
||||
| Activity |
IC50 = 156000 nM
|
[12] | |||
| Compound Name |
3-Nitrobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
M-NITROBENZAMIDE; Benzamide, 3-nitro-; Benzamide, m-nitro-; 3-Nitro-benzamide; 3-Nitrobenzamide, 98%; CHEMBL338567; MFCD00007984; EINECS 211-431-0; NSC 37327; BRN 0777185; NSC37327; 3-nitrophenylcarboxamide; ACMC-209nmr; DSSTox_CID_5732; DSSTox_RID_77897; DSSTox_GSID_25732; Oprea1_317236; MLS002415746; Benzamide, m-nitro- (8CI); SCHEMBL894417; ARONIS014977; DTXSID5025732; CTK2F3334; HMS3039O04; ZINC153288; KS-000013XS; KS-000045AA; Tox21_200090; ANW-34897; BDBM50106195; NSC-37327; STL071228; AKOS000283200; MCULE-3313077224; NCGC00091263-01; NCGC00091263-02; NCGC00257644-01; AC-10271; AM808235; AS-19826; NCI60_003478; SMR001370909; ST080656; DB-054679; FT-0616234; N0321; Y9712; AE-562/40173655; J-512967
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| Activity |
IC50 = 160000 nM
|
[6] | |||
| Compound Name |
N-Cyclopropyl-4-[4-[(8-methoxy-2-methyl-3-oxo-4H-1,4-benzoxazin-6-yl)methyl]piperazin-1-yl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407979; SCHEMBL531516; SCHEMBL531749; BDBM50438262
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| Activity |
EC50 = 162000 nM
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[5] | |||
| Compound Name |
4-Fluorobenzamide
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Investigative | Compound Info | ||
| Synonyms |
p-Fluorobenzamide; Benzamide, 4-fluoro-; p-Fluorobenzoic acid amide; Benzamide, p-fluoro-; 4-Fluoro-benzamide; UNII-YB79F3XB1G; MFCD00007992; YB79F3XB1G; CHEMBL125596; 4-Fluorobenzamide, 98%; EINECS 212-535-9; BRN 1859744; 4fluorobenzamide; 4-fluorobenzoamide; 4-fluoro benzamide; PubChem3407; ACMC-209pp5; SCHEMBL52708; 4-09-00-00954 (Beilstein Handbook Reference); cid_71572; KSC448E5B; MLS000060705; SCHEMBL8259366; CTK3E8250; DTXSID60231717; OTAVA-BB 1375215; HMS2482G08; ZINC407004; KS-00000F6W; ANW-37575; BDBM50106200; NSC102765; SBB086057; STK301243; AKOS001282873; AS00831; CM13176; CS-W016478; MCULE-5735061019; NSC-102765; PS-9071; VZ29067; 3,3-DIETHYLOXADICARBOCYANINEIODIDE; BR-47676; SC-06870; SMR000065508; SY013152; AB0061825; DB-056615; AM20060900; F0279; FT-0618506; FT-0618507; ST45151001; 24F759; M-6140; W-104173; Q27294434; F3147-3717
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| Activity |
IC50 = 200000 nM
|
[6] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 10 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Nicotinamide
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Investigative | Compound Info | ||
| Synonyms |
niacinamide; 3-Pyridinecarboxamide; pyridine-3-carboxamide; Nicotinic acid amide; vitamin PP; Papulex; Aminicotin; Amixicotyn; Nicobion; Nicotylamide; Nikotinamid; Savacotyl; Benicot; Dipegyl; Endobion; Hansamid; Pelmine; Nicotinic amide; Delonin amide; Pelonin amide; Vi-Nicotyl; Austrovit PP; Inovitan PP; Vitamin B; Nicosylamide; Nicotilamide; Nicotililamido; Amnicotin; Niacevit; Nicamina; Nicamindon; Nicofort; Nicomidol; Nicotamide; Nicovitina; Nicovitol; Nicozymin; Niocinamide; Niozymin; Niamide; Nicasir; Nicogen; Nicota; Nicotol; Nicovit; Niko-tamin; 3-Carbamoylpyridine; Nicotine acid amide; Nandervit-N; Pyridine-3-carboxylic acid amide; Niavit PP; Nicosan 2; Nicotine amide; beta-Pyridinecarboxamide; Nikotinsaeureamid; Nicotylamidum; Mediatric; Nicotinsaureamid; Pyridine, 3-carbamoyl-; 3-Pyridinecarboxylic acid amide; Nicotinamidum; m-(Aminocarbonyl)pyridine; Acid amide; Factor pp; Nicotinamida; Nicovel; Vitamin B (VAN); Pelmin; Amid kyseliny nikotinove; Witamina PP; PP-Faktor; Amide PP; Nicotinsaureamid [German]; Nikotinsaeureamid [German]; Amid kyseliny nikotinove [Czech]; Nicotinamidum [INN-Latin]; Nicotinamida [INN-Spanish]; Nictoamide; CCRIS 1901; Dipigyl; HSDB 1237; Vi-noctyl; AI3-02906; Nicotinamide (Vitamin B3); NSC 13128; b-Pyridinecarboxamide; Niacinamide [USP]; UNII-25X51I8RD4; 3-(aminocarbonyl)pyridine; MFCD00006395; .beta.-Pyridinecarboxamide; CHEMBL1140; MLS000069714; 25X51I8RD4; NSC13128; Niacinamide (USP); NSC-13128; NSC-27452; Nicotinamide, 99%; NCGC00093354-03; NCGC00093354-05; SMR000058212; DSSTox_CID_929; Niacinamide;Nicotinic acid amide;Vitamin B3; WLN: T6NJ CVZ; DSSTox_RID_75873; DSSTox_GSID_20929; Niacinamide [USAN]; Enduramide; B3, Vitamin; Vitamin B 3; B 3, Vitamin; 3 Pyridinecarboxamide; SR-01000721872; Nicotinsaureamid Jenapharm; EINECS 202-713-4; Jenapharm, Nicotinsaureamid; Niacotinamide; Nicotinamid; nicotin-amide; Nicotinsaeureamid; 3-Amidopyridine; DEA No. 1405; Nicotinamide,(S); Vitamin B3 amide; 3-yridinecarboxamide; Nicotinamide [INN]; ACMC-20aizz; Mediatric (Salt/Mix); niacin - Vitamin B3; Opera_ID_775; Niacinamide(Vitamin B3); bmse000281; MolMap_000061; EC 202-713-4; SCHEMBL2926; Nicotinamide (JP17/INN); KSC237G2T; MLS001424246; SCHEMBL6278767; SGCUT00176; ZINC5878; DTXSID2020929; SCHEMBL19978192; BDBM27507; Nicotinamide, niacin, vitamin B3; HMS2052M21; HMS2090B05; HMS2093H03; HMS2236J03; HMS3370F21; HMS3394M21; HMS3655M20; HMS3713B22; HMS3884A16; Pharmakon1600-01505397; BCP07322; HY-B0150; Nicotinamide (Vitamin B3) solution; NSC27452; to_000073; Nicotinamide 1.0 mg/ml in Methanol; Nicotinamide, >=98.5% (HPLC); Nicotinamide, >=99.5% (HPLC); Tox21_111202; Tox21_201716; Tox21_302776; ANW-75549; BBL013003; NSC759115; s1899; SBB004283; STL163867; AKOS005715850; Tox21_111202_1; CCG-101149; CS-1968; DB02701; MCULE-3532732201; NC00399; NSC-759115; Nicotinamide, >=98% (HPLC), powder; NCGC00093354-04; NCGC00093354-06; NCGC00093354-09; NCGC00256432-01; NCGC00259265-01; AS-13845; Nicotinamide, puriss., 99.0-101.0%; SC-18039; Nicotinamide 10 microg/mL in Acetonitrile; Nicotinamide, tested according to Ph.Eur.; SBI-0206826.P001; DB-057754; FT-0631517; FT-0672696; FT-0773644; N0078; N1651; ST51037366; SW197779-3; EN300-15612; Niacinamide, meets USP testing specifications; 3418-EP2281816A1; 3418-EP2281818A1; 3418-EP2285778A1; 3418-EP2287165A2; 3418-EP2295424A1; 3418-EP2307377A1; 3418-EP2307378A1; 3418-EP2308858A1; 3418-EP2308874A1; 3418-EP2311808A1; 3418-EP2311829A1; C00153; D00036; J10422; Nicotinamide (Niacinamide), analytical standard; W-3583; 11783-EP2269610A2; 11783-EP2289510A1; 11783-EP2316457A1; 11783-EP2316458A1; 11783-EP2316825A1; 11783-EP2316826A1; 11783-EP2316827A1; 11783-EP2316828A1; AB00373895-13; AB00373895_15; AB00373895_16; Nicotinamide, Vetec(TM) reagent grade, >=98%; A845925; AC-907/25014114; Q192423; Q-201470; SR-01000721872-3; SR-01000721872-4; SR-01000721872-5; Z33546463; F2173-0513; A186B02E-6C70-4E54-9739-79398D439AAA
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| Activity |
IC50 = 210000 nM
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[26] | |||
| Compound Name |
CID 66716715
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407977; SCHEMBL531770; BDBM50438264; 4-[4-[(8-methoxy-2-methyl-3-oxo-4H-1,4-benzoxazin-6-yl)methyl]piperazin-1-yl]-N-methylbenzamide
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| Activity |
EC50 = 251000 nM
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[5] | |||
| Compound Name |
4-Hydroxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
p-Hydroxybenzamide; 4-Hydroxy-benzamide; Benzamide, 4-hydroxy-; UNII-9OU5YD093J; MFCD00007997; 9OU5YD093J; CHEMBL123617; 4-oxidanylbenzamide; EINECS 210-602-7; NSC 524134; ACMC-1APVC; para-hydroxybenzoic amide; AI3-15540; para-hydroxy benzoic amide; 4-Hydroxybenzamide, 98%; 4-hydroxybenzene carboxamide; Oprea1_692786; SCHEMBL162830; SCHEMBL10792133; CTK2F7050; KS-00000VNF; DTXSID10210931; ZINC157088; 4-hydroxybenzamide 41911-58-4; 4-HYDROXY-BENZOIC ACID,AMIDE; ANW-34012; BDBM50106201; NSC524134; SBB058350; AKOS000121433; DS-9435; MCULE-2259075244; NSC-524134; NCGC00341573-01; AK151255; DB-054032; FT-0618687; ST51016241; V0567; EN300-18541; C-4822; AB00443728-03; A833505; AE-562/40219003; W-105070; Q27272839
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| Activity |
IC50 = 280000 nM
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[6] | |||
| Compound Name |
4-Chlorobenzamide
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Investigative | Compound Info | ||
| Synonyms |
p-Chlorobenzamide; Benzamide, 4-chloro-; 4-Chloro-benzamide; p-Chlorobenzoic acid amide; Benzamide, p-chloro-; UNII-260CV6K0MR; MFCD00007993; 260CV6K0MR; CHEMBL121999; EINECS 210-601-1; BRN 0774622; Benzamide, p-chloro- (6CI,7CI,8CI); AI3-09668; NSC74687; 4-chloranylbenzamide; PubChem3619; 4-chlorobenzenecarboxamide; 4-Chlorobenzamide, 98%; ACMC-209my5; SCHEMBL77931; 4-09-00-00985 (Beilstein Handbook Reference); SCHEMBL8269185; CTK2F4399; KS-00000LIG; DTXSID50210930; OTAVA-BB 1375258; ZINC152995; ACT08121; EBD31562; ANW-34011; BBL025862; BDBM50106192; NSC-74687; NSC406894; STL283912; AKOS000266483; AS02680; CS-W019519; MCULE-1584747431; NSC-406894; VZ28827; AC-10270; AK113058; SY048513; AB0013809; DB-013433; FT-0618169; ST50824531; A833504; W-109581; Q27254022; F3147-3719
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| Activity |
IC50 = 300000 nM
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[6] | |||
| Compound Name |
6-[2-Fluoro-5-[(4-oxo-3H-phthalazin-1-yl)methyl]benzoyl]-2,6-diazatricyclo[7.3.1.05,13]trideca-1(12),9(13),10-trien-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323225; BDBM50427926
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| Activity |
IC50 = 387000 nM
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[12] | |||
| Compound Name |
3,5-Dichloro-N-(2-chlorophenyl)-2-hydroxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1814050; BDBM50350108
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| Activity |
IC50 = 500000 nM
|
[10] | |||
| Compound Name |
3,5-Dichloro-N-(3-chlorophenyl)-2-hydroxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1814051; Benzamide, 3,5-dichloro-N-(3-chlorophenyl)-2-hydroxy-; SCHEMBL8672680; DTXSID00210288; BDBM50350106
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| Activity |
IC50 = 500000 nM
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[10] | |||
| Compound Name |
5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-Dihydroxypyrrolidin-2-YL]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]adenosine
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Investigative | Compound Info | ||
| Synonyms |
[(2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl]methyl-ADP; CHEMBL1230692; adenosine 5'-diphosphate (hydroxymethyl)pyrrolidinediol; ADP-HPD; ADP-(hydroxymethyl)pyrrolidinediol; BDBM50350107; Q27120396
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| Activity |
IC50 > 1000000 nM
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[10] | |||
| Compound Name |
4-Aminobenzamide
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Investigative | Compound Info | ||
| Synonyms |
p-Aminobenzamide; Benzamide, 4-amino-; 4-Amino-benzamide; p-Carbamoylaniline; p-Aminobenzoic acid amide; Benzamide, p-amino-; 4-amino benzamide; MFCD00007999; UNII-77722I6PAC; 4-Aminobenzamide, 98%; CHEMBL332444; 77722I6PAC; CCRIS 6792; EINECS 220-612-3; NSC 36963; NSC 233920; aminobenzamide-4; p-aminobenzylamide; 4-amino-bezamide; p-amino benzamide; 4-carbamoylaniline; para amino benzamide; 4-Oxobedfordiaicacid; 4-aminobenzoyl amide; EC 220-612-3; DSSTox_CID_18814; DSSTox_RID_79401; DSSTox_GSID_38814; Oprea1_069284; SCHEMBL56532; KSC490G7L; Benzamide, p-amino- (8CI); ACMC-209h23; DTXSID7038814; CTK3J0375; ZINC157169; KS-000009SL; NSC36963; Tox21_301656; ANW-26377; BBL011581; BDBM50106190; NSC-36963; NSC233920; SBB028159; STK291024; AKOS000119620; AC-4411; AM84879; CS-W017757; MCULE-3871926059; NE10538; NSC-233920; NCGC00255641-01; AK151254; AS-14565; BP-20138; SC-25679; SY004554; DB-004076; A0631; FT-0617551; ST45026820; W-107053; Q27266557; F2190-0450; Z1262254357
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| Activity |
IC50 = 1800000 nM
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[6] | |||
| Compound Name |
4-Bromobenzamide
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Investigative | Compound Info | ||
| Synonyms |
p-Bromobenzamide; Benzamide, 4-bromo-; Benzamide, p-bromo-; 4-Bromo-benzamide; p-Bromobenzoic acid amide; 4-Bromobenzamide, 97%; MFCD00007991; CHEMBL339059; EINECS 211-817-9; NSC 404792; BRN 1859981; 4-Bromo benzamide; NSC404792; PubChem3737; ACMC-209obe; 4-bromobenzoic acid amide; DIMETHYLTINDILAURATE; 4-09-00-01023 (Beilstein Handbook Reference); KSC353E3D; SCHEMBL615632; Benzamide, 4-bromo- (9CI); CTK2F3231; KS-00000LHG; DTXSID90220098; OTAVA-BB 1375914; ZINC406945; ACT08095; STR03150; ANW-35784; BDBM50106186; EBD209942; KM1312; STL367696; AKOS000202550; AS00920; CS-W004151; MCULE-2481755947; NSC-404792; AK-76760; BC002543; SC-50159; SY020099; AB0020566; B4216; FT-0617857; ST50406436; V1495; AE-562/42287617; Z33546526
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| Activity |
IC50 = 2200000 nM
|
[6] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Screening and structural analysis of flavones inhibiting tankyrases. J Med Chem. 2013 May 9;56(9):3507-17. | ||||
| REF 2 | 5-Benzamidoisoquinolin-1-ones and 5-(-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2). J Med Chem. 2011 Apr 14;54(7):2049-59. | ||||
| REF 3 | Design, synthesis and biological evaluation of 4-amidobenzimidazole acridine derivatives as dual PARP and Topo inhibitors for cancer therapy. Eur J Med Chem. 2017 Sep 29;138:1135-1146. | ||||
| REF 4 | Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) inhi... J Med Chem. 2009 Feb 12;52(3):868-77. | ||||
| REF 5 | Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose)polymerase inhibitors. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4501-5. | ||||
| REF 6 | Modeling of poly(ADP-ribose)polymerase (PARP) inhibitors. Docking of ligands and quantitative structure-activity relationship analysis. J Med Chem. 2001 Nov 8;44(23):3786-94. | ||||
| REF 7 | Structure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases. J Med Chem. 2013 Sep 12;56(17):7049-59. | ||||
| REF 8 | 4-(Phenoxy) and 4-(benzyloxy)benzamides as potent and selective inhibitors of mono-ADP-ribosyltransferase PARP10/ARTD10. Eur J Med Chem. 2018 Aug 5;156:93-102. | ||||
| REF 9 | Synthesis of substituted 5[H]phenanthridin-6-ones as potent poly(ADP-ribose)polymerase-1 (PARP1) inhibitors. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1687-90. | ||||
| REF 10 | Discovery and structure-activity relationships of modified salicylanilides as cell permeable inhibitors of poly(ADP-ribose) glycohydrolase (PARG). J Med Chem. 2011 Aug 11;54(15):5403-13. | ||||
| REF 11 | US patent application no. 9227982B2, 4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors | ||||
| REF 12 | Design, synthesis, and biological evaluation of a series of benzo[de][1,7]naphthyridin-7(8H)-ones bearing a functionalized longer chain appendage as novel PARP1 inhibitors. J Med Chem. 2013 Apr 11;56(7):2885-903. | ||||
| REF 13 | Development and structural analysis of adenosine site binding tankyrase inhibitors. Bioorg Med Chem Lett. 2016 Jan 15;26(2):328-333. | ||||
| REF 14 | Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors. J Med Chem. 2013 Jun 13;56(11):4320-42. | ||||
| REF 15 | Structure-based design of 2-aminopyridine oxazolidinones as potent and selective tankyrase inhibitors. ACS Med Chem Lett. 2013 Oct 21;4(12):1218-23. | ||||
| REF 16 | Identification of low micromolar dual inhibitors for aldose reductase (ALR2) and poly (ADP-ribose) polymerase (PARP-1) using structure based design approach. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2324-2330. | ||||
| REF 17 | Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors. Bioorg Med Chem. 2009 Nov 1;17(21):7537-41. | ||||
| REF 18 | Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases. Eur J Med Chem. 2016 Aug 8;118:316-27. | ||||
| REF 19 | Selective inhibition of PARP10 using a chemical genetics strategy. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4770-4773. | ||||
| REF 20 | Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase. J Med Chem. 2000 Nov 2;43(22):4084-97. | ||||
| REF 21 | Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14. Bioorg Med Chem Lett. 2018 Jun 15;28(11):2050-2054. | ||||
| REF 22 | Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics. Bioorg Med Chem. 2015 Aug 1;23(15):4139-4149. | ||||
| REF 23 | Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach. J Med Chem. 2017 Dec 28;60(24):10013-10025. | ||||
| REF 24 | Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity. J Med Chem. 2017 Jan 26;60(2):814-820. | ||||
| REF 25 | Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides. J Med Chem. 2018 Dec 13;61(23):10767-10792. | ||||
| REF 26 | Identification of novel PARP-1 inhibitors: Drug design, synthesis and biological evaluation. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4557-61. | ||||
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