Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T05114 | Target Info | |||
| Target Name | Chymase (CYM) | ||||
| Synonyms |
Mast cell protease I; CYH; Alpha-chymase
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| Target Type | Clinical trial Target | ||||
| Gene Name | CMA1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 17 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Methyl 3-(1-(6-(5-chloro-2-methoxybenzyl)-2,5-dioxo-1,4-diazepane-4-carboxamido)propyl)benzoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL248181; SCHEMBL1185882; BDBM50210737
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| Activity |
IC50 = 51400 nM
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[1] | |||
| Compound Name |
(S)-2-[3-(4-Cyano-benzoylamino)-2,2-dimethyl-undecanoylamino]-3-phenyl-propionic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL111745; BDBM50073132; N-[2,2-Dimethyl-3-[(4-cyanobenzoyl)amino]undecanoyl]-L-phenylalanine ethyl ester
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| Activity |
IC50 = 62000 nM
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[2] | |||
| Compound Name |
3-[3-(4-Chloro-benzenesulfonyl)-2,4-dioxo-imidazolidin-1-yl]-benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL69849; SCHEMBL7825119; BDBM50058988; 3-[3-(4-chlorophenyl)sulfonyl-2,4-dioxoimidazolidin-1-yl]benzoic acid
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| Activity |
IC50 = 65000 nM
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[3] | |||
| Compound Name |
6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-N-(1-phenylbutyl)-1,4-diazepane-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL391821; SCHEMBL1185816; BDBM50210732; 6-[(5-chloro-2-methoxyphenyl)methyl]-3,7-dioxo-N-(1-phenylbutyl)-1,4-diazepane-1-carboxamide
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| Activity |
IC50 = 69300 nM
|
[1] | |||
| Compound Name |
6-(3,5-Difluoroanilino)-9-(2,2-difluoroethyl)purine-2-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
compound 33 [PMID: 19908842]; CHEMBL578159; MLS002471784; GTPL8874; SCHEMBL3346407; HMS2213P07; HMS3348G08; BDBM50303436; NCGC00182115-01; NCGC00182115-02; SMR001395198; Q27076570; 9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-9H-purine-2-carbonitrile
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| Activity |
IC50 = 89125.09 nM
|
[4] | |||
| Compound Name |
5-Chloro-2-benzothiazolinone
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Investigative | Compound Info | ||
| Synonyms |
5-chlorobenzo[d]thiazol-2(3H)-one; 2(3H)-Benzothiazolone, 5-chloro-; 5-chloro-3H-1,3-benzothiazol-2-one; 5-CHLOROBENZOTHIAZOLONE; 5-Chloro-2(3H)-benzothiazolone; 5-Chloro-2-benzothiazolone; 5-Chloro-1,3-benzothiazol-2(3H)-one; Chlorobenzothiazolinone; 95%; CHEMBL2381489; 2-Benzothiazolol, 5-chloro-; PubChem13573; ACMC-209fce; 5-Chlorobenzothiazol-2-ol; KSC494O8T; 2-oxo-5-chlorobenzothiazoline; SCHEMBL507970; 5-chloro-3H-benzothiazol-2-one; CTK3J4789; DTXSID50345337; 5-chloro-1,3-benzothiazol-2-ol; KS-00000ZP7; STR05612; ZINC2528031; ANW-24156; BDBM50434116; MFCD00060125; AKOS006230208; CS-W016931; PS-3378; VZ30253; 5-Chloro-2-benzothiazolinone, AldrichCPR; SC-46605; 5-Chloro-1,3-benzothiazol-2(3H)-one #; DB-029110; FT-0620238; 5-chloro-2,3-dihydro-1,3-benzothiazol-2-one; K-5990; J-517387
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| Activity |
IC50 = 90000 nM
|
[5] | |||
| Compound Name |
[4-[3-(Aminomethyl)phenyl]piperidin-1-yl]-[5-(2-pyridin-2-ylethynyl)furan-2-yl]methanone;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1944897
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-{4-[3-(4-Chloro-benzenesulfonyl)-2,4-dioxo-imidazolidin-1-yl]-phenyl}-acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL67334; SCHEMBL7835283; BDBM50059008; N-[4-[3-(4-chlorophenyl)sulfonyl-2,4-dioxoimidazolidin-1-yl]phenyl]acetamide
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
[4-(3-Aminomethylphenyl)-piperidin-1-yl]-[5-(2-fluorophenylethynyl)-furan-2-yl]-methanone trifluoroacetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1944727; SCHEMBL6804030
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
1-Phenyl-3-phenylmethanesulfonyl-imidazolidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL69090; BDBM50058986
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
6-(5-Chloro-2-methoxybenzyl)-N-benzhydryl-3,7-dioxo-1,4-diazepane-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL396301; SCHEMBL1186735; BDBM50210723; N-benzhydryl-6-[(5-chloro-2-methoxyphenyl)methyl]-3,7-dioxo-1,4-diazepane-1-carboxamide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[3-(4-Chloro-benzenesulfonyl)-2,4-dioxo-imidazolidin-1-yl]-benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL302046; SCHEMBL7825815; BDBM50058991; 1-(4-carboxyphenyl)-3-(4-chlorobenzenesulfonyl)-imidazolidin-2,4-dione; 4-[3-(4-chlorophenyl)sulfonyl-2,4-dioxoimidazolidin-1-yl]benzoic acid
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| Activity |
IC50 = 100000 nM
|
[3] | |||
| Compound Name |
3-[1-(5-Phenylethynyl-furan-2-carbonyl)-piperidin-4-yl]-benzylamine trifluoroacetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1944726; SCHEMBL1381804
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
6-(5-Chloro-2-methoxybenzyl)-N-benzyl-N-methyl-3,7-dioxo-1,4-diazepane-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL398023; SCHEMBL1185410; BDBM50210726; N-benzyl-6-[(5-chloro-2-methoxyphenyl)methyl]-N-methyl-3,7-dioxo-1,4-diazepane-1-carboxamide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Brintonamide A
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4173913; BDBM50288833
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| Activity |
IC50 = 101000 nM
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[7] | |||
| Compound Name |
(S)-Ethyl 1-(5-(4-phenethoxybenzyl)-1,2,4-oxadiazol-3-yl)-6-amino-1-oxohexan-2-ylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL211561; BDBM50187800
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| Activity |
Ki ~ 150000 nM
|
[8] | |||
| Compound Name |
N-[(2S)-6-Amino-1-[5-[[4-[2-(3,4-dichlorophenyl)ethoxy]phenyl]methyl]-1,2,4-oxadiazol-3-yl]-1-oxohexan-2-yl]-3,4-difluorobenzamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL536972
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| Activity |
Ki ~ 150000 nM
|
[9] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 13 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
6-Chloroindole
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Investigative | Compound Info | ||
| Synonyms |
6-Chloro-1H-indole; 1H-Indole, 6-chloro-; 6-chloro indole; MFCD00005681; 6-Chloroindole, 99%; CHEMBL511085; 6-chloro-indole; NSC58083; EINECS 241-449-4; 6-chlor-1H-indole; PubChem1669; 6-chloro-1-H-indole; 6-Chloro-1H-indole #; SCHEMBL75475; KSC174M9P; ACMC-209e81; CTK0H4697; YTYIMDRWPTUAHP-UHFFFAOYSA-; DTXSID70169794; ZINC153934; ACN-P001106; ACN-S002831; ACT02478; ALBB-006051; BCP00061; KS-000004YN; ANW-22703; BBL013273; BDBM50434114; GEO-02877; NSC-58083; SBB004059; STK503689; AKOS000265598; AC-6211; CS-W001973; FS-1732; LS20474; MCULE-2699338313; SB34263; AK-27245; AM803344; BR-27245; SC-01721; SY002338; AB0014923; DB-031742; FT-0621074; FT-0621075; ST50824296; EN300-39394; A-1716; C17089; 422C332; Q27151419; Z1695906697
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| Activity |
IC50 = 340000 nM
|
[5] | |||
| Compound Name |
6-Chlorooxindole
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Investigative | Compound Info | ||
| Synonyms |
6-chloroindolin-2-one; 6-Chloro-1,3-dihydro-2H-indol-2-one; 6-Chloro-2-oxindole; 6-chloro-1,3-dihydroindol-2-one; 6-Chloro-2-indolinone; 6-Chloro 2-oxindole; 2H-Indol-2-one, 6-chloro-1,3-dihydro-; 6-chloroindole-2(3h)-one; MFCD00209962; 6-chloro-2,3-dihydro-1H-indol-2-one; 6-chloro-1,3-dihydro-indol-2-one; CHEMBL1232568; 6-Chlorooxindole, 98%; 6-chloro-oxindol; 6-chloro oxindole; 6-chloro-oxindole; zlchem 927; PubChem1674; 6-chloro-2-oxo-indole; 6-ctiloro-2-oxo-indole; 6-chloroindol-2(3h)-one; ACMC-1B12V; KSC492O1P; SCHEMBL221280; 6-Chloro-2-oxindole, 97%; IND066; CENVPIZOTHULGJ-UHFFFAOYSA-; CTK3J2717; DTXSID00353003; ZLD0393; ZINC157269; ACT06122; ALBB-021329; STR08222; ANW-32484; BBL009871; BDBM50434122; CC0122; SBB058442; STK709735; 6-Chloro-1,3,-dihydro-indol-2-one; AKOS000119599; AB04797; AC-2683; CS-W008657; MCULE-4425259060; KS-000004Z5; 6-chloro-1,3-dihydro-2h-indole-2-one; 6-chloroindole-1,3-dihydro(2h)-2-one; 6-chloro- 1,3-dihydro-2H-indol-2-one; AC-22698; AK-29404; BR-29404; SC-05371; SY002545; AB0008330; FT-0640375; ST50407077; EN300-17337; M-2864; 341C378; 5W-0082; Q27460049; F0001-1479
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| Activity |
IC50 = 470000 nM
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[5] | |||
| Compound Name |
(S)-2-[3-(4-Cyano-benzoylamino)-2,2-dimethyl-heptanoylamino]-3-phenyl-propionic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL109601; BDBM50073134; N-[2,2-Dimethyl-3-[(4-cyanobenzoyl)amino]heptanoyl]-L-phenylalanine ethyl ester
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| Activity |
IC50 = 510000 nM
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[2] | |||
| Compound Name |
6-Bromooxindole
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Investigative | Compound Info | ||
| Synonyms |
6-bromoindolin-2-one; 6-Bromo-2-oxindole; 6-Bromo-1,3-dihydro-2H-indol-2-one; 6-bromooxindol; 6-bromo-1,3-dihydroindol-2-one; 6-BROMO-2,3-DIHYDRO-1H-INDOL-2-ONE; 6-BROMO-2-OXYINDOLE; 6-BROMO-1,3-DIHYDRO-INDOL-2-ONE; 6-Bromo-2-indolinone; MFCD02179605; 2H-INDOL-2-ONE, 6-BROMO-1,3-DIHYDRO-; CHEMBL2381492; 6-bromoxindole; 6-bromoindolinone; 6-Bromo-oxindole; zlchem 59; 6-bromo-2 oxindole; PubChem7320; ACMC-209sci; 6-Bromooxindole, 97%; 6-bromo-2H-indol-2-one; SCHEMBL19982; 6-BROMO-2-OXOINDOLE; KSC492Q2P; 6-Bromo-2-oxindole, 97%; 6-BROMO-2-OXOINDOLINE; CTK3J2827; DTXSID90378341; EBD8293; ZLB0046; ACN-S004443; ACT02488; BCP26407; ZINC2577874; ANW-41008; BBL102683; BDBM50434121; MFCD22576660; STL556488; AKOS005258781; 6-bromo-1,2-dihydro-2h-indol-2-one; CM14364; CS-W008941; FS-2852; LS40256; PB24760; KS-000002Y9; 6- Bromo-1,3-dihydro-2H-indol-2-one; AK-26491; AM804635; BC003237; BR-26491; SC-07541; SY004439; AB0019541; DB-007138; B3601; FT-0601184; B-1302; 4-BROMO-1,3-DIHYDRO-2H-INDOLIN-2-ONE; 365B409; Q-102630; 6-Bromo-1,3-dihydro-2H-indol-2-one6-Bromooxindole; Q27452315
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| Activity |
IC50 = 570000 nM
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[5] | |||
| Compound Name |
4-Chloroindolin-2-One
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Investigative | Compound Info | ||
| Synonyms |
4-Chloro-2-oxindole; 4-CHLOROOXINDOLE; 4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE; 4-chloro-1,3-dihydroindol-2-one; 2H-Indol-2-one, 4-chloro-1,3-dihydro-; 4-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE; 4-chloro-2,3-dihydro-1H-indol-2-one; CHEMBL2380324; MFCD03787567; 2H-Indol-2-one,4-chloro-1,3-dihydro-; SCHEMBL624585; CTK4E5350; DTXSID80363201; KS-00000K1R; ZINC1393667; ANW-48985; BDBM50434119; SBB054564; AKOS000276784; AB15885; CS-W022163; MCULE-5507778018; AC-13967; AK-34054; BR-34054; SC-99199; SY009372; AB0023340; DB-066359; A4539; AM20030323; FT-0680473; W4375; S-3169; 5W-0090; 870C773; Q-102625
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| Activity |
IC50 > 1000000 nM
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[5] | |||
| Compound Name |
6-Chloroisoindolin-1-one
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Investigative | Compound Info | ||
| Synonyms |
6-Chloro-2,3-dihydro-1H-isoindol-1-one; 6-CHLORO-1-ISOINDOLINONE; 6-chloro-2,3-dihydroisoindol-1-one; 6-CHLORO-2,3-DIHYDRO-ISOINDOL-1-ONE; CHEMBL2381486; PubChem16925; SCHEMBL1760377; CTK1G8817; DTXSID50500404; 8589AB; BDBM50434113; MFCD08234734; ZINC39237328; AKOS006285499; MB05675; 6-chloranyl-2,3-dihydroisoindol-1-one; AK112120; AS-42840; 6-chloro-2, 3-dihydro-1H-isoindol-1-one; 6-chloro-2,3-dihydro-1H-isoindole-1-one; AB0085116; DB-072415; CS-0082122; FT-0757871; Y-3750; A831728; J-518620; Q27452313
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
6-Chloro-1-methylindolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2381490; 6-chloro-1-methyl-3H-indol-2-one; 6-chloro-1-methyl-1,3-dihydro-2h-indol-2-one; SCHEMBL1925736; BDBM50434115; ZINC83964561; 1-Methyl-6-chloro-2,3-dihydro-1H-indole-2-one
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| Activity |
IC50 > 1000000 nM
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[5] | |||
| Compound Name |
2-(1-Methoxyethylidene)-4-cyclopentene-1,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL48887; SCHEMBL5135404; BDBM50101138; 2-(1'-methoxyethylidene)cyclopent-4-ene-1,3-dione; 2-(1-methoxyethylidene)cyclopent-4-ene-1,3-dione; 2-(1-Methoxy-ethylidene)-cyclopent-4-ene-1,3-dione
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| Activity |
IC50 > 1000000 nM
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[10] | |||
| Compound Name |
Vaborbactam
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Investigative | Compound Info | ||
| Synonyms |
RPX-7009; RPX7009; UNII-1C75676F8V; CHEMBL3317857; 1C75676F8V; Vaborbactam [INN]; RPX 7009; Vaborbactam. RPX7009; Vaborbactam (USAN/INN); Vaborbactam [USAN:INN]; SCHEMBL620289; GTPL10871; Vabomere (vaborbactam + meropenem); EX-A2589; BDBM50089084; MFCD28502176; AKOS032961376; CS-6445; DB12107; SB17184; compound 9f [PMID: 25782055]; NCGC00510003-01; HY-19930; D10998; Q27252228
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| Activity |
IC50 > 1000000 nM
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[11] | |||
| Compound Name |
Oxindole
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Investigative | Compound Info | ||
| Synonyms |
Indolin-2-one; 2-Oxindole; 2-Indolinone; 1,3-Dihydro-2H-indol-2-one; 1,3-Dihydroindol-2-one; Oxindol; 2-Oxoindoline; Indol-2(3H)-one; 2H-Indol-2-one, 1,3-dihydro-; 2-Oxindoline; MFCD00005711; 2-OXOINDOLE; 1,3-dihydro-indol-2-one; 2,3-dihydro-1H-indol-2-one; UNII-0S9338U62H; NSC 274863; dihydroindolone; 0S9338U62H; Oxindole, 97%, pure; Indoline-2-one; DICLOFENAC IMPURITY E; Dihydroindolon; 2Oxindole; 2-Ketoindoline; indolin 2-one; Indolone, dihydro-; 1H-indol-2-one; 3H-indol-2-one; INDOLINONE; zlchem 289; PubChem7177; indolin-2(1H)-one; 2(1H,3H)indolone; 2-Oxindole, 97%; ACMC-209mdq; 2(1H,3H)-indolone; 2,3-Dihydroindole-2-one; SCHEMBL19504; 5-21-08-00007 (Beilstein Handbook Reference); KSC159M9T; ARONIS23976; CHEMBL40823; 1,3-dihydro-2H-indol-2-on; ARONIS023792; IND017; SCHEMBL4096312; SCHEMBL4787144; SCHEMBL4787148; SCHEMBL9305641; CTK0F9699; DTXSID80870389; ZLC0108; HMS1647D16; 1,3-dihydro-(2H)-indol-2-One; 1,3-Dihydro-2H-indol-2-one #; o-(Aminophenyl)-acetic acid lactam; ACT06984; BCP21784; CS-M2997; EBD53114; HY-Y0061; KS-000046EW; STR01316; ZINC2020050; ANW-33276; BBL010498; BDBM50434120; CX1001; NSC274863; RW3303; s4861; SBB004215; STK336410; AKOS000119409; 1,3-DIHYDRO-INDOL-2-ONE-D4; AB00523; AC-3269; CCG-266121; CG-0513; MCULE-2638897351; NSC-274863; KS-0000019Q; 2-Oxindole pound>>Diclofenac Impurity E; AK-49964; AM807053; BP-12514; BR-49964; SC-05596; SY004718; 2-Oxindole, purum, >=97.0% (HPLC); 2H-Indol-2-one, 1,3-dihydro- (9CI); AB0010842; DB-011627; BB 0257524; FT-0631265; O0272; ST45053125; AZ0001-0391; EN300-20422; C12312; M-3413; 28249-EP2313371A1; 71692-EP2308867A2; 71692-EP2308870A2; 72340-EP2292593A2; 72340-EP2295550A2; 72340-EP2298778A1; 72340-EP2305688A1; 72340-EP2307421A1; 72340-EP2308867A2; 72340-EP2308870A2; 005O711; 147141-EP2281822A1; 147141-EP2292613A1; 153189-EP2281822A1; 174512-EP2280953A1; AH-034/32845032; J-400304; Q2018788; F0918-7910; Z1245635865
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| Activity |
IC50 > 1000000 nM
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[5] | |||
| Compound Name |
7-Chloroindolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
7-Chlorooxindole; 7-Chloro-1,3-dihydro-2H-indol-2-one; 7-Chloro-2-oxindole; 7-chloro-1,3-dihydroindol-2-one; 2H-Indol-2-one, 7-chloro-1,3-dihydro-; CHEMBL2381488; MFCD06656001; 7-chloro-2-oxo-1,2-dihydro-indole; 7- Chlorooxindole; PubChem8305; 7-chlor-oindolin-2-one; ACMC-1AG47; KSC911G1B; 7-Chloro-2-oxindole, 97%; IND016; SCHEMBL1162926; CTK8B1310; ACT06669; EBD50541; KS-00000J9V; ZINC4369030; ANW-25707; BDBM50434117; AKOS005258603; AB25436; CM14306; CS-W008306; MCULE-8508297770; QC-4363; 1H-Indazole-3-carboxylicacid,7-chloro-; 2H-Indol-2-one,7-chloro-1,3-dihydro-; AC-22699; AK-31070; AS-32983; 7-CHLORO-1,3-DIHYDRO-INDOL-2-ONE; AB0030808; FT-0656933; X3054; K-6669; Q-102632
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
4-Phenyl-2-phenylcarboxamidopentanoic anhydride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL131747; BDBM50075115
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| Activity |
IC50 > 1000000 nM
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[12] | |||
| Compound Name |
5-Chlorooxindole
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Investigative | Compound Info | ||
| Synonyms |
5-chloroindolin-2-one; 5-Chloro-2-oxindole; 5-Chloro-1,3-dihydro-2H-indol-2-one; 5-Chloro-2-indolinone; 5-chloro-1,3-dihydroindol-2-one; 2H-Indol-2-one, 5-chloro-1,3-dihydro-; 5-Chloro-1,3-dihydro-indol-2-one; MFCD00191927; CHEMBL2381491; 5-CHLOROINDOLE-2(3H)-ONE; 5-CHLORO-2,3-DIHYDRO-1H-INDOL-2-ONE; 2-Indolinone, 5-chloro-; isobornylacetate; 5-Chlorooxindol; 5-chloro oxindole; 5-chloro-oxindole; PubChem1673; ACMC-1C4AO; EC 412-200-9; DSSTox_CID_31456; DSSTox_RID_97342; DSSTox_GSID_57667; SCHEMBL154614; 5-Chloro-2-oxindole, 98%; DTXSID6057667; CTK0H9114; KS-00000ZJX; WWJLCYHYLZZXBE-UHFFFAOYSA-; ZINC161358; ACT03556; ALBB-006976; BCP26861; STR09458; Tox21_113839; 5-chloro-1,3-dihydro-indole-2-one; ANW-22818; BBL012997; BDBM50434118; CCG-47695; GEO-00772; QC-523; SBB003879; STK509606; AKOS000119598; AB04636; AC-5466; FS-1780; MCULE-8270180184; Indol-2-one, 5-chloro-1,3-dihydro-; NCGC00253720-01; BR-32268; SC-01823; 5-Chloro-1,3-dihydro-2H-indol-2-one #; DB-007029; A5121; AM20090789; FT-0601329; ST50405629; B-2268; 72287-EP2308867A2; 72287-EP2308870A2; 630C750; SR-01000637295-1; BRD-K79714066-001-01-6; Z256709066
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| Activity |
IC50 > 1000000 nM
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[5] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Development of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as orally active human chymase inhibitors. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3435-9. | ||||
| REF 2 | N-[2,2-dimethyl-3-(N-(4-cyanobenzoyl)amino)nonanoyl]-L-phenylalanine ethyl ester as a stable ester-type inhibitor of chymotrypsin-like serine proteases: structural requirements for potent inhibition of alpha-chymotrypsin. J Med Chem. 1999 Jan 28;42(2):312-23. | ||||
| REF 3 | Substituted 3-(phenylsulfonyl)-1-phenylimidazolidine-2,4-dione derivatives as novel nonpeptide inhibitors of human heart chymase. J Med Chem. 1997 Jul 4;40(14):2156-63. | ||||
| REF 4 | Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem. 2010 Jan 14;53(1):52-60. | ||||
| REF 5 | Discovery of potent, selective chymase inhibitors via fragment linking strategies. J Med Chem. 2013 Jun 13;56(11):4465-81. | ||||
| REF 6 | Structure-based library design and the discovery of a potent and selective mast cell -tryptase inhibitor as an oral therapeutic agent. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1049-54. | ||||
| REF 7 | Discovery, Synthesis, Pharmacological Profiling, and Biological Characterization of Brintonamides A-E, Novel Dual Protease and GPCR Modulators from a Marine Cyanobacterium. J Med Chem. 2018 Jul 26;61(14):6364-6378. | ||||
| REF 8 | Novel, potent, selective, and orally bioavailable human betaII-tryptase inhibitors. Bioorg Med Chem Lett. 2006 Aug 1;16(15):4085-9. | ||||
| REF 9 | Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3434-9. | ||||
| REF 10 | Total synthesis of human chymase inhibitor methyllinderone and structure--activity relationships of its derivatives. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1695-7. | ||||
| REF 11 | Discovery of a Cyclic Boronic Acid -Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. J Med Chem. 2015 May 14;58(9):3682-92. | ||||
| REF 12 | Symmetrical anhydride-type serine protease inhibitors: structure-activity relationship studies of human chymase inhibitors. Bioorg Med Chem Lett. 1999 Feb 8;9(3):413-8. | ||||
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