Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T05031 | Target Info | |||
| Target Name | PI3-kinase beta (PIK3CB) | ||||
| Synonyms |
p110beta; PtdIns3kinase subunit p110beta; PtdIns3kinase subunit beta; PtdIns-3-kinase subunit p110-beta; PtdIns-3-kinase subunit beta; Phosphatidylinositol 4,5bisphosphate 3kinase catalytic subunitbeta isoform; Phosphatidylinositol 4,5bisphosphate 3kinase 110 kDa catalyticsubunit beta; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; PIK3C1; PI3kinase subunit beta; PI3Kbeta; PI3K-beta; PI3-kinase subunit beta
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| Target Type | Clinical trial Target | ||||
| Gene Name | PIK3CB | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 103 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Dasatinib
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Approved | Compound Info | ||
| Synonyms |
Sprycel (TN); BMS 354825; BMS-354825; BMS-354825, Sprycel, BMS354825, Dasatinib; BMS354825; Dasatinib (USAN); Dasatinib [USAN]; Dasatinib anhydrous; Dasatinib, BMS 354825; Dasatinibum; Sprycel; Spyrcel
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Sorafenib
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Approved | Compound Info | ||
| Synonyms |
Nexavar; Sorafenibum; Sorafenib [INN]; Nexavar (TN); Sorafenib (INN); N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea; N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea; N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcar bamoyl)-4-pyridyloxy)phenyl)urea; 4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide; 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate; 4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide; 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE; Sorafenib (Pan-TK inhibitor)
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
PMID28460551-Compound-2
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Patented | Compound Info | ||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
IC87114
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Investigative | Compound Info | ||
| Synonyms |
IC-87114; 371242-69-2; IC87114; 2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one; IC 87114; UNII-9HC746B1KF; 2-[(6-AMINO-9H-PURIN-9-YL)METHYL]-5-METHYL-3-(2-METHYLPHENYL)-4(3H)-QUINAZOLINONE; 9HC746B1KF; CHEMBL1213082; CHEBI:90686; D-030; 2-[(6-aminopurin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-one; 2-[(6-Amino-9h-Purin-9-Yl)methyl]-5-Methyl-3-(2-Methylphenyl)quinazolin-4(3h)-One; BiomolKI2_000002; GNWHRHGTIBRNSM-UHFFFAOYSA-N; PubChem22453; MLS006011148; SCHEMBL360745; GTPL9376; EX-A326
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| Activity |
IC50 = 75000 nM
|
[2] | |||
| Compound Name |
(R)-2-(3-Benzylmorpholino)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL477787; BDBM50262406
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Tert-Butyl {4-[4-Amino-1-(Propan-2-Yl)-1h-Pyrazolo[3,4-D]pyrimidin-3-Yl]-2-Methoxyphenyl}carbamate
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Investigative | Compound Info | ||
| Synonyms |
tert-butyl 4-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenylcarbamate; SCHEMBL2429870; CHEMBL1241481; Q27467124; tert-butyl 4-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d] pyrimidin-3-yl)-2-methoxyphenylcarbamate; tert-butyl N-[4-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl]carbamate
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[b]thiophene-5-carbaldehyde
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2437351; CHEMBL1241684; 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[b] thiophene-5-carbaldehyde; 2-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1-benzothiophene-5-carbaldehyde
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
10-(4-Methoxyphenyl)-2-morpholin-4-ylbenzo[g]chromen-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3915703; BDBM50200519
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-p-Tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3782102; CHEMBL1241142; ZINC8581882; 3-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine; 3-(4-Methylphenyl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine; 3-(4-methylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
2-Morpholin-4-yl-10-phenylbenzo[g]chromen-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3945937; BDBM50200518
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(S)-5,5-Dimethyl-2-(3-phenylmorpholino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL469059; BDBM50262359
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
1-Benzyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241585; 1-benzyl-3-naphthalen-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
5,5-Dimethyl-2-(3-(naphthalen-2-ylmethyl)morpholino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL476953; SCHEMBL1177016; BDBM50262409; 5,5-dimethyl-2-[3-(naphthalen-2-ylmethyl)morpholin-4-yl]-4,6-dihydro-1,3-benzothiazol-7-one
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Phenol, 3-[4-amino-7-(1-methylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL407936; CHEMBL1241269; CTK3D2700; DTXSID00459534; 3-(4-amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidin-5-yl)phenol
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
3-(2,3-Dimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241145; 3-(2,3-dimethylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
(R)-5,5-Dimethyl-2-(3-phenylmorpholino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL512470; BDBM50262358
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
4-(5-Morpholin-4-yl-7-oxothieno[3,2-b]pyran-3-yl)benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2322231; SCHEMBL13000075; BDBM50427465
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
1-Cyclopentyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241584; 1-cyclopentyl-3-naphthalen-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
1-Isopropyl-3-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3610353; CHEMBL1241390; US9765037, Compound 16; BDBM340889; 1-propan-2-yl-3-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-amine; 1-isopropyl-3-(pyridin-3-yl)-1H-pyrazolo[3,4- d]pyrimidin-4-amine
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
(R)-2-(3-((1H-Indol-3-yl)methyl)morpholino)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL514061; SCHEMBL1177185; BDBM50262410; 2-[(3R)-3-(1H-indol-3-ylmethyl)morpholin-4-yl]-5,5-dimethyl-4,6-dihydro-1,3-benzothiazol-7-one
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
3-(4-Methylphenyl)-5-morpholin-4-ylthieno[3,2-b]pyran-7-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2326970; SCHEMBL13000110; BDBM50427472
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
1-Allyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241488; 3-naphthalen-2-yl-1-prop-2-enylpyrazolo[3,4-d]pyrimidin-4-amine
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
3-(Naphthalen-2-yl)-1-phenethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5136625; CHEMBL1242382; 3-naphthalen-2-yl-1-(2-phenylethyl)pyrazolo[3,4-d]pyrimidin-4-amine
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
4-(2-Amino-1,3-benzothiazol-6-yl)-1-ethylpyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600778; BDBM50107242
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| Activity |
IC50 = 50118.72 nM
|
[6] | |||
| Compound Name |
3-(3-Bromo-5-methoxyphenyl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3607978; CHEMBL1242200; 3-(3-bromo-5-methoxyphenyl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
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| Activity |
IC50 = 50300 nM
|
[1] | |||
| Compound Name |
2-[5-[(2-Fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-5-methoxyphenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2018265; BDBM50381608
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| Activity |
IC50 = 51750 nM
|
[7] | |||
| Compound Name |
3-(H-Imidazo[1,2-a]pyridin-7-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242665
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| Activity |
IC50 = 52000 nM
|
[1] | |||
| Compound Name |
1-Methyl-1h-pyrrolo[2,3-c]pyridin-5-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1645109; SCHEMBL3481247; CTK8E3269; BDBM50333225; ZINC66259917; AKOS006363557; 1-methylpyrrolo[2,3-c]pyridin-5-amine
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| Activity |
IC50 = 57000 nM
|
[8] | |||
| Compound Name |
8-Ethyl-11-(4-methoxyphenyl)-13-morpholin-4-yl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589321; BDBM50094952
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| Activity |
IC50 = 58430 nM
|
[9] | |||
| Compound Name |
5-(Pyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1645098; BDBM50333213
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| Activity |
IC50 = 62000 nM
|
[8] | |||
| Compound Name |
4-(Benzylamino)-2-morpholin-4-yl-1H-pyrimidin-6-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2158425; BDBM50393993
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| Activity |
IC50 = 63000 nM
|
[10] | |||
| Compound Name |
4-(2-Amino-1,3-benzothiazol-6-yl)-1-methylpyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600777; BDBM50107241
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| Activity |
IC50 = 63095.73 nM
|
[6] | |||
| Compound Name |
3-(Benzofuran-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3613345; CHEMBL1241490; 3-(1-benzofuran-5-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
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| Activity |
IC50 = 67200 nM
|
[1] | |||
| Compound Name |
11-(4-Methoxyphenyl)-13-morpholin-4-yl-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589323; BDBM50094954
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| Activity |
IC50 = 78290 nM
|
[9] | |||
| Compound Name |
5-(2-Amino-1,3-benzothiazol-6-yl)-N,N-dimethylpyridine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600697; BDBM50107271
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| Activity |
IC50 = 79432.82 nM
|
[6] | |||
| Compound Name |
6-[6-(Methylaminomethyl)pyridin-3-yl]-1,3-benzothiazol-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600686; BDBM50107262
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| Activity |
IC50 = 79432.82 nM
|
[6] | |||
| Compound Name |
5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-3-methylthiophene-2-carbaldehyde
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2468032; CHEMBL1241947; 5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-3-methylthiophene-2-carbaldehyde
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| Activity |
IC50 = 80000 nM
|
[1] | |||
| Compound Name |
2-Pyridin-4-yl-benzooxazol-5-ylamine
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Investigative | Compound Info | ||
| Synonyms |
2-(pyridin-4-yl)-1,3-benzoxazol-5-amine; 2-(pyridin-4-yl)benzo[d]oxazol-5-amine; 2-pyridin-4-yl-1,3-benzoxazol-5-amine; CHEMBL1645099; 2-(4-pyridyl)benzoxazole-5-ylamine; Oprea1_262137; CBDivE_012963; SCHEMBL4076162; CTK4H3354; DTXSID90352904; ZINC155043; ALBB-006224; 2-(4-Pyridinyl)-5-benzoxazolamine; 1121AE; BBL012052; BDBM50333214; MFCD00448006; SBB007305; STK026134; 2-Pyridin-4-ylbenzooxazol-5-yl amine; AKOS000108388; CCG-109259; MCULE-8999136327; VS-03182; 5-amino-2-(pyridine-4-yl)benzo[d]oxazole; 5-amino-2-(pyridine-4-yl) benzo[d]oxazole; BB 0245215; EU-0041953; H2652; ST50024827; SR-01000465976; SR-01000465976-1
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| Activity |
IC50 = 81000 nM
|
[8] | |||
| Compound Name |
2-(Aminomethyl)-N-benzyl-6-morpholin-4-ylpyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2158432; BDBM50393991
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| Activity |
IC50 = 87000 nM
|
[10] | |||
| Compound Name |
3-(3-Aminophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241357; 3-(3-aminophenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
8-Chloro-6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064569; BDBM50389429
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
5-(4-Amino-1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242750
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(4-Nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL1320032; CHEMBL1241358; 3-(4-nitrophenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Tert-Butyl-3-Naphthalen-2-Yl-1h-Pyrazolo[3,4-D]pyrimidin-4-Amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1231371; 1-tert-butyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; NA-PP2; SCHEMBL1964558; 1-tert-butyl-3-naphthalen-2-ylpyrazolo[3,4-d]pyrimidin-4-amine; BDBM50345704; NCGC00167637-01; Q27458432; 1-tert-butyl-3-(2-naphthyl)pyrazolo[3,4-d]pyrimidin-4-amine; 4-Amino-1-tert-butyl-3-(2-naphthyl)pyrazolo[3,4-d]pyrimidine; 1-(tert-butyl)-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3)
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
5-Methoxy-2-[5-[(3-nitrophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]phenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2018271; BDBM50381604
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1-Isopropyl-3-(3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2467650; CHEMBL1242029; 3-(3-methoxyphenyl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3616915; CHEMBL1241391; US9765037, Compound 18; BDBM340891; 1-propan-2-yl-3-pyrimidin-5-ylpyrazolo[3,4-d]pyrimidin-4-amine; 1-isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4- d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-o-Tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241144; SCHEMBL21048476; 3-(2-methylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
5-Methyl-2-[5-[(4-nitrophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2018413; BDBM50381606
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-Methoxy-6-phenyl-3-(5-pyridin-4-yl-[1,2,4]oxadiazol-3-yl)-pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL565432; BAS 08315390; ZINC498608; BDBM50302394; STL004588; AKOS001696103; CCG-119395; MCULE-5737154573; 2-methoxy-6-phenyl-3-[5-(pyridin-4-yl)-1,2,4-oxadiazol-3-yl]pyridine; 3-(2-methoxy-6-phenylpyridin-3-yl)-5-(pyridin-4-yl)-1,2,4-oxadiazole
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-(4-Amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(4-Amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-phenol; CHEMBL1241355; J-002258; (6Z)-6-(4-amino-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-ylidene)cyclohexa-2,4-dien-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Isopropyl-3-(isoquinolin-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242207
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-(3-Methylbutyl)-3-naphthalen-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242474
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(2-Chloroquinolin-3-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242663
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Methyl-3-(4-phenylmethoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL130425; CHEMBL1242206
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
2-[4-Amino-3-(3-ethoxy-4-methoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]ethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242753
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(1-Isopropyl-4-(methylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241942
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Isopropyl-3-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242660; SCHEMBL3602391; BDBM50345734; 1-propan-2-yl-3-(3,4,5-trimethoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1h-pyrazolo[3,4-d]pyrimidin-4-amine,3-phenyl-; 3-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (17); SCHEMBL408618; PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE, 3-PHENYL-; SCHEMBL8326897; CHEMBL1241104; BDBM123758; BDBM178081; ZINC8581881; MB69429; 3-phenyl-2H-pyrazolo[3,4-d]pyrimidin-4-amine; 3-phenyl-1h-pyrazolo[3,4-d]pyrimidine-4-amine; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-phenyl-
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
5-(2-Amino-7-fluoro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-tert-butylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064572; BDBM50389421
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
1-(Cyclopropylmethyl)-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5065412; CHEMBL1242473; 1-(cyclopropylmethyl)-3-naphthalen-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine; Ibrutinib N-2; Ibrutinib deacryloylpiperidine; MFCD20270360; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(4-phenoxyphenyl)-; C17H13N5O; SCHEMBL200349; CHEMBL1242204; BCP08092; CS-M2418; KS-00000A8A; 3209AH; ABP001124; ZINC64527573; AKOS024464512; AKOS032949962; CM11014; DS-7365; AC-28742; AK161694; DA-25126; HY-78727; SC-01281; SY032999; FT-0696694; 4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyri; Z2753057767; 3-(4-phenoxyphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(4-Aminophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241356; 3-(4-aminophenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(3-(Benzyloxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242291; SCHEMBL21048477; 3-(3-phenylmethoxyphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(1,2,3,4-Tetrahydronaphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241440; 3-(1,2,3,4-tetrahydronaphthalen-2-yl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
6-(4-Amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241864
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Isopropyl-3-(2,3-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3613209; CHEMBL1242751; 3-(2,3-dimethoxyphenyl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-Methyl-3-(3-phenylphenyl)pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242849
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(4-Tert-butylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5088174; CHEMBL1241240; 3-(4-tert-butylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(Naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3605078; CHEMBL1241441; BDBM123759; BDBM178082; 3-naphthalen-2-yl-2H-pyrazolo[3,4-d]pyrimidin-4-amine; 3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (18)
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
2-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenylamino)propan-1-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3605044; CHEMBL1241486; 2-[4-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyanilino]propan-1-ol
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
Tert-butyl 5-(4-amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indole-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3604275; CHEMBL1242853; tert-butyl 5-(4-amino-1-cyclopentylpyrazolo[3,4-d]pyrimidin-3-yl)indole-1-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(3-(2,6-Dichlorobenzyloxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242292; 3-[3-[(2,6-dichlorophenyl)methoxy]phenyl]-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
5-[[(5,6-Dimethyl-4-thieno[2,3-d]pyrimidinyl)thio]methyl]-2-furancarboxylic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL579219; MLS000098595; HMS1735N05; HMS2472F22; ZINC3495367; BDBM50302390; AKOS016644433; MCULE-7517981492; SMR000065125; SR-01000074855; SR-01000074855-1; Q27210712; Z20229806
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
8-Methyl-7-[2-(4-methylpiperazin-1-yl)ethoxy]-2-morpholin-4-yl-1,3-benzoxazin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL244672; BDBM50401468
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
3-(3-(Benzyloxy)-4-methyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242025
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorobenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3616930; CHEMBL1241771; ZINC43465534; 4-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorobenzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
2-(4-Amino-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242383; SCHEMBL14655830; 2-(4-amino-3-naphthalen-2-ylpyrazolo[3,4-d]pyrimidin-1-yl)acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
3-(3-Nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241389; 3-(3-nitrophenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
5-(4-Amino-1-((piperidin-3-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-chlorophenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241858
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
2-[5-[(4-Fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-5-methoxyphenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2018266; BDBM50381603
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1,7-Dimethyl-1H-pyrazolo[3,4-b]quinolin-3-yl 2-phenoxyacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL568574; BDBM50302391
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
3-(3-Phenoxyphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242205
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorobenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3608290; CHEMBL1241680; 5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorobenzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-[6-(2-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064478; SCHEMBL3098937; BDBM50389389
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
3-(4-Biphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL5065122; CHEMBL1242850; 3-(4-phenylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
5-[4-Amino-1-(2,2-diethoxyethyl)pyrazolo[3,4-d]pyrimidin-3-yl]-1,3-benzoxazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
eCF309; eCF-309; eCF 309; GTPL9571; CHEMBL3800481; SCHEMBL22773819; BDBM200300; cid_122163152; AKOS030211008; ZINC585672921; compound 12 [Fraser et al., 2016]; J3.595.265I
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
2-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)acetonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2439340; CHEMBL1240545; 2-[4-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)phenyl]acetonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
5-(4-Amino-1-((4-phenyloxazol-5-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1241482
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
1-[6-[5-(Tert-butylsulfamoyl)pyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-phenylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2057359; BDBM50387533
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
4-N-Benzyl-6-morpholin-4-ylpyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2158430; BDBM50393992; SR-01000648934; SR-01000648934-1
Click to Show/Hide
|
||||
| Activity |
IC50 = 110000 nM
|
[10] | |||
| Compound Name |
11-(3-Methoxyphenyl)-13-morpholin-4-yl-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589322; BDBM50094953
Click to Show/Hide
|
||||
| Activity |
IC50 = 113450 nM
|
[9] | |||
| Compound Name |
4-(1-(7-Fluoro-3-methyl-2-(2-pyridinyl)-4-quinolinyl)-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-6-methyl-2-pyrimidinamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2171928; SCHEMBL2124906; BDBM50396615
Click to Show/Hide
|
||||
| Activity |
Ki ~ 125000 nM
|
[16] | |||
| Compound Name |
1-(Cyclopropylmethyl)-4-(2-aminobenzothiazole-6-yl)pyridine-2(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600779; BDBM50107243
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 125892.54 nM
|
[6] | |||
| Compound Name |
N-Benzyl-4-methyl-6-morpholin-4-ylpyrimidin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SMR000108181; MLS000112267; ChemDiv1_009220; Cambridge id 6768656; Oprea1_577115; cid_721057; CHEMBL1327614; BDBM37251; HMS613D02; HMS2505H22; ZINC123002; STK831409; AKOS003595284; MCULE-6054493502; EU-0010714; AB00118664-01; N-Benzyl-4-methyl-6-morpholinopyrimidine-2-amine; SR-01000486033; benzyl-(4-methyl-6-morpholino-pyrimidin-2-yl)amine; SR-01000486033-1; N-benzyl-4-methyl-6-(morpholin-4-yl)pyrimidin-2-amine; 4-methyl-6-(4-morpholinyl)-N-(phenylmethyl)-2-pyrimidinamine; 4-methyl-6-morpholin-4-yl-N-(phenylmethyl)pyrimidin-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[10] | |||
| Compound Name |
1-(Cyclopropylmethyl)-4-[2-(oxan-4-ylmethylamino)-1,3-benzothiazol-6-yl]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600781; BDBM50107248
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 199526.23 nM
|
[6] | |||
| Compound Name |
1-(Cyclopropylmethyl)-4-[2-[[(1R)-1-(oxan-4-yl)ethyl]amino]-1,3-benzothiazol-6-yl]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600782; BDBM50107254
Click to Show/Hide
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||||
| Activity |
IC50 ~ 199526.23 nM
|
[6] | |||
| Compound Name |
1-(Cyclopropylmethyl)-4-[2-[[(1S)-1-(oxan-4-yl)ethyl]amino]-1,3-benzothiazol-6-yl]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600783; BDBM50107255
Click to Show/Hide
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||||
| Activity |
IC50 ~ 199526.23 nM
|
[6] | |||
| Compound Name |
1-(Cyclopropylmethyl)-4-[2-[(1,1-dioxothian-4-yl)methylamino]-1,3-benzothiazol-6-yl]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600784; BDBM50107256
Click to Show/Hide
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||||
| Activity |
IC50 ~ 199526.23 nM
|
[6] | |||
| Compound Name |
trans-4-[[[6-[1-(Cyclopropylmethyl)-1,2-dihydro-2-oxo-4-pyridinyl]-2-benzothiazolyl]amino]methyl]-cyclohexanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
AZ044; CHEMBL3600785; BDBM50107257; SB19683
Click to Show/Hide
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||||
| Activity |
IC50 ~ 199526.23 nM
|
[6] | |||
| Compound Name |
N-[7-Methyl-6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064566; BDBM50389416
Click to Show/Hide
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||||
| Activity |
IC50 = 199526.23 nM
|
[11] | |||
| Compound Name |
4-(2-Amino-1,3-benzothiazol-6-yl)-1-(2-methoxyethoxy)pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600780; BDBM50107244
Click to Show/Hide
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||||
| Activity |
IC50 ~ 199526.23 nM
|
[6] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 19 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
PMID28870136-Compound-52
Click to Show/Hide
|
Patented | Compound Info | ||
| Activity |
IC50 = 400000 nM
|
[2] | |||
| Compound Name |
PMID28870136-Compound-48
Click to Show/Hide
|
Patented | Compound Info | ||
| Activity |
IC50 = 800000 nM
|
[2] | |||
| Compound Name |
13-Morpholin-4-yl-11-(morpholin-4-ylmethyl)-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589373; BDBM50094944
Click to Show/Hide
|
||||
| Activity |
IC50 = 323450 nM
|
[9] | |||
| Compound Name |
Chembl4228200
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50460340
Click to Show/Hide
|
||||
| Activity |
IC50 = 355000 nM
|
[17] | |||
| Compound Name |
13-Morpholin-4-yl-11-(1-morpholin-4-ylethyl)-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589374; BDBM50094945
Click to Show/Hide
|
||||
| Activity |
IC50 = 418160 nM
|
[9] | |||
| Compound Name |
Chembl4229035
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50460339
Click to Show/Hide
|
||||
| Activity |
IC50 = 430000 nM
|
[17] | |||
| Compound Name |
CID 44621448
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205767; SCHEMBL3222900; BDBM50401153; 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(2,2,2-trifluoroethyl)pyridine-3-sulfonamide
Click to Show/Hide
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||||
| Activity |
IC50 = 12589254.12 nM
|
[18] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N,N-diethylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205771; SCHEMBL3226533; BDBM50401144
Click to Show/Hide
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||||
| Activity |
IC50 = 25118864.32 nM
|
[18] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-benzylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205770; SCHEMBL3225926; BDBM50401145
Click to Show/Hide
|
||||
| Activity |
IC50 = 25118864.32 nM
|
[18] | |||
| Compound Name |
5-(2-Amino-5-fluoro-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205763; SCHEMBL3258676; BDBM50401150
Click to Show/Hide
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||||
| Activity |
IC50 = 31622776.6 nM
|
[18] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-propylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205764; SCHEMBL3234064; BDBM50401151
Click to Show/Hide
|
||||
| Activity |
IC50 = 31622776.6 nM
|
[18] | |||
| Compound Name |
CID 44621449
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205768; SCHEMBL13536557; BDBM50401147
Click to Show/Hide
|
||||
| Activity |
IC50 = 31622776.6 nM
|
[18] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-phenylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205769; SCHEMBL3232284; BDBM50401142
Click to Show/Hide
|
||||
| Activity |
IC50 = 31622776.6 nM
|
[18] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)pyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205773; SCHEMBL3228404; BDBM50401149
Click to Show/Hide
|
||||
| Activity |
IC50 = 39810717.06 nM
|
[18] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-methylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205774; SCHEMBL3234736; BDBM50401143
Click to Show/Hide
|
||||
| Activity |
IC50 = 39810717.06 nM
|
[18] | |||
| Compound Name |
7-(5-Methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2203312; SCHEMBL3262808; BDBM50401141
Click to Show/Hide
|
||||
| Activity |
IC50 = 39810717.06 nM
|
[18] | |||
| Compound Name |
7-[5-(2,2-Dimethylazetidin-1-yl)sulfonylpyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205772; BDBM50401146
Click to Show/Hide
|
||||
| Activity |
IC50 = 50118723.36 nM
|
[18] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205766; SCHEMBL3226712; BDBM50401152; ZINC95562659
Click to Show/Hide
|
||||
| Activity |
IC50 = 50118723.36 nM
|
[18] | |||
| Compound Name |
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-propan-2-ylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2205765; SCHEMBL3226438; BDBM50401148
Click to Show/Hide
|
||||
| Activity |
IC50 = 63095734.45 nM
|
[18] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. | ||||
| REF 2 | Small molecules targeting phosphoinositide 3-kinases. Medchemcomm. 2012;3:1337-55. | ||||
| REF 3 | 4-(1,3-Thiazol-2-yl)morpholine derivatives as inhibitors of phosphoinositide 3-kinase. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4316-20. | ||||
| REF 4 | Synthesis of linear and angular aryl-morpholino-naphth-oxazines, their DNA-PK, PI3K, PDE3A and antiplatelet activity. Bioorg Med Chem Lett. 2016 Nov 15;26(22):5534-5538. | ||||
| REF 5 | Synthesis and cancer stem cell-based activity of substituted 5-morpholino-7H-thieno[3,2-b]pyran-7-ones designed as next generation PI3K inhibitors. J Med Chem. 2013 Mar 14;56(5):1922-39. | ||||
| REF 6 | Discovery of potent, selective small molecule inhibitors of alpha-subtype of type III phosphatidylinositol-4-kinase (PI4KIIIalpha). Bioorg Med Chem Lett. 2015 Aug 15;25(16):3189-93. | ||||
| REF 7 | Synthesis, biological evaluation and molecular docking studies of 1,3,4-oxadiazole derivatives as potential immunosuppressive agents. Bioorg Med Chem. 2012 May 15;20(10):3359-67. | ||||
| REF 8 | Discovery of novel class 1 phosphatidylinositide 3-kinases (PI3K) fragment inhibitors through structure-based virtual screening. Bioorg Med Chem Lett. 2011 Jan 15;21(2):829-35. | ||||
| REF 9 | Design, synthesis and biological evaluation of novel condensed pyrrolo[1,2-c]pyrimidines featuring morpholine moiety as PI3Kalpha inhibitors. Eur J Med Chem. 2015 Jun 24;99:1-13. | ||||
| REF 10 | Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing Phosphoinositide 3-kinase (PI3K) p110 isoform inhibitors through structure-based fragment optimisation. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6665-70. | ||||
| REF 11 | SAR studies around a series of triazolopyridines as potent and selective PI3K inhibitors. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5257-63. | ||||
| REF 12 | Phosphoinositide-3-kinase (PI3K) inhibitors: identification of new scaffolds using virtual screening. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5842-7. | ||||
| REF 13 | Synthesis, DNA-PK inhibition, anti-platelet activity studies of 2-(N-substituted-3-aminopyridine)-substituted-1,3-benzoxazines and DNA-PK and PI3K inhibition, homology modelling studies of 2-morpholino-(7,8-di and 8-substituted)-1,3-benzoxazines. Eur J Med Chem. 2012 Nov;57:85-101. | ||||
| REF 14 | eCF309: a potent, selective and cell-permeable mTOR inhibitor. Medchemcomm. 2016;7:471-7. | ||||
| REF 15 | Discovery of novel PI3K/ inhibitors as potential agents for inflammation. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4546-9. | ||||
| REF 16 | Discovery and in vivo evaluation of dual PI3K/ inhibitors. J Med Chem. 2012 Sep 13;55(17):7667-85. | ||||
| REF 17 | Design and synthesis of 1,4-substituted 1H-1,2,3-triazolo-quinazolin-4(3H)-ones by Huisgen 1,3-dipolar cycloaddition with PI3K isoform selective activity. Bioorg Med Chem Lett. 2018 Apr 1;28(6):1005-1010. | ||||
| REF 18 | Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4613-8. | ||||
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