TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T05031	PI3-kinase beta	D0E6XR	Dasatinib	Approved	3062316	C22H26ClN7O2S	488	CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO	IC50 ~ 50000 nM	Poor binder
T05031	PI3-kinase beta	D0W5HK	Sorafenib	Approved	216239	C21H16ClF3N4O3	464.8	CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F	IC50 ~ 50000 nM	Poor binder
T05031	PI3-kinase beta	D01RYO	Gefitinib	Patented	123631	C22H24ClFN4O3	446.9	COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4	IC50 ~ 50000 nM	Poor binder
T05031	PI3-kinase beta	D0YX2B	PMID28460551-Compound-2	Patented	5329102	C22H27FN4O2	398.5	CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\\2/C3=C(C=CC(=C3)F)NC2=O)C	IC50 ~ 50000 nM	Poor binder
T05031	PI3-kinase beta	B02ATY	3-(3-Bromo-5-methoxyphenyl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905184	C15H16BrN5O	362.22	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=CC(=C3)Br)OC)N	IC50 = 50300 nM	Poor binder
T05031	PI3-kinase beta	B04JPS	1-Methyl-1h-pyrrolo[2,3-c]pyridin-5-amine	Investigative	53323901	C8H9N3	147.18	CN1C=CC2=CC(=NC=C21)N	IC50 = 57000 nM	Poor binder
T05031	PI3-kinase beta	B05ZXD	8-Ethyl-11-(4-methoxyphenyl)-13-morpholin-4-yl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione	Investigative	122180794	C22H27N5O2S	425.5	CCN1C2=NC(=NC(=C2C3CCCN3C1=S)N4CCOCC4)C5=CC=C(C=C5)OC	IC50 = 58430 nM	Poor binder
T05031	PI3-kinase beta	B0EYR7	3-(3-Aminophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905260	C11H10N6	226.24	C1=CC(=CC(=C1)N)C2=C3C(=NC=NC3=NN2)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	B0H6BQ	8-Chloro-6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine	Investigative	66552523	C12H10ClN5O2S	323.76	CS(=O)(=O)C1=CN=CC(=C1)C2=CN3C(=NC(=N3)N)C(=C2)Cl	IC50 ~ 100000 nM	Poor binder
T05031	PI3-kinase beta	B0P6IU	(R)-2-(3-Benzylmorpholino)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one	Investigative	44578074	C20H24N2O2S	356.5	CC1(CC2=C(C(=O)C1)SC(=N2)N3CCOC[C@H]3CC4=CC=CC=C4)C	IC50 ~ 50000 nM	Poor binder
T05031	PI3-kinase beta	B1R2OA	5-(4-Amino-1-cycloheptyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol	Investigative	24905327	C18H20FN5O	341.4	C1CCCC(CC1)N2C3=NC=NC(=C3C(=N2)C4=CC(=C(C=C4)F)O)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	B1WJT8	Tert-Butyl {4-[4-Amino-1-(Propan-2-Yl)-1h-Pyrazolo[3,4-D]pyrimidin-3-Yl]-2-Methoxyphenyl}carbamate	Investigative	24905150	C20H26N6O3	398.5	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=C(C=C3)NC(=O)OC(C)(C)C)OC)N	IC50 ~ 50000 nM	Poor binder
T05031	PI3-kinase beta	B2F6BW	2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[b]thiophene-5-carbaldehyde	Investigative	24905163	C17H15N5OS	337.4	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(S3)C=CC(=C4)C=O)N	IC50 = 50000 nM	Poor binder
T05031	PI3-kinase beta	B2KQ0L	4-(Benzylamino)-2-morpholin-4-yl-1H-pyrimidin-6-one	Investigative	136227361	C15H18N4O2	286.33	C1COCCN1C2=NC(=CC(=O)N2)NCC3=CC=CC=C3	IC50 = 63000 nM	Poor binder
T05031	PI3-kinase beta	B2O3PM	10-(4-Methoxyphenyl)-2-morpholin-4-ylbenzo[g]chromen-4-one	Investigative	134143151	C24H21NO4	387.4	COC1=CC=C(C=C1)C2=C3C(=CC4=CC=CC=C42)C(=O)C=C(O3)N5CCOCC5	IC50 ~ 50000 nM	Poor binder
T05031	PI3-kinase beta	B2OF9R	3-(4-Nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905261	C11H8N6O2	256.22	C1=CC(=CC=C1C2=C3C(=NC=NC3=NN2)N)[N+](=O)[O-]	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	B2S0VM	1-Tert-Butyl-3-Naphthalen-2-Yl-1h-Pyrazolo[3,4-D]pyrimidin-4-Amine	Investigative	5059890	C19H19N5	317.4	CC(C)(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=CC=CC=C4C=C3)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	B2UR1X	3-p-Tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905250	C12H11N5	225.25	CC1=CC=C(C=C1)C2=C3C(=NC=NC3=NN2)N	IC50 = 50000 nM	Poor binder
T05031	PI3-kinase beta	B36SBQ	2-Morpholin-4-yl-10-phenylbenzo[g]chromen-4-one	Investigative	134147904	C23H19NO3	357.4	C1COCCN1C2=CC(=O)C3=CC4=CC=CC=C4C(=C3O2)C5=CC=CC=C5	IC50 ~ 50000 nM	Poor binder
T05031	PI3-kinase beta	B3T6JH	5-Methoxy-2-[5-[(3-nitrophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]phenol	Investigative	136254186	C16H13N3O5S	359.4	COC1=CC(=C(C=C1)C2=NN=C(O2)SCC3=CC(=CC=C3)[N+](=O)[O-])O	IC50 ~ 100000 nM	Poor binder
T05031	PI3-kinase beta	B41NUR	1-Isopropyl-3-(3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905169	C15H17N5O	283.33	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=CC=C3)OC)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	B4CWO6	(S)-5,5-Dimethyl-2-(3-phenylmorpholino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one	Investigative	44578040	C19H22N2O2S	342.5	CC1(CC2=C(C(=O)C1)SC(=N2)N3CCOC[C@@H]3C4=CC=CC=C4)C	IC50 ~ 50000 nM	Poor binder
T05031	PI3-kinase beta	B4HX3I	1-Isopropyl-3-(pyrimidin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905171	C12H13N7	255.28	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CN=CN=C3)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	B4QMH0	1-Benzyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905273	C22H17N5	351.4	C1=CC=C(C=C1)CN2C3=NC=NC(=C3C(=N2)C4=CC5=CC=CC=C5C=C4)N	IC50 = 50000 nM	Poor binder
T05031	PI3-kinase beta	B4QU3L	3-o-Tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905254	C12H11N5	225.25	CC1=CC=CC=C1C2=C3C(=NC=NC3=NN2)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	B50MRB	5-Methyl-2-[5-[(4-nitrophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]phenol	Investigative	135981194	C16H13N3O4S	343.4	CC1=CC(=C(C=C1)C2=NN=C(O2)SCC3=CC=C(C=C3)[N+](=O)[O-])O	IC50 ~ 100000 nM	Poor binder
T05031	PI3-kinase beta	B56QAB	2-Methoxy-6-phenyl-3-(5-pyridin-4-yl-[1,2,4]oxadiazol-3-yl)-pyridine	Investigative	913795	C19H14N4O2	330.3	COC1=C(C=CC(=N1)C2=CC=CC=C2)C3=NOC(=N3)C4=CC=NC=C4	IC50 ~ 100000 nM	Poor binder
T05031	PI3-kinase beta	B59FVI	2-(4-Amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenol	Investigative	135947977	C11H9N5O	227.22	C1=CC=C(C(=C1)C2=C3C(=NC=NC3=NN2)N)O	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	B5B6CH	5,5-Dimethyl-2-(3-(naphthalen-2-ylmethyl)morpholino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one	Investigative	11998564	C24H26N2O2S	406.5	CC1(CC2=C(C(=O)C1)SC(=N2)N3CCOCC3CC4=CC5=CC=CC=C5C=C4)C	IC50 ~ 50000 nM	Poor binder
T05031	PI3-kinase beta	B5E8FS	1-Isopropyl-3-(isoquinolin-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905215	C17H16N6	304.3	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)C=NC=C4)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	B5LG4V	1-(3-Methylbutyl)-3-naphthalen-2-ylpyrazolo[3,4-d]pyrimidin-4-amine	Investigative	52943258	C20H21N5	331.4	CC(C)CCN1C2=NC=NC(=C2C(=N1)C3=CC4=CC=CC=C4C=C3)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	B5X8EO	3-(2-Chloroquinolin-3-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905220	C17H15ClN6	338.8	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=CC=CC=C4N=C3Cl)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	B63WDX	1-Methyl-3-(4-phenylmethoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	52942202	C19H17N5O	331.4	CN1C2=NC=NC(=C2C(=N1)C3=CC=C(C=C3)OCC4=CC=CC=C4)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	B6B1OC	4-N-Benzyl-6-morpholin-4-ylpyrimidine-2,4-diamine	Investigative	71458543	C15H19N5O	285.34	C1COCCN1C2=NC(=NC(=C2)NCC3=CC=CC=C3)N	IC50 = 110000 nM	Poor binder
T05031	PI3-kinase beta	B6CXI2	1-(Cyclopropylmethyl)-4-[2-(oxan-4-ylmethylamino)-1,3-benzothiazol-6-yl]pyridin-2-one	Investigative	122184540	C22H25N3O2S	395.5	C1CC1CN2C=CC(=CC2=O)C3=CC4=C(C=C3)N=C(S4)NCC5CCOCC5	IC50 ~ 199526.23 nM	Poor binder
T05031	PI3-kinase beta	B6HO8X	Phenol, 3-[4-amino-7-(1-methylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-	Investigative	11230964	C15H16N4O	268.31	CC(C)N1C=C(C2=C(N=CN=C21)N)C3=CC(=CC=C3)O	IC50 = 50000 nM	Poor binder
T05031	PI3-kinase beta	B7BFQ1	3-(2,3-Dimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905255	C13H13N5	239.28	CC1=C(C(=CC=C1)C2=C3C(=NC=NC3=NN2)N)C	IC50 = 50000 nM	Poor binder
T05031	PI3-kinase beta	B7D0OZ	1-(Cyclopropylmethyl)-4-[2-[[(1R)-1-(oxan-4-yl)ethyl]amino]-1,3-benzothiazol-6-yl]pyridin-2-one	Investigative	122184541	C23H27N3O2S	409.5	C[C@H](C1CCOCC1)NC2=NC3=C(S2)C=C(C=C3)C4=CC(=O)N(C=C4)CC5CC5	IC50 ~ 199526.23 nM	Poor binder
T05031	PI3-kinase beta	B7ILR1	2-[4-Amino-3-(3-ethoxy-4-methoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]ethanol	Investigative	52940797	C16H19N5O3	329.35	CCOC1=C(C=CC(=C1)C2=NN(C3=NC=NC(=C23)N)CCO)OC	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	B89CGE	3-(1-Isopropyl-4-(methylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenol	Investigative	24905257	C15H17N5O	283.33	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=CC=C3)O)NC	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	B8AEZ3	5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-3-methylthiophene-2-carbaldehyde	Investigative	24905157	C14H15N5OS	301.37	CC1=C(SC(=C1)C2=NN(C3=NC=NC(=C23)N)C(C)C)C=O	IC50 = 80000 nM	Poor binder
T05031	PI3-kinase beta	B8AW2L	1-Isopropyl-3-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905177	C17H21N5O3	343.4	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=C(C(=C3)OC)OC)OC)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	B8DEK3	3-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	14638904	C11H9N5	211.22	C1=CC=C(C=C1)C2=C3C(=NC=NC3=NN2)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	B8JP6R	2-[5-[(2-Fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-5-methoxyphenol	Investigative	136254189	C16H13FN2O3S	332.4	COC1=CC(=C(C=C1)C2=NN=C(O2)SCC3=CC=CC=C3F)O	IC50 = 51750 nM	Poor binder
T05031	PI3-kinase beta	B8SKH9	11-(4-Methoxyphenyl)-13-morpholin-4-yl-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione	Investigative	122180796	C26H27N5O2S	473.6	COC1=CC=C(C=C1)C2=NC(=C3C4CCCN4C(=S)N(C3=N2)C5=CC=CC=C5)N6CCOCC6	IC50 = 78290 nM	Poor binder
T05031	PI3-kinase beta	B8ZND1	5-(2-Amino-7-fluoro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-tert-butylpyridine-3-sulfonamide	Investigative	66552524	C15H17FN6O2S	364.4	CC(C)(C)NS(=O)(=O)C1=CN=CC(=C1)C2=CN3C(=NC(=N3)N)C=C2F	IC50 ~ 100000 nM	Poor binder
T05031	PI3-kinase beta	B93CLF	1-(Cyclopropylmethyl)-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905247	C19H17N5	315.4	C1CC1CN2C3=NC=NC(=C3C(=N2)C4=CC5=CC=CC=C5C=C4)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	B9QG3A	3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	22346757	C17H13N5O	303.32	C1=CC=C(C=C1)OC2=CC=C(C=C2)C3=C4C(=NC=NC4=NN3)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	B9UYD5	4-(2-Amino-1,3-benzothiazol-6-yl)-1-ethylpyridin-2-one	Investigative	122184538	C14H13N3OS	271.34	CCN1C=CC(=CC1=O)C2=CC3=C(C=C2)N=C(S3)N	IC50 = 50118.72 nM	Poor binder
T05031	PI3-kinase beta	B9ZOK0	3-(4-Aminophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905259	C11H10N6	226.24	C1=CC(=CC=C1C2=C3C(=NC=NC3=NN2)N)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	BB1E5A	(R)-5,5-Dimethyl-2-(3-phenylmorpholino)-5,6-dihydrobenzo[d]thiazol-7(4H)-one	Investigative	44578039	C19H22N2O2S	342.5	CC1(CC2=C(C(=O)C1)SC(=N2)N3CCOC[C@H]3C4=CC=CC=C4)C	IC50 ~ 50000 nM	Poor binder
T05031	PI3-kinase beta	BB48DP	3-(3-(Benzyloxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905264	C18H15N5O	317.3	C1=CC=C(C=C1)COC2=CC=CC(=C2)C3=C4C(=NC=NC4=NN3)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	BBCR35	3-(1,2,3,4-Tetrahydronaphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905268	C15H15N5	265.31	C1CC2=CC=CC=C2CC1C3=C4C(=NC=NC4=NN3)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	BBRF19	4-(5-Morpholin-4-yl-7-oxothieno[3,2-b]pyran-3-yl)benzonitrile	Investigative	44181599	C18H14N2O3S	338.4	C1COCCN1C2=CC(=O)C3=C(O2)C(=CS3)C4=CC=C(C=C4)C#N	IC50 ~ 50000 nM	Poor binder
T05031	PI3-kinase beta	BBWU45	6-(4-Amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)quinolin-2(1H)-one	Investigative	24905227	C19H18N6O	346.4	C1CCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CC5=C(C=C4)NC(=O)C=C5)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	BC23WJ	3-(H-Imidazo[1,2-a]pyridin-7-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905246	C15H15N7	293.33	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=NC=CN4C=C3)N	IC50 = 52000 nM	Poor binder
T05031	PI3-kinase beta	BC7R5H	5-(2-Amino-1,3-benzothiazol-6-yl)-N,N-dimethylpyridine-2-carboxamide	Investigative	122184479	C15H14N4OS	298.4	CN(C)C(=O)C1=NC=C(C=C1)C2=CC3=C(C=C2)N=C(S3)N	IC50 = 79432.82 nM	Poor binder
T05031	PI3-kinase beta	BCB25A	1-Cyclopentyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24866805	C20H19N5	329.4	C1CCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CC5=CC=CC=C5C=C4)N	IC50 = 50000 nM	Poor binder
T05031	PI3-kinase beta	BCZ1W7	3-(Benzofuran-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905195	C16H15N5O	293.32	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)OC=C4)N	IC50 = 67200 nM	Poor binder
T05031	PI3-kinase beta	BD4B2E	1-Isopropyl-3-(2,3-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905178	C16H19N5O2	313.35	CC(C)N1C2=NC=NC(=C2C(=N1)C3=C(C(=CC=C3)OC)OC)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	BD6AQ8	1-(Cyclopropylmethyl)-4-[2-[[(1S)-1-(oxan-4-yl)ethyl]amino]-1,3-benzothiazol-6-yl]pyridin-2-one	Investigative	122184542	C23H27N3O2S	409.5	C[C@@H](C1CCOCC1)NC2=NC3=C(S2)C=C(C=C3)C4=CC(=O)N(C=C4)CC5CC5	IC50 ~ 199526.23 nM	Poor binder
T05031	PI3-kinase beta	BDJU98	1-Isopropyl-3-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905170	C13H14N6	254.29	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CN=CC=C3)N	IC50 = 50000 nM	Poor binder
T05031	PI3-kinase beta	BDR9I6	1-(Cyclopropylmethyl)-4-[2-[(1,1-dioxothian-4-yl)methylamino]-1,3-benzothiazol-6-yl]pyridin-2-one	Investigative	122184543	C22H25N3O3S2	443.6	C1CC1CN2C=CC(=CC2=O)C3=CC4=C(C=C3)N=C(S4)NCC5CCS(=O)(=O)CC5	IC50 ~ 199526.23 nM	Poor binder
T05031	PI3-kinase beta	BF35LM	1-Methyl-3-(3-phenylphenyl)pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	52944356	C18H15N5	301.3	CN1C2=NC=NC(=C2C(=N1)C3=CC=CC(=C3)C4=CC=CC=C4)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	BFDQ87	(R)-2-(3-((1H-Indol-3-yl)methyl)morpholino)-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one	Investigative	11998563	C22H25N3O2S	395.5	CC1(CC2=C(C(=O)C1)SC(=N2)N3CCOC[C@H]3CC4=CNC5=CC=CC=C54)C	IC50 ~ 50000 nM	Poor binder
T05031	PI3-kinase beta	BFHI16	3-(4-Tert-butylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905213	C15H17N5	267.33	CC(C)(C)C1=CC=C(C=C1)C2=C3C(=NC=NC3=NN2)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	BFQ45P	trans-4-[[[6-[1-(Cyclopropylmethyl)-1,2-dihydro-2-oxo-4-pyridinyl]-2-benzothiazolyl]amino]methyl]-cyclohexanecarboxylic acid	Investigative	122184544	C24H27N3O3S	437.6	C1CC(CCC1CNC2=NC3=C(S2)C=C(C=C3)C4=CC(=O)N(C=C4)CC5CC5)C(=O)O	IC50 ~ 199526.23 nM	Poor binder
T05031	PI3-kinase beta	BG28WI	3-(Naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	11543481	C15H11N5	261.279	C1=CC=C2C=C(C=CC2=C1)C3=C4C(=NC=NC4=NN3)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	BGPS06	N-[7-Methyl-6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide	Investigative	66552467	C15H15N5O3S	345.4	CC1=CC2=NC(=NN2C=C1C3=CC(=CN=C3)S(=O)(=O)C)NC(=O)C	IC50 = 199526.23 nM	Poor binder
T05031	PI3-kinase beta	BGUS85	11-(3-Methoxyphenyl)-13-morpholin-4-yl-8-phenyl-6,8,10,12-tetrazatricyclo[7.4.0.02,6]trideca-1(13),9,11-triene-7-thione	Investigative	122180795	C26H27N5O2S	473.6	COC1=CC=CC(=C1)C2=NC(=C3C4CCCN4C(=S)N(C3=N2)C5=CC=CC=C5)N6CCOCC6	IC50 = 113450 nM	Poor binder
T05031	PI3-kinase beta	BH8LE3	2-Pyridin-4-yl-benzooxazol-5-ylamine	Investigative	736009	C12H9N3O	211.22	C1=CC2=C(C=C1N)N=C(O2)C3=CC=NC=C3	IC50 = 81000 nM	Poor binder
T05031	PI3-kinase beta	BHMW36	5-(Pyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine	Investigative	53318614	C10H8N6	212.21	C1=CN=CC=C1C2=NC3=NC(=NN3C=C2)N	IC50 = 62000 nM	Poor binder
T05031	PI3-kinase beta	BIZ01Y	2-(Aminomethyl)-N-benzyl-6-morpholin-4-ylpyrimidin-4-amine	Investigative	71454917	C16H21N5O	299.37	C1COCCN1C2=NC(=NC(=C2)NCC3=CC=CC=C3)CN	IC50 = 87000 nM	Poor binder
T05031	PI3-kinase beta	BJ39AZ	2-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenylamino)propan-1-ol	Investigative	24905198	C18H24N6O2	356.4	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=C(C=C3)NC(C)CO)OC)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	BJX7C0	3-(4-Methylphenyl)-5-morpholin-4-ylthieno[3,2-b]pyran-7-one	Investigative	44181720	C18H17NO3S	327.4	CC1=CC=C(C=C1)C2=CSC3=C2OC(=CC3=O)N4CCOCC4	IC50 ~ 50000 nM	Poor binder
T05031	PI3-kinase beta	BKNW03	4-(1-(7-Fluoro-3-methyl-2-(2-pyridinyl)-4-quinolinyl)-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-6-methyl-2-pyrimidinamine	Investigative	50938829	C30H27FN6	490.6	CC1=CC(=NC(=N1)N)C2=CC3=C(C=C2)C(CN3C4=C(C(=NC5=C4C=CC(=C5)F)C6=CC=CC=N6)C)(C)C	Ki ~ 125000 nM	Poor binder
T05031	PI3-kinase beta	BLIS49	Tert-butyl 5-(4-amino-1-cyclopentyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indole-1-carboxylate	Investigative	24905187	C23H26N6O2	418.5	CC(C)(C)OC(=O)N1C=CC2=C1C=CC(=C2)C3=NN(C4=NC=NC(=C34)N)C5CCCC5	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	BM1X3O	1-Allyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905271	C18H15N5	301.3	C=CCN1C2=NC=NC(=C2C(=N1)C3=CC4=CC=CC=C4C=C3)N	IC50 = 50000 nM	Poor binder
T05031	PI3-kinase beta	BM24CI	3-(3-(2,6-Dichlorobenzyloxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905265	C18H13Cl2N5O	386.2	C1=CC(=CC(=C1)OCC2=C(C=CC=C2Cl)Cl)C3=C4C(=NC=NC4=NN3)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	BM4IQ7	5-[[(5,6-Dimethyl-4-thieno[2,3-d]pyrimidinyl)thio]methyl]-2-furancarboxylic acid methyl ester	Investigative	2612441	C15H14N2O3S2	334.4	CC1=C(SC2=C1C(=NC=N2)SCC3=CC=C(O3)C(=O)OC)C	IC50 ~ 100000 nM	Poor binder
T05031	PI3-kinase beta	BM76KW	8-Methyl-7-[2-(4-methylpiperazin-1-yl)ethoxy]-2-morpholin-4-yl-1,3-benzoxazin-4-one	Investigative	17756679	C20H28N4O4	388.5	CC1=C(C=CC2=C1OC(=NC2=O)N3CCOCC3)OCCN4CCN(CC4)C	IC50 ~ 100000 nM	Poor binder
T05031	PI3-kinase beta	BMY85O	3-(3-(Benzyloxy)-4-methyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905284	C19H17N5O	331.4	CC1=C(C=C(C=C1)C2=C3C(=NC=NC3=NN2)N)OCC4=CC=CC=C4	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	BN1U3V	4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorobenzonitrile	Investigative	24905237	C15H13FN6	296.3	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=C(C=C3)C#N)F)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	BN5EC3	1-(Cyclopropylmethyl)-4-(2-aminobenzothiazole-6-yl)pyridine-2(1H)-one	Investigative	78319187	C16H15N3OS	297.4	C1CC1CN2C=CC(=CC2=O)C3=CC4=C(C=C3)N=C(S4)N	IC50 ~ 125892.54 nM	Poor binder
T05031	PI3-kinase beta	BN5G4A	4-(2-Amino-1,3-benzothiazol-6-yl)-1-methylpyridin-2-one	Investigative	122184537	C13H11N3OS	257.31	CN1C=CC(=CC1=O)C2=CC3=C(C=C2)N=C(S3)N	IC50 = 63095.73 nM	Poor binder
T05031	PI3-kinase beta	BN5VC1	2-(4-Amino-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)acetamide	Investigative	24905275	C17H14N6O	318.33	C1=CC=C2C=C(C=CC2=C1)C3=NN(C4=NC=NC(=C34)N)CC(=O)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	BNL39O	3-(3-Nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905214	C11H8N6O2	256.22	C1=CC(=CC(=C1)[N+](=O)[O-])C2=C3C(=NC=NC3=NN2)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	BNT01I	4-(2-Amino-1,3-benzothiazol-6-yl)-1-(2-methoxyethoxy)pyridin-2-one	Investigative	122184539	C15H15N3O3S	317.4	COCCON1C=CC(=CC1=O)C2=CC3=C(C=C2)N=C(S3)N	IC50 ~ 199526.23 nM	Poor binder
T05031	PI3-kinase beta	BOM52F	6-[6-(Methylaminomethyl)pyridin-3-yl]-1,3-benzothiazol-2-amine	Investigative	122184468	C14H14N4S	270.35	CNCC1=NC=C(C=C1)C2=CC3=C(C=C2)N=C(S3)N	IC50 = 79432.82 nM	Poor binder
T05031	PI3-kinase beta	BOVT82	5-(4-Amino-1-((piperidin-3-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-chlorophenol	Investigative	24905299	C17H19ClN6O	358.8	C1CC(CNC1)CN2C3=NC=NC(=C3C(=N2)C4=CC(=C(C=C4)Cl)O)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	BQT46Z	2-[5-[(4-Fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-5-methoxyphenol	Investigative	136244246	C16H13FN2O3S	332.4	COC1=CC(=C(C=C1)C2=NN=C(O2)SCC3=CC=C(C=C3)F)O	IC50 ~ 100000 nM	Poor binder
T05031	PI3-kinase beta	BREC19	1,7-Dimethyl-1H-pyrazolo[3,4-b]quinolin-3-yl 2-phenoxyacetate	Investigative	44610761	C20H17N3O3	347.4	CC1=CC2=NC3=C(C=C2C=C1)C(=NN3C)OC(=O)COC4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T05031	PI3-kinase beta	BSMU04	3-(Naphthalen-2-yl)-1-phenethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905274	C23H19N5	365.4	C1=CC=C(C=C1)CCN2C3=NC=NC(=C3C(=N2)C4=CC5=CC=CC=C5C=C4)N	IC50 = 50000 nM	Poor binder
T05031	PI3-kinase beta	BT6N0R	3-(3-Phenoxyphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905262	C17H13N5O	303.32	C1=CC=C(C=C1)OC2=CC=CC(=C2)C3=C4C(=NC=NC4=NN3)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	BUZ06A	5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorobenzonitrile	Investigative	24905236	C15H13FN6	296.3	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC(=C(C=C3)F)C#N)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	BUZS61	N-Benzyl-4-methyl-6-morpholin-4-ylpyrimidin-2-amine	Investigative	721057	C16H20N4O	284.36	CC1=CC(=NC(=N1)NCC2=CC=CC=C2)N3CCOCC3	IC50 = 130000 nM	Poor binder
T05031	PI3-kinase beta	BW20GR	N-[6-(2-Methoxyphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]acetamide	Investigative	25129383	C15H14N4O2	282.3	CC(=O)NC1=NN2C=C(C=CC2=N1)C3=CC=CC=C3OC	IC50 ~ 100000 nM	Poor binder
T05031	PI3-kinase beta	BWS24D	3-(4-Biphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Investigative	24905267	C17H13N5	287.32	C1=CC=C(C=C1)C2=CC=C(C=C2)C3=C4C(=NC=NC4=NN3)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	BXB01F	5-[4-Amino-1-(2,2-diethoxyethyl)pyrazolo[3,4-d]pyrimidin-3-yl]-1,3-benzoxazol-2-amine	Investigative	122163152	C18H21N7O3	383.4	CCOC(CN1C2=NC=NC(=C2C(=N1)C3=CC4=C(C=C3)OC(=N4)N)N)OCC	IC50 ~ 100000 nM	Poor binder
T05031	PI3-kinase beta	BXD89Y	2-(4-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl)acetonitrile	Investigative	24905166	C16H16N6	292.34	CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC=C(C=C3)CC#N)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	BXW73J	5-(4-Amino-1-((4-phenyloxazol-5-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-fluorophenol	Investigative	24905308	C21H15FN6O2	402.4	C1=CC=C(C=C1)C2=C(OC=N2)CN3C4=NC=NC(=C4C(=N3)C5=CC(=C(C=C5)F)O)N	IC50 = 100000 nM	Poor binder
T05031	PI3-kinase beta	BYWH65	1-[6-[5-(Tert-butylsulfamoyl)pyridin-3-yl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-phenylurea	Investigative	70686339	C22H23N7O3S	465.5	CC(C)(C)NS(=O)(=O)C1=CN=CC(=C1)C2=CN3C(=NC(=N3)NC(=O)NC4=CC=CC=C4)C=C2	IC50 ~ 100000 nM	Poor binder
T05031	PI3-kinase beta	D00ZIK	IC87114	Investigative	9908783	C22H19N7O	397.4	CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C=NC5=C(N=CN=C54)N	IC50 = 75000 nM	Poor binder