Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T02653 | Target Info | |||
| Target Name | HUMAN mineralocorticoid receptor (MR) | ||||
| Synonyms |
Nuclear receptor subfamily 3 group C member 2; Mineralocorticoid receptor; MLR; MCR; Inner ear mineralocorticoid receptor; Delta
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| Gene Name | NR3C2 | ||||
| Biochemical Class | Nuclear hormone receptor | ||||
| UniProt ID | |||||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Lecanindole D
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|
Investigative | Compound Info | ||
| Synonyms |
Lecanindole D; CHEMBL1076438
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| Activity |
IC50 > 3000000 nM
|
[1] | |||
| Compound Name |
(3R)-3-[1-(4-Fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2426663; BDBM50440242
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| Activity |
EC50 > 5000000 nM
|
[2] | |||
| Compound Name |
(3S)-3-[1-(4-Fluorophenyl)indazol-5-yl]-2,2-dimethyl-3-phenyl-N-(1,3,4-thiadiazol-2-yl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2426662; BDBM50440243
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| Activity |
EC50 > 5000000 nM
|
[2] | |||
| Compound Name |
Lecanindole B
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1087512; BDBM50312005
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| Activity |
IC50 > 10000000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144. J Nat Prod. 2009 Nov;72(11):1944-8. | ||||
| REF 2 | Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5442-7. | ||||
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