Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T02024 | Target Info | |||
| Target Name | HUMAN inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) | ||||
| Synonyms |
Superoxide-inducible protein 12; SOI12; Probable inosine-5'-monophosphate dehydrogenase IMD1; NAD-dependent inosine monophosphate dehydrogenase; Inosine dehydrogenase; IMPDH-I; IMPDH 1; IMPDH; IMPD1; IMPD 1; IMPD; IMP dehydrogenase 1; IMP dehydrogenase
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| Gene Name | IMPDH1 | ||||
| Biochemical Class | CH-OH donor oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 9 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Adenosine
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Approved | Compound Info | ||
| Synonyms |
Adenosine, homopolymer; Adenine 9-beta-D-arabinofuranoside; Adenine-9-beta-D-ribofuranoside; Beta-D-Ribofuranoside, adenine-9; EA6C60C2-6AFB-4264-A2F0-541373DB950E; (2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; 4-Aminopyrazolo[3,4-d]pyrimidine ribonucleoside; 6-Amino-9-.beta.-ribofuranosyl-9H-purine; 6-Amino-9-beta-D-ribofuranosyl-9H-purine; 6-Amino-9beta-D-ribofuranosyl-9H-purine; 9-(beta-D-Arabinofuranosyl)adenine; 9-beta-D-Ribofuranosidoadenine; 9-beta-D-Ribofuranosyl-9H-purin-6-amine; 9-beta-D-Ribofuranosyladenine; 9beta-D-Ribofuranosyladenine
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| Activity |
Ki ~ 100000 nM
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[1] | |||
| Compound Name |
N-(4-Chlorophenyl)-2-phenoxypropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL561640; TimTec1_006358; Oprea1_760846; Oprea1_796355; SCHEMBL10175988; HMS1552A22; BDBM50294184; STK099703; AKOS000646806; AKOS016283268; MCULE-9707079380; N-(4-chlorophenyl)-2-phenoxypropanamide, A; ST50012820; AG-690/15442367; N-(4-chlorophenyl)-2-phenoxypropanamide, Compound A
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| Activity |
EC50 ~ 50000 nM
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[2] | |||
| Compound Name |
N-(4-Methoxyphenyl)-2-(2-thiazol-4-ylbenzimidazol-1-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
ChemDiv2_003770; Oprea1_300621; CHEMBL1957232; SCHEMBL10175974; BDBM81423; HMS1379L08; ZINC3899852; MCULE-2515829006; IDI1_002485; N-(4-methoxyphenyl)-2-[2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetamide
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| Activity |
IC50 ~ 50000 nM
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[3] | |||
| Compound Name |
(4E)-6-(4,6-Dimethoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL437376; ALBB-031479; BBL035127; BDBM50331101; MFCD22375170; STL426069; ZINC28824028; AKOS016374092; VS-12899
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| Activity |
IC50 = 67000 nM
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[4] | |||
| Compound Name |
(Z)-6-(2,4-Dimethoxy-5-(oxazol-5-yl)phenyl)-4-methylhex-4-enoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL487565; BDBM50275687
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| Activity |
Ki = 97300 nM
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[5] | |||
| Compound Name |
Adenosine 5''-methylenebis(sulfonamide)
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL476563; BDBM50263249
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| Activity |
Ki ~ 100000 nM
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[1] | |||
| Compound Name |
(E)-3-[4-[[(4-Cyano-3-methoxyphenyl)carbamoylamino]methyl]phenyl]-N-hydroxyprop-2-enamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1215175; BDBM50416541
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
6-(2,4-Dimethoxy-3-methyl-5-(oxazol-5-yl)phenyl)-4-methylhex-4-enoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL487564; BDBM50275686
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| Activity |
Ki ~ 100000 nM
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[5] | |||
| Compound Name |
2-[5-O-[(5'-Adenylyloxy)phosphonyl]-beta-D-ribofuranosyl]-4-carbamoylfuran
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143998
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| Activity |
Ki = 135120 nM
|
[7] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase. Bioorg Med Chem. 2008 Aug 1;16(15):7462-9. | ||||
| REF 2 | Triazole inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. J Med Chem. 2009 Aug 13;52(15):4623-30. | ||||
| REF 3 | Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH. Bioorg Med Chem Lett. 2012 Mar 1;22(5):1985-8. | ||||
| REF 4 | Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycoph... Bioorg Med Chem. 2010 Nov 15;18(22):8106-11. | ||||
| REF 5 | Mycophenolic acid analogs with a modified metabolic profile. Bioorg Med Chem. 2008 Oct 15;16(20):9340-5. | ||||
| REF 6 | Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure. Bioorg Med Chem. 2010 Aug 15;18(16):5950-64. | ||||
| REF 7 | Isosteric analogues of nicotinamide adenine dinucleotide derived from furanfurin, thiophenfurin, and selenophenfurin as mammalian inosine monophosphate dehydrogenase (type I and II) inhibitors. J Med Chem. 1998 May 7;41(10):1702-7. | ||||
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