Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T01943 | Target Info | |||
| Target Name | Plasmodium Beta-hydroxyacyl-ACP dehydratase (Malaria FabZ) | ||||
| Synonyms |
fabZ; Fatty acid synthesis protein; Beta-hydroxyacyl-ACP dehydratase; 17 kDa actomyosin component; (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; (3R)-hydroxymyristoyl-ACP dehydrase
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| Target Type | Clinical trial Target | ||||
| Gene Name | Malaria FabZ | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-(4-Chloro-2-hydroxy-phenoxy)-5,7-dihydroxy-chromen-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2426553; BDBM50440627
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| Activity |
IC50 = 90000 nM
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[1] | |||
| Compound Name |
3-(4-Chloro-2-hydroxy-phenoxy)chromen-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2426550; BDBM50440624
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
7-(4-Chloro-2-Hydroxyphenoxy)-4-Methyl-2h-Chromen-2-One
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2426548; BDBM50440626; Q27458817; CHJ
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
3-(4-Chloro-2-hydroxy-phenoxy)-6-hydroxy-chromen-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2426551; BDBM50440623
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
7-(4-Chloro-2-hydroxyphenoxy)-4-ethylchromen-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2426549; BDBM50440625
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI). J Med Chem. 2013 Oct 10;56(19):7516-26. | ||||
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