Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T01575 | Target Info | |||
| Target Name | Sphingosine-1-phosphate lyase 1 (SGPL1) | ||||
| Synonyms |
hSPL; Sphingosine-1-phosphate aldolase; SPL 1; SP-lyase 1; S1PL; KIAA1252
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| Target Type | Clinical trial Target | ||||
| Gene Name | SGPL1 | ||||
| Biochemical Class | Carbon-carbon lyase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Fingolimod
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|
Approved | Compound Info | ||
| Synonyms |
2-Amino-2-(4-octylphenethyl)propane-1,3-diol
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| Activity |
IC50 = 52000 nM
|
[1] | |||
| Compound Name |
THI
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Investigative | Compound Info | ||
| Synonyms |
2-acetyl-5-tetrahydroxybutyl imidazole
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[2-[(4-Methoxyphenyl)methylamino]-1-phenylethyl]-5-methyl-1,2-oxazole-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3797451; BDBM50500990
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
N-[2-[(4-Methoxy-2,5-dimethylphenyl)methylamino]-1-(2-methoxyphenyl)ethyl]-5-methyl-1,2-oxazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3799145; BDBM50500993
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Orally active 7-substituted (4-benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as active-site inhibitors of sphingosine 1-phosphate lyase for the treatment of multiple sclerosis. J MedChem. 2014 Jun 26;57(12):5074-84. | ||||
| REF 2 | Hit-to-lead evaluation of a novel class of sphingosine 1-phosphate lyase inhibitors. Bioorg Med Chem Lett. 2016 May 1;26(9):2297-302. | ||||
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