Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T01318 | Target Info | |||
| Target Name | Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) | ||||
| Synonyms |
PFF0160c; Mitochondrially bound dihydroorotate-ubiqui oxidoreductase; Dihydroorotate oxidase of Plasmodium falciparum; Dihydroorotate dehydrogenase of Plasmodium falciparum; DHOdehase of Plasmodium falciparum; DHODase; DHODH of Plasmodium falciparum; DHOD
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| Target Type | Successful Target | ||||
| Gene Name | Malaria DHOdehase | ||||
| Biochemical Class | CH-CH donor oxidoreductase | ||||
| UniProt ID | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Diethyl [(dibenzo[b,d]thiophen-2-ylamino)methylidene]propanedioate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL218467; SCHEMBL18120678; BDBM50269005
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| Activity |
IC50 = 5400000000 nM
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[1] | |||
| Compound Name |
Ethyl (Z)-2-cyano-3-[(9-ethylcarbazol-3-yl)amino]prop-2-enoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL218703; SCHEMBL18120679; BDBM50268993
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| Activity |
IC50 = 32000000000 nM
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[1] | |||
| References | Top | ||||
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| REF 1 | Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase. J Med Chem. 2007 Jan 25;50(2):186-91. | ||||
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