Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T01249 | Target Info | |||
| Target Name | HUMAN dCTP pyrophosphatase 1 | ||||
| Synonyms |
XTP3-transactivated gene A protein ; RS21C6 ; Deoxycytidine-triphosphatase 1; dCTPase 1
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| Gene Name | DCTPP1 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 7 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
MDI-P
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|
Phase 3 | Compound Info | ||
| Synonyms |
CHEMBL595840; 60986-80-3; 5-methyl-3,6-diphenylisoxazolo[4,5-c]pyridin-4(5H)-one; 3,6-Diphenyl-5-methylisoxazolo[4,5-c]pyridin-4(5H)-one; 3,6-DIPHENYL-5-METHYLISOXAZOLO(4,5-C)PYRIDIN-4(5H)-ONE; AC1Q3XQS; AC1Q3XQT; AC1N5X7T; MLS002153017; SCHEMBL3663640; GTPL6218; CTK5B2529; cid_4250909; DTXSID10401226; LCNDUGHNYMJGIW-UHFFFAOYSA-N; HMS2206G07; 5-methyl-3,6-diphenyl-isoxazolo[4,5-c]pyridine-4(5H)-one; ZINC394853; HMS3358C19; BDBM50305859; AKOS024323421; MCULE-8467817198; SMR001229079; FT-0714059
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
1-[(4-Methoxyphenyl)methyl]benzimidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1945696; 1-(4-methoxybenzyl)-1H-benzimidazole; F3243-0689; SCHEMBL12771538; 1-(p-methoxybenzyl)benzimidazole; ZINC8022694; BDBM50150027; STK870474; AKOS001368887; CCG-291389; MCULE-4848443524; 1-(benzimidazolylmethyl)-4-methoxybenzene; 1-(4-methoxybenzyl)-1H-benzo[d]imidazole; ST50329792; VU0411551-2; 1-[(4-methoxyphenyl)methyl]-1H-1,3-benzodiazole; Z216546526
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
6-[4-[(4-Benzylpiperidin-1-yl)methyl]phenyl]-5-methyl-3-phenyl-[1,2]oxazolo[4,5-c]pyridin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4060259; BDBM50260223
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-(4-Methoxybenzyl)-2-methyl-1H-benzimidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3770720; SCHEMBL14006013; BDBM50150030; STL259793; AKOS003118350; MCULE-4694833287; ST45184688; 1-[(4-methoxyphenyl)methyl]-2-methylbenzimidazole; 4-methoxy-1-[(2-methylbenzimidazolyl)methyl]benzene
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
5-Methyl-2,3-diphenyl-6-[4-(pyrrolidin-1-ylmethyl)phenyl]furo[3,2-c]pyridin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4081583; BDBM50260213
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3,5-Dimethyl-6-phenyl-[1,2]oxazolo[4,5-c]pyridin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087587; BDBM50260238
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-(4-Methoxybenzyl)-5,6-dimethyl-1H-benzimidazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3770495; SCHEMBL15579167; BDBM50150029; STL511211; ZINC31903301; AKOS002329256; CCG-290043; MCULE-3348422737; ST50813894; 1-[(4-methoxyphenyl)methyl]-5,6-dimethylbenzimidazole; 1-[(5,6-dimethylbenzimidazolyl)methyl]-4-methoxybenzene
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3219-3225. | ||||
| REF 2 | Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. J Med Chem. 2016 Feb 11;59(3):1140-1148. | ||||
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