Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T01138 | Target Info | |||
| Target Name | HUMAN solute carrier family 6 member 15 (SLC6A15) | ||||
| Synonyms |
Transporter v7-3; Sodium-dependent neutral amino acid transporter B(0)AT2; Sodium-coupled branched-chain amino-acid transporter 1; Sodium- and chloride-dependent neurotransmitter transporter NTT73
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| Gene Name | SLC6A15 | ||||
| Biochemical Class | SLC6A15 subfamily | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 10 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Desloratadine
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Approved | Compound Info | ||
| Synonyms |
Aerius; Allex; Azomyr; Claramax; Clarinex; Denosin; Desalex; Descarboethoxyloratadine; Descarboethoxyoratidine; Desloratidine; Neoclarityn; Opulis; Clarinex RediTabs; Desloratadine [USAN]; Essex brand of desloratadine; Schering brand of desloratadine; Sch 34117; Aerius (TN); Claramax (TN); Clarinex (TN); NeoClarityn (TN); Sch-34117; Schering-Plough brand of desloratadine; Desloratadine (USAN/INN); 8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine; 8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
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| Activity |
IC50 = 172000 nM
|
[1] | |||
| Compound Name |
PegCNTF
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Phase 1 | Compound Info | ||
| Synonyms |
Piperidine, 1-acetyl-4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-; Sch-37370; 117796-52-8; Sch 37370; UNII-GA60WRR45J; N-Acetyldesloratadine; GA60WRR45J; CHEMBL10971; RESPATADINE; ethanone, 1-[4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl]-; AC1L1TPN; AC1Q5KQ9; SCHEMBL3071641; GTPL1853; DTXSID10151911; FLTBEMVEAFMWDD-UHFFFAOYSA-N; ZINC596712; BDBM50007473; 1-Acetyl-4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cycloheptal(1,2-b)pyridin-11-ylidine)piperidine; SCH-37370
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| Activity |
IC50 = 54800 nM
|
[1] | |||
| Compound Name |
Phenyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3357038; BDBM50031244
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| Activity |
IC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
13-Chloro-2-(1-propylsulfonylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3357031; BDBM50031270
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| Activity |
IC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
2-Cyano Loratadine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3357025; Loratadine 2-Nitrile; CTK8E8115; DTXSID30652531; BDBM50031235; ZINC22055198; AKOS030255716; FT-0665291
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| Activity |
IC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
N-Methyldesloratadine
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Investigative | Compound Info | ||
| Synonyms |
8-Chloroazatadine; N-Methyl Desloratadine; Loratadine related compound B; 8-Chloro azatadine; UNII-70V8053T5G; Loratadine EP Impurity G; CHEMBL420316; 8-Chloro-5,6-dihydro-11H-benzo[5,6]Cyclohepto[1,2-b]pyridine-11-one; MFCD06411084; 70V8053T5G; C20H21ClN2; Loratadine impurity G [EP]; Loratadine related compound B [USP]; Loratadine related compound B RS [USP]; PubChem20737; SCHEMBL4460572; CTK6I2215; KS-00000JCF; DTXSID40191502; ACT04866; BCP31809; ZINC2015181; BDBM50031228; STL481882; AKOS005216035; DS-7427; AC-26333; AK161939; SC-83250; SY110869; DB-002621; FT-0671893; 092C896; 8-Chloro-6,11-dihydro-11-(1-methyl-4-piperidinylid; Q27265894; N-Methyl Desloratadine;8-Chloroazatadine;N-Methyldesloratadine
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| Activity |
IC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
4-Cyano Loratadine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3357021; Loratadine 4-Nitrile; CTK8E8121; DTXSID90652532; BDBM50031237; ZINC22055202; AKOS030255717; FT-0665292
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| Activity |
IC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
2-Hydroxymethyl Loratadine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3357026; CTK8E8118; DTXSID40652608; BDBM50031278; ZINC22060836; AKOS030255734; FT-0669794
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| Activity |
IC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
Benzyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3357039; BDBM50031123
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| Activity |
IC50 ~ 80000 nM
|
[1] | |||
| Compound Name |
Tert-butyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3357036; BDBM50031230
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| Activity |
IC50 ~ 80000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Loratadine and analogues: discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B(0)AT2. J Med Chem. 2014 Nov 26;57(22):9473-9. | ||||
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