TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T01138	HUMAN solute carrier family 6 member 15	D01GBY	Desloratadine	Approved	124087	C19H19ClN2	310.8	C1CC2=C(C=CC(=C2)Cl)C(=C3CCNCC3)C4=C1C=CC=N4	IC50 = 172000 nM	Poor binder
T01138	HUMAN solute carrier family 6 member 15	D0C2HI	PegCNTF	Phase 1	60680	C21H21ClN2O	352.9	CC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1	IC50 = 54800 nM	Poor binder
T01138	HUMAN solute carrier family 6 member 15	B8QI6L	Phenyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate	Investigative	18337327	C26H23ClN2O2	430.9	C1CC2=C(C=CC(=C2)Cl)C(=C3CCN(CC3)C(=O)OC4=CC=CC=C4)C5=C1C=CC=N5	IC50 ~ 80000 nM	Poor binder
T01138	HUMAN solute carrier family 6 member 15	BES4I5	13-Chloro-2-(1-propylsulfonylpiperidin-4-ylidene)-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene	Investigative	118721923	C22H25ClN2O2S	417	CCCS(=O)(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1	IC50 ~ 80000 nM	Poor binder
T01138	HUMAN solute carrier family 6 member 15	BHB1X9	2-Cyano Loratadine	Investigative	29976517	C23H22ClN3O2	407.9	CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=C(C=C4)C#N)C=C(C=C3)Cl)CC1	IC50 ~ 80000 nM	Poor binder
T01138	HUMAN solute carrier family 6 member 15	BQ7RS8	N-Methyldesloratadine	Investigative	31843	C20H21ClN2	324.8	CN1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1	IC50 ~ 80000 nM	Poor binder
T01138	HUMAN solute carrier family 6 member 15	BT51MJ	4-Cyano Loratadine	Investigative	29976521	C23H22ClN3O2	407.9	CCOC(=O)N1CCC(=C2C3=C(CCC4=C(C=CN=C42)C#N)C=C(C=C3)Cl)CC1	IC50 ~ 80000 nM	Poor binder
T01138	HUMAN solute carrier family 6 member 15	BTLB02	2-Hydroxymethyl Loratadine	Investigative	29981724	C23H25ClN2O3	412.9	CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=C(C=C4)CO)C=C(C=C3)Cl)CC1	IC50 ~ 80000 nM	Poor binder
T01138	HUMAN solute carrier family 6 member 15	BUHD07	Benzyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate	Investigative	18337326	C27H25ClN2O2	444.9	C1CC2=C(C=CC(=C2)Cl)C(=C3CCN(CC3)C(=O)OCC4=CC=CC=C4)C5=C1C=CC=N5	IC50 ~ 80000 nM	Poor binder
T01138	HUMAN solute carrier family 6 member 15	BV4UJ2	Tert-butyl 4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidine-1-carboxylate	Investigative	118721925	C24H27ClN2O2	410.9	CC(C)(C)OC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1	IC50 ~ 80000 nM	Poor binder