Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T00863 | Target Info | |||
| Target Name | HUMAN lysyl oxidase (LOX) | ||||
| Synonyms |
Protein-lysine 6-oxidase
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| Gene Name | LOX | ||||
| Biochemical Class | CH-NH(2) donor oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 13 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4238380
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463617; EiM08-06765; STK655429; STL318230; ZINC31820337; AKOS005585964; AKOS022125722; MCULE-5748078362; 6-(2,5-dimethyl-3-furyl)-2-phenyl-1,2-dihydro-3H-pyrazolo[3,4-b]pyridin-3-one; 6-(2,5-dimethylfuran-3-yl)-2-phenyl-1,2-dihydro-3H-pyrazolo[3,4-b]pyridin-3-one; 6-(2,5-dimethylfuran-3-yl)-2-phenyl-1H-pyrazolo[3,4-b]pyridin-3(2H)-one; 6-(2,5-dimethylfuran-3-yl)-2-phenyl-2,7-dihydro-3H-pyrazolo[3,4-b]pyridin-3-one
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| Activity |
IC50 = 50000 nM
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[1] | |||
| Compound Name |
[3-[4-(Aminomethyl)pyridin-2-yl]oxyphenyl]-[(3S,4S)-3-fluoro-4-hydroxypyrrolidin-1-yl]methanone;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4092740; BDBM50266787
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| Activity |
IC50 = 52000 nM
|
[2] | |||
| Compound Name |
(2-(Trifluoromethyl)pyridin-4-yl)methanamine hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
(2-(TRIFLUOROMETHYL)PYRIDIN-4-YL)METHANAMINE HCL; [2-(Trifluoromethyl)pyridin-4-yl]methanamine hydrochloride; 4-(Aminomethyl)-2-(trifluoromethyl)pyridine hydrochloride; CHEMBL4066637; CTK8C0921; DTXSID40743489; 2582AA; ANW-65474; MFCD12400889; PS-11574; DB-092356; [2-(trifluoromethyl)pyridin-4-yl]methanamine;hydrochloride; 4-Pyridinemethanamine, 2-(trifluoromethyl)-, hydrochloride (1:1); 1-[2-(Trifluoromethyl)pyridin-4-yl]methanamine--hydrogen chloride (1/1)
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| Activity |
IC50 = 54000 nM
|
[2] | |||
| Compound Name |
3-Tert-Butyl-1-phenyl-2-pyrazolin-5-one
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Investigative | Compound Info | ||
| Synonyms |
5-tert-butyl-2-phenyl-4H-pyrazol-3-one; CHEMBL4241417; 3-tert-Butyl-1-phenyl-1H-pyrazol-5(4H)-one; MFCD00051762; 3H-Pyrazol-3-one, 5-(1,1-dimethylethyl)-2,4-dihydro-2-phenyl-; 3-(tert-butyl)-1-phenyl-2-pyrazolin-5-one; NSC57945; Maybridge1_001591; SCHEMBL7528553; CTK5C4203; HMS546A07; DTXSID30288874; BDBM50463616; BTB 07042; CCG-54368; NSC-57945; SBB039881; AKOS000271442; ZINC100023293; MCULE-9741439096; PS-11150; ST097005; BB 0219324; FT-0616391; 2-Pyrazolin-5-one, 3-tert-butyl-1-phenyl-; J3.613.734G; 1-Phenyl-3-tert-butyl-1H-pyrazole-5(4H)-one; 3-(tert-Butyl)-1-phenyl-1H-pyrazol-5(4H)-one; SR-01000596944; SR-01000596944-1; SR-01000596944-2; 5-(tert-butyl)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one; 5-tert-Butyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one #; 3H-Pyrazol-3-one,5-(1,1-dimethylethyl)-2,4-dihydro-2-phenyl-
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| Activity |
IC50 = 75000 nM
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[1] | |||
| Compound Name |
3-[4-(Aminomethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy-N-methoxybenzamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4105137; SCHEMBL18049915; BDBM50266826
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| Activity |
IC50 = 83000 nM
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[2] | |||
| Compound Name |
6-(2-Methoxyphenyl)-2-phenyl-1H-pyrazolo[3,4-b]pyridine-3,4(2H,7H)-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4242081; ZINC8971918; BDBM50463619; STK232209; STK851698; AKOS001769847; AKOS005630625; MCULE-9840435266; 4-hydroxy-6-(2-methoxyphenyl)-2-phenyl-1,2-dihydro-3H-pyrazolo[3,4-b]pyridin-3-one
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| Activity |
IC50 = 91000 nM
|
[1] | |||
| Compound Name |
[2-(3-Phenoxyphenoxy)-6-(trifluoromethyl)pyridin-4-yl]methanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4089707; SCHEMBL18049923; BDBM50266840
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| Activity |
IC50 = 93000 nM
|
[2] | |||
| Compound Name |
Chembl4237334
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Investigative | Compound Info | ||
| Synonyms |
BDBM50463614; EiM08-06401; STL232274; STL310217; ZINC20720124; AKOS016401980; AKOS022138677; MCULE-2187498403; 2-phenyl-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridin-3(2H)-one; 2-phenyl-6-(2-thienyl)-1,2-dihydro-3H-pyrazolo[3,4-b]pyridin-3-one; 2-phenyl-6-(thiophen-2-yl)-1,2-dihydro-3H-pyrazolo[3,4-b]pyridin-3-one; 2-phenyl-6-(thiophen-2-yl)-2,7-dihydro-3H-pyrazolo[3,4-b]pyridin-3-one
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[4-(Aminomethyl)-5-(4-hydroxybutoxy)pyridin-3-yl]oxybutan-1-ol;dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL536484
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| Activity |
IC50 = 100000 nM
|
[3] | |||
| Compound Name |
2-[4-(Aminomethyl)-5-(2-hydroxyethoxy)pyridin-3-yl]oxyethanol;trihydrate;dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL536719
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| Activity |
IC50 = 100000 nM
|
[3] | |||
| Compound Name |
2-Mercapto-3-phenylpyrido[2,3-d]pyrimidin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1927732; 3-phenyl-2-sulfanyl-3H,4H-pyrido[2,3-d]pyrimidin-4-one; Pyrido[2,3-d]pyrimidin-4(1H)-one,2,3-dihydro-3-phenyl-2-thioxo-; 3-phenyl-2-thioxo-1H-pyrido[3,2-e]pyrimidin-4-one; SCHEMBL9385552; CTK4C2581; DTXSID30526263; BDBM50463613; ZINC12505242; AKOS001354687; AKOS016874068; MCULE-4066581615; NE57339; Propyl (3,4-dichlorophenyl)carbamodithioate; EN300-26511; Z55664353; 3-PHENYL-2-SULFANYLIDENE-1H-PYRIDO[2,3-D]PYRIMIDIN-4-ONE; 3-phenyl-2-thioxo-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one; 3-Phenyl-2-sulfanylidene-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one; 3-phenyl-2-sulfanylidene-2H,3H,4H,8H-pyrido[2,3-d]pyrimidin-4-one
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Aminopropanenitrile
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Investigative | Compound Info | ||
| Synonyms |
3-aminopropionitrile; 2-Cyanoethylamine; Aminopropionitrile; BETA-AMINOPROPIONITRILE; Propanenitrile, 3-amino-; 3-Aminopropiononitrile; beta-Cyanoethylamine; beta-Alaninenitrile; Propionitrile, 3-amino-; beta-Aminoethyl cyanide; beta-Alaminenitrile; UNII-38D5LJ4KH2; NSC 40641; 3-amino-propionitrile; .beta.-Alaninenitrile; .beta.-Cyanoethylamine; .beta.-Aminopropionitrile; H2NCH2CH2CN; MFCD00014820; 38D5LJ4KH2; CHEMBL1618272; 3-Aminopropionitrile, 98%, stabilized; HSDB 2897; EINECS 205-786-0; BRN 1698848; cyanoethylamine; aminoethylcyanide; b-Alaminenitrile; b-Alaninenitrile; CCRIS 8134; b-Cyanoethylamine; 3-Aminopropanitrile; EINECS 268-598-8; b-Aminoethyl cyanide; 3-aminopropanonitrile; Propanenitrile, 3-amino-, N-C11-13-isoalkyl derivs.; n-(2-cyanoethyl)amine; PubChem19134; beta-amino propionitrile; beta-amino-propionitrile; (C12-C18)Alkyl alkoxyethyleneaminonitrile; Lopac-A-3134; .beta.-Aminoethyl cyanide; (C11-C13)Branched alkyl aminoethylenenitrile; WLN: Z2CN; ACMC-1B8B9; Lopac0_000055; C(#N)CC[N]; DTXSID6048418; AGSPXMVUFBBBMO-UHFFFAOYSA-; CTK3J0853; KS-00000UZX; 3-amino-propionitrile, AldrichCPR; SODIUMBITARTRATE,MONOHYDRATE; CS-D1507; HY-Y1750; NSC40641; STR02529; ZINC1530259; ANW-43145; BBL101609; BDBM50232678; NSC-40641; Propanenitrile, 3-amino-, N-(3-(C12-18-alkyloxy)propyl) derivs.; STL555405; AKOS000121388; NCGC00015048-01; NCGC00015048-02; NCGC00015048-03; NCGC00015048-05; NCGC00162054-01; SC-15686; 3-Aminopropionitrile stabilized with K2CO3; A0408; FT-0615060; C05670; 97104-EP2298731A1; 97104-EP2305660A1; Q3614347; W-109080
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3R)-3-[4-(Aminomethyl)-6-(trifluoromethyl)pyridin-2-yl]oxy-N-phenylpiperidine-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4081837; SCHEMBL18050094; BDBM50266812
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-(3,5-Diethoxypyridin-4-yl)methanamine dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL537401
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| Activity |
IC50 > 1000000 nM
|
[3] | |||
| Compound Name |
1-[3-(Benzyloxy)-5-ethoxypyridin-4-yl]methanamine dihydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL536951
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| Activity |
IC50 > 1000000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Inhibition of the LOX enzyme family members with old and new ligands. Selectivity analysis revisited. Bioorg Med Chem Lett. 2018 Oct 1;28(18):3113-3118. | ||||
| REF 2 | Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2). J Med Chem. 2017 May 25;60(10):4403-4423. | ||||
| REF 3 | Alkylamino derivatives of 4-aminomethylpyridine as inhibitors of copper-containing amine oxidases. J Med Chem. 2005 Feb 10;48(3):664-70. | ||||
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