Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T88304 Target Info
Target Name DNA [cytosine-5]-methyltransferase 1 (DNMT1)
Synonyms MCMT; M.HsaI; Dnmt1; DNMT; DNA methyltransferase HsaI; DNA MTase HsaI; DNA (cytosine5)methyltransferase 1; DNA (cytosine-5)-methyltransferase 1; CXXCtype zinc finger protein 9; CXXC9; CXXC-type zinc finger protein 9; AIM
Target Type Clinical trial Target
Gene Name DNMT1
Biochemical Class Methyltransferase
UniProt ID
DNMT1_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
World Intellectual Property Organization (WIPO)
Patent ID WO2015073360
Title Dnmt Inhibitors.
Abstract RNA molecules inhibiting a DNMT and methods and compositions incorporating or generating the RNA molecules are described.
Applicant(s) New England Biolabs Inc
Representative Drug(s) D01CGQ Drug Info Ki = 27.88 nM Click to Show More [1]
2 D0E7OA Drug Info Ki = 135.2 nM [1]
3 D0KE4E Drug Info Ki = 434.1 nM [1]
4 D0LK4R Drug Info Ki = 917.5 nM [1]
5 D0G6ON Drug Info Ki = 2003 nM [1]
Patent ID WO2014011573
Title Oligonucleotide Inhibitors of Dna Methyltransferases and Their Use In Treating Diseases.
Abstract Modified oligonucleotides comprising CpG sites, wherein the cytosine is replaced by cytosine analogs are provided as well as methods of making the oligonucleotides and their use in inhibiting DNA Methyltransferase, inhibiting or reversing methylation of genes and in treating cancer, tumorigenesis and hyper-proliferative disorders.
Applicant(s) Metheor Therapeutics Corporation
Representative Drug(s) D0U5CK Drug Info IC50 = 4.22 nM Click to Show More [1]
2 D0HA0J Drug Info IC50 = 295 nM [1]
3 D0W9VZ Drug Info IC50 = 363 nM [1]
4 D0QY0N Drug Info IC50 = 1430 nM [1]
5 D02WRM Drug Info IC50 = 1940 nM [1]
Patent ID WO2014072371
Title Indole Derivatives, Pharmaceutical Compositions Containing Such Indoles and Their Use As Dna Methylation Modulators.
Abstract The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer hematological malignancy, proliferative diseases, genetic diseases, neurological disorders and immunological disorders.
Applicant(s) Ikerchem Sl
Representative Drug(s) D09FMS Drug Info IC50(DNMT1) = 3530 nM Click to Show More [1]
2 D0RT6C Drug Info IC50 = 6850 nM [1]
3 D0K4YF Drug Info IC50 = 13810 nM [1]
4 D05DSL Drug Info IC50 = 22520 nM [1]
5 D04JIH Drug Info IC50 = 39440 nM [1]
6 D0YK6K Drug Info N.A. [1]
References  Top
REF 1 DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30.

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