Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T85115 Target Info
Target Name Prokineticin receptor-1 (PROKR1)
Synonyms Prokineticin receptor 1; PROKR1; Gprotein coupled receptor ZAQ; Gprotein coupled receptor 73; GPR73a
Target Type Patented-recorded Target
Gene Name PROKR1
Biochemical Class GPCR rhodopsin
UniProt ID
PKR1_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
United States Patent and Trademark Office (USPTO)
Patent ID US9475795
Title Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases
Abstract The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof: (I) in which m, n, W, X, Y, Z, R1, R2, R3 and R4 are as defined in the specification, for use in the treatment or prevention of a diseases o conition mediated by a prokineticin, such as psychiatric and neurological conditions.
Applicant(s) Takeda Pharmaceutical Company Limited
Representative Drug(s) D0U5VO Drug Info IC50 = 410 nM Click to Show More [1]
2 D00LHT Drug Info IC50 = 810 nM [1]
3 D0X1ZY Drug Info IC50 = 5600 nM [1]
Patent ID US9475795
Title Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases
Abstract The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof: (I) in which m, n, W, X, Y, Z, R1, R2, R3 and R4 are as defined in the specification, for use in the treatment or prevention of a diseases o conition mediated by a prokineticin, such as psychiatric and neurological conditions.
Applicant(s) Takeda Pharmaceutical Company Limited
Representative Drug(s) D0U5VO Drug Info IC50 = 410 nM Click to Show More [1]
2 D00LHT Drug Info IC50 = 810 nM [1]
3 D0X1ZY Drug Info IC50 = 5600 nM [1]
Patent ID US9475795
Title Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases
Abstract The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof: (I) in which m, n, W, X, Y, Z, R1, R2, R3 and R4 are as defined in the specification, for use in the treatment or prevention of a diseases o conition mediated by a prokineticin, such as psychiatric and neurological conditions.
Applicant(s) Takeda Pharmaceutical Company Limited
Representative Drug(s) D0U5VO Drug Info IC50 = 410 nM Click to Show More [1]
2 D00LHT Drug Info IC50 = 810 nM [1]
3 D0X1ZY Drug Info IC50 = 5600 nM [1]
Patent ID US10167273
Title Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases
Abstract The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof in which q, R11, R12, R13 and R14 are as defined in the specification, for use in therapy.
Applicant(s) Takeda Pharmaceutical Company Limited
Representative Drug(s) D04LJF Drug Info IC50 = 3730 nM [2]
References  Top
REF 1 Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases. US9475795.
REF 2 Sulfonyl piperidine derivatives and their use for treating prokineticin mediated diseases. US10167273.

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