Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T84486 Target Info
Target Name Oxytocin receptor (OTR)
Synonyms OT-R
Target Type Successful Target
Gene Name OXTR
Biochemical Class GPCR rhodopsin
UniProt ID
OXYR_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
United States Patent and Trademark Office (USPTO)
Patent ID US20170114040
Title Substituted Triazole Derivatives As Oxytocin Antagonists.
Applicant(s) Ixchelsis Limited
Representative Drug(s) D0RF1V Drug Info IC50 = 1.8 nM Click to Show More [1]
2 D03AOX Drug Info IC50 = 4.2 nM [1]
3 D0J5QP Drug Info IC50 = 9 nM [1]
4 D02CAU Drug Info IC50 = 14 nM [1]
Patent ID US20150073032
Title Pyrrolidine Derivatives As Oxytocin/Vasopressin 1A Receptors Antagonists.
Applicant(s) Obseva Sa
Representative Drug(s) D0BU3L Drug Info IC50 = 81 nM; Ki = 52 nM Click to Show More [1]
2 D03ZGF Drug Info N.A. [1]
3 D0J5IB Drug Info N.A. [1]
4 D0LW9R Drug Info N.A. [1]
5 D0N4RI Drug Info N.A. [1]
Patent ID US20150072995
Title Treatment of Male Sexual Dysfunction.
Applicant(s) Ixchelsis Ltd
Representative Drug(s) D0H0QR Drug Info IC50 = 6.3 nM [1]
Patent ID US9579305
Title Oxytocin Receptor Antagonist Therapy In The Luteal Phase for Implantation and Pregnancy In Women Undergoing Assisted Reproductive Technologies.
Applicant(s) Ferring Bv
Patent ID US8071594
Title Substituted Diketopiperazines and Their Use As Oxytocin Antagonists.
Applicant(s) Glaxo Group Limited
Patent ID US5726172
Title Tocolytic Oxytocin Receptor Antagonists.
Applicant(s) Merck & Co., Inc
References  Top
REF 1 A patent review of oxytocin receptor antagonists 2013-2017.Expert Opin Ther Pat. 2017 Dec;27(12):1287-1290.

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