Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T59190 Target Info
Target Name Protein kinase C zeta (PRKCZ)
Synonyms Protein kinase C zeta type; PKC2; NPKC-zeta
Target Type Patented-recorded Target
Gene Name PRKCZ
Biochemical Class Kinase
UniProt ID
KPCZ_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
United States Patent and Trademark Office (USPTO)
Patent ID US8889696
Title Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof
Abstract Compounds useful as antiproliferative agents according to Formula (I), wherein n, A, R1, R2, and Ar1 are as defined herein, and salts thereof; antibody conjugates, pharmaceutical compositions, methods of treatment, and synthetic methods are provided.
Applicant(s) Temple University—Of The Commonwealth System Of Higher Education
Representative Drug(s) D0T2KT Drug Info IC50 > 10000nM [1]
Patent ID US8889696
Title Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof
Abstract Compounds useful as antiproliferative agents according to Formula (I), wherein n, A, R1, R2, and Ar1 are as defined herein, and salts thereof; antibody conjugates, pharmaceutical compositions, methods of treatment, and synthetic methods are provided.
Applicant(s) Temple University—Of The Commonwealth System Of Higher Education
Representative Drug(s) D0T2KT Drug Info IC50 > 10000nM [1]
Patent ID US8889672
Title Compounds, formulations, and methods of protein kinase C inhibition
Abstract The invention provides a method of inhibiting atypical protein kinase C (aPKC) comprising contacting an aPKC with a compound having a structure selected from the group consisting of structural formulas (I) to (IX). The invention further provides a method of inhibiting or reducing vascular permeability. The method comprising administering to a subject a composition comprising an amount of a compound having a structure selected from the group consisting of structural formulas (I) to (IX) effective to inhibit or reduce vascular permeability. A method of treating or preventing a disease or disorder characterized by abnormal vascular permeability, a method of inhibiting angiogenesis, a method of inhibiting cancer cell proliferation, a formulation, and a method of preparing a formulation also are provided.
Applicant(s) The Regents of The University of Michigan; The Penn State Research Foundation
Representative Drug(s) D0Y7KX Drug Info IC50 = 6000 nM Click to Show More [2]
2 D0CV8T Drug Info IC50 = 6000 nM [2]
3 D03VKC Drug Info IC50 = 62000 nM [2]
Patent ID US8889672
Title Compounds, formulations, and methods of protein kinase C inhibition
Abstract The invention provides a method of inhibiting atypical protein kinase C (aPKC) comprising contacting an aPKC with a compound having a structure selected from the group consisting of structural formulas (I) to (IX). The invention further provides a method of inhibiting or reducing vascular permeability. The method comprising administering to a subject a composition comprising an amount of a compound having a structure selected from the group consisting of structural formulas (I) to (IX) effective to inhibit or reduce vascular permeability. A method of treating or preventing a disease or disorder characterized by abnormal vascular permeability, a method of inhibiting angiogenesis, a method of inhibiting cancer cell proliferation, a formulation, and a method of preparing a formulation also are provided.
Applicant(s) The Regents of The University of Michigan; The Penn State Research Foundation
Representative Drug(s) D0Y7KX Drug Info IC50 = 6000 nM Click to Show More [2]
2 D0CV8T Drug Info IC50 = 6000 nM [2]
3 D03VKC Drug Info IC50 = 62000 nM [2]
Patent ID US8889672
Title Compounds, formulations, and methods of protein kinase C inhibition
Abstract The invention provides a method of inhibiting atypical protein kinase C (aPKC) comprising contacting an aPKC with a compound having a structure selected from the group consisting of structural formulas (I) to (IX). The invention further provides a method of inhibiting or reducing vascular permeability. The method comprising administering to a subject a composition comprising an amount of a compound having a structure selected from the group consisting of structural formulas (I) to (IX) effective to inhibit or reduce vascular permeability. A method of treating or preventing a disease or disorder characterized by abnormal vascular permeability, a method of inhibiting angiogenesis, a method of inhibiting cancer cell proliferation, a formulation, and a method of preparing a formulation also are provided.
Applicant(s) The Regents of The University of Michigan; The Penn State Research Foundation
Representative Drug(s) D0Y7KX Drug Info IC50 = 6000 nM Click to Show More [2]
2 D0CV8T Drug Info IC50 = 6000 nM [2]
3 D03VKC Drug Info IC50 = 62000 nM [2]
References  Top
REF 1 Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof. US8889696.
REF 2 Compounds, formulations, and methods of protein kinase C inhibition. US8889672.

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