Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T21507 Target Info
Target Name Fatty acid-binding protein 5 (FABP5)
Synonyms Psoriasis-associated fatty acid-binding protein homolog; PA-FABP; Fatty acid-binding protein, epidermal; Fatty Acid BindingProtein mal1; Epidermal-type fatty acid-binding protein; E-FABP
Target Type Patented-recorded Target
Gene Name FABP5
Biochemical Class Fatty acid binding protein
UniProt ID
FABP5_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
World Intellectual Property Organization (WIPO)
Patent ID WO2014146995
Title Urea Derivatives and Their Use As Fatty-Acid Binding Protein (Fabp) Inhibitors.
Abstract The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, W, A and B are as described herein, compositions including the compounds and methods of using the compounds.
Applicant(s) F. Hoffmann-La Roche Ag
Representative Drug(s) D01TJW Drug Info IC50 = 3790 nM Click to Show More [1]
2 D00RDL Drug Info IC50 = 6350 nM [1]
3 D03CJT Drug Info IC50 = 13670 nM [1]
4 D05XAT Drug Info IC50 = 19560 nM [1]
5 D00KCT Drug Info IC50 = 23620 nM [1]
United States Patent and Trademark Office (USPTO)
Patent ID US2014029723
Title Compositions, formulations and Methods for Treating Ocular Diseases.
Representative Drug(s) D0CT9O Drug Info IC50 = 20 nM Click to Show More [1]
2 D01NVM Drug Info IC50 = 30 nM [1]
3 D0SK0L Drug Info IC50 = 40 nM [1]
4 D0R9RK Drug Info IC50 = 66 nM [1]
5 D08IIV Drug Info IC50 = 90 nM [1]
6 D0U2SI Drug Info IC50 = 1240 nM [1]
Patent ID US20130116234
Title Aryl-Quinoline Derivatives.
Representative Drug(s) D06JEA Drug Info IC50 = 51.2 nM Click to Show More [1]
2 D0RZ9C Drug Info IC50 = 62.3 nM [1]
3 D07PLJ Drug Info IC50 = 63.8 nM [1]
4 D05WXM Drug Info IC50 = 79.8 nM [1]
5 D01CDK Drug Info IC50 = 96.1 nM [1]
6 D01GOO Drug Info IC50 = 182 nM [1]
7 D0ND3H Drug Info IC50 = 183 nM [1]
8 D08SNH Drug Info IC50 = 314 nM [1]
9 D09VOD Drug Info IC50 = 4786 nM [1]
References  Top
REF 1 Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76.

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