Target and Its Patented Drug(s)
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T16685 | Target Info | |||
| Target Name | RET G691S mutant (RET G691S) | ||||
| Synonyms | RET51 G691S mutant; Proto-oncogene tyrosine-protein kinase receptor Ret G691S mutant; Proto-oncogene c-Ret G691S mutant; PTC G691S mutant; Cadherin family member 12 G691S mutant; CDHR16 G691S mutant; CDHF12 G691S mutant | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | RET | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Patent(s) and the Corresponding Patented Drug(s) | Top | ||||
|---|---|---|---|---|---|
| World Intellectual Property Organization (WIPO) | |||||
| Patent ID | WO2014050781 | ||||
| Title | Ret Inhibitor. | ||||
| Abstract | A compound represented by general formula (I) (the symbols in the formula are as defined in the description), a salt thereof, or the like is a RET inhibitor or RET tyrosine kinase inhibitor that can be used as an agent for the prevention or treatment of disorders including cancers and cancer metastases having mutations in RET. | ||||
| Applicant(s) | Chugai Pharmaceutical Co., Ltd | ||||
| Representative Drug(s) | D0O9JD | Drug Info | IC50 = 9.5 nM | [1] | |
| United States Patent and Trademark Office (USPTO) | |||||
| Patent ID | US20140272958 | ||||
| Title | Ret Inhibitor. | ||||
| Applicant(s) | Chugai Pharmaceutical | ||||
| Representative Drug(s) | D0O9JD | Drug Info | IC50 = 9.5 nM | [1] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. | ||||
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