Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0O9JD
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| Drug Name |
Benzo(b)carbazol-11-one compound 2
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| Synonyms |
PMID27646564-Compound-10-1
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|
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| Drug Type |
Small molecular drug
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| Company |
Chugai Pharmaceutical
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| Structure |
 |
Download2D MOL |
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Proto-oncogene c-Ret (RET) | Target Info | Inhibitor | [1] |
| RET G691S mutant (RET G691S) | Target Info | Inhibitor | [1] | |
| RET M918T mutant (RET M918T) | Target Info | Inhibitor | [1] | |
| RET S891A mutant (RET S891A) | Target Info | Inhibitor | [1] | |
| RET V804L mutant (RET V804L) | Target Info | Inhibitor | [1] | |
| RET V804M mutant (RET V804M) | Target Info | Inhibitor | [1] | |
| RET Y791F mutant (RET Y791F) | Target Info | Inhibitor | [1] | |
| Target's Patent Info | Proto-oncogene c-Ret (RET) | Target's Patent Info | [1] | |
| RET G691S mutant (RET G691S) | Target's Patent Info | [1] | ||
| RET M918T mutant (RET M918T) | Target's Patent Info | [1] | ||
| RET S891A mutant (RET S891A) | Target's Patent Info | [1] | ||
| RET V804L mutant (RET V804L) | Target's Patent Info | [1] | ||
| RET V804M mutant (RET V804M) | Target's Patent Info | [1] | ||
| RET Y791F mutant (RET Y791F) | Target's Patent Info | [1] | ||
| KEGG Pathway | Endocytosis | |||
| Pathways in cancer | ||||
| Thyroid cancer | ||||
| Central carbon metabolism in cancer | ||||
| Pathway Interaction Database | Signaling events regulated by Ret tyrosine kinase | |||
| Posttranslational regulation of adherens junction stability and dissassembly | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Dopaminergic Neurogenesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | RET kinase inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jan;27(1):91-99. | |||
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