Target and Its Patented Drug(s)
Target General Information | Top | ||||
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Target ID | T07217 | Target Info | |||
Target Name | Fatty acid-binding protein 4 (FABP4) | ||||
Synonyms | Fatty acid-binding protein, adipocyte; Adipocyte-type fatty acid-binding protein; Adipocyte lipid-binding protein; Adipocyte fatty-acid-binding protein; Adipocyte fatty binding protein; ALBP; AFABP; A-FABP | ||||
Target Type | Patented-recorded Target | ||||
Gene Name | FABP4 | ||||
Biochemical Class | Fatty acid binding protein | ||||
UniProt ID |
Patent(s) and the Corresponding Patented Drug(s) | Top | ||||
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World Intellectual Property Organization (WIPO) | |||||
Patent ID | WO2014146995 | ||||
Title | Urea Derivatives and Their Use As Fatty-Acid Binding Protein (Fabp) Inhibitors. | ||||
Abstract | The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, W, A and B are as described herein, compositions including the compounds and methods of using the compounds. | ||||
Applicant(s) | F. Hoffmann-La Roche Ag | ||||
Representative Drug(s) | D01TJW | Drug Info | IC50 = 50 nM | Click to Show More | [1] |
2 | D03CJT | Drug Info | IC50 = 100 nM | [1] | |
3 | D05XAT | Drug Info | IC50 = 140 nM | [1] | |
4 | D00KCT | Drug Info | IC50 = 150 nM | [1] | |
5 | D00RDL | Drug Info | IC50 = 520 nM | [1] | |
United States Patent and Trademark Office (USPTO) | |||||
Patent ID | US8889683 | ||||
Title | Substituted Quinoxalines As Inhibitors of Fatty Acid Binding Protein. | ||||
Representative Drug(s) | D0Q9LM | Drug Info | Kd = 0.1 nM | Click to Show More | [1] |
2 | D0L4EU | Drug Info | Kd = 7100 nM | [1] | |
3 | D0MO1P | Drug Info | Kd = 323360 nM | [1] | |
4 | D08SLP | Drug Info | Kd = 340430 nM | [1] | |
5 | D05UGS | Drug Info | Kd = 377400 nM | [1] | |
Patent ID | US2014029723 | ||||
Title | Compositions, formulations and Methods for Treating Ocular Diseases. | ||||
Representative Drug(s) | D0R9RK | Drug Info | IC50 = 10 nM | Click to Show More | [1] |
2 | D0SK0L | Drug Info | IC50 = 10 nM | [1] | |
3 | D01NVM | Drug Info | IC50 = 20 nM | [1] | |
4 | D0CT9O | Drug Info | IC50 = 20 nM | [1] | |
5 | D0U2SI | Drug Info | IC50 = 110 nM | [1] | |
6 | D08IIV | Drug Info | IC50 = 1290 nM | [1] | |
Patent ID | US20130116234 | ||||
Title | Aryl-Quinoline Derivatives. | ||||
Representative Drug(s) | D06JEA | Drug Info | IC50 = 13.2 nM | Click to Show More | [1] |
2 | D0RZ9C | Drug Info | IC50 = 13.3 nM | [1] | |
3 | D05WXM | Drug Info | IC50 = 16.5 nM | [1] | |
4 | D07PLJ | Drug Info | IC50 = 25 nM | [1] | |
5 | D01CDK | Drug Info | IC50 = 32.6 nM | [1] | |
6 | D0ND3H | Drug Info | IC50 = 36.1 nM | [1] | |
7 | D08SNH | Drug Info | IC50 = 42.3 nM | [1] | |
8 | D09VOD | Drug Info | IC50 = 42.4 nM | [1] | |
9 | D01GOO | Drug Info | IC50 = 45.4 nM | [1] |
References | Top | ||||
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REF 1 | Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):767-76. |
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