Patent(s) and the Corresponding Patented Drug(s) |
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World Intellectual Property Organization (WIPO) |
Patent ID |
WO2013074986 |
Title |
Inhibitors of C-Jun-N-Terminal Kinase (Jnk). |
Abstract |
The present invention provides novel compounds according to Formula (I): where Ring A, Ring B, X, L1, L2, RA, RC, RD, RE, m, n, and p are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of human diseases associated with kinase activity, for example, proliferative diseases, neurodegenerative diseases, metabolic disorders, inflammatory diseases, and cardiovascular diseases. |
Applicant(s) |
Dana-Farber Cancer Institute, Inc |
Representative Drug(s) |
D0ZU8L |
Drug Info
|
IC50 = 0.5 nM |
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[1] |
2
|
D08JOC
|
Drug Info
|
IC50 = 0.8 nM
|
[1] |
3
|
D0RQ8Q
|
Drug Info
|
IC50 = 1 nM
|
[1] |
Patent ID |
WO2010091310 |
Title |
Inhibitors of Jun N-Terminal Kinase. |
Abstract |
The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula (I): or a salt or solvate thereof, wherein ring A, Ca, Cb, Z, R5, W and Cy are defined herein. The disclosure further provides pharmaceutical compositions including the compounds of the present disclosure and methods of making and using the compounds and compositions of the present disclosure, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease. |
Applicant(s) |
Elan Pharmaceuticals, Inc |
Representative Drug(s) |
D0X2SG |
Drug Info
|
IC50 = 6 nM |
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[1] |
2
|
D0W8BL
|
Drug Info
|
IC50 = 9 nM
|
[1] |
3
|
D08DNZ
|
Drug Info
|
IC50 = 11 nM
|
[1] |
4
|
D0L2MS
|
Drug Info
|
IC50 = 2200 nM
|
[1] |
Patent ID |
WO2010015803 |
Title |
Diazaindole Derivatives and Their Use In The Inhibition of C-Jun N-Terminal Kinase. |
Abstract |
The invention relates to diazaindole derivatives represented by the general formula (I): where A, E, G, R1, R2, R3 and R4 are defined herein, or pharmaceutically acceptable salts thereof, their use in the inhibition of c-Jun N-terminal kinase (JNK) activity, their use in medicine and particularly in the treatment of neurodegenerative disorders, inflammatory diseases, autoimmune diseases and/or organ failure. The invention also provides processes for the manufacture of said diazaindole derivatives and compositions containing them. |
Applicant(s) |
Eisai R & D Management Co. Ltd |
Representative Drug(s) |
D05SJB |
Drug Info
|
IC50 = 32 nM |
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[1] |
2
|
D07KMK
|
Drug Info
|
IC50 = 40 nM
|
[1] |
3
|
D0VR1O
|
Drug Info
|
IC50 = 85 nM
|
[1] |
4
|
D0T6IZ
|
Drug Info
|
IC50 = 129 nM
|
[1] |
5
|
D04BIF
|
Drug Info
|
IC50 = 178 nM
|
[1] |
6
|
D0U9RB
|
Drug Info
|
IC50 = 1700 nM
|
[1] |
7
|
D0JB7I
|
Drug Info
|
IC50 > 2000 nM
|
[1] |
Patent ID |
WO2008095944 |
Title |
7-Azaindole Derivatives and Their Use In The Inhibition of C-Jun N-Terminal Kinase. |
Abstract |
The present invention provides a compound of formula (I); or a pharmaceutically acceptable salt thereof, the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in the inhibition of c-Jun N-terminal kinase (JNK) activity and the use in medicine and particularly in the treatment of neurodegenerative disorders, inflammatory diseases and/or and autoimmune diseases. The invention also provides processes for the manufacture of said compounds of formula (I) or a pharmaceutically acceptable salt thereof and compositions containing them. |
Applicant(s) |
Eisai R & D Management Co. Ltd |
Representative Drug(s) |
D05SJB |
Drug Info
|
IC50 = 32 nM |
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[1] |
2
|
D07KMK
|
Drug Info
|
IC50 = 40 nM
|
[1] |
3
|
D0VR1O
|
Drug Info
|
IC50 = 85 nM
|
[1] |
4
|
D0T6IZ
|
Drug Info
|
IC50 = 129 nM
|
[1] |
5
|
D04BIF
|
Drug Info
|
IC50 = 178 nM
|
[1] |
6
|
D0U9RB
|
Drug Info
|
IC50 = 1700 nM
|
[1] |
7
|
D0JB7I
|
Drug Info
|
IC50 > 2000 nM
|
[1] |
Patent ID |
WO2013091670 |
Title |
Novel Jnk Inhibitor Molecules for Treatment of Various Diseases. |
Abstract |
The present invention relates to the use of novel JNK inhibitor molecules and their use in a method of treatment of the human or animal body by therapy. |
Applicant(s) |
COMBETTE, Jean-Marc et al |
Representative Drug(s) |
D0Q4WA |
Drug Info
|
IC50 = 103 nM |
[1] |
Patent ID |
WO2011071491 |
Title |
Isotopologues of 4-[9-(Tetrahydro-Furan-3-Yl)-8-(2, 4, 6- Trifluoro-Phenylamino)-9H-Purin-2-Ylamino]-Cyclohexan-1-Ol. |
Abstract |
Provided herein are isotopologues of Compound 1, which are enriched with isotopes such as, for example, deuterium. Pharmaceutical compositions comprising the isotope-enriched compounds, and methods of using such compounds are also provided. |
Applicant(s) |
Signal Pharmaceuticals |
Representative Drug(s) |
D06JRV |
Drug Info
|
IC50 = 6 nM |
[1] |
Patent ID |
WO2010069833 |
Title |
Pyrimidin- 2 -Ylamino Derivatives and Their Use To Treat Inflammation. |
Abstract |
Compounds of formula (I) modulate JNK wherein X1 and X2 are each simultaneously N or CH; X3 is CH-R2 or N-SO2R, where R is lower alkyl; R1 is aryl or heteroaryl, substituted with 0-3 lower alkyl radicals; R2 is formula (II), where R3 is H, lower acyl, or an amino acid, or a pharmaceutically acceptable salt thereof. |
Applicant(s) |
F. Hoffmann-La Roche Ag |
Representative Drug(s) |
D0H4HD |
Drug Info
|
IC50 = 114 nM |
[1] |
Patent ID |
WO2008028860 |
Title |
Benzotriazole Kinase Modulators. |
Abstract |
The invention is concerned with novel benzotriazole derivatives of Formula (I) Wherein R, R1, R2, R3, and m are as defined in the description and the claims, as well as physiologically acceptable salts thereof. These compounds are JNK and CDK modulators. |
Applicant(s) |
F. Hoffmann-La Roche Ag |
Representative Drug(s) |
D0H4HD |
Drug Info
|
IC50 = 114 nM |
[1] |