miRNA General Information
miRNA Mature ID hsa-miR-92b-3p
miRNA Stemloop AC MI0003560
miRNA Stemloop ID hsa-mir-92b
Sequence uauugcacucgucccggccucc
TTD Target(s) Regulated by This miRNA Integrin alpha-V (ITGAV) Clinical trial Target Target Info [1]
Protein arginine methyltransferase 5 (PRMT5) Clinical trial Target Target Info [2]
Dickkopf-related protein 3 (DKK3) Clinical trial Target Target Info [3]
Phosphatase and tensin homolog (PTEN) Literature-reported Target Target Info [4]
Integrin alpha-6 (ITGA6) Literature-reported Target Target Info [5]
Solute carrier family 15 member 1 (SLC15A1) Literature-reported Target Target Info [6]
CDK inhibitor 1C p57Kip2 (CDKN1C) Literature-reported Target Target Info [7]
Suppressor of tumorigenicity 15 protein (ST15) Literature-reported Target Target Info [8]
Mothers against decapentaplegic homolog 3 (SMAD3) Preclinical Target Target Info [9]
Protein(s) Regulated by This miRNA Disabled homolog 2-interacting protein Regulated Protein [10]
Ras-related protein Rab-23 Regulated Protein [11]
Serine/threonine-protein kinase NLK Regulated Protein [12]
REF 1 MicroRNA-92b represses invasion-metastasis cascade of esophageal squamous cell carcinoma. Oncotarget. 2016 Apr 12;7(15):20209-22.
REF 2 Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells. Mol Cell Biol. 2008 Oct;28(20):6262-77.
REF 3 MiR-92b inhibitor promoted glioma cell apoptosis via targeting DKK3 and blocking the Wnt/beta-catenin signaling pathway. J Transl Med. 2013 Dec 11;11:302.
REF 4 EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency. EMBO J. 2012 May 2;31(9):2207-21.
REF 5 Integrin 6 promotes esophageal cancer metastasis and is targeted by miR-92b. Oncotarget. 2017 Jan 24;8(4):6681-6690.
REF 6 MicroRNA-92b regulates expression of the oligopeptide transporter PepT1 in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2011 Jan;300(1):G52-9.
REF 7 MicroRNAs 221 and 222 bypass quiescence and compromise cell survival. Cancer Res. 2008 Apr 15;68(8):2773-80.
REF 8 Inhibition of miR-92b suppresses nonsmall cell lung cancer cells growth and motility by targeting RECK. Mol Cell Biochem. 2014 Feb;387(1-2):171-6.
REF 9 The miR-92b functions as a potential oncogene by targeting on Smad3 in glioblastomas. Brain Res. 2013 Sep 5;1529:16-25.
REF 10 miR-92b targets DAB2IP to promote EMT in bladder cancer migration and invasion.Oncol Rep. 2016 Sep;36(3):1693-701.
REF 11 RAB23, regulated by miR-92b, promotes the progression of esophageal squamous cell carcinoma.Gene. 2016 Dec 20;595(1):31-38.
REF 12 miR-92b controls glioma proliferation and invasion through regulating Wnt/beta-catenin signaling via Nemo-like kinase.Neuro Oncol. 2013 May;15(5):578-88.

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