miRNA General Information
miRNA Mature ID hsa-miR-630
miRNA Stemloop AC MI0003644
miRNA Stemloop ID hsa-mir-630
Sequence aguauucuguaccagggaaggu
TTD Target(s) Regulated by This miRNA Insulin-like growth factor I receptor (IGF1R) Successful Target Target Info [1]
Apoptosis regulator Bcl-2 (BCL-2) Successful Target Target Info [2]
Apoptosis regulator Bcl-W (BCL-W) Clinical trial Target Target Info [3]
Forkhead box protein M1 (FOXM1) Literature-reported Target Target Info [4]
Metastasis adhesion protein (MTDH) Literature-reported Target Target Info [5]
Yes-associated protein 1 (YAP1) Literature-reported Target Target Info [6]
Protein(s) Regulated by This miRNA Dual specificity protein phosphatase CDC14A Regulated Protein [7]
EKC/KEOPS complex subunit TP53RK Regulated Protein [8]
Zinc finger protein SNAI2 Regulated Protein [9]
References
REF 1 Upregulation of miR-150* and miR-630 induces apoptosis in pancreatic cancer cells by targeting IGF-1R. PLoS One. 2013 May 10;8(5):e61015.
REF 2 miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13944-9.
REF 3 miR-122 targets an anti-apoptotic gene, Bcl-w, in human hepatocellular carcinoma cell lines. Biochem Biophys Res Commun. 2008 Oct 24;375(3):315-20.
REF 4 MicroRNA-630 Suppresses Epithelial-to-Mesenchymal Transition by Regulating FoxM1 in Gastric Cancer Cells. Biochemistry (Mosc). 2017 Jun;82(6):707-714.
REF 5 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins. Nat Methods. 2011 May 15;8(7):559-64.
REF 6 Phospho-Np63 is a key regulator of the cisplatin-induced microRNAome in cancer cells. Cell Death Differ. 2011 Jul;18(7):1220-30.
REF 7 Inhibition of miR-630 enhances the cell resistance to radiation by directly targeting CDC14A in human glioma. Am J Transl Res. 2017 Mar 15;9(3):1255-1265.
REF 8 Novel Epigenetic CREB-miR-630 Signaling Axis Regulates Radiosensitivity in Colorectal Cancer. PLoS One. 2015 Aug 11;10(8):e0133870.
REF 9 Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility.J Clin Invest. 2013 Mar;123(3):1082-95.

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